Project

Design and synthesis of cyclic peptides with improved therapeutic potential by molecular grafting of peptide loop sequences onto steroid scaffolds

Duration
01 October 2015 → 28 February 2019
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
Keywords
cyclic peptides bioavailability protein-protein interactions bile acids peptide based drug
 
Project description

We here aim to develop a new “CLIPS”-like strategy towards cyclic steroid-based peptides based components which can be applied for interference with protein-protein interactions. Cysteine-flanked biologically active peptides will be grafted onto a steroid derivative. Besides conformational restriction of the peptide, we aim at increasing the bioavailability .