The PrOFS project envisions a systemic change, enabled by the close collaboration of a broad range of leading scientists and the main stakeholders regarding the fight against fraud in sports in Flanders. For the first time, a multidisciplinary project is presented that not only investigates the complex nature of fraud in sports, but also uses scientific methods to develop and test practical tools and solutions in optimizing the fight against fraud in sports. Particular focus is put on those types of fraud in sports (i.e. match-fixing, human trafficking, bribery, and financial and social fraud, including money laundering) that are most strongly present, yet lack an integrated counter approach.