Research Explorer

Project

Dissection of the cis-regulatory landscape of FOXL2 in development and disease
Code
3E020614
Duration
01 October 2014 → 31 May 2020
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Genetics
    • Systems biology
  • Medical and health sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
    • Gynaecology and obstetrics
    • Molecular and cell biology
    • Morphological sciences
Keywords
developmental disorders
 
Project description
 

Studies of individuals with a genetic disease lacking coding mutations but with a non-coding genetic defect provided many insights into the function of cis-regulatory elements. An example of this is FOXL2, encoding a forkhead transcription factor playing a role in ovarian development. Here we aim to dissect the cis-regulatory landscape of FOXL2 and to identify and validate ovary-specific enhancers