Models of portal hypertension and cirrhosis are used to study the role of ER stress in the development of angiogenesis and fibrosis in the liver and splanchnic circulation. We hypothesize that in PHT and cirrhosis, strategies inhibiting ER stress (by using silencing RNA’s or JIK/Tao3K knockout mice) can decrease inflammation and hypoxia leading to less angiogenesis and fibrosis formation. But that on the other hand, strategies normalising neo-vessels or inhibiting angiogenesis with anti-PLGF may reduce ER stress and hypoxia.