Research Explorer

Project

Inhibiting pathogenic bone loss in arthritis: a proof of concept study
Acronym
Sn-osteoclast 2
Code
F2016/IOF-CONTT/300
Duration
15 July 2016 → 14 January 2018
Funding
Regional and community funding: Industrial Research Fund
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
arthritis
 
Project description
 

We have found a target for inhibiting osteoclastogenesis by means of interfering with cell fusion. This target is highly expressed in RA, a disease characterized by detrimental bone loss. In this ConcepTT grant, we will further validate the potential of the anti-Sn therapy in inflammation induced bone loss and will further refine the therapeutic potential by investigating the role of Sn in a TNF independent RA model.