The study of human migration and mobility has developed into an important area in archaeology as it provides essential information for understanding historical processes. My aim is to develop novel and further refine existing physicochemical approaches to extract information concerning migration/mobility and diet via elemental and isotopic analysis of fossil skeletal remains (teeth, bones). A combination of high-end analytical instrumentation will be relied upon: multi-collector ICP – mass spectrometry for Sr isotopic analysis (predominantly for provenancing purposes), and laser ablation ICP – mass spectrometry for spatially (and thus, temporally) resolved analysis (life history research). Ample attention will be devoted to existing pitfalls: potential post-mortem alteration that has taken place (diagenesis) and the link between various locations and the corresponding isotopic signatures. The merits of several proxies as indicator of diagenesis will be evaluated and novel approaches will be tested. A more reliable characteristic for a geographical region than the Sr-87/Sr-86 isotope ratio of the underlying bedrock will be aimed at by analyzing remains from domesticated animals. Different ICP-MS techniques will be utilized and their capabilities and limitations in analysis of skeletal remains will be assessed in the context of data quality. Finally, the methods developed will be deployed in challenging real-life cases in cooperation with a team of archaeologists.