Research Explorer

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Project

RNA-MAGIC: RNA-based bioMArkers and tarGets In asthma and Chronic Obstructive Pulmonary Disease (COPD)

Outputs and Outcomes

Publications

Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy

Pieterjan MerckxGRIET CONICKXEvy BlommeTania MaesKen BrackeGuy BrusselleStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Bram BogaertAliona DebisschopThomas EhouarneHannelore Van EeckhoutteJoyceline De VolderAn JacobsEline PottieRiet De RyckeAurélie CrabbéPieter MestdaghIne LentackerGuy BrusselleChristophe StoveSandra VerstraelenTania MaesKen BrackeStefaan De SmedtKoen Raemdonck et al.

A1 Journal Article in NANO LETTERS

Trajectory of neutrophilic responses in a mouse model of pollutant-aggravated allergic asthma

Joyceline De VolderAnnelies BontinckKatrien De GroveIris DirvenValerie HaeltermanGuy JoosGuy BrusselleTania Maes

A1 Journal Article in ENVIRONMENTAL POLLUTION

RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD

Hannelore Van EeckhoutteChantal DonovanRichard Y. KimThomas M. ConlonMeshal AnsariHaroon KhanRanjith JayaramanNicole G. HansbroYves DondelingerTom DelangheAllison M. BealBrad GeddesJohn BertinTom Vanden BergheJoyceline De VolderTania MaesPeter VandenabeeleBart M. VanaudenaerdeDieter DeforceSonja SkevinFilip Van NieuwerburghFien VerhammeGuy JoosSobia IdreesHerbert B. SchillerAli Önder YildirimAlen FaizMathieu BertrandGuy BrussellePhilip M. HansbroKen Bracke et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Unlocking lncRNA functions through high-throughput CRISPR-interference screens in an in vitro airway inflammation model

Fien GysensPieter MestdaghKen BrackeTania Maes

IL-10 producing regulatory B cells are decreased in blood from smokers and COPD patients

Merel JacobsSven VerschraegenBihiyga SalhiJasper AnckaertPieter MestdaghGuy BrusselleKen Bracke

A1 Journal Article in RESPIRATORY RESEARCH

miR449 protects airway regeneration by controlling AURKA/HDAC6-mediated ciliary disassembly

Merit WildungChristian HerrDietmar RiedelCornelia WiedwaldAlena MoiseenkoFidel RamirezHataitip TasenaMaren HeimerlMihai AlevraNaira MovsisyanMaike SchuldtLarisa Volceanov-HahnSharen ProvoostTabea Noethe-MenchenDiana UrregoBernard FreytagJulia WallmeierChristoph BeisswengerRobert BalsMaarten van den BergeWim TimensPieter S. HiemstraCorry-Anke BrandsmaTania MaesStefan AndreasIrene H. HeijinkLuis A. PardoMuriel Lize et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A 3′‐end capture sequencing method for high‐throughput targeted gene expression profiling

Eric de Bony de LavergneFien GysensNurten YigitJasper AnckaertCeline EveraertEveline Vanden EyndeKimberly VerniersWillem van SnippenbergWim TrypsteenPieter Mestdagh

A1 Journal Article in BIOTECHNOLOGY JOURNAL

Unlocking the secrets of long non-coding RNAs in asthma

Fien GysensPieter MestdaghEric de Bony de LavergneTania Maes

A1 Journal Article in THORAX

CiLiQuant : quantification of RNA junction reads based on their circular or linear transcript origin

Annelien MorlionEva HulstaertMarieke VrommanJasper AnckaertCeline EveraertJo VandesompelePieter Mestdagh

A2 Journal Article in FRONTIERS IN BIOINFORMATICS

Identification of asthma associated microRNAs in bronchial biopsies

Mirjam RoffelIlse M. BoudewijnJos L.L. van NijnattenAlen FaizCorneel J. VermeulenAntoon J. van OosterhoutKaren AffleckWim TimensKen BrackeTania MaesIrene H. HeijinkCorry-Anke BrandsmaMaarten van den Berge et al.

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

MiR-223 is increased in lungs of patients with COPD and modulates cigarette smoke-induced pulmonary inflammation

Mirjam RoffelTania MaesCorry-Anke BrandsmaMaarten van den BergeBart M. VanaudenaerdeGuy JoosGuy BrusselleIrene H. HeijinkKen Bracke

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Messenger RNA capture sequencing of extracellular RNA from human biofluids using a comprehensive set of spike-in controls

Eva HulstaertAnneleen DecockAnnelien MorlionCeline EveraertKimberly VerniersJustine NuytensNele NijsGary P. SchrothScott KuerstenStephen M. GrossPieter MestdaghJo Vandesompele et al.

A2 Journal Article in STAR PROTOCOLS

Pulmonary surfactant as a versatile biomaterial to fight COVID-19

Lore HermanStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Custom long non-coding RNA capture enhances detection sensitivity in different human sample types

Annelien MorlionCeline EveraertJustine NuytensEva HulstaertJo VandesompelePieter Mestdagh

A1 Journal Article in RNA BIOLOGY

Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease

Evy BlommeSharen ProvoostElise De SmetKatrien De GroveHannelore Van EeckhoutteJoyceline De VolderPhilip M HansbroMatteo BonatoMarina SaettaSara WijnantFien VerhammeGuy JoosKen BrackeGuy BrusselleTania Maes et al.

A1 Journal Article in CLINICAL & TRANSLATIONAL IMMUNOLOGY

Spotlight on microRNAs in allergy and asthma

Julie WeidnerSabine BartelAyse KilicUlrich M. ZisslerHarald RenzJurgen SchwarzeCarsten B. Schmidt-WeberTania MaesAna RebaneSusanne Krauss-EtschmannMadeleine Radinger et al.

A1 Journal Article in ALLERGY

miR-223 : a key regulator in the innate immune response in asthma and COPD

Mirjam RoffelKen BrackeIrene H. HeijinkTania Maes

A1 Journal Article in FRONTIERS IN MEDICINE

Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy

Pieterjan MerckxJoris LammensGust NuyttenBram BogaertRoberta GuagliardoTania MaesChris VervaetThomas De BeerStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

COVID-19, asthma, and inhaled corticosteroids : another beneficial effect of inhaled corticosteroids?

Tania MaesKen BrackeGuy Brusselle

Editorial material

Inhaled corticosteroids and COVID-19 reply

Tania MaesKen BrackeGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting neutrophils in asthma : a therapeutic opportunity?

Joyceline De VolderLars VereeckeGuy JoosTania Maes

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Charting extracellular transcriptomes in the human biofluid RNA atlas

Eva HulstaertAnnelien MorlionFrancisco Avila CobosKimberly VerniersJustine NuytensEveline Vanden EyndeNurten YigitJasper AnckaertAnja GeertsPieter HindryckxPeggy JacquesGuy BrusselleKen BrackeTania MaesThomas MalfaitThierry DerveauxVirginie NinclausCaroline Van CauwenberghKristien RoelensEllen RoetsDimitri HemelsoetKelly TillemanLieve BrochezS KuerstenLM SimonS KargA Kautzky-WillersM LeutnerC NöhammerO SlabyRW PrinsJ KosterSteve LefeverGP SchrothJo VandesompelePieter Mestdagh et al.

A1 Journal Article in CELL REPORTS

The role of miR-155 in cigarette smoke-induced pulmonary inflammation and COPD

Elise De SmetHannelore Van EeckhoutteFrancisco Avila CobosEvy BlommeFien VerhammeSharen ProvoostStijn VerledenKoen VenkenTania MaesGuy JoosPieter MestdaghGuy BrusselleKen Bracke et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Asthma and air pollution : recent insights in pathogenesis and clinical implications

Annelies BontinckTania MaesGuy Joos

A1 Journal Article in CURRENT OPINION IN PULMONARY MEDICINE

Letter from Belgium

Editorial material