Research Explorer

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Project

Elucidating the details of the interaction between specific nutrients-microbiota-intestinal health and the consequences for inflammatory diseases

Outputs & Impact

Publications & research data ( 33 )

CARD14 signaling in intestinal epithelial cells induces intestinal inflammation and intestinal transit delay

Aigerim AidarovaMarieke CarelsMira HaegmanYasmine DriegeSteven TimmermansEline Van DammeJavier Aguilera-LizarragaMaria Francesca ViolaRita de Cassia de Oliveira CollacoJoan Manils et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

A crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS

Louise NuyttensMarah HeyerickMaxime RoesElise MoensCéline Van DenderCharlotte WallaeysTino HochepiedSteven TimmermansJolien VandewalleClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis

Céline Van DenderSteven TimmermansMaxime RoesMadeleine HellemansElise MoensLouise NuyttensMaarten ClaesBart RomanKarolien De BosscherJolien Vandewalle et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Multi-step pathway engineering in probiotic Saccharomyces boulardii for abscisic acid production in the gut

Femke Van GaeverPaul VandecruysYasmine DriegeSeo Woo KimJohan M. TheveleinRudi BeyaertJens Staal

A2 Journal Article in METABOLIC ENGINEERING COMMUNICATIONS

Unraveling mitochondrial pyruvate dysfunction to mitigate hyperlactatemia and lethality in sepsis

Louise NuyttensMarah HeyerickGeike HeremansElise MoensMaxime RoesCéline Van DenderLiesbet De BusJohan DecruyenaereJan De WaeleJolien Vandewalle et al.

A1 Journal Article in CELL REPORTS

Generation of a new Paneth cell-specific Cre-recombinase transgenic mouse line

Natalia Garcia GonzalezCharlotte WallaeysWendy ToussaintTino HochepiedSylviane DewaeleSomara De BeulRobin Van LokeJolien VandewalleSteven TimmermansClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Modulation of glucocorticoid receptor function under iron overload

Wanting ZhuTineke VanderhaeghenSteven TimmermansJolien VandewalleMelanie EggermontNicolette J. D. VerhoogClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Detection of chimeric alpha-defensin transcripts and peptides in mouse Paneth cells

Steven TimmermansCharlotte WallaeysSomara De BeulNatalia Garcia GonzalezClaude Libert

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The phytohormone abscisic acid enhances remyelination in mouse models of multiple sclerosis

Femke Van GaeverFleur MingneauSam VanherleYasmine DriegeMira HaegmanElien Van WonterghemJunhua XieRoosmarijn VandenbrouckeJerome J. A. HendriksRudi Beyaert et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Comparative analysis of hepatic gene expression profiles in murine and porcine sepsis models

Fëllanza HalimiTineke VanderhaeghenSteven TimmermansSiska CroubelsClaude LibertJolien Vandewalle

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Céline Van DenderSteven TimmermansVille PaakinahoTineke VanderhaeghenJolien VandewalleMaarten ClaesBruno GarciaBart RomanJan De WaeleSiska Croubels et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Identification and characterization of multiple Paneth cell types in the mouse small intestine

Steven TimmermansCharlotte WallaeysNatalia Garcia GonzalezLotte PollarisYvan SaeysClaude Libert

A1 Journal Article in CELLS

Paneth cell TNF signaling induces gut bacterial translocation and sepsis

Charlotte WallaeysNatalia Garcia GonzalezSteven TimmermansJolien VandewalleTineke VanderhaeghenSomara De BeulHester DufoorMelanie EggermontElise MoensVictor Bosteels et al.

A1 Journal Article in CELL HOST & MICROBE

CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation

Paul A O'SullivanAigerim AidarovaInna AfoninaJoan ManilsTeresa L M ThurstonRachel InstrellMichael HowellStefan BoeingSashini RanawanaMelanie Herpels et al.

A1 Journal Article in BIOCHEMICAL JOURNAL

Polo-like kinase 1 (PLK1) is a novel CARD14-binding protein in keratinocytes

Stella IliakiMarja KreikeNatalia Ferreras MorenoFemke De MeyerAigerim AidarovaHarald BraunClaude LibertInna AfoninaRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Sofie DesmetJonathan ThommisTineke VanderhaeghenEdmee VandenboornDorien ClarisseYunkun LiSteven TimmermansDaria FijalkowskaDariusz RatmanEvelien Van Hamme et al.

A1 Journal Article in MOLECULAR METABOLISM

Chimeric and mutant CARD9 constructs enable analyses of conserved and diverged autoinhibition mechanisms in the CARD-CC protein family

Jens StaalYasmine DriegeFemke Van GaeverJill SteelsRudi Beyaert

A1 Journal Article in FEBS JOURNAL

The impact of hepatocyte-specific deletion of hypoxia-inducible factors on the development of polymicrobial sepsis with focus on GR and PPARα function

Tineke VanderhaeghenSteven TimmermansMelanie EggermontDeepika WattsJolien VandewalleCharlotte WallaeysLouise NuyttensJoyca De TemmermanTino HochepiedSylviane Dewaele et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Berberine-microbiota interplay : orchestrating gut health through modulation of the gut microbiota and metabolic transformation into bioactive metabolites

Tessa DehauMarc CherletSiska CroubelsMichiel Van de VlietEvy GoossensFilip Van Immerseel

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Mitochondrial dysfunction in inflammation and autoimmunity

Jens StaalLuz BlancoAndras Perl

Editorial material

A20 is a master switch of IL-33 signalling in macrophages and determines IL-33-induced lung immunity

Aurora Holgado MuñozZhuangzhuang LiuAigerim AidarovaChristina MüllerMira HaegmanYasmine DriegeMarja KreikeCharlotte ScottInna AfoninaRudi Beyaert

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Normal lymphocyte homeostasis and function in MALT1 protease-resistant HOIL-1 knock-in mice

Ioannis SkordosYasmine DriegeMira HaegmanMarja KreikeJens StaalAnnelies DemeyerRudi Beyaert

A1 Journal Article in FEBS JOURNAL

A high dose of dietary berberine improves gut wall morphology, despite an expansion of enterobacteriaceae and a reduction in beneficial microbiota in broiler chickens

Tessa DehauMarc CherletSiska CroubelsFilip Van ImmerseelEvy Goossens

A1 Journal Article in MSYSTEMS

Editorial : protein phosphorylation and dephosphorylation in plant-microbe interactions

Jianbin SuYi-Ju LuJens StaalAgnieszka Ludwikow

Editorial material

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De Bruyne et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

CARD14 signalling ensures cell survival and cancer associated gene expression in prostate cancer cells

Domien VannesteJens StaalMira HaegmanYasmine DriegeMarieke CarelsElien Van NuffelPieter De BleserYvan SaeysRudi BeyaertInna Afonina

A1 Journal Article in BIOMEDICINES

Omics technologies in poultry health and productivity - part 1 : current use in poultry research

Tessa DehauRichard DucatelleFilip Van ImmerseelEvy Goossens

A1 Journal Article in AVIAN PATHOLOGY

Omics technologies in poultry health and productivity – part 2 : future applications in the poultry industry

Evy GoossensTessa DehauRichard DucatelleFilip Van Immerseel

A1 Journal Article in AVIAN PATHOLOGY

Engineering a highly sensitive biosensor for abscisic acid in mammalian cells

Seo Woo KimKûbra AlciFemke Van GaeverYasmine DriegeKeylla BicalhoGeert GoeminneClaude LibertAlain GoossensRudi BeyaertJens Staal

A1 Journal Article in FEBS LETTERS

Unraveling the functional roles of endogenous phytohormones in mammals

Seo Woo KimRudi BeyaertAlain GoossensJens Staal

Sepsis : a failing starvation response

Jolien VandewalleClaude Libert

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer

Steven TimmermansJolien VandewalleClaude Libert

A1 Journal Article in CELLS

Phytohormones : multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

Seo Woo KimAlain GoossensClaude LibertFilip Van ImmerseelJens StaalRudi Beyaert

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Activities ( 0 )

Results

Impact narratives ( 0 )

Patents ( 0 )