Research Explorer

Project

Development and functional characterization of inhibitors targeting specific inflammatory caspases
Code
3G030212N
Duration
01 January 2012 → 31 December 2015
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Laboratory medicine
    • Laboratory medicine
  • Agricultural and food sciences
    • Food sciences and (bio)technology
Keywords
caspase inflammation proteomics Immune response inflammasome medicinal chemistry
 
Project description
 

The inflammatory caspases modulate immune respones, but their undesired activation is associated with immune disorders in humans. However, the development of inhibitors that can discriminate between different inflammatory caspases is still a major challenge. Here we will develop new classes of inhibitors that target specific inflammatory caspases. Such inhibitors will offer tremendous opportunities for studying the signaling pathways of inflammatory caspases, and for therapeutic intervention.