The TripleTOF 6600 is the big brother of the 5600 that comes with enhanced sensitivity and resolution. It is also coupled to a capillary flow liquid chromatography system (Eksigent LC425). The redesigned TOF entrance optics of the 6600 avoid downtime and allow for scheduled ionization which decreases downtime of the instrument, while analytical columns can be mounted directly on the new optiflow Turbo V source, reducing the risk of peakbroadening. These improvements significantly increase quantitative robustness and allow for larger experiments and sample batches to be reproducibly quantified. The instrument is capable of both Data-Dependent acquisition and sequential window acquisition of all theorethical mass spectra (SWATH).