Research Explorer

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Researcher

Tom Van Maerken

Awards & Distinctions

134 Results

2023

Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

Exploration of neuroblastoma xenograft models for the analysis of tumoral cell-free RNA in murine blood plasma

Jill DeleuHanne Van DroogenbroeckJasper AnckaertJilke De WildeKaat DurinckLiselot MusJustine NuytensMuhammad RishfiKathleen SchoofsFranki Speleman et al.

Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma

Jill DeleuHanne Van DroogenbroeckJasper AnckaertAnneleen DecockJilke De WildeKaat DurinckLiselot MusJustine NuytensMuhammad RishfiKathleen Schoofs et al.

A2 Journal Article in EXRNA

Extracellular RNA in liquid biopsies : entering a new era for cancer treatment monitoring?

Jill DeleuBram De WildeTom Van MaerkenJo Vandesompele

Longitudinal evaluation of serum microRNAs as biomarkers for neuroblastoma burden and therapeutic p53 reactivation

Alan Van GoethemJill DeleuNurten YigitCeline EveraertMyrthala Moreno-SmithSanjeev A VasudevanFjoralba ZekaFleur DemuynckEveline BarbieriFranki Speleman et al.

A2 Journal Article in NAR CANCER

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertJilke De WildeJasper AnckaertKaat DurinckJustine NuytensMuhammad RishfiFranki Speleman et al.

2022

Digital PCR-based evaluation of nucleic acid extraction kit performance for the co-purification of cell-free DNA and RNA

Jill DeleuKathleen SchoofsAnneleen DecockKimberly VerniersSofie RoelandtAngie DenolfJoke VerrethBram De WildeTom Van MaerkenKatleen De Preter et al.

A1 Journal Article in HUMAN GENOMICS

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

Whole transcriptome profiling of liquid biopsies from tumor xenografted mouse models enables specific monitoring of tumor-derived RNA

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertKimberly VerniersTom Van MaerkenBram De WildeJo VandesompeleAnneleen Decock

Whole transcriptome profiling of liquid biopsies from tumor xenografted mouse models enables specific monitoring of tumor-derived RNA

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertKimberly VerniersTom Van MaerkenBram De WildeJo VandesompeleAnneleen Decock

Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertJilke De WildeJasper AnckaertKaat DurinckJustine NuytensMuhammad RishfiFranki Speleman et al.

A2 Journal Article in NAR CANCER

2021

A G316A polymorphism in the ornithine decarboxylase gene promoter modulates MYCN-driven childhood neuroblastoma

Laura D. GambleStefania PurgatoMichelle J. HendersonSimone Di GiacomoAmanda J. RussellPaolo PiginiJayne MurrayEmanuele ValliGiorgio MilazzoFederico M. Giorgi et al.

A1 Journal Article in CANCERS

Whole transcriptome profiling of liquid biopsies from tumor xenografted mouse models enables specific monitoring of tumor-derived RNA

Vanessa VermeirssenJill DeleuCeline EveraertAnnelien MorlionKimberly VerniersJasper AnckaertJo VandesompeleTom Van MaerkenAnneleen DecockBram De Wilde

Whole transcriptome profiling of liquid biopsies from tumor xenografted mouse models enables specific monitoring of tumor-derived RNA

Vanessa VermeirssenJill DeleuAnnelien MorlionCeline EveraertKimberly VerniersTom Van MaerkenBram De WildeJo VandesompeleAnneleen Decock

2020

Whole transcriptome profiling of liquid biopsies from tumor xenografted mouse models enables specific monitoring of tumor-derived RNA

Jill DeleuVanessa VermeirssenCeline EveraertAnnelien MorlionKimberly VerniersJasper AnckaertJo VandesompeleTom Van MaerkenAnneleen DecockBram De Wilde

2019

A recurrent and transesophageal echocardiography-associated outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae complex in cardiac surgery patients

Tom Van MaerkenEls De BrabandereAudrey NoëlLiselotte CoorevitsPascal De WaegemaekerRaina AblorhStefaan BouchezINGRID HERCKHarlinde PeperstraetePierre Bogaerts et al.

A1 Journal Article in ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL

ALK positively regulates MYCN activity through repression of HBP1 expression

Shana ClaeysGeertrui DeneckerKaat DurinckBieke DecaestekerLiselot MusSiebe LoontiensSuzanne VanhauwaertKristina AlthoffCaroline WigerupDaniel Bexell et al.

A1 Journal Article in ONCOGENE

Cost-effective and robust genotyping using double-mismatch allele-specific quantitative PCR

Steve LefeverAli RihaniJoni Van der MeulenFilip PattynTom Van MaerkenJo Van DorpeJan HellemansJo Vandesompele

A1 Journal Article in SCIENTIFIC REPORTS

Nosocomial outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae among cardiothoracic surgical patients : causes and consequences

A NoëlC VastradeS DupontM de BarsyTD HuangTom Van MaerkenIsabel Leroux-RoelsB DelaereL MellyB Rondelet et al.

A1 Journal Article in JOURNAL OF HOSPITAL INFECTION

Whole transcriptome profiling of liquid biopsies from patient-derived xenograft (PDX) models

Vanessa VermeirssenAnneleen DecockKimberly VerniersCeline EveraertAnnelien MorlionJill DeleuTom Van MaerkenBram De WildeJo Vandesompele

2018

Analytical and pre-analytical performance characteristics of a novel cartridge-type blood gas analyzer for point-of-care and laboratory testing

Matthijs OyaertTom Van MaerkenSILKE BRIDTSSilvi Van LoonHeleen LavergeVeronique Stove

A1 Journal Article in CLINICAL BIOCHEMISTRY

Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients

Fjoralba ZekaAnneleen DecockAlan Van GoethemKatrien VanderheydenFleur DemuynckTim LammensHetty HelsmoortelJoëlle VermeulenRosa NogueraAna P. Berbegall et al.

A1 Journal Article in JCI INSIGHT

Circulating microRNA biomarkers for metastatic neuroblastoma

Fjoralba ZekaAlan Van GoethemTim LammensAnneleen DecockHetty HelsmoortelGenevieve LaureysMichael HogartyEveline BarbieriJason ShohetFrank Berthold et al.

Clinical burden of hepatitis E virus infection in a tertiary care center in Flanders, Belgium

Lien CattoirFREDERIK VAN HOECKETom Van MaerkenEline NysINGE RYCKAERTMatthias De BoulleAnja GeertsXavier VerhelstIsabelle ColleVeronik Hutse et al.

A1 Journal Article in JOURNAL OF CLINICAL VIROLOGY

Longitudinal evaluation of murine serum microRNAs as biomarkers for neuroblastoma burden and therapeutic TP53 reactivation

Alan Van GoethemNurten YigitCeline EveraertMyrthala Moreno-SmithSanjeev A VasudevanFjoralba ZekaFleur DemunckEveline BarbieriFranki SpelemanPieter Mestdagh et al.

Meticulous plasma isolation is essential to avoid false low-level viraemia in Roche Cobas HIV-1 viral load assays

Virginie MortierLeen VancoillieKenny DauweDelfien StaelensEls DemecheleerMarlies SchauvliegeSylvie DinakisTom Van MaerkenGéraldine DessillyJean Ruelle et al.

A1 Journal Article in ANTIVIRAL THERAPY

Performance of the preanalytical check module of the Stago STA R Max2 mechanical endpoint detection analyzer for assessing the impact of hemolysis, lipemia, and icterus on aPTT and PT

LISA FLORINMatthijs OyaertTom Van MaerkenKatrien Devreese

A1 Journal Article in INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY

Pharmacological restoration of tumour suppressor protein p53 in neuroblastoma : seeking synergy and non-invasive biomarkers

Alan Van GoethemJo VandesompeleTom Van Maerken

A2 Journal Article in BELGIAN JOURNAL OF MEDICAL ONCOLOGY

The ornithine decarboxylase G316A promoter polymorphism impacts neuroblastoma clinical outcome and may identify patients particularly susceptible to polyamine inhibition

Laura GambleStefania PurgatoSimone Di GiacomoAmanda RussellPaolo PiginiEmanuele ValliLesley AshtonTom Van MaerkenJo VandesompeleRogier Versteeg et al.

Thorough in silico and in vitro cDNA analysis of 21 putative BRCA1 and BRCA2 splice variants and a complex tandem duplication in BRCA2 allowing the identification of activated cryptic splice donor sites in BRCA2 exon 11

Annelot BaertEva MachackovaIlse CoeneCarol CreminKristin TurnerCheryl Portigal-ToddMarie Jill AsratJennifer NukAllison MindlinSean Young et al.

A1 Journal Article in HUMAN MUTATION

2017

A negative lactate dehydrogenase activity corrected after sample neuraminidase treatment

Matthijs OyaertTom Van MaerkenEvelien BauwensVeronique StoveJoris Delanghe

A1 Journal Article in CLINICA CHIMICA ACTA

Accelerating drug development for neuroblastoma - New drug development strategy : an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Europe Neuroblastoma project

Lucas MorenoHubert CaronBirgit GeoergerAngelika EggertGudrun SchleiermacherPenelope BrockDominique Valteau-CouanetLouis CheslerJohannes SchulteKatleen De Preter et al.

A1 Journal Article in EXPERT OPINION ON DRUG DISCOVERY

Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assay

Annelot BaertJulie DepuydtTom Van MaerkenBruce PoppeFransiska MalfaitTim Van DammeSylvia De NobeleGianpaolo PerlettiKim De LeeneerKathleen Claes et al.

A1 Journal Article in ONCOLOGY REPORTS

Analytical and diagnostic performance evaluation of the new Sysmex UF-5000 for automated urine sediment analysis

Matthijs OyaertRuben GovaertJoris DelangheVeronique StoveTom Van Maerken

Copy number variation analysis and methylome profiling of a GNAQ-mutant primary meningeal melanocytic tumor and its liver metastasis

Heidi VN Küsters-VandeveldeVIBEKE KRUSETom Van MaerkenTom BoterbergRolph PfundtDavid CreytensCaroline Van den BroeckeTrudi C MachielsenChristian KoelscheAndreas von Deimling et al.

A1 Journal Article in EXPERIMENTAL AND MOLECULAR PATHOLOGY

Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma

Alan Van GoethemNurten YigitMyrthala Moreno-SmithSanjeev A VasudevanEveline BarbieriFranki SpelemanJason ShohetJo VandesompeleTom Van Maerken

A1 Journal Article in ONCOTARGET

HBP1 is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysGeertrui DeneckerIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerTom Van MaerkenBram De WildeGenevieve LaureysKristina Althoff et al.

Hepatitis E virus serology and PCR : does the methodology matter?

Lien CattoirFREDERIK VAN HOECKETom Van MaerkenEVELINE NYSINGE RYCKAERTMatthias De BoulleAnja GeertsXavier VerhelstIsabelle ColleVeronik Hutse et al.

A1 Journal Article in ARCHIVES OF VIROLOGY

Identifying familial hypercholesterolemia in pediatric and adult patients : is screening relevant in a tertiary care setting?

Timothy CammaertMatthijs OyaertErnst RietzschelJean De SchepperTom Van MaerkenVeronique Stove

MicroRNA expression analysis using small RNA sequencing discovery and RT-qPCR-based validation

Alan Van GoethemPieter MestdaghTom Van MaerkenJo Vandesompele

Bookchapter in Functional genomics : methods and protocols

Restoration of p53 in neuroblastoma : seeking synergy and non-invasive biomakers

Alan Van GoethemTom Van MaerkenJo Vandesompele

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Geertrui DeneckerShana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerTom Van MaerkenBram De WildeGenevieve LaureysKristina Althoff et al.

The HBP1 tumour suppressor is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysGeertrui DeneckerBieke DecaestekerEls JanssensCandy KumpsSara De BrouwerIrina LambertzAnnelies FieuwSuzanne VanhauwaertKristina Althoff et al.

2016

An international survey of surveillance schemes for unaffected BRCA1 and BRCA2 mutation carriers

Dana Madorsky-FeldmanMiri Sklair-LevyTamar PerriYael LaitmanShani Paluch-ShimonRita SchmutzlerKerstin RhiemJenny LesterBeth Y KarlanChristian F Singer et al.

A1 Journal Article in BREAST CANCER RESEARCH AND TREATMENT

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Huong D MeeksHonglin SongKyriaki MichailidouManjeet K BollaJoe DennisQin WangDaniel BarrowdaleDebra FrostLesley McGuffogSteve Ellis et al.

A1 Journal Article in JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE

Depletion of tRNA-halves enables effective small RNA sequencing of low-input murine serum samples

Alan Van GoethemNurten YigitCeline EveraertMyrthala Moreno-SmithLiselot MusEveline BarbieriFranki SpelemanPieter MestdaghJason ShohetTom Van Maerken et al.

A1 Journal Article in SCIENTIFIC REPORTS

Evaluation of the role of germline RECQL variants in Belgian patients referred for genetic testing in the context of familial breast/ovarian cancer

Greet WiemeIlse CoeneLiselotte VergoteBruce PoppeFransiska MalfaitTom Van MaerkenKim De LeeneerKathleen Claes

Identification of non-invasive biomarkers for treatment response in neuroblastoma by circulating miRNA profiling

Alan Van GoethemNurten YigitMythala Moreno-SmithCeline EveraertOlivier DelattrePieter MestdaghSaurabh AgarwalEveline BarbieriIsabelle Janoueix-LeroseyJason Shohet et al.

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation

Annelot BaertJulie DepuydtTom Van MaerkenBruce PoppeFransiska MalfaitKatrien StormJenneke van den EndeTim Van DammeSylvia De NobeleGianpaolo Perletti et al.

A1 Journal Article in BREAST CANCER RESEARCH

Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2

Valentina SilvestriDaniel BarrowdaleAnna Marie MulliganSusan L NeuhausenStephen FoxBeth Y KarlanGillian MitchellPaul JamesDarcy L ThullKristin K Zorn et al.

A1 Journal Article in BREAST CANCER RESEARCH

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenBram De Wilde et al.

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenBram De Wilde et al.

The HBP1 tumor suppressor is an epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzAlan Van GoethemCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenKristina AlthoffJohannes SchulteJean-Baptiste Demoulin et al.

2015

Assessing associations between the AURKA-HMMR-TPX2-TUBG1 functional module and breast cancer risk in BRCA1/2 mutation carriers

Ignacio BlancoKaroline KuchenbaeckerDaniel CuadrasXianshu WangDaniel BarrowdaleGorka Ruiz de GaribayPablo LibradoAlejandro Sánchez-GraciaJulio RozasNúria Bonifaci et al.

A1 Journal Article in PLOS ONE

BRCA1, BRCA2 and PALB2 mutations and CHEK2 c. 1100delC in different South African ethnic groups diagnosed with premenopausal and/or triple negative breast cancer

FZ FranciesT WainsteinKim De LeeneerA CairnsM MurdochS NietzH CubaschBruce PoppeTom Van MaerkenBrecht Crombez et al.

A1 Journal Article in BMC CANCER

Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers

P PeterlongoJ Chang-ClaudeKB MoysichA RudolphRK SchmutzlerJ SimardP SoucyRA EelesDF EastonU Hamann et al.

A1 Journal Article in CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genome wide expression profiling of p53 regulated miRNAs in neuroblastoma

Ali RihaniAlan Van GoethemMaté OngenaertSara De BrouwerPieter-Jan VoldersSaurabh AgarwalKatleen De PreterPieter MestdaghJason ShohetFranki Speleman et al.

A1 Journal Article in SCIENTIFIC REPORTS

HBP1 downregulation through mutant ALK represents a novel mechanism for cooperative MYCN activation in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenKristina AlthoffJohannes SchulteJean-Baptiste Demoulin et al.

Hepatitis E virus serology and PCR : does the methodology matter?

Lien CattoirFREDERIK VAN HOECKETom Van MaerkenEVELINE NYSINGE RYCKAERTMatthias De BoulleAnja GeertsXavier VerhelstHans Van VlierbergheElizaveta Padalko

Identification of miRNAs contributing to neuroblastoma chemoresistance

Duncan AyersPieter MestdaghTom Van MaerkenJo Vandesompele

A1 Journal Article in COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL

Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma

Ali RihaniJo VandesompeleFranki SpelemanTom Van Maerken

A1 Journal Article in CANCER CELL INTERNATIONAL

Oncogenetic testing and follow-up for women with familial breast/ovarian cancer, Li-Fraumeni syndrome and Cowden syndrome

Jo RobaysSabine StordeurFrank HulstaertTom Van MaerkenKathleen ClaesNicolas JaninGert MatthijsDaphné 't Kint de RoodenbekeMartine BerlièreHans Wildiers et al.

Oncogenetic testing for persons with hereditary endocrine cancer syndromes

Joan VlayenMarie BexBert BravenboerKathleen ClaesBruno LapauwAlexandre PersuKris PoppeUrielle UllmanTom Van MaerkenLaurent Vroonen et al.

Oncogenetic testing, diagnosis and follow-up in Birt-Hogg-Dubé syndrome, familial atypical multiple mole melanoma syndrome and neurofibromatosis 1 and 2

Jo RobaysSabine StordeurFrank HulstaertJean-François BaurainLieve BrochezTeofila CaplanusiKathleen ClaesEric LegiusSylvie RotteyDirk Schrijvers et al.

Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors

Melanie SchwermerSangkyun LeeJohannes KoesterTom Van MaerkenHarald StephanAngelika EggertKatharina MorikJohannes H SchulteAlexander Schramm

A1 Journal Article in ONCOTARGET

Synergistic combined molecular treatment targeting the HBP1 tumor suppressor gene in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemAnneleen BeckersCandy KumpsTom Van MaerkenJohannes SchulteKatleen De PreterFranki Speleman

The G2 micronucleus-assay for the analysis of in vitro chromosomal radiosensitivity in individuals carrying a BRCA1 mutation

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeSylvia De NobeleKim De LeeneerKathleen ClaesAnne Vral

The HBP1 tumour suppressor at multiple regulatory cross roads in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemAnneleen BeckersCandy KumpsTom Van MaerkenJohannes SchulteKatleen De PreterFranki Speleman

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel R CarterAlex CazesBelamy B CheungMarilena De Mariano et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

2014

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Karoline B KuchenbaeckerSusan L NeuhausenMark RobsonDaniel BarrowdaleLesley McGuffogAnna Marie MulliganIrene L AndrulisAmanda B SpurdleMarjanka K SchmidtRita K Schmutzler et al.

A1 Journal Article in BREAST CANCER RESEARCH

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients

Ali RihaniBram De WildeFjorabla ZekaGenevieve LaureysNadine FrancotteGian Paolo ToniniSimona CocoRogier VersteegRosa NogueraJohannes H Schulte et al.

A1 Journal Article in PLOS ONE

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients

Ali RihaniBram De WildeFjoralba ZekaGenevieve LaureysNadine FrancotteGian Paolo ToniniSimona CocoRogier VersteegRosa NogueraJohannes Schulte et al.

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients

Ali RihaniBram De WildeFjoralba ZekaGenevieve LaureysNadine FrancotteGian Paolo ToniniSimona CocoRogier VersteegRosa NogueraJohannes Schulte et al.

Characterization of ALK driven molecular networks identifies perturbed RET and cholinergic signaling in neuroblastoma

Irina LambertzCandy KumpsShana ClaeysSven LindlerAnneleen BeckersEls JanssensMarilena De MarianoSara De BrouwerJay GibbonsGenevieve Laureys et al.

Characterization of the p53 network and new therapeutic opportunities in neuroblastoma

Ali RihaniJo VandesompeleTom Van Maerken

Clinical burden of hepatitis E infections in Belgium

Elizaveta PadalkoFREDERIK VAN HOECKETom Van MaerkenLien CattoirEVELINE NYSINGE RYCKAERTMatthias De BoulleAnja GeertsXavier VerhelstIsabelle Colle et al.

Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma

Alan Van GoethemGwen NicholsFranki SpelemanJo VandesompeleTom Van Maerken

Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma

Alan Van GoethemGwen NicholsFranki SpelemanJo VandesompeleTom Van Maerken

Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma

Alan Van GoethemGwen NicholsFranki SpelemanJo VandesompeleTom Van Maerken

Evaluation of targeted drugs in combination with the MDM2 antagonist RG7388 in neuroblastoma

Alan Van GoethemGwen NicholsFranki SpelemanJo VandesompeleTom Van Maerken

Genetisch geïnspireerde toekomstperspectieven voor de therapie van het neuroblastoom

Bram De WildeTom Van MaerkenKatleen De PreterNadine Van RoyGenevieve LaureysJo VandesompeleFranki Speleman

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma

Ali RihaniTom Van MaerkenBram De WildeFjoralba ZekaGenevieve LaureysKoen NorgaGian Paolo ToniniSimona CocoRogier VersteegRosa Noguera et al.

A1 Journal Article in PEDIATRIC BLOOD & CANCER

MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance

Giuseppe BaroneDeborah A TweddleJason M ShohetLouis CheslerLucas MorenoAndrew DJ PearsonTom Van Maerken

A1 Journal Article in CURRENT DRUG TARGETS

Pharmacologic activation of wild-type p53 by nutlin therapy in childhood cancer

Tom Van MaerkenAli RihaniAlan Van GoethemAnne De PaepeFranki SpelemanJo Vandesompele

A1 Journal Article in CANCER LETTERS

Targeted analysis of TP53 pathway SNPs in neuroblastoma patients

Ali RihaniBram De WildeFjoralba ZekaGenevieve LaureysNadine FrancotteGian Paolo ToniniSimona CocoRogier VersteegRosa NogueraJohannes Schulte et al.

The G2 micronucleus assay for the analysis of in vitro chromosomal radiosensitivity in individuals carrying a BRCA1 or BRCA2 mutation

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeSylvia De NobeleKim De LeeneerKathleen ClaesAnne Vral

The G2-micronucleus assay for the detection of in vitro chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers

Annelot BaertJulie DepuydtBruce PoppeTom Van MaerkenFransiska MalfaitTim Van DammeKim De LeeneerKathleen ClaesAnne Vral

The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity

Shana ClaeysCandy KumpsIrina LambertzSara De BrouwerSven LindnerAlan Van GoethemTom Van MaerkenJorge VialardJan CoolsJohannes Schulte et al.

The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity

Shana ClaeysCandy KumpsIrina LambertzSara De BrouwerSven LindnerAlan Van GoethemTom Van MaerkenJorge VialardJan CoolsJohannes Schulte et al.

2013

Development of an S-G2 micronucleus assay for the detection of in vitro chromosomal radiosensitivity in high-risk women subjected to early mammography screening for breast cancer

Anne VralJulie DepuydtAnnelot BaertBruce PoppeTom Van MaerkenFransiska MalfaitKim De LeeneerMarc D'HoogheKathleen Claes

Effective Alu repeat based RT-qPCR normalization in cancer cell perturbation experiments

Ali RihaniTom Van MaerkenFilip PattynGert Van PeerAnneleen BeckersSara De BrouwerCandy KumpsEvelien MetsJoni Van der MeulenPieter Rondou et al.

A1 Journal Article in PLOS ONE

Focal DNA copy number changes in neuroblastoma target MYCN regulated genes

Candy KumpsAnnelies FieuwPieter MestdaghBjörn MentenSteve LefeverFilip PattynSara De BrouwerTom SanteJohannes Hubertus SchulteAlexander Schramm et al.

A1 Journal Article in PLOS ONE

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H. SchulteRosa NogueraRaymond L. Stallings et al.

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

Identifying and validating DNA methylation biomarkers: the example of neuroblastoma

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

Selective inhibition of the p53–MDM2 interaction by nutlin drugs: a new therapeutic perspective for neuroblastoma

Tom Van MaerkenAli RihaniAlan Van GoethemAnne De PaepeFranki SpelemanJo Vandesompele

A2 Journal Article in PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE

2012

Clinicopathological significance of indoleamine 2,3-dioxygenase 1 expression in colorectal cancer

Liesbeth FerdinandeChristine DecaesteckerLaurine VersetAnne MathieuXavier Moles LopezAndra-Maria NegulescuTom Van MaerkenIsabelle SalmonClaude CuvelierPieter Demetter

A1 Journal Article in BRITISH JOURNAL OF CANCER

Genome-wide promoter methylation analysis in neuroblastoma identifies prognostic methylation biomarkers.

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

A1 Journal Article in GENOME BIOLOGY

Hepatitis E seroprevalence in Belgium

FREDERIK VAN HOECKETom Van MaerkenMatthias De BoulleHans Van VlierbergheIsabelle ColleElizaveta Padalko

Hepatitis E seroprevalence in Belgium

FREDERIK VAN HOECKETom Van MaerkenMatthias De BoulleAnja GeertsHans Van VlierbergheIsabelle ColleElizaveta Padalko

Hepatitis E seroprevalence in East and West Flanders, Belgium

FREDERIK VAN HOECKETom Van MaerkenMatthias De BoulleAnja GeertsHans Van VlierbergheIsabelle ColleElizaveta Padalko

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Promoter methylation analysis identifies prognostic methylation biomarkers in neuroblastoma

Anneleen DecockMaté OngenaertJasmien HoebeeckKatleen De PreterGert Van PeerWim Van CriekingeRuth LadensteinJohannes H SchulteRosa NogueraRaymond L Stallings et al.

Serological assessment of HEV in unexplained acute hepatitis

Tom Van MaerkenFREDERIK VAN HOECKERita De KimpeElizaveta Padalko

2011

EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells

An De WeerJoni Van der MeulenPieter RondouTom TaghonTorsten A KonradKatleen De PreterPieter MestdaghTom Van MaerkenNadine Van RoyMarta Jeison et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Functional analysis of the p53 pathway in neuroblastoma cells using the small-molecule MDM2 antagonist Nutlin-3

Tom Van MaerkenAli RihaniDaniel DreidaxSarah De ClercqNurten YigitJean-Christophe MarineFrank WestermannAnne De PaepeJo VandesompeleFranki Speleman

A1 Journal Article in MOLECULAR CANCER THERAPEUTICS

Kankerceldood en p53

Bea PauwelsPeter VandenbergheTom Van MaerkenFilip LardonKarin Vanderkerken

Bookchapter in Kanker biomedisch bekeken

New options for molecular therapy of neuroblastoma: from p53 to gene therapy

Tom Van MaerkenFranki SpelemanJo Vandesompele

Pharmacological activation of p53 and gene therapy as emerging treatment options for neuroblastoma

Tom Van MaerkenAli RihaniAnne De PaepeJo VandesompeleFranki Speleman

A2 Journal Article in BELGIAN JOURNAL OF MEDICAL ONCOLOGY

Selectieve inhibitie van de p53–MDM2 interactie door nutlin-3 als een nieuwe therapeutische strategie voor neuroblastoom

Tom Van MaerkenAli RihaniAnne De PaepeJo VandesompeleFranki Speleman

A2 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE KINDERARTS = JOURNAL DU PEDIATRE BELGE

2010

A rapid and simple assay to determine pegylated erythropoietin in human serum

Tom Van MaerkenAnnemieke DhondtJoris Delanghe

A1 Journal Article in JOURNAL OF APPLIED PHYSIOLOGY

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Pieter MestdaghErik FredlundFilip PattynAli RihaniTom Van MaerkenJoëlle VermeulenCandy KumpsBjörn MentenKatleen De PreterAlexander Schramm et al.

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Pieter MestdaghE FredlundFilip PattynAli RihaniTom Van MaerkenJoëlle VermeulenCandy KumpsBjörn MentenKatleen De PreterA Schramm et al.

A1 Journal Article in ONCOGENE

Development of a new method for selective determination of CERA (Continuous Erythropoietin Receptor Activator) in human serum

Tom Van MaerkenAnnemieke DhondtJoris Delanghe

Evaluation of the analytical performance of nephelometric assays on a Dimension Vista 500 analyzer

Tom Van MaerkenJoris Delanghe

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

Sara De BrouwerKatleen De PreterCandy KumpsPiotr ZabrockiMichael PorcuEllen M WesterhoutArjan LakemanJo VandesompeleJasmien HoebeeckTom Van Maerken et al.

A1 Journal Article in CLINICAL CANCER RESEARCH

2009

Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma

Tom Van MaerkenDevanand SarkarFranki SpelemanPaul DentWilliam A. WeissPaul B. Fisher

A1 Journal Article in Journal of Cellular Physiology

Antitumor Activity of the Selective MDM2 Antagonist Nutlin-3 Against Chemoresistant Neuroblastoma With Wild-Type p53

Tom Van MaerkenLiesbeth FerdinandeJasmien TaildemanIrina LambertzNurten YigitLiesbeth VercruysseAli RihaniMartin MichaelisJindrich CinatlClaude Cuvelier et al.

A1 Journal Article in JOURNAL OF THE NATIONAL CANCER INSTITUTE

Astrocyte elevated gene-1 contributes to the pathogenesis of neuroblastoma

Seok-Geun LeeHyun Y. JeonZhaozhong SuJoanna E. RichardsNikollaq VozhillaDevanand SarkarTom Van MaerkenPaul B. Fisher

A1 Journal Article in Oncogene

Downregulation of miR-449a is essential for the survival of EVI1 positive leukemic cells through modulation of NOTCH1 and BCL2

An De WeerPieter MestdaghKatleen De PreterJoni Van der MeulenPieter Van VlierbergheTom Van MaerkenNadine Van RoyMarta JeisonIsaac YanivBarbara Cauwelier et al.

Escape from p53-mediated tumor surveillance in neuroblastoma: switching off the p14(ARF)-MDM2-p53 axis

Tom Van MaerkenJo VandesompeleAli RihaniAnne De PaepeFranki Speleman

A1 Journal Article in Cell Death & Differentiation

Meta-mining of Neuroblastoma and Neuroblast Gene Expression Profiles Reveals Candidate Therapeutic Compounds

Katleen De PreterSara De BrouwerTom Van MaerkenFilip PattynA SchrammA EggertJo VandesompeleFranki Speleman

A1 Journal Article in CLINICAL CANCER RESEARCH

The emerging molecular pathogenesis of neuroblastoma : implications for improved risk assessment and targeted therapy

Nadine Van RoyKatleen De PreterJasmien HoebeeckTom Van MaerkenFilip PattynPieter MestdaghJoëlle VermeulenJo VandesompeleFranki Speleman

A1 Journal Article in GENOME MEDICINE

Using real-time qPCR to evaluate RNAi-mediated gene silencing

Tom Van MaerkenPieter MestdaghS De ClercqFilip PattynNurten YigitAnne De PaepeJ C MarineFranki SpelemanJo Vandesompele

A2 Journal Article in BioTechniques Protocol Guide

2008

Real-time qPCR as a tool for evaluating RNAi-mediated gene silencing

Tom Van MaerkenPieter MestdaghSarah De ClercqFilip PattynNurten YigitAnne De PaepeJean-Christophe MarineFranki SpelemanJo Vandesompele

A2 Journal Article in Bioradiations

2006

Small-molecule MDM2 antagonists as a new therapy concept for neuroblastoma

Tom Van MaerkenFranki SpelemanJ VERMEULENIrina LambertzSarah De ClercqEls De SmetNurten YigitV COPPENSJan PhilippéAnne De Paepe et al.

A1 Journal Article in CANCER RESEARCH

2005

The role of serum erythropoietin levels in diagnosis and classification of erythrocytosis/polycythemia

Tom Van Maerken

A2 Journal Article in HAEMATOLOGICA-THE HEMATOLOGY JOURNAL

2004

Familial and congenital polycythemias: A diagnostic approach

Tom Van MaerkenK HUNNINCKL CALLEWAERTYves BenoitGenevieve LaureysJ VERLOOY

A1 Journal Article in JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

1999

Granulosa explants in serum-free culture: progesterone as an autocrine survival factor

Sylvie MusscheChristophe Van SteenkisteTom Van MaerkenKatharina D'Herde