Research Explorer

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Researcher

Srinath Govindarajan

Awards & Distinctions

18 Results

2024

Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells

Tan-Yun ChengT PraveenaSrinath GovindarajanCatarina F AlmeidaDaniel G PellicciWellington C ArkinsIldiko Van RhijnKoen VenkenDirk ElewautDale I Godfrey et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2023

Bacterial quorum-sensing peptides as immune modulators present in systemic circulation

Anton De SpiegeleerAmélie DescampsSrinath GovindarajanJulie CoudenysKevin Van der borghtHannah HirmzNele Van Den NoortgateDirk ElewautBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOMOLECULES

2021

The calcium dynamics of human dental pulp stem cells stimulated with tricalcium silicate-based cements determine their differentiation and mineralization outcome

Elanagai RathinamSrinath GovindarajanSivaprakash RajasekharanHeidi DeclercqDirk ElewautPeter De CosterLuc MartensLuc Leybaert

A1 Journal Article in SCIENTIFIC REPORTS

Transcriptomic profiling of human dental pulp cells treated with tricalcium silicate-based cements by RNA sequencing

Elanagai RathinamSrinath GovindarajanSivaprakash RajasekharanHeidi DeclercqDirk ElewautPeter De CosterLuc Martens

A1 Journal Article in CLINICAL ORAL INVESTIGATIONS

2020

A role for iNKT cells in sarcopenia

Anton De SpiegeleerHasan KahyaNele Van Den NoortgateEvelien WynendaeleTine DecruySrinath GovindarajanDirk Elewaut

An unexpected role for iNKT cells in skeletal muscle homeostasis

Anton De SpiegeleerHasan KahyaNele Van Den NoortgateEvelien WynendaeleTine DecruySrinath GovindarajanDirk Elewaut

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids

Srinath GovindarajanEveline VerheugenKoen VenkenDjoere GaublommeMargaux MaelegheerEva ClootsFien GysensBruno De GeestTan‐Yun ChengD Branch Moody et al.

A1 Journal Article in EMBO REPORTS

Quorum sensing molecules as a novel microbial factor impacting muscle cells

Anton De SpiegeleerDirk ElewautNele Van Den NoortgateYorick JanssensNathan DebunneSelien Van LangenhoveSrinath GovindarajanBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

2018

It takes 'guts' to cause joint inflammation : role of innate-like T cells

Céline MortierSrinath GovindarajanKoen VenkenDirk Elewaut

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas Savvides et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1

Yehudi BlochLaura BouchareychasRomain MerceronKatarzyna SkladanowskaLien Van den BosscheSammy DetrySrinath GovindarajanDirk ElewautFilomeen HaerynckMelissa Dullaers et al.

A1 Journal Article in IMMUNITY

2017

A20 inhibition of STAT1 expression in myeloid cells : a novel endogenous regulatory mechanism preventing development of enthesitis

Katelijne De WildeArne MartensStijn LambrechtPeggy JacquesMichael DrennanKarlijn DebusschereSrinath GovindarajanJulie CoudenysEveline VerheugenFien Windels et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma

Mérédis FavreauE MenuDjoere GaublommeK VanderkerkenS FaictK MaesE De BruyneSrinath GovindarajanMichael DrennanSerge Van Calenbergh et al.

A1 Journal Article in LEUKEMIA

Mechanistic insights into the regulation of iNKT development and cytokine production

Srinath GovindarajanDirk ElewautMichael Drennan

2016

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

2015

An optimized method for isolating and expanding invariant natural killer T cells from mouse spleen

Srinath GovindarajanDirk ElewautMichael Drennan

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

2014

The Thymic Microenvironment Differentially Regulates Development and Trafficking of Invariant Natural Killer T Cell Sublineages

Michael DrennanSrinath GovindarajanKatelijne De WildeSusan SchlennerCarl WareSergei NedospasovHans-Reimer RodewaldDirk Elewaut

The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages

Michael DrennanSrinath GovindarajanKatelijne De WildeSusan M SchlennerCarl WareSergei NedospasovHans-Reimer RodewaldDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY