Research Explorer

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Researcher

Silke Geurs

Awards & Distinctions

11 Results

2023

HDAC6 : one protein, two domains, diverse therapeutic opportunities : inhibitor synthesis and validation in cellular disease models

Silke GeursMatthias D'hoogheKarolien De BosscherDorien Clarisse

The zinc-binding group effect : lessons from non-hydroxamic acid vorinostat analogs

Silke GeursDorien ClarisseKarolien De BosscherMatthias D'hooghe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2022

Carboxylic acid bioisosteres in medicinal chemistry : synthesis and properties

Kato BredaelSilke GeursDorien ClarisseKarolien De BosscherMatthias D'hooghe

A1 Journal Article in JOURNAL OF CHEMISTRY

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

Silke GeursDorien ClarisseFreya BaeleJorick FranceusTom DesmetKarolien De BosscherMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

The notorious Z.B.G. : synthesis and biological evaluation of potent HDAC6 selective inhibitors with a non-hydroxamic acid zinc-binding group to overcome therapeutic limitations

The principal pivot : new potent HDAC6 selective inhibitors with a non-hydroxamic acid zinc binding group for applications beyond oncology

The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma

Silke GeursDorien ClarisseEleni StaessensKarolien De BosscherMatthias D'hooghe

The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma

Silke GeursEleni StaessensDorien ClarisseKarolien De BosscherMatthias D'hooghe

2019

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

Yves DepetterSilke GeursRob De VreeseSophie GoethalsElien VandoornAlien LaevensJonas SteenbruggeEvelyne MeyerPascal de TullioMarc Bracke et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves DepetterSilke GeursJorick FranceusDamijan KnezTom DesmetKarolien De BosscherOlivier De WeverStanislav GobecMatthias D'hooghe

A1 Journal Article in CHEMISTRYSELECT

2018

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Yves DepetterSilke GeursFlore Vanden BusscheRob De VreeseJorick FranceusTom DesmetOlivier De WeverMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM