Research Explorer

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Ruben Van Paemel

Publicaties & datasets

Prijzen & Erkenningen

50 Resultaten

2025

A benchmark of DNA methylation deconvolution methods for tumoral fraction estimation using DecoNFlow

Edoardo GiuiliSofie Van de VeldeSam KintMaísa Renata Ferro Dos SantosLotte CornelliSofie RoelandtKathleen SchoofsRenske ImschootRuben Van PaemelLeander Meuris et al.

Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling

The exRNAQC ConsortiumJasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert Dhondt et al.

A1 Artikel in een tijdschrift in NATURE COMMUNICATIONS

2024

A fast, affordable and minimally-invasive diagnostic test for Cancer of Unknown Primary (CUP) using DNA methylation profiling

Jilke De WildeRuben Van PaemelAndries De KokerSofie RoelandtSofie Van de VeldeNico CallewaertJo Van DorpeDavid CreytensBram De WildeKatleen De Preter

A1 Artikel in een tijdschrift in LABORATORY INVESTIGATION

Diagnosis of pediatric central nervous system tumors using methylation profiling of cfDNA from cerebrospinal fluid

Lotte CornelliRuben Van PaemelMaísa Renata Ferro Dos SantosSofie RoelandtLeen WillemsJelle VandersteeneEdward BaertLiselot MusNadine Van RoyBram De Wilde et al.

A1 Artikel in een tijdschrift in CLINICAL EPIGENETICS

2023

Case series on clinical applications of liquid biopsy in pediatric solid tumors : towards improved diagnostics and disease monitoring

Nina U. GelineauAstrid van BarneveldAtia SamimLieke Van ZogchelNathalie LakMichelle L. TasYvette MatserAnnelies M. C. Mavinkurve-GroothuisMartine van GrotelJószef Zsiros et al.

A1 Artikel in een tijdschrift in FRONTIERS IN ONCOLOGY

Cell-free DNA as a diagnostic and prognostic biomarker in pediatric rhabdomyosarcoma

Nathalie S.M. LakLieke M.J. van ZogchelLily Zappeij-KannegieterAhmad JavadiRuben Van PaemelCharlotte VandeputteKatleen De PreterBram De WildeMathieu ChicardYasmine Iddir et al.

A1 Artikel in een tijdschrift in JCO PRECISION ONCOLOGY

Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Whole genome sequencing and inheritance-based variant filtering as a tool for unraveling missing heritability in pediatric cancer

Charlotte DerpoorterRuben Van PaemelKatrien VandemeulebroeckeJolien VanhoorenBram De WildeGenevieve LaureysTim Lammens

A1 Artikel in een tijdschrift in PEDIATRIC HEMATOLOGY AND ONCOLOGY

2022

From conception to birth of a paediatric research community

Eva DegraeuweLaurens Van CampEline HermansRuben Van PaemelTine VanhaverbekeNele De LangheAnn RaesJohan Vande WalleMirko Petrovic

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

The feasibility of using liquid biopsies as a complementary assay for copy number aberration profiling in routinely collected paediatric cancer patient samples

Ruben Van PaemelCharlotte VandeputteLennart RamanJolien Van ThorreLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeAndries De KokerBjörn Menten et al.

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF CANCER

When DNA gets in the way in RNA-seq experiments, a sequel

Jasper VerwiltMaria D. GiraldezWim TrypsteenRuben Van PaemelKatleen De PreterPieter MestdaghJo Vandesompele

2021

Expanding the diagnostic toolbox in pediatric oncology : exploration of the value of the cell-free DNA methylome

Ruben Van PaemelBram De WildeKatleen De Preter

Genome-wide study of the effect of blood collection tubes on the cell-free DNA methylome

Ruben Van PaemelAndries De KokerChrista CaggianoAnnelien MorlionPieter MestdaghBram De WildeJo VandesompeleKatleen De Preter

A1 Artikel in een tijdschrift in EPIGENETICS

Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study

Ruben Van PaemelAndries De KokerCharlotte VandeputteLieke van ZogchelTim LammensGenevieve LaureysJo VandesompeleGudrun SchleiermacherMathieu ChicardNadine Van Roy et al.

A1 Artikel in een tijdschrift in EPIGENETICS

Multisystem inflammatory syndrome in children related to COVID-19 : a systematic review

Levi HosteRuben Van PaemelFilomeen Haerynck

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF PEDIATRICS

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

2020

Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA

Ruben Van PaemelAndries De KokerCharlotte VandeputteLieke Van ZogchelTim LammensGenevieve LaureysJo VandesompeleGudrun SchleiermacherMatthieu ChicardNadine Van Roy et al.

Multisystem inflammatory syndrome in children related to COVID-19 : a systematic review

Levi HosteRuben Van PaemelFilomeen Haerynck

Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles

Celine EveraertHetty HelsmoortelAnneleen DecockEva HulstaertRuben Van PaemelKimberly VerniersJustine NuytensJasper AnckaertNele NijsJoeri Tulkens et al.

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control study-important considerations for liquid biopsies

Anneleen DecockJasper AnckaertCeline EveraertJustine NuytensScott KuerstenAn HendrixJo VandesompelePieter MestdaghBert DhondtRuben Van Paemel et al.

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : a review

Ruben Van PaemelROSALIE VLUGKatleen De PreterNadine Van RoyFranki SpelemanLeen WillemsTim LammensGenevieve LaureysGudrun SchleiermacherGodelieve AM Tytgat et al.

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF PEDIATRICS

The pitfalls and promise of liquid biopsies for diagnosing and treating solid tumors in children : as review (vol 179, pg 191, 2020)

Ruben Van PaemelRoos VlugKatleen De PreterNadine Van RoyFranki SpelemanLeen WillemsTim LammensGenevieve LaureysGudrun SchleiermacherGodelieve A. M. Tytgat et al.

When DNA gets in the way : a cautionary note for DNA contamination in extracellular RNA-seq studies

Jasper VerwiltWim TrypsteenRuben Van PaemelKatleen De PreterMD GiraldezPieter MestdaghJo Vandesompele

A1 Artikel in een tijdschrift in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2019

A fast, affordable and minimally-invasive diagnostic test for Cancer of Unknown Primary (CUP) using DNA methylation profiling

Jilke De WildeRuben Van PaemelCharlotte VandeputteAndries De KokerJoni Van der MeulenMalaïka Van der LindenNico CallewaertJo Van DorpeDavid CreytensBram De Wilde et al.

A versatile method for circulating cell-free DNA methylome profiling by reduced representation bisulfite sequencing

Andries De KokerRuben Van PaemelBram De WildeKatleen De PreterNico Callewaert

Brain metastasis and renal cell carcinoma : prognostic scores assessment in the era of targeted therapies

Ziad El AliSylvie RotteyPhilippe BarthelemyNuria KoteckiRuben Van PaemelDaniel DevrientAhmad AwadaThierry GilDiane PannierThomas Ryckewaert et al.

A1 Artikel in een tijdschrift in ANTICANCER RESEARCH

Dramatic differences in RNA purification kit performance in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

Dramatic differences in RNA purification kit performance in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

Evaluating the impact of RNA purification kit and blood collection tube in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockJill DeleuOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty Helsmoortel et al.

Faster, cheaper and more accurate diagnosis of cancer of unknown primary (CUP) by using methylation profiling.

Jilke De WildeRuben Van PaemelCharlotte VandeputteAndries De KokerJoni Van der MeulenMalaïka Van der LindenNico CallewaertJo Van DorpeDavid CreytensBram De Wilde et al.

Minimally invasive classification of pediatric solid tumors using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study

Ruben Van PaemelAndries De KokerCharlotte VandeputteLieke van ZogchelTim LammensGenevieve LaureysJo VandesompeleGudrun SchleiermacherMathieu ChicardNadine Van Roy et al.

Non-invasive classification of pediatric tumor types using reduced representation bisulfite sequencing of cell-free DNA : a proof-of-principle study

Ruben Van PaemelA. De KokerCharlotte VandeputteL. M. J. van ZogchelM. ChicardTim LammensJo VandesompeleNadine Van RoyG. SchleiermacherG. A. M. Tytgat et al.

Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles

Celine EveraertHetty HelsmoortelAnneleen DecockEva HulstaertRuben Van PaemelKimberly VerniersJustine NuytensJasper AnckaertNele NijsJoeri Tulkens et al.

A1 Artikel in een tijdschrift in SCIENTIFIC REPORTS

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenL. van Zogchel et al.

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

Shallow whole genome sequencing on circulating cell-free DNA in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

Successful copy number alteration profiling using circulating cell-free tumor DNA as a non-invasive alternative for tissue biopsies in pediatric cancer patients

Charlotte VandeputteJolien Van ThorreRuben Van PaemelAndries De KokerLeen WillemsJo Van DorpeMalaïka Van der LindenJilke De WildeBjörn MentenLieke van Zogchel et al.

2018

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Non-invasive differential diagnosis of neuroblastoma with other paediatric solid tumors using methylation profiling of circulating cell-free DNA

Ruben Van PaemelAnneleen DecockCharlotte VandeputteTim LammensGenevieve LaureysFranki SpelemanWim Van CriekingeNadine Van RoyJo VandesompeleKatleen De Preter et al.

Shallow whole genome sequencing allows successful copy number profiling in formalin-fixed paraffin-embedded material in neuroblastoma patients

Charlotte VandeputteRuben Van PaemelBram De WildeMalaïka Van der LindenJo Van DorpeBjörn MentenFranki SpelemanNadine Van RoyKatleen De Preter

The extracellular RNA quality control (exRNAQC) study : controlling pre-analytical variables of RNA sequencing in blood-based precision medicine

Francisco Avila CobosAnneleen DecockKatleen De PreterBert DhondtOlivier De WeverBram De WildeCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

The extracellular RNA quality control (exRNAQC) study : controlling pre-analytical variables of RNA sequencing in blood-based precision medicine

Francisco Avila CobosAnneleen DecockKatleen De PreterOlivier De WeverBram De WildeBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

The potential of methylome sequencing in the diagnostic work : up of pediatric solid tumors

Ruben Van PaemelCharlotte VandeputteBram De WildeKatleen De PreterNadine Van RoyJo VandesompeleTim LammensWim Van CriekingeP. UltzNico Callewaert et al.

2017

Confirmation of an ARID2 defect in SWI/SNF-related intellectual disability

Ruben Van PaemelPauline De BruyneSaskia van der StraatenMarleen D'HondtUrlien FränkelAnnelies DheedeneBjörn MentenBert Callewaert

A1 Artikel in een tijdschrift in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Identification of genetic aberrations predisposing to familial Burkitt lymphoma using whole genome sequencing

Ruben Van PaemelCharlotte DerpoorterRein DemuynckEva TerrasBram De WildeTim LammensGenevieve Laureys