Research Explorer

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Researcher

Peter Brouckaert

Publications & Research Data

Awards & Distinctions

209 Results

2025

The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors

Stephen P. H. AlexanderDoriano FabbroChloe J. PeachAlasdair J. GibbEamonn KellyAlistair A. MathieEmma L. VealeJane F. ArmstrongElena FaccendaSimon D. Harding et al.

U Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

2021

Microcirculatory function during endotoxemia : a functional citrulline-arginine-NO pathway and NOS3 complex is essential to maintain the microcirculation

Karolina A. P. WijnandsDennis M. MeestersBenjamin VandendriesscheJacob J. BriedeHans M. H. van EijkPeter BrouckaertAnje CauwelsWouter H. LamersMartijn Poeze

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plasma nitric oxide handling and its metabolism to endocrine S-nitrosothiol and nitrite : role of ceruloplasmin and a novel function for postprandial triglyceride-rich lipoproteins

Kurt VranckenPeter BrouckaertArlin Blood

The concise guide to pharmacology 2021/22 : catalytic receptors

Stephen P. H. AlexanderDoriano FabbroEamonn KellyAlistair MathieJohn A. PetersEmma L. VealeJane F. ArmstrongElena FaccendaSimon D. HardingAdam J. Pawson et al.

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

2020

Safe eradication of large established tumors using neovasculature-targeted tumor necrosis factor-based therapies

Leander HuygheAlexander Van ParysAnje CauwelsSandra Van LintStijn De MunterJennyfer BultinckLennart ZabeauJeroen HostensAn GoethalsNele Vanderroost et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

2019

Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D : a novel mechanism for an old drug

Sofia-Iris BibliAndreas PapapetropoulosEfstathios K IliodromitisAndreas DaiberVoahanginirina RandriamboavonjySebastian StevenPeter BrouckaertAthanasia ChatzianastasiouKyriakos E KypreosDerek J Hausenloy et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

2017

Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice

Sara VandenwijngaertMelissa SwinnenAnn-Sophie WalravensManu BeerensHilde GillijnsEllen CaluweRobert E TainshDaniel I NathanKaitlin AllenPeter Brouckaert et al.

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Erectile dysfunction in heme-deficient nitric oxide-unresponsive soluble guanylate cyclase knock-in mice

Kelly DecaluwéBart PauwelsCharlotte BoydensRobrecht ThoonenEmmanuel S BuysPeter BrouckaertJohan Van de Voorde

A1 Journal Article in JOURNAL OF SEXUAL MEDICINE

Ferulic acid-4-O-sulfate rather than ferulic acid relaxes arteries and lowers blood pressure in mice

Evelien Van RymenantJohn Van CampBart PauwelsCharlotte BoydensLaura Vanden DaeleKatrijn BeerensPeter BrouckaertGuy SmaggheAsimina KerimiGary Williamson et al.

A1 Journal Article in JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Newly identified NO-sensor guanylyl cyclase/connexin 43 association is involved in cardiac electrical function

Pierre-Antoine CrassousPing ShuCan HuangRichard GordanPeter BrouckaertPaul D LampeLai-Hua XieAnnie Beuve

A1 Journal Article in JOURNAL OF THE AMERICAN HEART ASSOCIATION

Sensitivity to sevoflurane anesthesia is decreased in mice with a congenital deletion of guanylyl cyclase-1 alpha

Yasuko NagasakaMartin WeplerRobrecht ThoonenPatrick SipsKaitlin AllenJan A GrawVincent YaoSara M BurnsStefan MuensterPeter Brouckaert et al.

A1 Journal Article in BMC ANESTHESIOLOGY

The ability of nitric oxide to lower intraocular pressure is dependent on guanylyl cyclase

Stefan MuensterWolfgang S LiebGregor FabryKaitlin N AllenShivani S KamatAnn H GuyAna C DordeaLeandro TeixeiraRobert E TainshBinglan Yu et al.

A1 Journal Article in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Tyrosine phosphorylation of eNOS regulates myocardial survival after an ischaemic insult: role of PYK2

Sofia-Iris BibliZongmin ZhouSven ZukunftBeate FisslthalerIoanna AndreadouCsaba SzaboPeter BrouckaertIngrid FlemingAndreas Papapetropoulos

A1 Journal Article in CARDIOVASCULAR RESEARCH

2016

Androgen-sensitive hypertension associated with soluble guanylate cyclase-α₁ deficiency is mediated by 20-HETE

Ana C DordeaSara VandenwijngaertVictor GarciaRobert ET TainshDaniel I NathanKaitlin AllenMichael J RaherLaurel T TainshFan ZhangWolfgang S Lieb et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Distinct myocardial mechanisms underlie cardiac dysfunction in endotoxemic male and female mice

Ion A HobaiKanwal AzizEmmanuel S BuysPeter BrouckaertDeborah A SiwikWilson S Colucci

A1 Journal Article in SHOCK

Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies

Magdalena SipsM KrykbaevaTJ DiefenbachM GhebremichaelBA BowmanA-S DugastAW BoeschH StreeckDS KwonME Ackerman et al.

A1 Journal Article in MUCOSAL IMMUNOLOGY

Harnessing innate immunity to prevent and control HIV infection

Magdalena SipsGalit AlterPeter Brouckaert

HLA-C levels impact natural killer cell subset distribution and function

Magdalena SipsQingquan LiuMonia DraghiMusie GhebremichaelChristoph T BergerTodd J SuscovichYongtao SunBruce D WalkerMary CarringtonMarcus Altfeld et al.

A1 Journal Article in HUMAN IMMUNOLOGY

Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization, and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms

Younghye MoonJordan E BalkeDerik MadormaMichael P SiegelGary KnowelsPeter BrouckaertEmmanuel S BuysDavid J MarcinekJustin M Percival

A1 Journal Article in ANTIOXIDANTS & REDOX SIGNALING

Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/β-catenin inhibition

Aurelia De PauwPaul MassionBelaid SekkaliEmilie AndreCaroline DubrocaJana KmecovaCaroline BouzinAnn FriartCatherine SibillePatrick Gilon et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

2015

Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway

Sofia-Iris BibliIoanna AndreadouAthanasia ChatzianastasiouChristos TzimasDespina SanoudouEvangelia KraniasPeter BrouckaertCiro ColettaCsaba SzaboDimitrios T Kremastinos et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

Cardiovascular and pharmacological implications of haem-deficient NO-unresponsive soluble guanylate cyclase knock-in mice

Robrecht ThoonenAnje CauwelsKelly DecaluwéSandra GeschkaRobert E TainshJoris DelangheTino HochepiedLode De CauwerElke RoggeSofie Voet et al.

A1 Journal Article in NATURE COMMUNICATIONS

Citrulline supplementation improves organ perfusion and arginine availability under conditions with enhanced arginase activity

Karolina AP WijnandsDennis M MeestersKevin WY van BarneveldRuben GJ VisschersJacob J BriedéBenjamin VandendriesscheHans MH van EijkBabs AFM BessemsNadine van den HovenChristian JH von Wintersdorff et al.

A1 Journal Article in NUTRIENTS

Depleting MET-expressing tumor cells by ADCC provides a therapeutic advantage over inhibiting HGF/MET signaling

Anna HultbergVirginia MorelloLeander HuygheNatalie De JongeChristophe BlanchetotValérie HanssensGitte de BoeckKaren SilenceEls FestjensRaimond Heukers et al.

A1 Journal Article in CANCER RESEARCH

Guanylyl cyclase activation reverses resistive breathing–induced lung injury and inflammation

Constantinos GlynosDimitris ToumpanakisKonstantinos LoverdosVassiliki KaravanaZongmin ZhouChristina MagkouMaria DettorakiFotis PerlikosAthanasia PavlidouVasilis Kotsikoris et al.

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Oximes induce erection and are resistant to oxidative stress

Bart PauwelsCharlotte BoydensPeter BrouckaertJohan Van de Voorde

A1 Journal Article in JOURNAL OF SEXUAL MEDICINE

Relaxant and antioxidant capacity of the red wine polyphenols, resveratrol and quercetin, on isolated mice corpora cavernosa

Charlotte BoydensBart PauwelsKelly DecaluwéPeter BrouckaertJohan Van de Voorde

A1 Journal Article in JOURNAL OF SEXUAL MEDICINE

Transcriptome analysis in patients with chronic kidney disease on hemodialysis disclosing a key role for CD16⁺CX3CR1⁺ monocytes

Eva SchepersErica HouthuysAnnemieke DhondtGRIMBERT DE MEYERNathalie NeirynckPascal BernaertRafael Van den BerghPeter BrouckaertRaymond VanholderGriet Glorieux

A1 Journal Article in PLOS ONE

2014

A multiscale entropy-based tool for scoring severity of systemic inflammation

Benjamin VandendriesscheHarlinde PeperstraeteElke RoggePeter CauwelsEric HosteOliver StiedlPeter BrouckaertAnje Cauwels

A1 Journal Article in CRITICAL CARE MEDICINE

ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade

Karen SilenceTorsten DreierMahan MoshirPeter UlrichtsSofie ME GabrielsMichael SaundersHarald WajantPeter BrouckaertLeander HuygheTim Van Hauwermeiren et al.

A1 Journal Article in MABS

Extracellular ATP drives systemic inflammation, tissue damage and mortality

Anje CauwelsElke RoggeBenjamin VandendriesscheS ShivaPeter Brouckaert

A1 Journal Article in CELL DEATH & DISEASE

Heme-deficient NO-unresponsive sGC knock-in mice: novel aspects of NO sGC signaling in cardiovascular (patho)physiology

Robrecht ThoonenEmmanuel BuysAnje CauwelsKelly DecaluwéSandra GeschkaRobert TainshJoris DelangheTino HochepiedLode De CauwerElke Rogge et al.

Influence of cinaciguat on gastrointestinal motility in apo-sGC mice

Sarah CosynsLeander HuygheRobrecht ThoonenJohannes-Peter StaschPeter BrouckaertRomain Lefebvre

A1 Journal Article in NEUROGASTROENTEROLOGY AND MOTILITY

Loss of α1β1 soluble guanylate cyclase, the major nitric oxide receptor, leads to moyamoya and achalasia

Dominique HervéAnne PhilippiReda BelbouabMichel ZerahStéphane ChabrierSophie Collardeau-FrachonFrançoise BergamettiAurore EssongueEliane BerrouValérie Krivosic et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock

Benjamin VandendriesscheAn GoethalsAlba SimatsEvelien Van HammePeter BrouckaertAnje Cauwels

A2 Journal Article in BMC PHYSIOLOGY

Nitric oxide production by endotoxin preparations in TLR4-deficient mice

Anje CauwelsJennyfer BultinckRenske De ZwaefBenjamin VandendriesscheStefan MagezPeter Brouckaert

A1 Journal Article in NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Relaxant and antioxidant capacity of red wine polyphenols on isolated mice corpora cavernosa

Charlotte BoydensBart PauwelsKelly DecaluwéPeter BrouckaertJohan Van de Voorde

Role of the nitric oxide-soluble guanylyl cyclase pathway in obstructive airway diseases

Lisa DupontConstantinos GlynosKen BrackePeter BrouckaertGuy Brusselle

A1 Journal Article in PULMONARY PHARMACOLOGY & THERAPEUTICS

2013

BAY 58-2667 does not improve delayed gastric emptying in APO-SGC mice

Sarah CosynsJohannes Peter StaschPeter BrouckaertRomain Lefebvre

Brown adipose tissue blood flow and mass in obesity: a contrast ultrasound study in mice

Maëva ClerteDavid M BaronPeter BrouckaertLaura ErnandeMichael J RaherAidan W FlynnMichael H PicardKenneth D BlochEmmanuel S BuysMarielle Scherrer-Crosbie

A1 Journal Article in JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY

Cinaciguat in the gastrointestinal tract of apo-sGC mice

Sarah CosynsJohannes Peter StaschPeter BrouckaertRomain Lefebvre

Complex dynamics in systemic inflammation : quantification of coupling and targeting of the nitric oxide-soluble guanylate cyclase axis

Benjamin VandendriesschePeter BrouckaertAnje Cauwels

Heme deficiency of soluble guanylate cyclase induces gastroparesis

Sarah CosynsIngeborg DhaeseRobrecht ThoonenES BuysAnne VralPeter BrouckaertRomain Lefebvre

A1 Journal Article in NEUROGASTROENTEROLOGY AND MOTILITY

Of mice, men, and inflammation

Anje CauwelsBenjamin VandendriesschePeter Brouckaert

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis

Ion A HobaiEmmanuel S BuysJustin C MorseJessica EdgecombEric H WeissAntonis A ArmoundasXiuyun HouAlok R KhandelwalDeborah A SiwikPeter Brouckaert et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Soluble guanylate cyclase α₁-deficient mice: a novel murine model for primary open angle glaucoma

Emmanuel S BuysYu-Chien KoClemens AltSarah R HaytonAlexander JonesLaurel T TainshRuiyi RenAndrea GianiMaeva ClertéEmma Abernathy et al.

A1 Journal Article in PLOS ONE

The role of soluble guanylyl cyclase in Chronic Obstructive Pulmonary Disease

Constantinos GlynosLisa DupontTheodoros VassilakopoulosAndreas PapapetropoulosPeter BrouckaertAthanassios GiannisGuy JoosKen BrackeGuy Brusselle

A1 Journal Article in AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems

Benjamin VandendriesscheElke RoggeVera GoossensPeter VandenabeeleJohannes-Peter StaschPeter BrouckaertAnje Cauwels

A1 Journal Article in PLOS ONE

TLR2 activation causes no morbidity or cardiovascular failure, despite excessive systemic nitric oxide production

Anje CauwelsBenjamin VandendriesscheJennyfer BultinckBenedicte DescampsElke RoggeTom Van NieuwenhuysenMagdalena SipsChristian VanhovePeter Brouckaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

2012

Genetic modifiers of hypertension in soluble guanylate cyclase α1-deficient mice

Emmanuel S BuysMichael J RaherAndrew KirbyMohd ShahidDavid M BaronSarah R HaytonLaurel T TainshPatrick SipsKristen M RauwerdinkQingshang Yan et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Identification of renin signaling as a blood pressure modifying mechanism in soluble guanylate cyclase alpha(1)-deficient mice

Emmanuel BuysMichael RaherAndrew KirbyShahid MohdDavid BaronSarah HaytonLaurel TainshPatrick SipsKristen RauwerdinkRobert Tainsh et al.

In vivo noninvasive characterization of brown adipose tissue blood flow by contrast ultrasound in mice

David M BaronMaeva ClertePeter BrouckaertMichael J RaherAidan W FlynnHaihua ZhangEdward A CarterMichael H PicardKenneth D BlochEmmanuel S Buys et al.

A1 Journal Article in CIRCULATION-CARDIOVASCULAR IMAGING

Study on the involvement of soluble guanylyl cyclase and its different isoforms in carbon monoxide and carbon monoxide releasing molecule-2 induced vasodilatation

Kelly DecaluwéBart PauwelsSara VerpoestPeter BrouckaertJohan Van de Voorde

2011

Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis

Nele FestjensPieter BogaertAnjana BatniErica HouthuysEvelyn PletsDieter VanderschaegheBram LaukensBob AsselberghEef ParthoensRiet De Rycke et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Do-it-yourself: construction of a custom cDNA macroarray platform with high sensitivity and linear range

Tom BoonefaesErica HouthuysRafael Van den BerghSeppe Vander BekenGeert RaesPeter BrouckaertP De BaetselierJohan Grooten

A1 Journal Article in BMC BIOTECHNOLOGY

Genetic mapping of a modifier locus affecting blood pressure in soluble guanylate cyclase alpha 1-deficient mice

Emmanuel S BuysMichael J RaherAndrew KirbySarah R HaytonDavid M BaronPatrick SipsShahid MohdKristen M RauwerdinkQingshang YanLaurel T Tainsh et al.

Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice

Shizuka MinamishimaKotaro KidaKentaro TokudaHuiFang WangPatrick SipsShizuko KosugiJoseph B MandevilleEmmanuel S BuysPeter BrouckaertPhilip K Liu et al.

A1 Journal Article in CIRCULATION

Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene

Andrea U SteinbickerHeLing LiuKim JiramongkolchaiRajeev MalhotraElizabeth Y ChoeCornelius J BuschAmanda R GravelineSonya M KaoYasuko NagasakaFumito Ichinose et al.

A1 Journal Article in NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitrite regulation of shock

Anje CauwelsPeter Brouckaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastric fundus of apo-sGC mice

Sarah CosynsJP StaschPeter BrouckaertRomain Lefebvre

Relaxant effect of BAY 41-2272 and BAY 58-2667 in the gastrointestinal tract of apo-sGC mice

Sarah CosynsJohannes-Peter StaschPeter BrouckaertRomain Lefebvre

sGCα1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling

Sharon M CawleyStarsha KolodziejFumito IchinosePeter BrouckaertEmmanuel S BuysKenneth D Bloch

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Soluble guanylate cyclase-alpha(1) is required for the cardioprotective effects of inhaled nitric oxide

Yasuko NagasakaES BuysEster SpagnolliAndrea U SteinbickerSarah R HaytonKristen M RauwerdinkPeter BrouckaertWarren M ZapolKenneth D Bloch

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Study on the involvement of soluble guanylyl cyclase and its different isoforms in carbon monoxide and carbon monoxide releasing molecule-2 induced vasodilatation

Johan Van de VoordeKelly DecaluwéBart PauwelsSara VerpoestPeter Brouckaert

The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning

Patrick SipsPeter BrouckaertFumito Ichinose

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Toll-like receptor 4 signaling confers cardiac protection against ischemic injury via inducible nitric oxide synthase- and soluble guanylate cyclase-dependent mechanisms

E WangYan FengMing ZhangLin ZouYan LiEmmanuel S BuysPeigen HuangPeter BrouckaertWei Chao

A1 Journal Article in ANESTHESIOLOGY

2010

A method for the isolation and purification of mouse peripheral blood monocytes

Erica HouthuysKiavash MovahediPatrick De BaetselierJo A Van GinderachterPeter Brouckaert

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Generation and characterization of apo-soluble Guanylate Cyclase mice

Robrecht ThoonenPeter Brouckaert

In vitro and in vivo studies on the importance of the soluble guanylyl cyclase α1 subunit in penile erection

Kelly DecaluwéSofie NimmegeersRobrecht ThoonenEmanuel BuysPeter BrouckaertJohan Van de Voorde

A1 Journal Article in WORLD JOURNAL OF UROLOGY

In vivo experiments using soluble guanylyl cyclase Beta1 his 105 Phe mutant mice: no-vasodilatation and penile erection fully dependent on activation of SGC

Kelly DecaluwéSofie NimmegeersHendrik CoppensRobrecht ThoonenPeter BrouckaertJohan Van de Voorde

In vivo studies elucidating the functional role of soluble guanylyl cyclase (sGC) and its different isoforms in vasodilatation and penile erection

Kelly DecaluwéSofie NimmegeersRobrecht ThoonenPeter BrouckaertJohan Van de Voorde

Inhaled nitric oxide improves long-term outcome after successful cardiopulmonary resuscitation in mice

Shizuka MinamishimaPatrick SipsShizuko KosugiKentaro TokudaKotaro KidaPeter BrouckaertKenneth D BlochFumito Ichinose

Nitric oxide synthase isoforms play distinct roles during acute peritonitis

Jie NiRachel M McLoughlinAlexandre BrodovitchPierre MoulinPeter BrouckaertBarbara CasadeiOlivier FeronNicholas TopleyJean-Luc BalligandOlivier Devuyst

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

Reactive oxygen species and small-conductance calcium-dependent potassium channels are key mediators of inflammation-induced hypotension and shock

Anje CauwelsElke RoggeBen JanssenPeter Brouckaert

A1 Journal Article in JOURNAL OF MOLECULAR MEDICINE-JMM

Soluble guanylate cyclase α1β1 limits stroke size and attenuates neurological injury

Dimitriy N AtochinIzumi YuzawaQiAn LiKristen M RauwerdinkRajeev MalhotraJunLei ChangPeter BrouckaertCenk AyataMichael A MoskowitzKenneth D Bloch et al.

A1 Journal Article in STROKE

Studies on the importance of soluble guanylyl cyclase (SGC) isoforms in erectile function using transgenic mice

Kelly DecaluwéSofie NimmegeersRobrecht ThoonenEmmanuel BuysPeter BrouckaertJohan Van de Voorde

The alpha1 Isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for cardioprotective signaling

Patrick SipsPeter BrouckaertFumito Ichinose

Transcriptome analysis of monocytes and macrophages in mycobacterial infection and chronic kidney disease

Erica HouthuysPeter Brouckaert

2009

Gender-specific modulation of the response to arterial injury by soluble guanylate cyclase α1

Pieter VermeerschEmmanuel BuysPatrick SipsPeter PokreiszGlenn MarsboomHilde GillijnsMarijke PellensMieke DewerchinKenneth D BlochPeter Brouckaert et al.

A2 Journal Article in OPEN CARDIOVASCULAR MEDICINE JOURNAL

Hypertension in soluble guanylate cyclase alpha(1)-deficient mice is associated with hyperaldosteronism

Emmanuel S BuysMichael J RaherKristen M RauwerdinkPatrick SipsPeter BrouckaertKenneth D Bloch

In vitro and in vivo studies on the importance of the soluble guanylyl cyclase Alpha 1 subunit in penile erection

Kelly DecaluwéSofie NimmegeersRobrecht ThoonenPeter BrouckaertJohan Van de Voorde

In vitro and in vivo studies on the importance of the soluble guanylyl cyclase α1 subunit in penile erection

Kelly DecaluwéSofie NimmegeersRobrecht ThoonenEmanuel BuysPeter BrouckaertJohan Van de Voorde

Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner

Anje CauwelsEmmanuel S BuysRobrecht ThoonenLisa GearyJoris DelangheSruti ShivaPeter Brouckaert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice

Takefumi NishidaJia De YuShizuka MinamishimaPatrick SipsRobert J. SearlesEmmanuel S. BuysStefan JanssensPeter BrouckaertKenneth D. BlochFumito Ichinose

A1 Journal Article in CRITICAL CARE MEDICINE

sGCα1β1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models

Emmanuel S BuysAnje CauwelsMichael J RaherJonathan J PasseriIon HobaiSharon M CawleyKristen M RauwerdinkHélène ThibaultPatrick SipsRobrecht Thoonen et al.

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Small intestinal motility in soluble guanylate cyclase α₁ knockout mice

Ingeborg DhaeseGwen VannestePatrick SipsEmmanuel BuysPeter BrouckaertRomain Lefebvre

A1 Journal Article in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Role of EUTox in Uremic Toxin Research

Raymond VanholderO Abou-DeifA ArgilesU BaurmeisterJ BeigePeter BrouckaertPhilippe BrunetG CohenPP De DeynTB Drueke et al.

A1 Journal Article in SEMINARS IN DIALYSIS

Vascular smooth muscle relaxation in soluble guanylyl cyclase beta 1 his 105 phe mutant mice

Johan Van de VoordeSofie NimmegeersKelly DecaluwéRobrecht ThoonenPeter Brouckaert

Vascular smooth muscle relaxation in soluble guanylyl cyclase beta 1 his 105 phe mutant mice

Johan Van de VoordeSofie NimmegeersKelly DecaluwéRobrecht ThoonenPeter Brouckaert

2008

Critical role for small and large conductance calcium-dependent potassium channels in endotoxemia and TNF toxicity

Anje CauwelsPeter Brouckaert

A1 Journal Article in SHOCK

Functional importance of the sGC isoforms (alpha(1)beta(1) and alpha(2)beta(1)) in vascular smooth muscle relaxation

Sofie NimmegeersPatrick SipsE BUYSRobrecht ThoonenK DECALUWEPeter BrouckaertJohan Van de Voorde

Gender-specific hypertension and reaction to NO stimulation in sGC alpha 1-/-mice

Peter BrouckaertE BUYSPatrick SipsK BLOCHSofie NimmegeersJV DE VOORDEG VANNESTERomain Lefebvre

Gender-specific hypertension and responsiveness to nitric oxide in sGCα₁ knockout mice

Emmanuel BuysPatrick SipsPieter VermeerschMichael J RaherElke RoggeFumito IchinoseMieke DewerchinKenneth D BlochStefan JanssensPeter Brouckaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

Involvement of soluble guanylate cyclase alpha(1) and alpha(2), and SKCa channels in NANC relaxation of mouse distal colon

Ingeborg DhaeseGwen VannestePatrick SipsE BUYSPeter BrouckaertRomain Lefebvre

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

Phenotyping of NO-insensitive soluble guanylate cyclase beta1H105F Knockin mice

Peter BrouckaertRobrecht ThoonenEmmanuel BuysSofie NimmegeersElke RoggePatrick SipsKenneth D BlochJohan Van de Voorde

Role of the soluble guanylyl cyclase 1 subunit in mice corpus cavernosum smooth muscle relaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysKelly DecaluwéPeter BrouckaertJohan Van de Voorde

Role of the soluble guanylyl cyclase alpha(1)-subunit in mice corpus cavernosum smooth muscle relaxation

Sofie NimmegeersPatrick SipsE BuysKelly DecaluwéPeter BrouckaertJohan Van de Voorde

A1 Journal Article in INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH

Role of the soluble guanylyl cyclase α1/α2 subunits in the relaxant effect of CO and CORM-2 in murine gastric fundus

Ole De BackerEllen ElinckPatrick SipsEmmanuel BuysPeter BrouckaertRomain Lefebvre

A1 Journal Article in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Study of molecular and immunological factors that determine the sensitivity to the antitumor effect of Tumor Necrosis Factor

Leander HuyghePeter Brouckaert

TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways

MA RIVASRP CARNEVALECJ PROIETTIC ROSEMBLITW BEQUELINM SALATINOEH CHARREAUI FRAHMS SAPIAPeter Brouckaert et al.

A1 Journal Article in EXPERIMENTAL CELL RESEARCH

Vascular smooth muscle relaxation in soluble guanylyl cyclase 1 his 105 phe mutant mice

Sofie NimmegeersKelly DecaluwéRobrecht ThoonenPeter BrouckaertJohan Van de Voorde

Vascular smooth muscle relaxation in soluble guanylyl cyclase beta 1 his 105 phe mutant mice

Sofie NimmegeersKelly DecaluwéRobrecht ThoonenPeter BrouckaertJohan Van de Voorde

2007

Excessive endogenous systemic no production is not sufficient to cause shock, morbidity or mortality

Anje CauwelsJennyfer BultinckRenske De ZwaefPeter Brouckaert

Functional analysis of soluble guanylate cyclase isoforms using mouse transgenics : cardiovascular effects of targeted mutagenesis of the alpha 1 subunit

Patrick SipsPeter Brouckaert

Functional importance of the soluble guanylyl cyclase 11 Isoform in vasorelaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

A1 Journal Article in CARDIOVASCULAR RESEARCH

Gastric motility in soluble guanylate cyclase alpha(1) knock-out mice

Gwen VannesteIngeborg DhaesePatrick SipsE BUYSPeter BrouckaertRomain Lefebvre

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

Gender-specific and testosterone-dependent hypertension in soluble guanylate cyclase alpha(1)-deficient mice

Emmanuel S BuysPatrick SipsMichael J RaherAmanda R GravelineRobert J SearlesFumito IchinosePeter BrouckaertKenneth D Bloch

Protective role of soluble guanylate cyclase on the outcome of cardiac arrest and resuscitation in mice

T NISHIDARJ SEARLESEmmanuel BuysPeter BrouckaertKD BLOCHF ICHINOSE

Role of solubile guanylyl cyclase 11 (SGC11) isoform in mice corpus cavernosum smooth muscle relaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

Role of the soluble guanylyl cyclase α1 β1 (sGCα1β1) isoform in mice corpus cavernosum smooth muscle relaxation

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

Soluble guanylate cyclase-α1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia

Pieter VermeerschEmmanuel BuysPeter PokreiszGlenn MarsboomFumito IchinosePatrick SipsMarijke PellensHilde GillijnsMarc SwinnenAmanda Graveline et al.

A1 Journal Article in CIRCULATION

Survival of TNF toxicity: Dependence on caspases and NO

Anje CauwelsPeter Brouckaert

A1 Journal Article in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

2006

A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response: an update

Wim WaelputPeter BrouckaertDaniël BroekaertJan Tavernier

A1 Journal Article in CURRENT MEDICINAL CHEMISTRY

Anaphylactic shock depends on PI3K and eNOS-derived NO

Anje CauwelsBen JanssenEmmanuel BuysPatrick SipsPeter Brouckaert

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Anaphylactic shock depends on PI3K, Akt and eNOS-derived NO

Anje CauwelsB JANSSENE BUYSPatrick SipsPeter Brouckaert

Blocking tumor cell eicosanoid synthesis by GPx4 impedes tumor growth and malignancy

Ingeborg HeirmanDaisy GinnebergeB BRIGELIUS-FLOHEN HENDRICKXP AGOSTINISPeter BrouckaertPieter RottiersJohan Grooten

A1 Journal Article in FREE RADICAL BIOLOGY AND MEDICINE

Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide

Patrick SipsE BUYSElke RoggeS NIMMEGEERSM DEWERCHINJ VAN DE VOORDEPeter Brouckaert

High-output systemic NO production during (septic) shock depends on parenchymal cells and is not sufficient to cause shock and lethality

J BULTINCKR DE ZWAEFPeter BrouckaertAnje Cauwels

Hypertension and cardiac dysfunction in male mice deficient in the alpha 1 subunit of soluble guanylate cyclase

Emmanuel BuysMJ RAHERJJ PASSERIF ICHINOSEMH PICARDPatrick SipsPeter BrouckaertM SCHERRER-CROSBIEKD BLOCH

Soluble guanylate cyclase is essential for the pulmonary but not the systemic vasodilator response to NO and limits pulmonary vascular remodeling in response to chronic hypoxia

P VermeerschP PokreiszE BuysF IchinosG MarsboomKD BlochPeter BrouckaertStefaan Janssens

Systemic NO production during (septic) shock depends on parenchymal and not on hematopoietic cells: in vivo iNOS expression pattern in (septic) shock

Jennyfer BultinckPatrick SipsLuc VakaetPeter BrouckaertAnje Cauwels

A1 Journal Article in FASEB JOURNAL

The in vivo contribution of hematopoietic cells to systemic TNF and IL-6 production during endotoxemia

Jennyfer BultinckPeter BrouckaertAnje Cauwels

A1 Journal Article in CYTOKINE

Variation in ligand binding specificities of a novel class of poxvirus-encoded tumor necrosis factor-binding protein

MM RAHMANJW BARRETTPeter BrouckaertG MCFADDEN

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular smooth muscle relaxation in soluble guanylyl cyclase alpha 1 knockout mice

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

2005

A model for hyperacute hypotension and shock: Nitric oxide or no nitric oxide ?

Anje CauwelsB JANSSENPeter Brouckaert

Blood pressure in mice with a targeted deletion of the soluble guanylyl cyclase alpha 1 subunit

Peter BrouckaertE BUYSPatrick SipsElke RoggeM DEWERCHINAnje Cauwels

Dual role of endogenous nitric oxide in tumor necrosis factor shock: induced NO tempers oxidative stress

Anje CauwelsJennyfer BultinckPeter Brouckaert

A1 Journal Article in CMLS-CELLULAR AND MOLECULAR LIFE SCIENCES

Functional knockout of the soluble guanylate cyclase alpha 1 subunit leads to gender-specific hypertension while retaining sensitivity to nitric oxide

Patrick SipsES BUYSElke RoggeM DEWERCHINPeter Brouckaert

Gender-specific modulation of baseline vascular function and the response to arterial injury by soluble guanylate cyclase

P VermeerschES BuysM GlennP PokreiszM PellensH GillijnsM DewerchinPeter BrouckaertKD BlochStefaan Janssens

NO-mediated vascular smooth muscle relaxation in sGCα1 knock-out mice

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

NO-mediated vascular smooth muscle relaxation in sGCα1 knock-out mice

Sofie NimmegeersPatrick SipsEmmanuel BuysPeter BrouckaertJohan Van de Voorde

Soluble guanylate cyclase deficiency selectively abolishes NO-mediated pulmonary vasodilation and increases the pulmonary vascular remodeling response to chronic hypoxia

P VermeerschP PokreiszG MarsboomES BuysH GillijnsM PellensM SwinnenF IchinoseM DewerchinPeter Brouckaert et al.

Soluble guanylate cyclase deficiency selectively abolishes NO-mediated pulmonary vasodilation and increases the pulmonary vascular remodeling response to chronic hypoxia

P VermeerschP PokreiszG MarsboomES BuysH GillijnsM PellensM SwinnenF IchinoseM DewerchinPeter Brouckaert et al.

2004

Gender-specific hypertension in mice deficient in the alpha(1) subunit of soluble guanylate cyclase

ES BUYSPatrick SipsElke RoggeM DEWERCHINPeter Brouckaert

Janus faces of caspases and nitric oxide in TNF-induced lethal shock in mice

Anje CauwelsPeter Brouckaert

P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis

Stefan MagezCarine TruyensMakram MerimiMagdalena RadwanskaBenoît StijlemansPeter BrouckaertFrank BrombacherEtienne PaysPatrick De Baetselier

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Production and characterization of receptor-specific TNF muteins

Paul AmelootPeter Brouckaert

A4 Journal Article in METHODS IN MOLECULAR MEDICINE

Rapid downregulation of adipose tissue lipoprotein lipase activity on food deprivation: evidence that TNF-alpha is involved

GS WUPeter BrouckaertT OLIVECRONA

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tumor necrosis factor-alpha augmented tumor response in B16BL6 melanoma-bearing mice treated with stealth liposomal doxorubicin (DOXIL (R)) correlates with altered DOXIL (R) pharmacokinetics

Peter BrouckaertN TAKAHASHIST VAN TIELJeroen HostensAMM EGGERMONTALB SEYNHAEVEWalter FiersTLM TEN HAGEN

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

2003

Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2

Anje CauwelsBen JanssenAnouk WaeytensClaude CuvelierPeter Brouckaert

A1 Journal Article in INFLAMMATION RESEARCH

Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2

Anje CauwelsBen JanssenAnouk WaeytensClaude CuvelierPeter Brouckaert

A1 Journal Article in NATURE IMMUNOLOGY

2002

A role for leptin in the systemic inflammatory response syndrome and immune response

Wim WaelputPeter BrouckaertDaniël BroekaertJan Tavernier

A4 Journal Article in INFLAMMATION & ALLERGY : DRUG TARGETS

Bioavailability of recombinant tumor necrosis factor determines its lethality in mice.

Paul AmelootNozomi TakahashiBart EveraerdtJeroen HostensHP EUGSTERWalter FiersPeter Brouckaert

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Characterization of the interaction between murine tumour necrosis factor and monoclonal antibodies.

Paul AmelootWalter FiersWA BUURMANP DE BAETSELIERPeter Brouckaert

A1 Journal Article in CYTOKINE

Overexpression of alpha(1)-acid glycoprotein in transgenic mice leads to sensitisation to acute colitis.

Tino HochepiedAndy WullaertFG BERGERH BAUMANNPeter BrouckaertLothar SteidlerClaude Libert

A1 Journal Article in GUT

Relaxation by vasoactive intestinal polypeptide in the gastric fundus of nitric oxide synthase-deficient mice.

Joëlle DickWim Van MollePeter BrouckaertRomain Lefebvre

A1 Journal Article in JOURNAL OF PHYSIOLOGY-LONDON

2001

A mediator role for metallothionein in tumor necrosis factor-induced lethal shock

Wim WaelputDaniël BroekaertJoël VandekerckhovePeter BrouckaertJan TavernierClaude Libert

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Detection, characterisation and purification of a murine liver factor capable of desensitising towards the lethal activity of tumour necrosis factor.

Ben WielockxTino HochepiedJan StaelensWim Van MollePeter BrouckaertClaude Libert

A1 Journal Article in CYTOKINE

Heterotrimers formed by tumor necrosis factors of different species or muteins.

Paul AmelootWim DeclercqWalter FiersPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants.

Paul AmelootWalter FiersPieter De BleserCF WAREPeter VandenabeelePeter Brouckaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2000

Differential response of alpha(2)-macroglobulin-deficient mice in models of lethal TNF-induced inflammation.

Tino HochepiedPaul AmelootPeter BrouckaertF VAN LEUVENClaude Libert

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

Protection against TNF-induced lethal shock by soluble guanylate cyclase inhibition requires functional inducible nitric oxide synthase.

Anje CauwelsWim Van MolleB JANSSENBart EveraerdtP HUANGWalter FiersPeter Brouckaert

A1 Journal Article in IMMUNITY

The major acute-phase protein, serum amyloid P component, in mice is not involved in endogenous resistance against tumor necrosis factor alpha-induced lethal hepatitis, shock, and skin necrosis.

Wim Van MolleTino HochepiedPeter BrouckaertClaude Libert

A1 Journal Article in INFECTION AND IMMUNITY

Tumor necrosis factor-induced lethal hepatitis: pharmacological intervention with verapamil, tannic acid, picotamide and K76COOH.

Wim Van MolleJ VANDEN BERGHEPeter BrouckaertClaude Libert

A1 Journal Article in FEBS LETTERS

1999

Activation of caspases in lethal experimental hepatitis and prevention by acute phase proteins.

Wim Van MolleGeertrui DeneckerI RODRIGUEZPeter BrouckaertPeter VandenabeeleClaude Libert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Caspase-1 is not involved in experimental hepatitis in mouse.

Wim Van MollePeter BrouckaertClaude Libert

A1 Journal Article in FEBS LETTERS

Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.

Claude LibertBen WielockxGL HAMMONDPeter BrouckaertWalter FiersRW ELLIOTT

A1 Journal Article in GENOMICS

Onderzoek naar de mechanismen leidend tot Tumor Necrosis Factor-geïnduceerde leverschade en hypotensie

Wim Van MollePeter BrouckaertClaude Libert

The role of complement activation in tumour necrosis factor-induced lethal hepatitis.

Claude LibertBen WielockxB GRIJALBAWim Van MolleE KREMMERHR COLTENWalter FiersPeter Brouckaert

A1 Journal Article in CYTOKINE

1998

High-level constitutive expression of alpha(1)-acid glycoprotein and lack of protection against tumor necrosis factor-induced lethal shock in transgenic mice.

Claude LibertTino HochepiedFG BERGERH BAUMANNWalter FiersPeter Brouckaert

A1 Journal Article in TRANSGENIC RESEARCH

Leptin is a protective protein against the toxicity of TNF

N TakahashiWim WaelputYves GuisezPeter Brouckaert

Peter Brouckaert

Bookchapter in Encyclopedia of immunology

Studie van TNF toxiciteit in muismodellen

Bart EveraerdtPeter BrouckaertWalter Fiers

The role of endogenous IFN-gamma, TNF-alpha and IL-10 in LPS-induced nitric oxide release in a mouse model.

JCA TER STEEGEMWCM VAN DE VENPP FORGETPeter BrouckaertWA BUURMAN

A1 Journal Article in CYTOKINE

1997

al-Acid glycoprotein and al-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice

Wim Van MolleClaude LibertWalter FiersPeter Brouckaert

A2 Journal Article in J. Immunol. 159, 3555-3564, 1997

alpha(1)-acid glycoprotein and alpha(1)-antitrypsin inhibit TNF-induced but not anti-Fas-induced apoptosis of hepatocytes in mice.

W VANMOLLEClaude LibertWalter FiersPeter Brouckaert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

1996

al-Antitrypsin inhibits the lethal response to TNF in mice

Claude LibertWim Van MollePeter BrouckaertWalter Fiers

A2 Journal Article in J. Immunol. 157, 5126-5129, 1996

alpha(1)-antitrypsin inhibits the lethal response to TNF in mice.

Claude LibertWim Van MollePeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Inhibition of and sensitization to the lethal effects of tumor necrosis factor

Peter BrouckaertClaude LibertAnje CauwelsBart EveraerdtWim Van MollePaul AmelootYannick GansemansBernardo GrijalbaNozomi TakahashiMarie-José Truong et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

Murine IL-12 is involved in Calmette-Guerin Bacillus-induced sensitization and is by itself sufficient to sensitize mice to the lethal effects of human TNF.

Anje CauwelsWalter FiersPeter Brouckaert

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Platelet-activating factor is a mediator in tumor necrosis factor galactosamine-induced lethality.

Claude LibertWim Van MollePeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF INFLAMMATION

Tumor necrosis factor and the systemic inflammatory response syndrome.

Peter BrouckaertWalter Fiers

A1 Journal Article in CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY

1995

Anti-tumor activity of tumor necrosis factor in combination with interferon-gamma is not affected by prior tolerization.

N TAKAHASHIWalter FiersPeter Brouckaert

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Involvement of IFN-γ in Bacillus Calmette-Guérin-induced but not in tumor-induced sensitization to TNF-induced lethality

Anje CauwelsPeter BrouckaertJohan GrootenSui HuangMichel AguetWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Mechanism of tolerance to tumor-necrosis-factor - Receptor-specific pathway and selectivity.

N TAKAHASHIPeter BrouckaertWalter Fiers

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Optimalization and application in TNF-related models of a method to estimate NO production in vivo.

Wim Van MolleBart EveraerdtAnje CauwelsPeter BrouckaertWalter Fiers

1994

Mechanism of induction of tolerance to tumour-necrosis-factor (TNF): No involvement of modulators of TNF bioavailability or receptor-binding.

Nozomi TakahashiPeter BrouckaertMHA BEMELMANSWA BUURMANWalter Fiers

A1 Journal Article in CYTOKINE

Protection by alpha(1)-acid glycoprotein against tumor necrosis factor-induced lethality.

Claude LibertPeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Receptor-selective mutants of tumour necrosis factor in the therapy of cancer : preclinical studies

Peter BrouckaertPaul AmelootAnje CauwelsBart EveraerdtClaude LibertNozomi TakahashiWim Van MolleWalter Fiers

A1 Journal Article in CIRCULATORY SHOCK

Recombinant IL-1 receptor antagonist protects against TNF-induced lethality in mice.

Bart EveraerdtPeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.

Claude LibertNozomi TakahashiAnje CauwelsPeter BrouckaertH BLUETHMANNWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

1993

Cyclooxygenase inhibitors prevent the induction of tolerance to the toxic effects of tumor necrosis factor.

Nozomi TakahashiPeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOTHERAPY

HUMAN TNF MUTANTS WITH SELECTIVE ACTIVITY ON THE P55 RECEPTOR.

Xaveer Van OstadePeter VandenabeeleBart EveraerdtH LOETSCHERR GENTZM BROCKHAUSW LESSLAUERJan TavernierPeter BrouckaertWalter Fiers

A1 Journal Article in NATURE

Protection against tumor necrosis factor-induced lethality

Claude LibertBart EveraerdtNozomi TakahashiAnje CauwelsPeter BrouckaertWalter Fiers

Strategies to broaden the therapeutic margin of tumor necrosis factor

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiAnje CauwelsWalter Fiers

Tumor necrosis factor

Peter BrouckaertClaude Libert

Bookchapter in Acute Phase Proteins. Molecular Biology, Biochemistry, and Clinical Applications

TUMOR-NECROSIS-FACTOR, ITS RECEPTORS AND THE CONNECTION WITH INTERLEUKIN-1 AND INTERLEUKIN-6.

Peter BrouckaertClaude LibertB EVERAERDTNozomi TakahashiAnje CauwelsWalter Fiers

A1 Journal Article in IMMUNOBIOLOGY

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walter FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

COLEY VACCINE AND TNF THERAPY.

Peter BrouckaertWalter FiersFJ LEJEUNE

A1 Journal Article in NATURE

Limited involvement of interleukin-6 in the pathogenesis of lethal septic shock as revealed by the effect of monoclonal antibodies against interleukin-6 or its receptor in various murine models

Claude LibertAnne VinkPierre CouliePeter BrouckaertBart EveraerdtJacques Van SnickWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Selective species specificity of tumor-necrosis-factor for toxicity in the mouse.

Peter BrouckaertClaude LibertBart EveraerdtWalter Fiers

A1 Journal Article in LYMPHOKINE AND CYTOKINE RESEARCH

The glucocorticoid antagonist RU38486 mimics inicrleukin-1 in its sensitization to the lethal and interleukin-6-inducing properties of tumor-necrosis-factor.

Peter BrouckaertBart EveraerdtWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor necrosis factor : mechanism of action and its potential for anticancer therapy

W HersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckB EveraerdtJohan GrootenAnne LenaertsClaude LibertK Schulze-Osthoff et al.

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertEls DecosterDirk De ValckBart EveraerdtJohan GrootenAnne LenaertsClaude LibertK. Schulzeosthoff et al.

1991

Induction of tolerance allows separation of lethal and antitumor activities of tumor necrosis factor in mice

Nozomi TakahashiPeter BrouckaertWalter Fiers

A1 Journal Article in CANCER RESEARCH

Involvement of the liver, but not of IL-6, in IL-1-induced desensitization to the lethal effects of tumor necrosis factor

Claude LibertSigrid Van BladelPeter BrouckaertAlan ShawWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOLOGY

The influence of modulating substances on tumor necrosis factor and interleukin-6 levels after injection of murine tumor necrosis factor or lipopolysaccharide in mice

Claude LibertSigrid Van BladelPeter BrouckaertWalter Fiers

A1 Journal Article in JOURNAL OF IMMUNOTHERAPY

1990

In vitro and in vivo action of tumor necrosis factor

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanClaude LibertPhilip SuffysNozomi TakahashiJan TavernierSigrid Van Bladel et al.

Induction of interleukin 6 by human and murine recombinant interleukin 1 in mice

Claude LibertPeter BrouckaertAlan ShawWalter Fiers

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor-necrosis-factor : mechanism of action at the molecular, cellular and in vivo level

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtJohan GrootenAnne LenaertsClaude LibertP. SuffysNozomi TakahashiJan Tavernier et al.

A1 Journal Article in SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

1989

A role for Interleukin-1 in the invivo actions of tumor necrosis factor

Peter BrouckaertClaude LibertBart EveraerdtNozomi TakahashiWalter Fiers

A1 Journal Article in LYMPHOKINE RESEARCH

Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon γ

Peter BrouckaertDavid R SpriggsGeorge DemetriDonald W KufeWalter Fiers

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Four different interleukin-1 species sensitize to the lethal action of tumour necrosis factor

Bart EveraerdtPeter BrouckaertAlan ShawWalter Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Species specificity and involvement of other cytokines in endotoxic shock action of recombinant tumour necrosis factor in mice

Peter BrouckaertBart EveraerdtClaude LibertNozomi TakahashiWalter Fiers

A1 Journal Article in AGENTS AND ACTIONS

1987

Gene cloning and structure: function relationship of cytokines such as TNF and interleukins

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanPhilip SuffysJan TavernierPeter VandenabeeleBart VanhaesebroeckXaveer Van Ostade et al.

A1 Journal Article in IMMUNOLOGY LETTERS

Structure-function relationship of tumor necrosis factor and its mechanism of action

Walter FiersPeter BrouckaertAlfred L GoldbergIsis C KettelhutPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in CIBA FOUNDATION SYMPOSIA

Tumor necrosis factor: a potential antitumor agent?

Walter FiersRudi BeyaertPeter BrouckaertBart EveraerdtPhilip SuffysJan TavernierBart VanhaesebroeckFrans Van Roy

A1 Journal Article in JOURNAL OF INTERFERON RESEARCH

1986

In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-γ, on a syngeneic murine melanoma

Peter BrouckaertGeert Leroux-RoelsYves GuisezJan TavernierWalter Fiers

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER