Research Explorer

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Researcher

Pauline De Bruyne

Awards & Distinctions

88 Results

2025

Neonatal cholestasis progressing to a multisystem syndrome with liver cirrhosis in two siblings with FARSA deficiency : an evolving hepatological phenotype

Yoni AelvoetPATRICK VERLOOArnaud VanlanderSaskia Vande VeldeStephanie Van BiervlietPauline De BruyneLevi HosteAnnelies DheedeneLore PottieAnne Hoorens et al.

A2 Journal Article in JIMD REPORTS

2024

A case of paediatric seasonal eosinophilic oesophagitis

Saskia Vande VeldeJulie WillekensRuth De BruynePauline De BruyneStephanie Van Biervliet

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Familial chylomicronemia syndrome : a novel mutation in the lipoprotein lipase gene

Stephanie Van BiervlietSaskia Vande VeldePauline De BruyneBert CallewaertPATRICK VERLOORuth De Bruyne

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Historical perspective

Pauline De BruyneShinya ItoFacundo Garcia-Bournissen

Bookchapter in Essentials of translational pediatric drug development : from past needs to future oportunities

Population pharmacokinetics of lisinopril in hypertensive children and adolescents with normal to mildly reduced kidney function

Louis SandraEva DegraeuwePauline De BruyneSiegrid De BaereSiska CroubelsJan Van BocxlaerAnn RaesJohan Vande WalleElke GasthuysAn Vermeulen

A1 Journal Article in BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

2023

Diagnosis and management of Helicobacter pylori infection in children

Laura TochPauline De BruyneRuth De BruyneStephanie Van BiervlietSaskia Vande VeldeMyriam Van Winckel

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

2022

Population pharmacokinetics and Bayesian estimations of lisinopril at steady state in hypertensive children with mild to moderate renal impairment

Louis SandraEva DegraeuweElke GasthuysAn VermeulenPauline De BruyneAnn RaesJohan Vande Walle

Time is money in case of a button battery ingestion

Charlotte BosschaertKatrien Van RenterghemDirk Van de PutteLucas E MatthyssensSaskia Vande VeldePauline De BruyneRuth De BruyneEmma BeelStephanie Van Biervliet

A2 Journal Article in JPGN REPORTS

2021

Desmopressin oral lyophilisate in young children : new insights in pharmacokinetics and pharmacodynamics

Lien DosscheRobin MicheletPauline De BruyneCharlotte Van HerzeeleElke GasthuysSøren RittigAn VermeulenJohan Vande Walle

A1 Journal Article in ARCHIVES OF DISEASE IN CHILDHOOD

Herpetic oesophagitis in an immunocompetent infant with gastroesophageal reflux

EJE PeetersPauline De BruyneM Van WaasJC EscherM DoukasDM HendriksCEV Esch

Editorial material

Paediatric multiple magnet ingestion

M van WaasPauline De BruyneL de Ridder

Editorial material

Pharmacokinetics and blood pressure effects of ACE-inhibitors in children with hypertension

Louis SandraEva DegraeuweElke GasthuysAn VermeulenPauline De BruyneAnn RaesJohan Vande Walle

Successful liver transplantation in hyperornithinemia–hyperammonemia–homocitrullinuria syndrome : case report

Pauline De BruynePatrick VerlooJohan Van HoveBernard de HemptinneSaskia Vande VeldeMyriam Van WinckelStephanie Van BiervlietRuth De Bruyne

A1 Journal Article in PEDIATRIC TRANSPLANTATION

2020

An integrated paediatric population PK/PD analysis of dDAVP : how do PK differences translate to clinical outcomes?

Robin MicheletLien DosscheCharlotte Van HerzeelePauline De BruyneElke GasthuysJan Van BocxlaerJohan Vande WalleAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Medical devices that look like medicines : safety and regulatory concerns for children in Europe

Suzy HuijghebaertPauline De BruyneKarel AllegaertSaskia Vande VeldeRuth De BruyneStephanie Van BiervlietMyriam Van Winckel

A1 Journal Article in ARCHIVES OF DISEASE IN CHILDHOOD

2019

Fluoroquinolones for children : filling the gap

Kevin MeestersJohan Vande WalleYvan VandenplasPauline De Bruyne

Paediatric medecines intiatives : how far have we come?

Pauline De BruyneJohan Vande WalleKoen Norga

A2 Journal Article in BELGIAN JOURNAL OF PAEDIATRICS

The perspectives of parents, general practitioners, and community pharmacists about treating an ill child in primary care : a comparative study

Sigrid VerhelstPauline De BruyneMyriam Van WinckelKoen BousseryEline Tommelein

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

2018

A novel approach in paediatric drug research : the development of a juvenile pig model for pharmacokinetic/pharmacodynamic studies, using desmopressin as case 1

Elke GasthuysJoske MillecamMathias DevreeseAn VermeulenPauline De BruyneJohan Vande WalleJoris DelangheSiska Croubels

Does one size of desmopressin oral lyophilisate formulation really fits them all? : exploring the need to perform pharmacokinetic- and pharmacodynamic trials in children

Lien DosscheRobin MicheletAnn RaesPauline De BruyneJohan Vande Walle

Ethical considerations of researchers conducting pediatric clinical drug trials : a qualitative survey in two Belgian university children's hospitals

Wannes Van HoofKevin MeestersLien DosscheDaphné ChristiaensPauline De BruyneJohan Vande Walle

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Medical devices marketed as medicins : safety and regulatory concerns in children

S HuijghebaertPauline De BruyneMyriam Van WinckelK Allegaert

PK/PD studies in pigs leading to optimization of treatment dose in MNE?

Elke GasthuysLien DosscheSiska CroubelsPauline De BruyneMathias DevreeseAn VermeulenJohan Vande Walle

Paediatric drug development : an opportunity for academia to close the gap

Pauline De BruyneJohan Vande Walle

Pediatric drug development: towards maturity : desmopressin as a case

Elke GasthuysRobin MicheletLien DosschePauline De BruyneJohan Vande WalleAn VermeulenMathias DevreeseSiska Croubels

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsJoske MillecamStijn SchauvliegeThomas van BergenPauline De BruyneJohan Vande WalleMathias Devreese

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Population pharmacokinetic modeling of a desmopressin oral lyophilisate in growing piglets as a model for the pediatric population

Elke GasthuysAn VermeulenSiska CroubelsPauline De BruyneJoske MillecamJohan Vande WalleMathias Devreese

Systemic fluoroquinolone prescriptions for hospitalized children in Belgium, results of a multicenter retrospective drug utilization study

Kevin MeestersREINER MAUELEvelyn DhontJohan Vande WallePauline De Bruyne

A1 Journal Article in BMC INFECTIOUS DISEASES

The SAFE-PEDRUG project : an opportunity for academia to close the gap

Pauline De BruyneJohan Vande Walle

Toxicity of long-term use of proton pump inhibitors in children

Pauline De BruyneShinya Ito

A1 Journal Article in ARCHIVES OF DISEASE IN CHILDHOOD

2017

Adherence to labeling guidelines, the case of fluoroquinolones : results of a retrospective multicenter drug utilization study

Kevin MeestersREINER MAUELJohan Vande WallePauline De Bruyne

Are antihistamines effective in children? : a review of the evidence

Pauline De BruyneThierry ChristiaensKoen BousseryEls MehuysMyriam Van Winckel

A1 Journal Article in ARCHIVES OF DISEASE IN CHILDHOOD

Confirmation of an ARID2 defect in SWI/SNF-related intellectual disability

Ruben Van PaemelPauline De BruyneSaskia van der StraatenMarleen D'HondtUrlien FränkelAnnelies DheedeneBjörn MentenBert Callewaert

A1 Journal Article in AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Pediatrisch geneesmiddelenonderzoek : een opportuniteit voor academische onderzoeksgroepen

Pauline De BruyneJohan Vande Walle

A4 Journal Article in PERCENTIEL (NEDERLANDSE ED.)

The SAFE-PEDRUG initiative : an opportunity for academia to close the gap

Pauline De BruyneJohan Vande Walle

The SAFE-PEDRUG initiative : an opportunity for academia to close the gap

Pauline De BruyneJohan Vande Walle

Therapeutic efficacy and safety of ACE inhibitors in the hypertensive paediatric population : a review

Evelien SnauwaertJohan Vande WallePauline De Bruyne

A1 Journal Article in ARCHIVES OF DISEASE IN CHILDHOOD

2016

Bioequivalence in adults does not mean bioequivalence in children

Lien DosscheRobin MicheletPauline De BruyneJan Van BocxlaerAn VermeulenJohan Vande Walle

Bioequivalence in adults is not always bioequivalence in children

Lien DosscheAnn RaesPauline De BruyneRobin MicheletAn VermeulenJan Van BocxlaerJohan Vande Walle

Circadian rhythm of glomerular filtration and solute handling related to nocturnal enuresis

Lien DosscheAnn RaesPiet HoebekePauline De BruyneJohan Vande Walle

A1 Journal Article in JOURNAL OF UROLOGY

Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

Effect of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

Effects of food and pharmaceutical formulation on desmopressin pharmacokinetics in children

Robin MicheletLien DosschePauline De BruynePieter ColinKoen BousseryJohan Vande WalleJan Van BocxlaerAn Vermeulen

A1 Journal Article in CLINICAL PHARMACOKINETICS

Farmacotherapeutische actualiteit

Thierry ChristiaensPauline De BruyneLucas Van Bortel

Editorial material

How do researchers weigh ethical priciples in pediatric clinical trials?

Wannes Van HoofPauline De BruyneLien DosscheKevin MeestersSofie BekaertJohan Vande Walle

Infectiology 22 : use of fluoroquinoles in hospitalized children, preliminary report of a chart review in a Belgian children's hospital

Kevin MeestersPauline De BruyneREINER MAUELJohan Vande Walle

Nephrology 4 : therapeutic efficacy & safety of ACE inhibitors in the hypertensive paediatric population : a review

Evelien SnauwaertJohan Vande WallePauline De Bruyne

Paediatric drug development : an opportunity for academia to close the gap

Pauline De BruyneJohan Vande WalleMyriam Van Winckel

Predictive value of urinary osmolality in the early morning for desmopressin response

Lien DosscheAnn RaesReiner MauelPauline De BruyneAnn Sophie CornelisJohan Vande Walle

SAFE-PEDRUG : a new strategy for paediatric drug research

Pauline De BruyneKevin MeestersJohan Vande Walle

The potential use of piglets as human pediatric surrogate for preclinical pharmacokinetic and pharmacodynamic drug testing

Elke GasthuysTim VandecasteelePauline De BruyneJohan Vande WallePatrick De BackerPieter CornillieMathias DevreeseSiska Croubels

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Therapeutic efficacy and safety of ACE inhibitors in the hypertensive paediatric population : a review

Evelien SnauwaertJohan Vande WallePauline De Bruyne

Use of fluoroquinolones in hospitalized children : preliminary report of a chart review in a Belgian university children's hospital

Kevin MeestersPauline De BruyneREINER MAUELJohan Vande Walle

Vascular disorders of the liver

Ruth De BruynePauline De Bruyne

Bookchapter in Textbook of pediatric gastroenterology, hepatology and nutrition : a comprehensive guide to practice

2015

A substitution error leading to central anticholinergic syndrome

Pauline De BruyneKarl LoggheFilip Roelens

Angiotensin converting enzyme inhibitors in pediatrics : state of the art

Evelien SnauwaertPauline De BruyneJohan Vande Walle

Challenging factors for enuresis treatment: psychological problems and non-adherence

Charlotte Van HerzeelePauline De BruyneElke De BruyneJohan Vande Walle

A1 Journal Article in JOURNAL OF PEDIATRIC UROLOGY

Complicated urinary tract infection in a two months old infant : which drug to choose

Kevin MeestersReiner MauelPauline De BruyneJohan Vande Walle

Farmacotherapeutische actualiteit

Pauline De BruynePieter DepuydtLucas Van BortelThierry Christiaens

Editorial material

Fluoroquinolones in children where an old enemy becomes a friend

Pauline De BruyneReiner MauelJohan Vande Walle

Fluoroquinolones in children with urinary tract infections: old enemy or new friend? : a review of current litterature

Johan Vande WallePauline De BruyneREINER MAUELKevin Meesters

How safe is on-label drug use in paediatrics? : the case of first generation H1-antihistamines

Pauline De BruyneKoen BousseryThierry ChristiaensEls MehuysMyriam Van Winckel

Management of hypertension in children and adolescents

Pauline De BruyneJohan Vande Walle

A1 Journal Article in ACTA CLINICA BELGICA

Possible confounders in the reported association between autism spectrum disorder (ASD) and exposure to selective serotonin reuptake inhibitors (SSRIs) during pregnancy

Pauline De BruyneEran BarzilayGideon Koren

SAFE PEDDRUG: the next step in ethical paediatric drug research

K AllegaertPauline De BruyneReiner MauelJohan Vande Walle

SAFE-PEDRUG : a new strategy for paediatric drug research

Pauline De BruyneKevin MeestersJohan Vande Walle

Use of fluoroquinolones in hospitalized children : preliminary report of a chart review in a Belgian university children's hospital

Kevin MeestersPauline De BruyneReiner MauelJohan Vande Walle

2014

Adult bioequivalence studies insufficient for paediatric use: the case of desmopressin

Pauline De BruyneAnn De GuchtenaereCharlotte Van HerzeeleAnn RaesJo DehoornePiet HoebekeErik Van LaeckeJohan Vande Walle

Changes in presciption patterns of acid-suppressant medications by Belgian pediatricians: analysis of the national database, [1997-2009]

Pauline De BruyneThierry ChristiaensRobert Vander SticheleMyriam Van Winckel

A1 Journal Article in JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Pharmacokinetics of desmopressin administered as tablet and oral lyophilisate formulation in children with monosymptomatic nocurnal enuresis

Pauline De BruyneAnn De GuchtenaereCharlotte Van HerzeeleAnn RaesJo DehoornePiet HoebekeErik Van LaeckeJohan Vande Walle

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Safety profile of desmopressin tablet for enuresis in a prospective study

Charlotte Van HerzeelePauline De BruyneJonathan EvansPaul EggertHenri LottmannJens Peter NorgaardJohan Vande Walle

A1 Journal Article in ADVANCES IN THERAPY

Successful liver transplantation in hyperornithinemia-hyperammonemia-homocitrullinuria syndrome

Pauline De BruyneStephanie Van BiervlietMyriam Van WinckelSaskia Vande VeldePATRICK VERLOORuth De Bruyne

2013

Desmopressin melt improves response and compliance compared with tablet in treatment of primary monosymptomatic nocturnal enuresis

Kristiaan Vinter JuulCharlotte Van HerzeelePauline De BruyneSandra GobleJohan Vande WalleJens Peter Nørgaard

A1 Journal Article in EUROPEAN JOURNAL OF PEDIATRICS

Is there a gender difference in antidiuretic response to desmopressin in children?

Kristiaan Juul VinterSandra GoblePauline De BruyneJohan Vande WalleJens Peter Nørgaard

A2 Journal Article in OPEN JOURNAL OF PEDIATRICS

Weight depending dosing of desmopressin (dDAVP) in nocturnal enuresis

Pauline De BruyneAnn De GuchtenaereCharlotte Van HerzeeleAnn RaesJo DehoornePiet HoebekeErik Van LaeckeJohan Vande Walle

2012

Desmopressin oral lyophylysate formulation (MELT) : a solution for insufficient desmopressin tablet response in monosymptomatic nocturnal enuresis?

Pauline De BruyneAnn De GuchtenaereCharlotte Van HerzeeleJo DehoorneAnn RaesPiet HoebekeErik Van LaeckeJohan Vande Walle

Evolution of antireflux medication prescriptions in Belgium over the last decade

Pauline De BruyneRobert Vander SticheleThierry ChristiaensMarcus BogaertMyriam Van Winckel

First evidence for weight-dependent dosing of desmopressin

Pauline De BruyneAnn De Guchtenaere

2011

Liver transplantation for neonatal acute liver failure

Pauline De BruyneRuth De Bruyne

Person-to-person transmission of strongyloides stercoralis

Pauline De BruyneMyriam Van WinckelRuth De Bruyne

Pharmacokinetic characteristics of desmopressin oral lyophilisate (MELT) and tablet formulation in children

Ann De GuchtenaereCharlotte Van HerzeelePauline De BruyneJo DehoorneAnn RaesJohan Vande Walle

Pharmacokinetic characteristics of desmopressin oral lyophilisate (MELT) and tablet formulation in children.

Ann De GuchtenaerePiet HoebekeCharlotte Van HerzeeleJo DehoorneAnn RaesErik Van LaeckePauline De BruyneJohan Vande Walle

Pharmalogical treatment for gastroesophageal reflux disease in children

T KurpershoekPauline De BruyneEls Van de Vijver

A2 Journal Article in TIJDSCHRIFT VAN DE BELGISCHE KINDERARTS = JOURNAL DU PEDIATRE BELGE

W.J.H.M. van den Bosch, A.J. van der Heijden, R.N. Sukhai, J. Waveling (red.): Het pediatrisch formularium: een praktische leidraad (vijfde, herziene druk.)

Pauline De Bruyne

2010

Leverlijden, een verraderlijke verwikkeling van mucoviscidose

Hilde BoelaertEvelyn DhontKirya SchrierPauline De BruyneMarleen GenetelloEddy Robberecht

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2009

A potentially life-treatening complication after a blood transfusion : the importance of clinical awareness

Pauline De BruyneInge Van HauteANNIK DE JAEGERJef Willems

Importance of hepatitis A vaccination in children travelling to developing countries : 2 case reports

Pauline De BruyneRuth De BruyneBernard de HemptinneANNIK DE JAEGERStephanie Van Biervliet

Person-to-person transmission of strongyloides stercoralis in an immunocompromised patient

Pauline De BruyneMyriam Van WinckelRuth De Bruyne