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Researcher
Matthias D'hooghe
Profile
Projects
Publications
Activities
206
Results
2020
A de novo synthetic method to the access of N-substituted benzazepines
Lamiaa Ouchakour
Melinda Nonn
Matthias D'hooghe
Lorand Kiss
A1
Journal Article
in
JOURNAL OF FLUORINE CHEMISTRY
2020
Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties
Aleksandra Minić
Tim Van de Walle
Kristof Van Hecke
Jill Combrinck
Peter J. Smith
Kelly Chibale
Matthias D'hooghe
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2020
Development of antimalarial quinoline-based conjugates and anticancer nitroxoline derivatives
Tim Van de Walle
Matthias D'hooghe
Sven Mangelinckx
Dissertation
2020
Expedient synthesis of lupulones and their derivatization to 2,8-7H-dihydrochromen-7-ones
Lena Decuyper
Gurkirat Kaur
Charlotte Versyck
Eline Blondeel
Yves Depetter
Kristof Van Hecke
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRYOPEN
2020
Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents
Tim Van de Walle
Maya Boone
Julie Van Puyvelde
Jill Combrinck
Peter J. Smith
Kelly Chibale
Sven Mangelinckx
Matthias D'hooghe
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2020
Synthesis and penicillin‐binding protein inhibitory assessment of dipeptidic 4‐phenyl‐β‐lactams from α‐amino acid‐derived imines
Lena Decuyper
Marko Jukič
Izidor Sosič
Ana Maria Amoroso
Olivier Verlaine
Bernard Joris
Stanislav Gobec
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-AN ASIAN JOURNAL
2020
Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity
Tim Van de Walle
Marina Briand
Ana Mitrović
Izidor Sosič
Stanislav Gobec
Janko Kos
Leentje Persoons
Dirk Daelemans
Steven De Jonghe
Zorica Ubiparip
Tom Desmet
Kristof Van Hecke
Sven Mangelinckx
Matthias D'hooghe
A1
Journal Article
in
CHEMMEDCHEM
2020
Synthetic strategies in curcumin chemistry focused on anticancer applications
Atiruj Theppawong
Gurkirat Kaur
Vipan Kumar
John Van Camp
Matthias D'hooghe
A1
Journal Article
in
ARKIVOC
2020
2019
Deployment of aziridines for the synthesis of alkaloids and their derivatives
Lingamurthy Macha
Matthias D'hooghe
Hyun-Joon Ha
A1
Journal Article
in
SYNTHESIS-STUTTGART
2019
Design, synthesis and evaluation of monocyclic β-lactams as inhibitors of penicillin-binding proteins of resistant bacteria
Lena Decuyper
Matthias D'hooghe
Dissertation
2019
Electrophilic bromination in flow : a safe and sustainable alternative to the use of molecular bromine in batch
Reinout Van Kerrebroeck
Pieter Naert
Thomas Heugebaert
Matthias D'hooghe
Christian Stevens
A1
Journal Article
in
MOLECULES
2019
Reactivity of 3-oxo-β-lactams with respect to primary amines
Sari Deketelaere
Nicola Piens
Hannelore Goossens
Dietmar Hertsen
Lieselotte Crul
Lotte Demeurisse
Jelle De Moor
Elias Van Den Broeck
Karen Mollet
Kristof Van Hecke
Veronique Van Speybroeck
Matthias D'hooghe
C3
Conference
2019
Reactivity of 3-oxo-β-lactams with respect to primary amines
Sari Deketelaere
Nicola Piens
Hannelore Goossens
Dietmar Hertsen
Lieselotte Crul
Lotte Demeurisse
Jelle De Moor
Elias Van Den Broeck
Karen Mollet
Kristof Van Hecke
Veronique Van Speybroeck
Matthias D'hooghe
C3
Conference
2019
Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models
Yves Depetter
Silke Geurs
Rob De Vreese
Sophie Goethals
Elien Vandoorn
Alien Laevens
Jonas Steenbrugge
Evelyne Meyer
Pascal de Tullio
Marc Bracke
Matthias D'hooghe
Olivier De Wever
A1
Journal Article
in
INTERNATIONAL JOURNAL OF CANCER
2019
Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives
Tim Van de Walle
Atiruj Theppawong
Charlotte Grootaert
Steven De Jonghe
Leentje Persoons
Dirk Daelemans
Kristof Van Hecke
John Van Camp
Matthias D'hooghe
A1
Journal Article
in
MONATSHEFTE FUR CHEMIE
2019
Synthesis and first line in vitro evaluation of novel curcumin derivatives as anti-tumoral agents
Atiruj Theppawong
Matthias D'hooghe
John Van Camp
Dissertation
2019
Synthesis of 1,4‐thiazepane‐based curcuminoids with promising anticancer activity
Atiruj Theppawong
Tim Van de Walle
Kristof Van Hecke
Charlotte Grootaert
John Van Camp
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2019
Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors
Yves Depetter
Silke Geurs
Jorick Franceus
Damijan Knez
Tom Desmet
Karolien De Bosscher
Olivier De Wever
Stanislav Gobec
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRYSELECT
2019
Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates
Atiruj Theppawong
Tim Van de Walle
Charlotte Grootaert
Kristof Van Hecke
Nathalie Catry
Tom Desmet
John Van Camp
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRYOPEN
2019
Synthesis of selective HDAC6 inhibitors and their evaluation in cancer models
Yves Depetter
Matthias D'hooghe
Olivier De Wever
Dissertation
2019
α‐Unsaturated 3‐Amino‐1‐carboxymethyl‐β‐lactams as bacterial PBP inhibitors : synthesis and biochemical assessment
Lena Decuyper
Katarina Magdalenic
Marie Verstraete
Marko Jukič
Izidor Sosič
Eric Sauvage
Ana Maria Amoroso
Olivier Verlaine
Bernard Joris
Stanislav Gobec
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2019
2018
An update on the synthesis and reactivity of spiro-fused β-lactams
Hang Dao Thi
Matthias D'hooghe
A1
Journal Article
in
ARKIVOC
2018
Antibacterial and β-lactamase inhibitory activity of monocyclic β-lactams
Lena Decuyper
Marko Jukič
Izidor Sosič
Aleš Žula
Matthias D'hooghe
Stanislav Gobec
A1
Journal Article
in
MEDICINAL RESEARCH REVIEWS
2018
Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition
Yves Depetter
Silke Geurs
Flore Vanden Bussche
Rob De Vreese
Jorick Franceus
Tom Desmet
Olivier De Wever
Matthias D'hooghe
A1
Journal Article
in
MEDCHEMCOMM
2018
Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams
Lena Decuyper
Jorick Franceus
Shari Dhaene
Maarten Debruyne
Kevin Vandoorne
Nicola Piens
Griet Dewitte
Tom Desmet
Matthias D'hooghe
A1
Journal Article
in
ACS OMEGA
2018
Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase
Jorick Franceus
Lena Decuyper
Matthias D'hooghe
Tom Desmet
A1
Journal Article
in
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
2018
Formation of fluorinated amido esters through unexpected C3-C4 bond fission in 4-trifluoromethyl-3-oxo-β-lactams
Thi Hang Dao
Hannelore Goossens
Dietmar Hertsen
Valerie Otte
Tuyen Van Nguyen
Veronique Van Speybroeck
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-AN ASIAN JOURNAL
2018
In silico design and enantioselective synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-β-lactams as inhibitors of penicillin-binding proteins of resistant bacteria
Lena Decuyper
Sari Deketelaere
Lore Vanparys
Marko Jukič
Izidor Sosič
Eric Sauvage
Ana Maria Amoroso
Olivier Verlaine
Bernard Joris
Stanislav Gobec
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2018
Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones
Thi Hang Dao
Tuyen Van Nguyen
Matthias D'hooghe
A1
Journal Article
in
MONATSHEFTE FUR CHEMIE
2018
Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and their transformation into novel CF3-substituted amines and heterocyclic systems
Thi Hang Dao
Matthias D'hooghe
Tuyen Van Nguyen
Dissertation
2018
Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines
Atiruj Theppawong
Tim Van de Walle
Charlotte Grootaert
Margot Bultinck
Tom Desmet
John Van Camp
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRYOPEN
2018
Synthesis of nitrogen-containing curcumin analogues in the pursuit of new anticancer candidates
Atiruj Theppawong
Charlotte Grootaert
John Van Camp
Matthias D'hooghe
C3
Conference
2018
Synthesis, biology and structure-activity relationships of novel β-enaminone-, aza-aromatic- and thiazepanebased curcuminoids
Atiruj Theppawong
Charlotte Grootaert
John Van Camp
Matthias D'hooghe
C3
Conference
2018
Theoretical insight into the regioselective ring-expansions of bicyclic aziridinium ions
Esma B Boydas
Gamze Tanriver
Matthias D'hooghe
Hyun-Joon Ha
Veronique Van Speybroeck
Saron Catak
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2018
Use of 3-hydroxy-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of trifluoromethyl-containing aminopropanes, 1,3-oxazinan-2-ones, aziridines, and 1,4-dioxan-2-ones
Hang Dao Thi
Giang Le Nhat Thuy
Saron Catak
Veronique Van Speybroeck
Tuyen Van Nguyen
Matthias D'hooghe
A1
Journal Article
in
SYNTHESIS-STUTTGART
2018
2017
Asymmetric Synthesis of 3,4-Disubstituted 2-(Trifluoromethyl)pyrrolidines through Rearrangement of Chiral 2-(2,2,2-Trifluoro-1-hydroxyethyl)azetidines
Jeroen Dolfen
Esma Birsen Boydas
Veronique Van Speybroeck
Saron Catak
Kristof Van Hecke
Matthias D'hooghe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2017
Carbonylation of aziridines as a powerful tool for the synthesis of functionalized β-lactams
Nicola Piens
Matthias D'hooghe
A1
Journal Article
in
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2017
Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks
Nicola Piens
Kristof Van Hecke
Dieter Vogt
Matthias D'hooghe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2017
Concise synthesis of 3-(aminomethyl)pyrrolizidines via an In(OTf)3-mediated ring rearrangement of 2-[2-(1-pyrrolin-2-yl)-alkyl]aziridines
Jeroen Dolfen
Matthias D'hooghe
A1
Journal Article
in
SYNTHESIS-STUTTGART
2017
Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of PBPs of resistant bacteria
Sari Deketelaere
Lena Decuyper
Lore Vanparys
Marko Jukič
Izidor Sosič
Eric Sauvage
Paulette Charlier
Bernard Joris
Stanislav Gobec
Matthias D'hooghe
C3
Conference
2017
Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin binding proteins of resistant bacteria
Sari Deketelaere
Lena Decuyper
Lore Vanparys
Marko Jukič
Izidor Sosič
Eric Sauvage
Ana Maria Amoroso
Olivier Verlaine
Paulette Charlier
Bernard Joris
Stanislav Gobec
Matthias D'hooghe
C3
Conference
2017
Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin-binding proteins of resistant bacteria
Lena Decuyper
Sari Deketelaere
Lore Vanparys
Marko Jukic
Izidor Sosic
Eric Sauvage
Paulette Charlier
Bernard Joris
Stanislav Gobec
Matthias D'hooghe
C3
Conference
2017
Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents
Rob De Vreese
Carmen de Kock
Peter J Smith
Kelly Chibale
Matthias D'hooghe
A1
Journal Article
in
FUTURE MEDICINAL CHEMISTRY
2017
LiAlH4-induced thia-aza-Payne rearrangement of functionalized 2-(thiocyanatomethyl)aziridines into 2-(aminomethyl)thiiranes as an entry to 5-(chloromethyl)thiazolidin-2-ones
Jeroen Dolfen
Kristof Van Hecke
Matthias D'hooghe
A1
Journal Article
in
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2017
New strategies for the construction of heterocyclic systems through ring transformation of aziridines and azetidines
Jeroen Dolfen
Matthias D'hooghe
Dissertation
2017
Reactivity of 3-oxo-β-lactams with respect to primary amines : an experimental and computational approach
Nicola Piens
Hannelore Goossens
Dietmar Hertsen
Sari Deketelaere
Lieselotte Crul
Lotte Demeurisse
Jelle De Moor
Elias Van Den Broeck
Karen Mollet
Kristof Van Hecke
Veronique Van Speybroeck
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2017
Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors
Rob De Vreese
Matthias D'hooghe
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2017
Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and transformations into novel CF3-substituted amines and heterocyclic systems
Thi Hang Dao
Tuyen Nguyen Van
Matthias D'hooghe
C3
Conference
2017
Synthesis of bis-8-hydroxyquinolines via an imination or a Suzuki-Miyaura coupling approach
Rob De Vreese
Koen Muylaert
Cédric Maton
Lise Dereu
Frederique Taillieu
Thomas Harth
Rik Van Deun
Henk Vrielinck
Christian Stevens
Matthias D'hooghe
A1
Journal Article
in
TETRAHEDRON LETTERS
2017
Synthesis of new β-lactam building blocks and their application in heterocyclic chemistry
Nicola Piens
Matthias D'hooghe
Dissertation
2017
Synthesis of novel 4-ferrocenyl-1,2,3,4-tetrahydroquinolines and 4-ferrocenylquinolines via α-ferrocenyl carbenium ions as key intermediates
Aleksandra Minić
Dragana Stevanović
Mirjana Vukićević
Goran A Bogdanović
Matthias D'hooghe
Niko S Radulović
Rastko D Vukićević
A1
Journal Article
in
TETRAHEDRON
2017
Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold
Rob De Vreese
Lisa Galle
Yves Depetter
Jorick Franceus
Tom Desmet
Kristof Van Hecke
Veronick Benoy
Ludo Van Den Bosch
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2017
Synthesis of thiaheterocyclic benzohydroxamic acids and evaluation of their HDAC6 inhibitory activity
Rob De Vreese
Matthias D'hooghe
Dissertation
2017
Synthesis, biology and structure-activity relationships of novel β-enaminone-, aza-aromatic- and thiazepane-based curcuminoids
Atiruj Theppawong
Tim Van de Walle
Charlotte Grootaert
John Van Camp
Matthias D'hooghe
C3
Conference
2017
Synthetic approaches toward monocyclic 3-amino-β-lactams
Sari Deketelaere
Tuyen Van Nguyen
Christian Stevens
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRYOPEN
2017
Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles
Nicola Piens
Wim Aelterman
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
SYNLETT
2017
2016
A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones
Lena Decuyper
Nicola Piens
Jens Mincke
Jeroen Bomon
Bert De Schrijver
Karen Mollet
Karel De Winter
Tom Desmet
Matthias D'hooghe
A1
Journal Article
in
RSC ADVANCES
2016
Bicyclic aziridinium ions in azaheterocyclic chemistry : preparation and synthetic application of 1-azoniabicyclo[n.1.0]alkanes
Jeroen Dolfen
Nagendra Nath Yadav
Norbert De Kimpe
Matthias D'hooghe
Hyun-Joon Ha
A1
Journal Article
in
ADVANCED SYNTHESIS & CATALYSIS
2016
Catalytic carbonylation of aziridines to novel β-lactams as versatile building blocks in heterocyclic chemistry
Nicola Piens
Dieter Vogt
Matthias D'hooghe
C3
Conference
2016
Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity
Tom Verhaeghe
Karel De Winter
Magali Berland
Rob De Vreese
Matthias D'hooghe
Bernard Offmann
Tom Desmet
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2016
Deployment of small-ring azaheterocycles as building blocks for the synthesis of organofluorine compounds
Jeroen Dolfen
Norbert De Kimpe
Matthias D'hooghe
A1
Journal Article
in
SYNLETT
2016
Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-fused bicyclic β-lactams
Nicola Piens
Sven De Craene
Karen Mollet
Kristof Van Hecke
Matthias D'hooghe
C3
Conference
2016
Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams
Nicola Piens
Sven De Craene
Jorick Franceus
Karen Mollet
Kristof Van Hecke
Tom Desmet
Matthias D'hooghe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2016
Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams
Nicola Piens
Lena Decuyper
Saskia Vander Meeren
Jens Mincke
Jeroen Bomon
Bert De Schrijver
Karen Mollet
Karel De Winter
Tom Desmet
Matthias D'hooghe
C3
Conference
2016
LiAlH4-Induced selective ring rearrangement of 2-(2-cyanoethyl)aziridines toward 2-(aminomethyl)pyrrolidines and 3-aminopiperidines as eligible heterocyclic building blocks
Jeroen Dolfen
Karel Vervisch
Norbert De Kimpe
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2016
Recent progress in the use of functionalized β-lactams as building blocks in heterocyclic chemistry
Nicola Piens
Norbert De Kimpe
Matthias D'hooghe
Bookchapter
in
Progress in Heterocyclic Chemistry, volume 28
2016
Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors
Rob De Vreese
Yves Depetter
Tom Verhaeghe
Tom Desmet
Veronick Benoy
Wanda Haeck
Ludo Van Den Bosch
Matthias D'hooghe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2016
Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-β-lactams
Thi Hang Dao
Barbara Danneels
Tom Desmet
Kristof Van Hecke
Tuyen Van Nguyen
Matthias D'hooghe
A1
Journal Article
in
ASIAN JOURNAL OF ORGANIC CHEMISTRY
2016
Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids
Atiruj Theppawong
Rob De Vreese
Lore Vannecke
Charlotte Grootaert
John Van Camp
Matthias D'hooghe
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2016
Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones
Lena Decuyper
Nicola Piens
Saskia Vander Meeren
Jens Mincke
Jeroen Bomon
Bert De Schrijver
Karen Mollet
Karel De Winter
Tom Desmet
Matthias D'hooghe
C3
Conference
2016
Synthesis and cytotoxic evaluation of novel indenoisoquinoline-propan-2-ol hybrids
Tham Pham Thi
Lena Decuyper
Tan Luc Quang
Chinh Pham The
Tuyet Anh Dang Thi
Ha Thanh Nguyen
Thuy Giang Le Nhat
Tra Nguyen Thanh
Phuong Hoang Thi
Matthias D'hooghe
Tuyen Van Nguyen
A1
Journal Article
in
TETRAHEDRON LETTERS
2016
Synthesis of novel curcuminoids accommodating a central β-enaminone motif and their impact on cell growth and oxidative stress
Rob De Vreese
Charlotte Grootaert
Sander D'hoore
Atiruj Theppawong
Sam Van Damme
Maarten Van Bogaert
John Van Camp
Matthias D'hooghe
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2016
Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks
Thi Hang Dao
Lena Decuyper
Karen Mollet
Sara Kenis
Norbert De Kimpe
Tuyen Van Nguyen
Matthias D'hooghe
A1
Journal Article
in
SYNLETT
2016
2015
Expedient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones
Tuyet Anh Dang Thi
Yves Depetter
Karen Mollet
Hoang Thi Phuong
Doan Vu Ngoc
Chinh Pham The
Ha Thanh Nguyen
Thu Ha Nguyen Thi
Hung Huy Nguyen
Matthias D'hooghe
Tuyen Van Nguyen
A1
Journal Article
in
TETRAHEDRON LETTERS
2015
Quinoline-based antimalarial hybrid compounds
Stephanie Vandekerckhove
Matthias D'hooghe
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY
2015
Synthesis and anticancer properties of new (dihydro)pyranonaphthoquinones and their epoxy analogs
Anh Dang Thi Tuyet
Ha Vu Thi Thu
Thi Phuong Hoang
Ha Nguyen Thanh
Pham The Chinh
Vu Duc Cuong
Yves Depetter
Van Nguyen Tuyen
Matthias D'hooghe
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2015
Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones
Anka Pejović
Barbara Danneels
Tom Desmet
Ba Thi Cham
Tuyen Van Nguyen
Niko S Radulović
Rastko D Vukicević
Matthias D'hooghe
A1
Journal Article
in
SYNLETT
2015
Synthesis and cytotoxic evaluation of novel amide-triazole-linked triterpenoid-AZT conjugates
Thi Hang Dao
Nguyen Thi Kim Tuyet
Chinh Pham The
Ha Thanh Nguyen
Cham Ba Thi
Hoang Thi Phuong
Luu Van Boi
Tuyen Van Nguyen
Matthias D'hooghe
A1
Journal Article
in
TETRAHEDRON LETTERS
2015
Synthesis and cytotoxic evaluation of novel dihydrobenzo[h]cinnoline-5,6-diones
Tuyet Anh Dang Thi
Lena Decuyper
Hoang Thi Phuong
Doan Vu Ngoc
Ha Thanh Nguyen
Tra Thanh Nguyen
Thanh Do Huy
Hung Huy Nguyen
Matthias D'hooghe
Tuyen Van Nguyen
A1
Journal Article
in
TETRAHEDRON LETTERS
2015
Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones
Karen Mollet
Lena Decuyper
Saskia Vander Meeren
Nicola Piens
Karel De Winter
Tom Desmet
Matthias D'hooghe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2015
Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors
Rob De Vreese
Nicholas Van Steen
Tom Verhaeghe
Tom Desmet
Nadia Bougarne
Karolien De Bosscher
Veronick Benoy
Wanda Haeck
Ludo Van Den Bosch
Matthias D'hooghe
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2015
Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity
Stephanie Vandekerckhove
Sofie Van Herreweghe
Jasmine Willems
Barbara Danneels
Tom Desmet
Carmen de Kock
Peter J Smith
Kelly Chibale
Matthias D'hooghe
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2015
Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity
Nicola Piens
Rob De Vreese
Nympha De Neve
Kristof Van Hecke
Jan Balzarini
Norbert De Kimpe
Matthias D'hooghe
C3
Conference
2015
Ϲинтеза нових биолошки активних хетероцикличних једињења која садрже фероцен
Anka Pejović
Rastko Vukićević
Matthias D'hooghe
Dissertation
2015
2014
Application of 3-bromo-3-ethylazetidines and 3-ethylideneazetidines for the synthesis of functionalized azetidines
Sonja Stanković
Matthias D'hooghe
Tim Vanderhaegen
Kourosh Abbaspour Tehrani
Norbert De Kimpe
A1
Journal Article
in
SYNLETT
2014
Discovery of anxiolytic 2-ferrocenyl-1,3-thiazolidin-4-ones exerting GABA(A) receptor interaction via the benzodiazepine-binding site
Anka Pejović
Marija S Denić
Dragana Stevanović
Ivan Darnljanović
Mirjana Vukićević
Kalina Kostova
Maya Tavlinova-Kirilova
Pavle Randjelović
Nikola M Stojanović
Goran A Bogdanović
Polina Blagojević
Matthias D'hooghe
Niko S Radulović
Rastko D Vukićević
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2014
Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates
Chao Chen
Jef Van der Borght
Rob De Vreese
Matthias D'hooghe
Wim Soetaert
Tom Desmet
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2014
New strategies for the synthesis of fluorinated carbo- and heterocyclic compounds
Matthias Moens
Norbert De Kimpe
Matthias D'hooghe
Dissertation
2014
Nucleophile-dependent regio- and stereoselective ring opening of 1-azoniabicyclo[3.1.0]hexane tosylate
Mi-Kyung Ji
Dietmar Hertsen
Doo-Ha Yoon
Heesung Eum
Hannelore Goossens
Michel Waroquier
Veronique Van Speybroeck
Matthias D'hooghe
Norbert De Kimpe
Hyun-Joon Ha
A1
Journal Article
in
CHEMISTRY-AN ASIAN JOURNAL
2014
Reactivity of aziridinium salts in different solvents unraveled by a combined theoretical and experimental approach
Hannelore Goossens
Dietmar Hertsen
Karen Mollet
Saron Catak
Matthias D'hooghe
Frank De Proft
Paul Geerlings
Norbert De Kimpe
Michel Waroquier
Veronique Van Speybroeck
Bookchapter
in
Structure, bonding and reactivity of heterocyclic compounds
2014
Selective synthesis of cis- and trans-2-(methyl/phenyl)-3-(trifluoromethyl)aziridines and their regio- and stereospecific ring opening
Matthias Moens
Norbert De Kimpe
Matthias D'hooghe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2014
Selective synthesis of functionalized trifluoromethylated pyrrolidines, piperidines, and azepanes starting from 1-tosyl-2-(trifluoromethyl)aziridine
Jeroen Dolfen
Sara Kenis
Kristof Van Hecke
Norbert De Kimpe
Matthias D'hooghe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2014
Synthesis and biological evaluation of novel quinoline derivatives
Stephanie Vandekerckhove
Matthias D'hooghe
Dissertation
2014
Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates
Thi Hang Dao
Nguyen Thi Kim Tuyet
Chinh Pham The
Ha Thanh Nguyen
Cham Ba Thi
Tien Doan Duy
Matthias D'hooghe
Tuyen Van Nguyen
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2014
Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones
Lena Decuyper
Karen Mollet
Saskia Vander Meeren
Nicola Piens
Karel De Winter
Tom Desmet
Matthias D'hooghe
C3
Conference
2014
Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity
Nicola Piens
Karen Mollet
Hannelore Goossens
Saron Catak
Michel Waroquier
Karl W. Törnroos
Veronique Van Speybroeck
Norbert De Kimpe
Matthias D'hooghe
C3
Conference
2014
Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity
Stephanie Vandekerckhove
Tom Desmet
Hai Giang Tran
Carmen de Kock
Peter J Smith
Kelly Chibale
Matthias D'hooghe
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2014
Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity
Nicola Piens
Rob De Vreese
Nympha De Neve
Kristof Van Hecke
Jan Balzarini
Norbert De Kimpe
Matthias D'hooghe
A1
Journal Article
in
SYNTHESIS-STUTTGART
2014
Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity
Nicola Piens
Rob De Vreese
Nympha De Neve
Kristof Van Hecke
Jan Balzarini
Norbert De Kimpe
Matthias D'hooghe
C3
Conference
2014
Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks
Thi Hang Dao
Lena Decuyper
Karen Mollet
Sara Kennis
Norbert De Kimpe
Tuyen Nguyen Van
Matthias D'hooghe
C3
Conference
2014
2013
A convenient approach towards the 1-aminomethyl-1-fluorocycloalkane scaffold
Matthias Moens
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON LETTERS
2013
Application of functionalized β-lactams for the selective construction of new aza- and oxaheterocyclic systems
Karen Mollet
Norbert De Kimpe
Matthias D'hooghe
Dissertation
2013
Computational rationalization of the ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams
Hannelore Goossens
Saron Catak
Karen Mollet
Nicola Piens
Matthias D'hooghe
Norbert De Kimpe
Michel Waroquier
Veronique Van Speybroeck
C3
Conference
2013
Epihalohydrins in organic synthesis
Girija S Singh
Karen Mollet
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
CHEMICAL REVIEWS
2013
Evaluation of (4-aminobutyloxy)quinolines as a novel class of antifungal agents
Stephanie Vandekerckhove
Hai Giang Tran
Tom Desmet
Matthias D'hooghe
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2013
Exploration of aziridine- and β-lactam-based hybrids as both bioactive substances and synthetic intermediates in medicinal chemistry
Stephanie Vandekerckhove
Matthias D'hooghe
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY
2013
Nucleophile-directed selective transformation of cis-1-tosyl-2-toxyloxymethyl-3-(trifluoromethyl)aziridine into aziridines, azetidines, and benzo-fused dithianes, oxathianes, dioxanes, and (thio)morpholines
Sara Kenis
Matthias D'hooghe
Guido Verniest
Maaike Reybroeck
Tuyet Anh Dang Thi
Chinh Pham The
Tham Thi Pham
Karl W Törnroos
Nguyen Van Tuyen
Norbert De Kimpe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2013
Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A
Rob De Vreese
Tom Verhaeghe
Tom Desmet
Matthias D'hooghe
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2013
Synthesis and antiplasmodial evaluation of aziridine-(iso)quinoline hybrids and their ring-opening products
Stephanie Vandekerckhove
Sofie De Moor
Dries Segers
Carmen de Kock
Peter J Smith
Kelly Chibale
Norbert De Kimpe
Matthias D'hooghe
A1
Journal Article
in
MEDCHEMCOMM
2013
Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines
Stephanie Vandekerckhove
Christian Müller
Dieter Vogt
Carmen Lategan
Peter J Smith
Kelly Chibale
Norbert De Kimpe
Matthias D'hooghe
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2013
Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity
Matthias D'hooghe
Karel Vervisch
Karl W Törnroos
Tom Verhaeghe
Tom Desmet
Carmen Lategan
Peter J Smith
Kelly Chibale
Norbert De Kimpe
A1
Journal Article
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2013
Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and a study of their reactivity
Karen Mollet
Hannelore Goossens
Nicola Piens
Saron Catak
Michel Waroquier
Karl W Tornroos
Veronique Van Speybroeck
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2013
Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity
Nicola Piens
Karen Mollet
Hannelore Goossens
Saron Catak
Michel Waroquier
Karl W. Törnroos
Veronique Van Speybroeck
Norbert De Kimpe
Matthias D'hooghe
C3
Conference
2013
Synthesis of piperidin-4-ones starting from 2-(2-bromo-1,1-dimethylethyl)-azetidines and 2-(2-mesyloxyethyl)azetidines through a ring expansion-oxidation protocol
Karen Mollet
Matthias D'hooghe
Leen Broeckx
Barbara Danneels
Tom Desmet
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2013
Synthesis of six-membered azaheterocycles by means of the β-lactam synthon method
Karen Mollet
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
MINI-REVIEWS IN ORGANIC CHEMISTRY
2013
Synthesis of α-(trifluoromethyl)aziridines and -azetidines and their transformations into novel CF₃-substituted amines and heterocyclic systems
Sara Kenis
Norbert De Kimpe
Matthias D'hooghe
Dissertation
2013
2012
Asymmetric synthesis of 4-formyl-1-(ω-haloalkyl)-β-lactams and their transformation to functionalized piperazines and 1,4-diazepanes
Stijn Dekeukeleire
Matthias D'hooghe
Matthieu Vanwalleghem
Willem Van Brabandt
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2012
Biocatalytic production of novel glycolipids with cellodextrin phosphorylase
Hai Giang Tran
Tom Desmet
Karen Saerens
Hendrik Waegeman
Stephanie Vandekerckhove
Matthias D'hooghe
Inge Van Bogaert
Wim Soetaert
A1
Journal Article
in
BIORESOURCE TECHNOLOGY
2012
Chemical and enzymatic synthesis of 2-(2-carbamoylethyl)- and 2-(2-carboxyethyl)aziridines and their conversion into δ-lactams and γ-lactones
Karel Vervisch
Matthias D'hooghe
Floris PJT Rutjes
Norbert De Kimpe
A1
Journal Article
in
ORGANIC LETTERS
2012
Computational study on the formation of N-spiro bis-Aziridinium ions and their Nucleophile-induced ring opening reactions
Dietmar Hertsen
Saron Catak
Michel Waroquier
Matthias D'hooghe
Norbert De Kimpe
Veronique Van Speybroeck
C3
Conference
2012
DFT calculations on aziridines within the supermolecule approach
Hannelore Goossens
Saron Catak
Sonja Stanković
Matthias D'hooghe
Norbert De Kimpe
Michel Waroquier
Veronique Van Speybroeck
C3
Conference
2012
Design, synthesis and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids
Matthias D'hooghe
Karen Mollet
Rob De Vreese
Tim Jonckers
Géry Dams
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF MEDICINAL CHEMISTRY
2012
N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis
Rob De Vreese
Matthias D'hooghe
A1
Journal Article
in
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
2012
Radical-mediated nitrile translocation as the key step in the stereoselective transformation of 2-(4-chloro-2-cyanobutyl)aziridines to methyl cis-(1-arylmethyl-4-phenylpiperidin-2-yl)acetates
Karel Vervisch
Matthias D'hooghe
Karl W Törnroos
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2012
Regioselectivity in the ring opening of non-activated aziridines
Sonja Stanković
Matthias D'hooghe
Saron Catak
Heesung Eum
Michel Waroquier
Veronique Van Speybroeck
Norbert De Kimpe
Hyun-Joon Ha
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2012
Solvent-controlled selective transformation of 2-Bromomethyl-2-methylaziridines to functionalized Aziridines and Azetidines
Sonja Stanković
Hannelore Goossens
Saron Catak
Meniz Tezcan
Michel Waroquier
Veronique Van Speybroeck
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2012
Stereoselective synthesis of bicyclic tetrahydrofuran-fused β-lactams and their conversion into methyl cis-3-aminotetrahydrofuran-2-carboxylates
Karen Mollet
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2012
Study of non-activated 2-(bromomethyl)aziridines and 2-bromomethyl-2-methylaziridines as versatile synthons in heterocyclic chemistry
Sonja Stanković
Norbert De Kimpe
Matthias D'hooghe
Dissertation
2012
Synthesis of 1-alkyl-2-(trifluoromethyl)azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl)amines via intermediate azetidinium salts
Sara Kenis
Matthias D'hooghe
Guido Verniest
Anh Dang Thi Tuyet
Chinh Pham The
Tuyen Van Nguyen
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2012
Synthesis of 3-functionalized 3-methylazetidines
Sonja Stanković
Matthias D'hooghe
Kourosch Abbaspour Tehrani
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON LETTERS
2012
Synthesis of stereodefined 3,4-disubstituted piperidines through rearrangement of 2-(2-bromo-1,1-dimethylethyl)azetidines
Karen Mollet
Leen Broeckx
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
HETEROCYCLES
2012
2011
Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined computational and experimental study
Hannelore Goossens
Karel Vervisch
Saron Catak
Sonja Stanković
Matthias D'hooghe
Frank De Proft
Paul Geerlings
Norbert De Kimpe
Michel Waroquier
Veronique Van Speybroeck
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2011
Ring expansion of cyclobutylmethylcarbenium ions to cyclopentane or cyclopentene derivatives and metal-promoted analogous rearrangements
Erika Leemans
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
CHEMICAL REVIEWS
2011
Selective transformation of 2-halomethyl-2-methylaziridines to functionalized aziridines and azetidines
Sonja Stanković
Matthias D'hooghe
Saron Catak
Hannelore Goossens
Michel Waroquier
Veronique Van Speybroeck
Kourosch Abbaspour Tehrani
Norbert De Kimpe
C3
Conference
2011
Stereoselective synthesis of 1- and 4-haloalkyl-beta-lactams and their stereoselective transformation into novel azaheterocyclic compounds
Stijn Dekeukeleire
Norbert De Kimpe
Matthias D'hooghe
Dissertation
2011
Stereoselective synthesis of cis-3,4-disubstituted piperidines through ring transformation of 2-(2-mesyloxyethyl)azetidines
Karen Mollet
Saron Catak
Michel Waroquier
Veronique Van Speybroeck
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2011
Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone
Sara Kenis
Matthias D'hooghe
Guido Verniest
Vinh Duc Nguyen
Anh Dang Thi Tuyet
Tuyen Van Nguyen
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2011
Synthesis and reactivity of non-activated 2-(chloromethyl)aziridines
Sonja Stanković
Matthias D'hooghe
Jo Dewulf
Piet Bogaert
Robrecht Jolie
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON LETTERS
2011
Synthesis and reactivity of spiro-fused β-lactams
Girija S Singh
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2011
Synthesis of 2-(2-cyanoeyhyl)aziridines and their transformation into a variety of novel cyclic amino nitriles
Karel Vervisch
Norbert De Kimpe
Matthias D'hooghe
Dissertation
2011
Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores
Matthias D'hooghe
Sara Kenis
Karel Vervisch
Carmen Lategan
Peter Smith
Kelly Chibale
Norbert De Kimpe
A1
Journal Article
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2011
Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity
Matthias D'hooghe
Stephanie Vandekerckhove
Karen Mollet
Karel Vervisch
Stijn Dekeukeleire
Liesbeth Lehoucq
Carmen Lategan
Peter J Smith
Kelly Chibale
Norbert De Kimpe
A1
Journal Article
in
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
2011
Synthesis of 3-methoxyazetidines via an aziridine to azetidine rearrangement and theoretical rationalization of the reaction mechanism
Sonja Stanković
Saron Catak
Matthias D'hooghe
Hannelore Goossens
Kourosch Abbaspour Tehrani
Pieter Bogaert
Michel Waroquier
Veronique Van Speybroeck
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2011
Transformation of trans-4-aryl-3-chloro-1-(2-chloroethyl)azetidin-2-ones into 3-aryl-2-(ethylamino)propan-1-ols via intermediate 1-(1-aryl-2-chloro-3-hydroxypropyl)aziridines and trans-2-aryl-3-(hydroxymethyl)aziridines
Karen Mollet
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2011
2010
Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine to alkyl acrylates : application towards the synthesis of 2-(methoxycarbonyl)indolizidine
Matthias D'hooghe
Kourosch Abbaspour Tehrani
Christophe Buyck
Norbert De Kimpe
A1
Journal Article
in
ARKIVOC
2010
Intramolecular pi-pi stacking interactions in 2-substituted N,N-dibenzylaziridinium ions and their regioselectivity in nucleophilic ring-opening reactions
Saron Catak
Matthias D'hooghe
Norbert De Kimpe
Michel Waroquier
Veronique Van Speybroeck
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2010
Microwave-assisted regioselective ring opening of non-activated aziridines by lithium aluminium hydride
Sonja Stanković
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2010
Opposite regiospecific ring opening of 2-(cyanomethyl)aziridines by hydrogen bromide and benzyl bromide : experimental study and theoretical rationalization
Saron Catak
Matthias D'hooghe
Toon Verstraelen
Karen Hemelsoet
Andries Van Nieuwenhove
Hyun-Joon Ha
Michel Waroquier
Norbert De Kimpe
Veronique Van Speybroeck
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2010
Rhodium-catalysed hydroformylation of N-(2-propenyl)-β-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)but-1-enyl]acetamides
Stijn Dekeukeleire
Matthias D'hooghe
Christian Müller
Dieter Vogt
Norbert De Kimpe
A1
Journal Article
in
NEW JOURNAL OF CHEMISTRY
2010
Stereoselective synthesis of chiral 4-(1-chloroalkyl)-β-lactams starting from amino acids and their transformation into functionalized chiral azetidines and pyrrolidines
Stijn Dekeukeleire
Matthias D'hooghe
Karl Törnroos
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2010
Stereoselective synthesis of trans- and cis-2-aryl-3-(hydroxymethyl)aziridines through transformation of 4-aryl-3-chloro-β-lactams and study of their ring opening
Matthias D'hooghe
Karen Mollet
Stijn Dekeukeleire
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2010
Synthesis of 3,4-fused bicyclic β-lactams and their transformation into methyl cis-3-aminotetrahydrofuran-2-carboxylates
Erika Leemans
Matthias D'hooghe
Yves Dejaegher
Karl Törnroos
Norbert De Kimpe
A1
Journal Article
in
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2010
Synthesis of stereodefined piperidines from aziridines and their transformation into conformationally constrained amino acids, amino alcohols and 2,7-diazabicyclo[3.3.1]nonanes
Karel Vervisch
Matthias D'hooghe
Karl Törnroos
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2010
Systematic study of halide-induced ring opening of 2-substituted aziridinium salts and theoretical rationalization of the reaction pathways
Matthias D'hooghe
Saron Catak
Sonja Stanković
Michel Waroquier
Yongeun Kim
Hyun-Joon Ha
Veronique Van Speybroeck
Norbert De Kimpe
A1
Journal Article
in
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2010
Use of functionalized β-lactams as building blocks in heterocyclic chemistry
Matthias D'hooghe
Stijn Dekeukeleire
Erika Leemans
Norbert De Kimpe
A1
Journal Article
in
PURE AND APPLIED CHEMISTRY
2010
2009
A new approach towards 1-phenyl and 1-benzyl substituted 2-(aminomethyl)cyclopropanecarboxamides as novel derivatives of the antidepressant Milnacipran
Karel Vervisch
Matthias D'hooghe
Karl Törnroos
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2009
A new entry into cis-3-amino-2-methylpyrrolidines via ring expansion of 2-(2-hydroxyethyl)-3-methylaziridines
Matthias D'hooghe
Wim Aelterman
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2009
Diastereoselective Synthesis of Bicyclic gamma-Lactams via Ring Expansion of Monocydic beta-Lactams
Stijn Dekeukeleire
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2009
Nucleophile-dependent regioselective ring opening of 2-substituted N,N-dibenzylaziridinium ions : bromide versus hydride
Sae Young Yun
Saron Catak
Won Koo Lee
Matthias D'hooghe
Norbert De Kimpe
Veronique Van Speybroeck
Michel Waroquier
Yongeun Kim
Hyun-Joon Ha
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2009
One-pot synthesis of 3,3-dimethylpyrrolidine-2-carbonitriles from 4-chloro-2,2-dimethylbutanal in water
Matthias D'hooghe
Berten Van Driessche
Norbert De Kimpe
A1
Journal Article
in
HETEROCYCLES
2009
Synthesis and reactivity of 3-haloazetidines and 3-sulfonyloxyazetidines: a review
Willem Van Brabandt
Sven Mangelinckx
Matthias D'hooghe
Berten Van Driessche
Norbert De Kimpe
A1
Journal Article
in
CURRENT ORGANIC CHEMISTRY
2009
Synthesis of 2-(3-hydroxy-2-methyl-1-alkenyl)-1-pyrrolines and 2-(3-hydroxybutyl)-1-pyrroline using alpha-lithiated 2-methyl-1-pyrroline
Matthias D'hooghe
Kourosch Abbaspour Tehrani
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2009
Synthesis of 2-[(arylmethylene)amino]cyclopropanecarbonitriles via a two-step ring transformation of 2-(cyanomethyl)aziridines
Sven Mangelinckx
Matthias D'hooghe
Sietske Peeters
Norbert De Kimpe
A1
Journal Article
in
SYNTHESIS-STUTTGART
2009
Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity
Matthias D'hooghe
Stijn Dekeukeleire
Karen Mollet
Carmen Lategan
Peter Smith
Kelly Chibale
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF MEDICINAL CHEMISTRY
2009
2008
Azetidines, Azetines, and Azetes: Monocyclic
G SINGH
Matthias D'hooghe
Norbert De Kimpe
Bookchapter
in
Comprehensive Heterocyclic Chemistry III
2008
Coupling of 1-alkyl-2-(bromomethyl)aziridines with heteroatom-centered nucleophiles towards 2-[(heteroatom)methyl]aziridines
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
ARKIVOC
2008
Electrophile-induced bromocyclization of gamma,delta-unsaturated ketimines to intermediate I-pyrrolinium salts and their selective conversion into novel 5-alkoxymethyl-2-aryl-3-chloropyrroles and 2-aroylpyrroles
Matthias D'hooghe
C BUYCK
J CONTRERAS
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2008
Highly stereoselective synthesis of beta-lactams utilizing alpha-chloroimines as new and powerful chiral inductors
Matthias D'hooghe
Willem Van Brabandt
Stijn Dekeukeleire
Y DEJAEGHER
Norbert De Kimpe
A1
Journal Article
in
CHEMISTRY-A EUROPEAN JOURNAL
2008
Novel diastereoselective synthesis of bicyclic beta-lactams through radical cyclization and their reduction toward 2-(1-alkoxy-2-hydroxyethyl)piperidines and 2-(1-alkoxy-2-hydroxyethyl)azepanes
Erika Leemans
Matthias D'hooghe
Y DEJAEGHER
KW TOEMROOS
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2008
Novel synthesis of 2-aminopentanedinitriles from 2-(bromomethyl)aziridines and their transformation into 2-imino-5-methoxypyrrolidines and 5-methoxypyrrolidin-2-ones
Matthias D'hooghe
Andries Van Nieuwenhove
Willem Van Brabandt
M ROTTIERS
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2008
Reactivity of N-(omega-haloalkyl)-beta-lactams with regard to lithium aluminium hydride: novel synthesis of 1-(1-aryl-3-hydroxypropyl)aziridines and 3-aryl-3-(N-propylamino)propan-1-ols
Matthias D'hooghe
Stijn Dekeukeleire
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2008
Reduction of 5-(bromomethyl)-1-pyrrolinium bromides to 2-(bromomethyl)pyrrolidines and their transformation into piperidin-3-ones through an unprecedented ring expansion-oxidation protocol
Matthias D'hooghe
J BAELE
J CONTRERAS
Mark Boelens
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON LETTERS
2008
Regio- and stereocontrolled synthesis of novel 3-sulfonamido-2,3,4,5-tetrahydro-1,5-benzothiazepines from 2-(bromomethyl)- or 2-(sulfonyloxymethyl)aziridines
M KARIKOMI
Matthias D'hooghe
Guido Verniest
Norbert De Kimpe
A1
Journal Article
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2008
Synthesis and reactivity of novel alpha,alpha,beta- and alpha,alpha,delta-trichlorinated imines
Matthias D'hooghe
Bruno De Meulenaer
Norbert De Kimpe
A1
Journal Article
in
SYNLETT
2008
Synthesis and synthetic applications of 2-amino-3-halo-1-oxypropanes
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2008
Synthesis of novel 3-oxopiperidin-2-ones from methyl 2-alkoxy-5-amino-2-pentenoates
Y DEJAEGHER
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
SYNLETT
2008
Synthesis of trans-4-aryl-3-(3-chloropropyl)azetidin-2-ones and their transformation into trans- and cis-2-arylpiperidine-3-carboxylates
Matthias D'hooghe
Y DEJAEGHER
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2008
2007
Highly unusual conversion of 1-alkyl-2-(bromomethyl) aziridines into 1-alkyl-2-(N-alkyl-N-ethylaminomethyl)aziridines using methyllithium
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2007
Novel synthesis of 3,4-diaminobutanenitriles and 4-amino-2-butenenitriles from 2-(cyanomethyl)aziridines through intermediate aziridinium salts: An experimental and theoretical approach
Matthias D'hooghe
Veronique Van Speybroeck
A VAN NIEUWENHOVE
Michel Waroquier
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2007
Reactivity of 1-alkyl-2-(bromomethyl)aziridines towards n-butyllithium
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
ARKIVOC
2007
Ring opening of 2-(cyanomethyl)aziridines by acid chlorides: synthesis of novel 4-amino-2-butenenitrile derivatives through intermediate aziridinium salts
Matthias D'hooghe
Karel Vervisch
Andries Van Nieuwenhove
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON LETTERS
2007
Stereospecific aziridination of olefins via electrophile-induced cyclization of gamma,delta-unsaturated imines and subsequent hydrolytic rearrangement
Matthias D'hooghe
Mark Boelens
J PIQUEUR
Norbert De Kimpe
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2007
Synthesis and reactivity of C-heteroatom-substituted aziridines
GS SINGH
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
CHEMICAL REVIEWS
2007
Synthesis of 1-arylmethyl-2-(2-cyanoethyl)aziridines and their rearrangement into novel 2-(Aminomethyl)cyclopropanecarbonitriles
Matthias D'hooghe
Karel Vervisch
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2007
2006
2-(Bromomethyl)aziridines as versatile building blocks in organic chemistry
Matthias D'hooghe
Norbert De Kimpe
Dissertation
2006
A new approach towards 2-amino-1-aryloxy-3-methoxypropanes from 1-arylmethyl-2-(bromomethyl)aziridines
Matthias D'hooghe
A WATERINCKX
Tim Vanlangendonck
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2006
Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams
Willem Van Brabandt
Matthieu Vanwalleghem
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2006
Novel synthesis of cis-3,5-disubstituted morpholine derivatives
Matthias D'hooghe
Tim Vanlangendonck
KW TORNROOS
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2006
Opposite regioselectivity in the sequential ring-opening of 2-(alkanoyloxymethyl)aziridinium salts by bromide and fluoride in the synthesis of functionalized p-fluoro amines
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
SYNLETT
2006
Regio- and stereospecific ring opening of 1,1-dialkyl-2-(aryloxymethyl)aziridinium salts by bromide
Matthias D'hooghe
Veronique Van Speybroeck
Michel Waroquier
Norbert De Kimpe
A1
Journal Article
in
CHEMICAL COMMUNICATIONS
2006
Synthesis and reactivity of trans-2-aryl-3-chloroazetidines
Berten Van Driessche
Willem Van Brabandt
Matthias D'hooghe
Y DEJAEGHER
N DE-KIMPE
A1
Journal Article
in
TETRAHEDRON
2006
Synthesis of 1-arylmethyl-2-(cyanomethyl) aziridines and their ring transformation into methyl N-(2-cyanocyclopropyl) benzimidates
Matthias D'hooghe
Sven Mangelinckx
E PERSYN
Willem Van Brabandt
N KIMPE
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2006
Synthesis of chiral 1,5-disubstituted pyrrolidinones via electrophile-induced cyclization of 2-(3-butenyl)oxazolines derived from (1R,2S)- and (1S,2R)-norephedrine
I KANIZSAI
Z SZAKONYI
R SILLANPAA
Matthias D'hooghe
Norbert De Kimpe
F FULOP
A1
Journal Article
in
TETRAHEDRON-ASYMMETRY
2006
Synthetic approaches towards 2-iminothiazolidines: an overview
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2006
2005
A novel entry toward 2-imino-1,3-thiazolidines and 2-imino-1,3-thiazolines by ring transformation of 2-(thiocyanomethyl)aziridines
Matthias D'hooghe
A WATERINCKX
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2005
Coupling of 1-alkyl-2-(bromomethyl)aziridines with lithium dialkylcuprates towards 1,2-dialkylaziridines
Matthias D'hooghe
M ROTTIERS
R JOLIE
Norbert De Kimpe
A1
Journal Article
in
SYNLETT
2005
Ring opening of 2-(bromomethyl)-1-sulfonylaziridines towards 1,3-heteroatom substituted 2-aminopropane derivatives
Matthias D'hooghe
M ROTTIERS
I KERKAERT
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2005
Synthesis of bicyclic carbamates as precursors of Sedum alkaloid derivatives
Z SZAKONYI
Matthias D'hooghe
L KANIZSAI
F FULOP
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2005
2004
New synthesis of propargylic amines from 2-(bromomethyl)aziridines. Intermediacy of 3-bromoazetidinium salts
Matthias D'hooghe
Willem Van Brabandt
Norbert De Kimpe
A1
Journal Article
in
JOURNAL OF ORGANIC CHEMISTRY
2004
Ring opening reactions of 1-arenesulfonyl-2-(bromomethyl)aziridines
Matthias D'hooghe
I KERKAERT
M ROTTIERS
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2004
Synthesis of functionalized 1,4-dihydro-9,10-anthraquinones and anthraquinones by ring closing metathesis using Grubbs' catalyst
TN VAN
Matthias D'hooghe
S PATTYN
Norbert De Kimpe
A1
Journal Article
in
SYNLETT
2004
The mechanism of nucleophilic substitution of 1-alkyl-2-(tosyloxymethyl)-aziridines
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
SYNLETT
2004
2003
A new route towards N-(alpha-methoxybenzyl)aziridines
Matthias D'hooghe
A HOFKENS
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON LETTERS
2003
Novel synthesis of indolizidines and quinolizidines
KA TEHRANI
Matthias D'hooghe
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2003
Synthesis of N-(4-chlorobutyl)butanamide, a chlorinated amide isolated from Aloe sabaea
Matthias D'hooghe
Z SZAKONYI
F FULOP
Norbert De Kimpe
A1
Journal Article
in
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL
2003
Synthesis of quaternary allylammonium salts via ring opening of 1-benzyl-2-(bromomethyl)aziridines
Matthias D'hooghe
Willem Van Brabandt
Norbert De Kimpe
A1
Journal Article
in
TETRAHEDRON
2003
