Research Explorer

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Researcher

Matthias D'hooghe

218 Results

2022

Carboxylic acid bioisosteres in medicinal chemistry : synthesis and properties

Kato BredaelSilke GeursDorien ClarisseKarolien De BosscherMatthias D'hooghe

A1 Journal Article in JOURNAL OF CHEMISTRY

Covalent organic framework supported palladium catalysts

Hadi SalemiMaarten DebruyneVeronique Van SpeybroeckPascal Van Der VoortMatthias D'hoogheChristian Stevens

U Journal Article in Journal of Materials Chemistry A

Covalent organic framework supported palladium catalysts

Hadi SalemiMaarten DebruyneVeronique Van SpeybroeckPascal Van Der VoortMatthias D'hoogheChristian Stevens

A1 Journal Article in JOURNAL OF MATERIALS CHEMISTRY A

Fight against AMR – Synthesis of pyrrolidine-fused azetidin-2-ones as potential antibacterials

Sari DeketelaereJonas MortierChristian StevensMatthias D'hooghe

Identification of mercaptoacetamide-based HDAC6 inhibitors via a lean inhibitor strategy : screening, synthesis, and biological evaluation

Silke GeursDorien ClarisseJorick FranceusTom DesmetKarolien De BosscherMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma

Silke GeursDorien ClarisseEleni StaessensKarolien De BosscherMatthias D'hooghe

The ubiquitin binding domain of HDAC6 : a key regulator of aggresomal protein disposal and new therapeutic target to combat multiple myeloma

Silke GeursEleni StaessensDorien ClarisseKarolien De BosscherMatthias D'hooghe

Unexpected formation of N-(chloromethyl)acetamides during attempted Staudinger β-lactam synthesis

Sari DeketelaereElias Van Den BroeckLore CoolsKristof Van HeckeChristian StevensVeronique Van SpeybroeckMatthias D'hooghe

2021

Chemistry in flow motion : leveraging the benefits of microreactors for problematic batch reactions

Reinout Van KerrebroeckChristian StevensMatthias D'hooghe

Evolution of phosphorylases from N-acetylglucosaminide hydrolases in family GH3

Jorick FranceusJolien LormansLore CoolsMatthias D'hoogheTom Desmet

A1 Journal Article in ACS CATALYSIS

Recent contributions of quinolines to antimalarial and anticancer drug discovery research

Tim Van de WalleLore CoolsSven MangelinckxMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Unexpected formation of 2,2‐Dichloro‐N‐(chloromethyl)acetamides during attempted Staudinger 2,2‐Dichloro‐β‐lactam synthesis

Sari DeketelaereElias Van Den BroeckLore CoolsKristof Van HeckeChristian StevensVeronique Van SpeybroeckMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

2020

A de novo synthetic method to the access of N-substituted benzazepines

Matthias D'hooghe

A1 Journal Article in JOURNAL OF FLUORINE CHEMISTRY

Design and synthesis of novel ferrocene-quinoline conjugates and evaluation of their electrochemical and antiplasmodium properties

Aleksandra MinićTim Van de WalleKristof Van HeckeMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of antimalarial quinoline-based conjugates and anticancer nitroxoline derivatives

Tim Van de WalleMatthias D'hoogheSven Mangelinckx

Expedient synthesis of lupulones and their derivatization to 2,8-7H-dihydrochromen-7-ones

Lena DecuyperGurkirat KaurYves DepetterKristof Van HeckeMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Synthesis and biological evaluation of novel quinoline-piperidine scaffolds as antiplasmodium agents

Tim Van de WalleMaya BooneSven MangelinckxMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and penicillin‐binding protein inhibitory assessment of dipeptidic 4‐phenyl‐β‐lactams from α‐amino acid‐derived imines

Lena DecuyperMatthias D'hooghe

A1 Journal Article in CHEMISTRY-AN ASIAN JOURNAL

Synthesis of novel nitroxoline analogs with potent cathepsin B exopeptidase inhibitory activity

Tim Van de WalleZorica UbiparipTom DesmetKristof Van HeckeSven MangelinckxMatthias D'hooghe

A1 Journal Article in CHEMMEDCHEM

Synthetic strategies in curcumin chemistry focused on anticancer applications

Mr. Atiruj TheppawongGurkirat KaurJohn Van CampMatthias D'hooghe

A1 Journal Article in ARKIVOC

2019

Deployment of aziridines for the synthesis of alkaloids and their derivatives

Matthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

Design, synthesis and evaluation of monocyclic β-lactams as inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperMatthias D'hooghe

Electrophilic bromination in flow : a safe and sustainable alternative to the use of molecular bromine in batch

Reinout Van KerrebroeckPieter NaertThomas HeugebaertMatthias D'hoogheChristian Stevens

A1 Journal Article in MOLECULES

Reactivity of 3-oxo-β-lactams with respect to primary amines

Sari DeketelaereHannelore GoossensDietmar HertsenElias Van Den BroeckKaren MolletKristof Van HeckeVeronique Van SpeybroeckMatthias D'hooghe

Reactivity of 3-oxo-β-lactams with respect to primary amines

Sari DeketelaereHannelore GoossensDietmar HertsenElias Van Den BroeckKaren MolletKristof Van HeckeVeronique Van SpeybroeckMatthias D'hooghe

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

Yves DepetterSilke GeursRob De VreeseSophie GoethalsElien VandoornJonas SteenbruggeEvelyne MeyerMarc BrackeMatthias D'hoogheOlivier De Wever

A1 Journal Article in INTERNATIONAL JOURNAL OF CANCER

Synthesis and cytotoxic evaluation of monocarbonyl curcuminoids and their pyrazoline derivatives

Tim Van de WalleMr. Atiruj TheppawongCharlotte GrootaertKristof Van HeckeJohn Van CampMatthias D'hooghe

A1 Journal Article in MONATSHEFTE FUR CHEMIE

Synthesis and first line in vitro evaluation of novel curcumin derivatives as anti-tumoral agents

Mr. Atiruj TheppawongMatthias D'hoogheJohn Van Camp

Synthesis of 1,4‐thiazepane‐based curcuminoids with promising anticancer activity

Mr. Atiruj TheppawongTim Van de WalleKristof Van HeckeCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of indoline‐based benzhydroxamic acids as potential HDAC6 inhibitors

Yves DepetterSilke GeursJorick FranceusTom DesmetKarolien De BosscherOlivier De WeverMatthias D'hooghe

A1 Journal Article in CHEMISTRYSELECT

Synthesis of non‐symmetrical nitrogen‐containing curcuminoids in the pursuit of new anticancer candidates

Mr. Atiruj TheppawongTim Van de WalleCharlotte GrootaertKristof Van HeckeTom DesmetJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Synthesis of selective HDAC6 inhibitors and their evaluation in cancer models

Yves DepetterMatthias D'hoogheOlivier De Wever

α‐Unsaturated 3‐Amino‐1‐carboxymethyl‐β‐lactams as bacterial PBP inhibitors : synthesis and biochemical assessment

Lena DecuyperKatarina MagdalenicMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

2018

An update on the synthesis and reactivity of spiro-fused β-lactams

Matthias D'hooghe

A1 Journal Article in ARKIVOC

Antibacterial and β-lactamase inhibitory activity of monocyclic β-lactams

Lena DecuyperMatthias D'hooghe

A1 Journal Article in MEDICINAL RESEARCH REVIEWS

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

Yves DepetterSilke GeursFlore Vanden BusscheRob De VreeseJorick FranceusTom DesmetOlivier De WeverMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM

Chemoenzymatic approach toward the synthesis of 3-O-(α/β)-glucosylated 3-hydroxy-β-lactams

Lena DecuyperJorick FranceusShari DhaeneMaarten DebruyneTom DesmetMatthias D'hooghe

A1 Journal Article in ACS OMEGA

Exploring the sequence diversity in glycoside hydrolase family 13_18 reveals a novel glucosylglycerol phosphorylase

Jorick FranceusLena DecuyperMatthias D'hoogheTom Desmet

A1 Journal Article in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Formation of fluorinated amido esters through unexpected C3-C4 bond fission in 4-trifluoromethyl-3-oxo-β-lactams

Hang Dao ThiHannelore GoossensDietmar HertsenVeronique Van SpeybroeckMatthias D'hooghe

A1 Journal Article in CHEMISTRY-AN ASIAN JOURNAL

In silico design and enantioselective synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-β-lactams as inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperSari DeketelaereLore VanparysMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones

Hang Dao ThiMatthias D'hooghe

A1 Journal Article in MONATSHEFTE FUR CHEMIE

Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and their transformation into novel CF3-substituted amines and heterocyclic systems

Hang Dao ThiMatthias D'hooghe

Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines

Mr. Atiruj TheppawongTim Van de WalleCharlotte GrootaertTom DesmetJohn Van CampMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Synthesis of nitrogen-containing curcumin analogues in the pursuit of new anticancer candidates

Mr. Atiruj TheppawongCharlotte GrootaertJohn Van CampMatthias D'hooghe

Synthesis, biology and structure-activity relationships of novel β-enaminone-, aza-aromatic- and thiazepanebased curcuminoids

Mr. Atiruj TheppawongCharlotte GrootaertJohn Van CampMatthias D'hooghe

Theoretical insight into the regioselective ring-expansions of bicyclic aziridinium ions

Matthias D'hoogheVeronique Van SpeybroeckSaron Catak

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Use of 3-hydroxy-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of trifluoromethyl-containing aminopropanes, 1,3-oxazinan-2-ones, aziridines, and 1,4-dioxan-2-ones

Saron CatakVeronique Van SpeybroeckMatthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

2017

Asymmetric Synthesis of 3,4-Disubstituted 2-(Trifluoromethyl)pyrrolidines through Rearrangement of Chiral 2-(2,2,2-Trifluoro-1-hydroxyethyl)azetidines

Jeroen DolfenVeronique Van SpeybroeckSaron CatakKristof Van HeckeMatthias D'hooghe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Carbonylation of aziridines as a powerful tool for the synthesis of functionalized β-lactams

Nicola PiensMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Cobalt carbonyl-catalyzed carbonylation of functionalized aziridines to versatile β-lactam building blocks

Nicola PiensKristof Van HeckeMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Concise synthesis of 3-(aminomethyl)pyrrolizidines via an In(OTf)3-mediated ring rearrangement of 2-[2-(1-pyrrolin-2-yl)-alkyl]aziridines

Jeroen DolfenMatthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of PBPs of resistant bacteria

Sari DeketelaereLena DecuyperLore VanparysMatthias D'hooghe

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin binding proteins of resistant bacteria

Sari DeketelaereLena DecuyperLore VanparysMatthias D'hooghe

Design and synthesis of functionalized monocyclic 3-amino-1-carboxymethyl-beta-lactams as potential inhibitors of penicillin-binding proteins of resistant bacteria

Lena DecuyperSari DeketelaereLore VanparysMatthias D'hooghe

Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents

Rob De VreeseMatthias D'hooghe

A1 Journal Article in FUTURE MEDICINAL CHEMISTRY

LiAlH4-induced thia-aza-Payne rearrangement of functionalized 2-(thiocyanatomethyl)aziridines into 2-(aminomethyl)thiiranes as an entry to 5-(chloromethyl)thiazolidin-2-ones

Jeroen DolfenKristof Van HeckeMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

New strategies for the construction of heterocyclic systems through ring transformation of aziridines and azetidines

Jeroen DolfenMatthias D'hooghe

Reactivity of 3-oxo-β-lactams with respect to primary amines : an experimental and computational approach

Nicola PiensHannelore GoossensDietmar HertsenSari DeketelaereElias Van Den BroeckKaren MolletKristof Van HeckeVeronique Van SpeybroeckMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors

Rob De VreeseMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 4-(trifluoromethyl)azetidin-2-one building blocks and transformations into novel CF3-substituted amines and heterocyclic systems

Hang Dao ThiMatthias D'hooghe

Synthesis of bis-8-hydroxyquinolines via an imination or a Suzuki-Miyaura coupling approach

Rob De VreeseKoen MuylaertCédric MatonRik Van DeunHenk VrielinckChristian StevensMatthias D'hooghe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of new β-lactam building blocks and their application in heterocyclic chemistry

Nicola PiensMatthias D'hooghe

Synthesis of novel 4-ferrocenyl-1,2,3,4-tetrahydroquinolines and 4-ferrocenylquinolines via α-ferrocenyl carbenium ions as key intermediates

Matthias D'hooghe

A1 Journal Article in TETRAHEDRON

Synthesis of potent and selective HDAC6 inhibitors bearing a cyclohexane- or cycloheptane-annulated 1,5-benzothiazepine scaffold

Rob De VreeseYves DepetterJorick FranceusTom DesmetKristof Van HeckeMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of thiaheterocyclic benzohydroxamic acids and evaluation of their HDAC6 inhibitory activity

Rob De VreeseMatthias D'hooghe

Synthesis, biology and structure-activity relationships of novel β-enaminone-, aza-aromatic- and thiazepane-based curcuminoids

Mr. Atiruj TheppawongTim Van de WalleCharlotte GrootaertJohn Van CampMatthias D'hooghe

Synthetic approaches toward monocyclic 3-amino-β-lactams

Sari DeketelaereChristian StevensMatthias D'hooghe

A1 Journal Article in CHEMISTRYOPEN

Use of α,ω-dichloroketimine building blocks for the construction of 1-azabicyclo[3.1.0]hexanes, piperidines, pyridines, pyrroles and tetrahydroindoles

Nicola PiensMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

2016

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensJens MinckeJeroen BomonKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in RSC ADVANCES

Bicyclic aziridinium ions in azaheterocyclic chemistry : preparation and synthetic application of 1-azoniabicyclo[n.1.0]alkanes

Jeroen DolfenNorbert De KimpeMatthias D'hooghe

A1 Journal Article in ADVANCED SYNTHESIS & CATALYSIS

Catalytic carbonylation of aziridines to novel β-lactams as versatile building blocks in heterocyclic chemistry

Nicola PiensMatthias D'hooghe

Converting bulk sugars into prebiotics : semirational design of a transglucosylase with controlled selectivity

Tom VerhaegheKarel De WinterRob De VreeseMatthias D'hoogheTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

Deployment of small-ring azaheterocycles as building blocks for the synthesis of organofluorine compounds

Jeroen DolfenNorbert De KimpeMatthias D'hooghe

A1 Journal Article in SYNLETT

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-fused bicyclic β-lactams

Nicola PiensKaren MolletKristof Van HeckeMatthias D'hooghe

Diastereoselective synthesis of 3-acetoxy-4-(3-aryloxiran-2-yl)azetidin-2-ones and their transformation into 3,4-oxolane-fused bicyclic β-lactams

Nicola PiensJorick FranceusKaren MolletKristof Van HeckeTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Integrating biocatalytical processes into organic synthesis: nitrilase-mediated conversion of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones as a sustainable entry to functionalized γ-lactams and β-lactams

Nicola PiensLena DecuyperJens MinckeJeroen BomonKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

LiAlH4-Induced selective ring rearrangement of 2-(2-cyanoethyl)aziridines toward 2-(aminomethyl)pyrrolidines and 3-aminopiperidines as eligible heterocyclic building blocks

Jeroen DolfenKarel VervischNorbert De KimpeMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Recent progress in the use of functionalized β-lactams as building blocks in heterocyclic chemistry

Nicola PiensNorbert De KimpeMatthias D'hooghe

Bookchapter in Progress in Heterocyclic Chemistry, volume 28

Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

Rob De VreeseYves DepetterTom VerhaegheTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and applications of 3-methylene-4-(trifluoromethyl)azetidin-2-ones as building blocks for the preparation of mono- and spirocyclic 4-CF3-β-lactams

Hang Dao ThiBarbara DanneelsTom DesmetKristof Van HeckeMatthias D'hooghe

A1 Journal Article in ASIAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids

Mr. Atiruj TheppawongRob De VreeseCharlotte GrootaertJohn Van CampMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and chemical/enzymatic hydrolysis of 2-aryl-3-(2-cyanoethyl)aziridines and 4-(cyanomethyl)azetidin-2-ones

Lena DecuyperNicola PiensJens MinckeJeroen BomonKaren MolletKarel De WinterTom DesmetMatthias D'hooghe

Synthesis and cytotoxic evaluation of novel indenoisoquinoline-propan-2-ol hybrids

Lena DecuyperMatthias D'hooghe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of novel curcuminoids accommodating a central β-enaminone motif and their impact on cell growth and oxidative stress

Rob De VreeseCharlotte GrootaertSander D'hooreMr. Atiruj TheppawongJohn Van CampMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletSara KenisNorbert De KimpeMatthias D'hooghe

A1 Journal Article in SYNLETT

2015

Expedient stereoselective synthesis of new dihydropyrano- and dihydrofuranonaphthoquinones

Yves DepetterKaren MolletMatthias D'hooghe

A1 Journal Article in TETRAHEDRON LETTERS

Quinoline-based antimalarial hybrid compounds

Stephanie VandekerckhoveMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anticancer properties of new (dihydro)pyranonaphthoquinones and their epoxy analogs

Yves DepetterMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and antimicrobial/cytotoxic assessment of ferrocenyl oxazinanes, oxazinan-2-ones, and tetrahydropyrimidin-2-ones

Barbara DanneelsTom DesmetMatthias D'hooghe

A1 Journal Article in SYNLETT

Synthesis and cytotoxic evaluation of novel amide-triazole-linked triterpenoid-AZT conjugates

Hang Dao ThiMatthias D'hooghe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis and cytotoxic evaluation of novel dihydrobenzo[h]cinnoline-5,6-diones

Lena DecuyperMatthias D'hooghe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Karen MolletLena DecuyperNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

Rob De VreeseTom DesmetNadia BougarneKarolien De BosscherMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis of functionalized 3-, 5-, 6- and 8-aminoquinolines via intermediate (3-pyrrolin-1-yl)- and (2-oxopyrrolidin-1-yl)quinolines and evaluation of their antiplasmodial and antifungal activity

Stephanie VandekerckhoveBarbara DanneelsTom DesmetMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeNorbert De KimpeMatthias D'hooghe

Ϲинтеза нових биолошки активних хетероцикличних једињења која садрже фероцен

Anka PejovićMatthias D'hooghe

2014

Application of 3-bromo-3-ethylazetidines and 3-ethylideneazetidines for the synthesis of functionalized azetidines

Sonja StankovićMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

Discovery of anxiolytic 2-ferrocenyl-1,3-thiazolidin-4-ones exerting GABA(A) receptor interaction via the benzodiazepine-binding site

Anka PejovićMatthias D'hooghe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates

Chao ChenJef Van der BorghtRob De VreeseMatthias D'hoogheWim SoetaertTom Desmet

A1 Journal Article in CHEMICAL COMMUNICATIONS

New strategies for the synthesis of fluorinated carbo- and heterocyclic compounds

Matthias MoensNorbert De KimpeMatthias D'hooghe

Nucleophile-dependent regio- and stereoselective ring opening of 1-azoniabicyclo[3.1.0]hexane tosylate

Dietmar HertsenHannelore GoossensMichel WaroquierVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMISTRY-AN ASIAN JOURNAL

Reactivity of aziridinium salts in different solvents unraveled by a combined theoretical and experimental approach

Hannelore GoossensDietmar HertsenKaren MolletSaron CatakMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Bookchapter in Structure, bonding and reactivity of heterocyclic compounds

Selective synthesis of cis- and trans-2-(methyl/phenyl)-3-(trifluoromethyl)aziridines and their regio- and stereospecific ring opening

Matthias MoensNorbert De KimpeMatthias D'hooghe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Selective synthesis of functionalized trifluoromethylated pyrrolidines, piperidines, and azepanes starting from 1-tosyl-2-(trifluoromethyl)aziridine

Jeroen DolfenSara KenisKristof Van HeckeNorbert De KimpeMatthias D'hooghe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and biological evaluation of novel quinoline derivatives

Stephanie VandekerckhoveMatthias D'hooghe

Synthesis and cytotoxic evaluation of novel ester-triazole-linked triterpenoid-AZT conjugates

Hang Dao ThiMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones

Lena DecuyperKaren MolletNicola PiensKarel De WinterTom DesmetMatthias D'hooghe

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe

Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity

Stephanie VandekerckhoveTom DesmetHai Giang TranMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeNorbert De KimpeMatthias D'hooghe

A1 Journal Article in SYNTHESIS-STUTTGART

Synthesis of novel thymine-β-lactam hybrids and evaluation of their anti-tumor activity

Nicola PiensRob De VreeseNympha De NeveKristof Van HeckeNorbert De KimpeMatthias D'hooghe

Synthesis of trifluoromethylated azetidines, aminopropanes, 1,3-oxazinanes, and 1,3-oxazinan-2-ones starting from 4-trifluoromethyl-β-lactam building blocks

Hang Dao ThiLena DecuyperKaren MolletNorbert De KimpeMatthias D'hooghe

2013

A convenient approach towards the 1-aminomethyl-1-fluorocycloalkane scaffold

Matthias MoensMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Application of functionalized β-lactams for the selective construction of new aza- and oxaheterocyclic systems

Karen MolletNorbert De KimpeMatthias D'hooghe

Computational rationalization of the ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams

Hannelore GoossensSaron CatakKaren MolletNicola PiensMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Epihalohydrins in organic synthesis

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL REVIEWS

Evaluation of (4-aminobutyloxy)quinolines as a novel class of antifungal agents

Stephanie VandekerckhoveHai Giang TranTom DesmetMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Exploration of aziridine- and β-lactam-based hybrids as both bioactive substances and synthetic intermediates in medicinal chemistry

Stephanie VandekerckhoveMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

Nucleophile-directed selective transformation of cis-1-tosyl-2-toxyloxymethyl-3-(trifluoromethyl)aziridine into aziridines, azetidines, and benzo-fused dithianes, oxathianes, dioxanes, and (thio)morpholines

Sara KenisMatthias D'hoogheGuido VerniestNorbert De Kimpe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A

Rob De VreeseTom VerhaegheTom DesmetMatthias D'hooghe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis and antiplasmodial evaluation of aziridine-(iso)quinoline hybrids and their ring-opening products

Stephanie VandekerckhoveSofie De MoorDries SegersNorbert De KimpeMatthias D'hooghe

A1 Journal Article in MEDCHEMCOMM

Synthesis and antiplasmodial evaluation of novel (4-aminobutyloxy)quinolines

Stephanie VandekerckhoveNorbert De KimpeMatthias D'hooghe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2-aminomethyl-4-phenyl-1-azabicyclo[2.2.1]heptanes via LiAlH4-induced reductive cyclization of 2-(4-chloro-2-cyano-2-phenylbutyl) aziridines and evaluation of their antimalarial activity

Matthias D'hoogheKarel VervischTom VerhaegheTom DesmetNorbert De Kimpe

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and a study of their reactivity

Karen MolletHannelore GoossensNicola PiensSaron CatakMichel WaroquierVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of 2-hydroxy-1,4-oxazin-3-ones through ring transformation of 3-hydroxy-4-(1,2-dihydroxyethyl)-β-lactams and study of their reactivity

Nicola PiensKaren MolletHannelore GoossensSaron CatakMichel WaroquierVeronique Van SpeybroeckNorbert De KimpeMatthias D'hooghe

Synthesis of piperidin-4-ones starting from 2-(2-bromo-1,1-dimethylethyl)-azetidines and 2-(2-mesyloxyethyl)azetidines through a ring expansion-oxidation protocol

Karen MolletMatthias D'hoogheBarbara DanneelsTom DesmetNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of six-membered azaheterocycles by means of the β-lactam synthon method

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in MINI-REVIEWS IN ORGANIC CHEMISTRY

Synthesis of α-(trifluoromethyl)aziridines and -azetidines and their transformations into novel CF₃-substituted amines and heterocyclic systems

Sara KenisNorbert De KimpeMatthias D'hooghe

2012

Asymmetric synthesis of 4-formyl-1-(ω-haloalkyl)-β-lactams and their transformation to functionalized piperazines and 1,4-diazepanes

Stijn DekeukeleireMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Biocatalytic production of novel glycolipids with cellodextrin phosphorylase

Hai Giang TranTom DesmetKaren SaerensHendrik WaegemanStephanie VandekerckhoveMatthias D'hoogheInge Van BogaertWim Soetaert

A1 Journal Article in BIORESOURCE TECHNOLOGY

Chemical and enzymatic synthesis of 2-(2-carbamoylethyl)- and 2-(2-carboxyethyl)aziridines and their conversion into δ-lactams and γ-lactones

Karel VervischMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in ORGANIC LETTERS

Computational study on the formation of N-spiro bis-Aziridinium ions and their Nucleophile-induced ring opening reactions

Dietmar HertsenSaron CatakMichel WaroquierMatthias D'hoogheNorbert De KimpeVeronique Van Speybroeck

DFT calculations on aziridines within the supermolecule approach

Hannelore GoossensSaron CatakSonja StankovićMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

Design, synthesis and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids

Matthias D'hoogheKaren MolletRob De VreeseNorbert De Kimpe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

N-Heterocyclic carbene/Brønsted acid cooperative catalysis as a powerful tool in organic synthesis

Rob De VreeseMatthias D'hooghe

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Radical-mediated nitrile translocation as the key step in the stereoselective transformation of 2-(4-chloro-2-cyanobutyl)aziridines to methyl cis-(1-arylmethyl-4-phenylpiperidin-2-yl)acetates

Karel VervischMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Regioselectivity in the ring opening of non-activated aziridines

Sonja StankovićMatthias D'hoogheSaron CatakMichel WaroquierVeronique Van SpeybroeckNorbert De Kimpe

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Solvent-controlled selective transformation of 2-Bromomethyl-2-methylaziridines to functionalized Aziridines and Azetidines

Sonja StankovićHannelore GoossensSaron CatakMichel WaroquierVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Stereoselective synthesis of bicyclic tetrahydrofuran-fused β-lactams and their conversion into methyl cis-3-aminotetrahydrofuran-2-carboxylates

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Study of non-activated 2-(bromomethyl)aziridines and 2-bromomethyl-2-methylaziridines as versatile synthons in heterocyclic chemistry

Sonja StankovićNorbert De KimpeMatthias D'hooghe

Synthesis of 1-alkyl-2-(trifluoromethyl)azetidines and their regiospecific ring opening toward diverse α-(trifluoromethyl)amines via intermediate azetidinium salts

Sara KenisMatthias D'hoogheGuido VerniestNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3-functionalized 3-methylazetidines

Sonja StankovićMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis of stereodefined 3,4-disubstituted piperidines through rearrangement of 2-(2-bromo-1,1-dimethylethyl)azetidines

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in HETEROCYCLES

2011

Reactivity of activated versus nonactivated 2-(bromomethyl)aziridines with respect to sodium methoxide: a combined computational and experimental study

Hannelore GoossensKarel VervischSaron CatakSonja StankovićMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Ring expansion of cyclobutylmethylcarbenium ions to cyclopentane or cyclopentene derivatives and metal-promoted analogous rearrangements

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL REVIEWS

Selective transformation of 2-halomethyl-2-methylaziridines to functionalized aziridines and azetidines

Sonja StankovićMatthias D'hoogheSaron CatakHannelore GoossensMichel WaroquierVeronique Van SpeybroeckNorbert De Kimpe

Stereoselective synthesis of 1- and 4-haloalkyl-beta-lactams and their stereoselective transformation into novel azaheterocyclic compounds

Stijn DekeukeleireNorbert De KimpeMatthias D'hooghe

Stereoselective synthesis of cis-3,4-disubstituted piperidines through ring transformation of 2-(2-mesyloxyethyl)azetidines

Karen MolletSaron CatakMichel WaroquierVeronique Van SpeybroeckMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Straightforward synthesis of 1-alkyl-2-(trifluoromethyl)aziridines starting from 1,1,1-trifluoroacetone

Sara KenisMatthias D'hoogheGuido VerniestNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and reactivity of non-activated 2-(chloromethyl)aziridines

Sonja StankovićMatthias D'hoogheJo DewulfNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Synthesis and reactivity of spiro-fused β-lactams

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of 2-(2-cyanoeyhyl)aziridines and their transformation into a variety of novel cyclic amino nitriles

Karel VervischMatthias D'hooghe

Synthesis of 2-(aminomethyl)aziridines and their microwave-assisted ring opening to 1,2,3-triaminopropanes as novel antimalarial pharmacophores

Matthias D'hoogheSara KenisKarel VervischNorbert De Kimpe

A1 Journal Article in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of 2-amino-3-arylpropan-1-ols and 1-(2,3-diaminopropyl)-1,2,3-triazoles and evaluation of their antimalarial activity

Matthias D'hoogheStephanie VandekerckhoveKaren MolletKarel VervischStijn DekeukeleireNorbert De Kimpe

A1 Journal Article in BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3-methoxyazetidines via an aziridine to azetidine rearrangement and theoretical rationalization of the reaction mechanism

Sonja StankovićSaron CatakMatthias D'hoogheHannelore GoossensPieter BogaertMichel WaroquierVeronique Van SpeybroeckNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Transformation of trans-4-aryl-3-chloro-1-(2-chloroethyl)azetidin-2-ones into 3-aryl-2-(ethylamino)propan-1-ols via intermediate 1-(1-aryl-2-chloro-3-hydroxypropyl)aziridines and trans-2-aryl-3-(hydroxymethyl)aziridines

Karen MolletMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2010

Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine to alkyl acrylates : application towards the synthesis of 2-(methoxycarbonyl)indolizidine

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in ARKIVOC

Intramolecular pi-pi stacking interactions in 2-substituted N,N-dibenzylaziridinium ions and their regioselectivity in nucleophilic ring-opening reactions

Saron CatakMatthias D'hoogheNorbert De KimpeMichel WaroquierVeronique Van Speybroeck

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Microwave-assisted regioselective ring opening of non-activated aziridines by lithium aluminium hydride

Sonja StankovićMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Opposite regiospecific ring opening of 2-(cyanomethyl)aziridines by hydrogen bromide and benzyl bromide : experimental study and theoretical rationalization

Saron CatakMatthias D'hoogheToon VerstraelenKaren HemelsoetMichel WaroquierNorbert De KimpeVeronique Van Speybroeck

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Rhodium-catalysed hydroformylation of N-(2-propenyl)-β-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)but-1-enyl]acetamides

Stijn DekeukeleireMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in NEW JOURNAL OF CHEMISTRY

Stereoselective synthesis of chiral 4-(1-chloroalkyl)-β-lactams starting from amino acids and their transformation into functionalized chiral azetidines and pyrrolidines

Stijn DekeukeleireMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Stereoselective synthesis of trans- and cis-2-aryl-3-(hydroxymethyl)aziridines through transformation of 4-aryl-3-chloro-β-lactams and study of their ring opening

Matthias D'hoogheKaren MolletStijn DekeukeleireNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 3,4-fused bicyclic β-lactams and their transformation into methyl cis-3-aminotetrahydrofuran-2-carboxylates

Erika LeemansMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of stereodefined piperidines from aziridines and their transformation into conformationally constrained amino acids, amino alcohols and 2,7-diazabicyclo[3.3.1]nonanes

Karel VervischMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Systematic study of halide-induced ring opening of 2-substituted aziridinium salts and theoretical rationalization of the reaction pathways

Matthias D'hoogheSaron CatakSonja StankovićMichel WaroquierVeronique Van SpeybroeckNorbert De Kimpe

A1 Journal Article in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Use of functionalized β-lactams as building blocks in heterocyclic chemistry

Matthias D'hoogheStijn DekeukeleireErika LeemansNorbert De Kimpe

A1 Journal Article in PURE AND APPLIED CHEMISTRY

2009

A new approach towards 1-phenyl and 1-benzyl substituted 2-(aminomethyl)cyclopropanecarboxamides as novel derivatives of the antidepressant Milnacipran

Karel VervischMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

A new entry into cis-3-amino-2-methylpyrrolidines via ring expansion of 2-(2-hydroxyethyl)-3-methylaziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Diastereoselective Synthesis of Bicyclic gamma-Lactams via Ring Expansion of Monocydic beta-Lactams

Stijn DekeukeleireMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Nucleophile-dependent regioselective ring opening of 2-substituted N,N-dibenzylaziridinium ions : bromide versus hydride

Saron CatakMatthias D'hoogheNorbert De KimpeVeronique Van SpeybroeckMichel Waroquier

A1 Journal Article in CHEMICAL COMMUNICATIONS

One-pot synthesis of 3,3-dimethylpyrrolidine-2-carbonitriles from 4-chloro-2,2-dimethylbutanal in water

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in HETEROCYCLES

Synthesis and reactivity of 3-haloazetidines and 3-sulfonyloxyazetidines: a review

Sven MangelinckxMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in CURRENT ORGANIC CHEMISTRY

Synthesis of 2-(3-hydroxy-2-methyl-1-alkenyl)-1-pyrrolines and 2-(3-hydroxybutyl)-1-pyrroline using alpha-lithiated 2-methyl-1-pyrroline

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of 2-[(arylmethylene)amino]cyclopropanecarbonitriles via a two-step ring transformation of 2-(cyanomethyl)aziridines

Sven MangelinckxMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNTHESIS-STUTTGART

Synthesis of novel 2-alkoxy-3-amino-3-arylpropan-1-ols and 5-alkoxy-4-aryl-1,3-oxazinanes with antimalarial activity

Matthias D'hoogheStijn DekeukeleireKaren MolletNorbert De Kimpe

A1 Journal Article in JOURNAL OF MEDICINAL CHEMISTRY

2008

Azetidines, Azetines, and Azetes: Monocyclic

Matthias D'hoogheNorbert De Kimpe

Bookchapter in Comprehensive Heterocyclic Chemistry III

Coupling of 1-alkyl-2-(bromomethyl)aziridines with heteroatom-centered nucleophiles towards 2-[(heteroatom)methyl]aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in ARKIVOC

Electrophile-induced bromocyclization of gamma,delta-unsaturated ketimines to intermediate I-pyrrolinium salts and their selective conversion into novel 5-alkoxymethyl-2-aryl-3-chloropyrroles and 2-aroylpyrroles

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Highly stereoselective synthesis of beta-lactams utilizing alpha-chloroimines as new and powerful chiral inductors

Matthias D'hoogheStijn DekeukeleireNorbert De Kimpe

A1 Journal Article in CHEMISTRY-A EUROPEAN JOURNAL

Novel diastereoselective synthesis of bicyclic beta-lactams through radical cyclization and their reduction toward 2-(1-alkoxy-2-hydroxyethyl)piperidines and 2-(1-alkoxy-2-hydroxyethyl)azepanes

Erika LeemansMatthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Novel synthesis of 2-aminopentanedinitriles from 2-(bromomethyl)aziridines and their transformation into 2-imino-5-methoxypyrrolidines and 5-methoxypyrrolidin-2-ones

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Reactivity of N-(omega-haloalkyl)-beta-lactams with regard to lithium aluminium hydride: novel synthesis of 1-(1-aryl-3-hydroxypropyl)aziridines and 3-aryl-3-(N-propylamino)propan-1-ols

Matthias D'hoogheStijn DekeukeleireNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Reduction of 5-(bromomethyl)-1-pyrrolinium bromides to 2-(bromomethyl)pyrrolidines and their transformation into piperidin-3-ones through an unprecedented ring expansion-oxidation protocol

Matthias D'hoogheMark BoelensNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Regio- and stereocontrolled synthesis of novel 3-sulfonamido-2,3,4,5-tetrahydro-1,5-benzothiazepines from 2-(bromomethyl)- or 2-(sulfonyloxymethyl)aziridines

Matthias D'hoogheGuido VerniestNorbert De Kimpe

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis and reactivity of novel alpha,alpha,beta- and alpha,alpha,delta-trichlorinated imines

Matthias D'hoogheBruno De MeulenaerNorbert De Kimpe

A1 Journal Article in SYNLETT

Synthesis and synthetic applications of 2-amino-3-halo-1-oxypropanes

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of novel 3-oxopiperidin-2-ones from methyl 2-alkoxy-5-amino-2-pentenoates

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

Synthesis of trans-4-aryl-3-(3-chloropropyl)azetidin-2-ones and their transformation into trans- and cis-2-arylpiperidine-3-carboxylates

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

2007

Highly unusual conversion of 1-alkyl-2-(bromomethyl) aziridines into 1-alkyl-2-(N-alkyl-N-ethylaminomethyl)aziridines using methyllithium

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Novel synthesis of 3,4-diaminobutanenitriles and 4-amino-2-butenenitriles from 2-(cyanomethyl)aziridines through intermediate aziridinium salts: An experimental and theoretical approach

Matthias D'hoogheVeronique Van SpeybroeckMichel WaroquierNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Reactivity of 1-alkyl-2-(bromomethyl)aziridines towards n-butyllithium

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in ARKIVOC

Ring opening of 2-(cyanomethyl)aziridines by acid chlorides: synthesis of novel 4-amino-2-butenenitrile derivatives through intermediate aziridinium salts

Matthias D'hoogheKarel VervischNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Stereospecific aziridination of olefins via electrophile-induced cyclization of gamma,delta-unsaturated imines and subsequent hydrolytic rearrangement

Matthias D'hoogheMark BoelensNorbert De Kimpe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis and reactivity of C-heteroatom-substituted aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in CHEMICAL REVIEWS

Synthesis of 1-arylmethyl-2-(2-cyanoethyl)aziridines and their rearrangement into novel 2-(Aminomethyl)cyclopropanecarbonitriles

Matthias D'hoogheKarel VervischNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

2006

2-(Bromomethyl)aziridines as versatile building blocks in organic chemistry

Matthias D'hoogheNorbert De Kimpe

A new approach towards 2-amino-1-aryloxy-3-methoxypropanes from 1-arylmethyl-2-(bromomethyl)aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Asymmetric synthesis of 1-(2- and 3-haloalkyl)azetidin-2-ones as precursors for novel piperazine, morpholine, and 1,4-diazepane annulated beta-lactams

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Novel synthesis of cis-3,5-disubstituted morpholine derivatives

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Opposite regioselectivity in the sequential ring-opening of 2-(alkanoyloxymethyl)aziridinium salts by bromide and fluoride in the synthesis of functionalized p-fluoro amines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

Regio- and stereospecific ring opening of 1,1-dialkyl-2-(aryloxymethyl)aziridinium salts by bromide

Matthias D'hoogheVeronique Van SpeybroeckMichel WaroquierNorbert De Kimpe

A1 Journal Article in CHEMICAL COMMUNICATIONS

Synthesis and reactivity of trans-2-aryl-3-chloroazetidines

Berten Van DriesscheMatthias D'hooghe

A1 Journal Article in TETRAHEDRON

Synthesis of 1-arylmethyl-2-(cyanomethyl) aziridines and their ring transformation into methyl N-(2-cyanocyclopropyl) benzimidates

Matthias D'hoogheSven Mangelinckx

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Synthesis of chiral 1,5-disubstituted pyrrolidinones via electrophile-induced cyclization of 2-(3-butenyl)oxazolines derived from (1R,2S)- and (1S,2R)-norephedrine

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON-ASYMMETRY

Synthetic approaches towards 2-iminothiazolidines: an overview

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

2005

A novel entry toward 2-imino-1,3-thiazolidines and 2-imino-1,3-thiazolines by ring transformation of 2-(thiocyanomethyl)aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Coupling of 1-alkyl-2-(bromomethyl)aziridines with lithium dialkylcuprates towards 1,2-dialkylaziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

Ring opening of 2-(bromomethyl)-1-sulfonylaziridines towards 1,3-heteroatom substituted 2-aminopropane derivatives

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of bicyclic carbamates as precursors of Sedum alkaloid derivatives

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

2004

New synthesis of propargylic amines from 2-(bromomethyl)aziridines. Intermediacy of 3-bromoazetidinium salts

Matthias D'hoogheWillem Van BrabandtNorbert De Kimpe

A1 Journal Article in JOURNAL OF ORGANIC CHEMISTRY

Ring opening reactions of 1-arenesulfonyl-2-(bromomethyl)aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of functionalized 1,4-dihydro-9,10-anthraquinones and anthraquinones by ring closing metathesis using Grubbs' catalyst

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

The mechanism of nucleophilic substitution of 1-alkyl-2-(tosyloxymethyl)-aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in SYNLETT

2003

A new route towards N-(alpha-methoxybenzyl)aziridines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON LETTERS

Novel synthesis of indolizidines and quinolizidines

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in TETRAHEDRON

Synthesis of N-(4-chlorobutyl)butanamide, a chlorinated amide isolated from Aloe sabaea

Matthias D'hoogheNorbert De Kimpe

A1 Journal Article in ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Synthesis of quaternary allylammonium salts via ring opening of 1-benzyl-2-(bromomethyl)aziridines

Matthias D'hoogheWillem Van BrabandtNorbert De Kimpe

A1 Journal Article in TETRAHEDRON