Research Explorer

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Researcher

Marjolijn Renard

Publications & Research Data

Awards & Distinctions

73 Results

2024

Interpretation and classification of FBN1 variants associated with Marfan syndrome : consensus recommendations from the Clinical Genome Resource’s FBN1 variant curation expert panel

A. DrackleyC. SomervilleP. ArnaudL. M. BaudhuinN. HannaM. L. KlugeK. KotzerC. BoileauL. BronickiBert Callewaert et al.

A1 Journal Article in GENOME MEDICINE

Mitral annular disjunction in heritable thoracic aortic disease : insights from the Montalcino Aortic Consortium

Kishan L AsokanJennifer R LandesWannes RendersLaura Muiño MosqueraJulie De BackerDavid W JantzenAnji T YetmanGisela Teixido-TuraArturo EvangelistaRichmond Jeremy et al.

A1 Journal Article in JOURNAL OF THE AMERICAN HEART ASSOCIATION

Unraveling Marfan hearts : ultrastructural evidence for myocardial remodeling and cardiomyopathy

Violette DeleeuwSimon D'hulstAnthony DemolderFelke SteijnsMarjolijn RenardRiet De RyckeJo Van DorpeLaura Muiño MosqueraKatrien FrancoisKálmán Benke et al.

2023

Unraveling the role of TGFβ signaling in thoracic aortic aneurysm and dissection using Fbn1 mutant mouse models

Violette DeleeuwEric CarlsonMarjolijn RenardKeith D. ZientekPhillip A. WilmarthAshok P. ReddyElise C. ManaloSara F. TufaDouglas R. KeeneMargie Olbinado et al.

A1 Journal Article in MATRIX BIOLOGY

2021

Pathogenic variants in THSD4, encoding the ADAMTS-like 6 protein, predispose to inherited thoracic aortic aneurysm

Sandy ElbitarMarjolijn RenardPauline ArnaudNadine HannaMarie-Paule JacobDong-Chuan GuoKo TsutsuiMarie-Sylvie GrossKetty KesslerLaurent Tosolini et al.

A1 Journal Article in GENETICS IN MEDICINE

2020

Ambulatory electrocardiographic monitoring and ectopic beat detection in conscious mice

Felke SteijnsMáté István TóthAnthony DemolderLars Emil LarsenJana DesloovereMarjolijn RenardRobrecht RaedtPatrick SegersJulie De BackerPatrick Sips

A1 Journal Article in SENSORS

Fibrillin-1, function and dysfunction in myocardial tissue : observations in Marfan syndrome

Felke SteijnsJulie De BackerMarjolijn RenardPatrick Sips

MEK1/2 inhibition in murine heart and aorta after oral administration of refametinib supplemented drinking water

Felke SteijnsNathalie BrackeMarjolijn RenardJulie De BackerPatrick SipsNathan DebunneEvelien WynendaeleFrederick VerbekeBart De SpiegeleerLaurence Campens

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Slc2a10 knock-out mice deficient in ascorbic acid synthesis recapitulate aspects of arterial tortuosity syndrome and display mitochondrial respiration defects

Annekatrien BoelJoyce BurgerMarine VanhomwegenAude BeyensMarjolijn RenardSander BarnhoornChristophe CasteleynDieter ReinhardtBenedicte DescampsChristian Vanhove et al.

A1 Journal Article in HUMAN MOLECULAR GENETICS

Spontaneous right ventricular pseudoaneurysms and increased arrhythmogenicity in a mouse model of Marfan syndrome

Felke SteijnsMarjolijn RenardMarine VanhomwegenPetra VermassenJana DesloovereRobrecht RaedtLars Emil LarsenMáté István TóthJulie De BackerPatrick Sips

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Variants in ADRB1 and CYP2C9 : association with response to atenolol and losartan in Marfan Syndrome

Sara L. Van DriestLynn A. SleeperBruce D. GelbShaine A. MorrisHarry C. DietzGeoffrey A. ForbusElizabeth GoldmuntzArvind HoskoppalJeanne JamesTeresa M. Lee et al.

A1 Journal Article in JOURNAL OF PEDIATRICS

2019

Intercalated discs : specialized cytoskeletal anchors in cardiac muscle

Jolanda van HengelMaarten De SmetAnna KremerSaskia LippensMarjolijn RenardChristophe AmpeBieke Vanslembrouck

Reply: More genes for thoracic aortic aneurysms and dissections

Marjolijn RenardDianna M MilewiczJulie De Backer

A1 Journal Article in JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

2018

A heart for fibrillin : spatial arrangement in adult wild-type murine myocardial tissue

Felke SteijnsJolanda van HengelPatrick SipsJulie De BackerMarjolijn Renard

A1 Journal Article in HISTOCHEMISTRY AND CELL BIOLOGY

Clinical validity of genes for heritable thoracic aortic aneurysm and dissection

Marjolijn RenardCatherine FrancisRajarshi GhoshAlan F ScottP Dane WitmerLesley C AdèsGregor U AndelfingerPauline ArnaudCatherine BoileauBert Callewaert et al.

A1 Journal Article in JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice

Marjolijn RenardSuzanne VanhauwaertMarine VanhomwegenAli RihaniNiels VandammeSteven GoossensGeert BerxPieter Van VlierbergheJody J HaighBieke Decaesteker et al.

A1 Journal Article in SCIENTIFIC REPORTS

Sex, pregnancy and aortic disease in Marfan syndrome

Marjolijn RenardLaura Muiño MosqueraElise ManaloSara TufaEric CarlsonDouglas KeeneJulie De BackerLynn Sakai

SmgGDS, a new piece in the thoracic aortic aneurysm and dissection puzzle

Marjolijn Renard

Editorial material

Tailoring the American College of Medical Genetics and Genomics and the Association for Molecular Pathology guidelines for the interpretation of sequenced variants in the FBN1 gene for Marfan syndrome : proposal for a disease- and gene-specific guideline

Laura Muiño MosqueraFelke SteijnsTjorven AudenaertIlse MeerschautAnne De PaepeWouter SteyaertSofie SymoensPaul CouckeBert CallewaertMarjolijn Renard et al.

A1 Journal Article in CIRCULATION-GENOMIC AND PRECISION MEDICINE

TGFβ and aortic disease severity in MFS

Marjolijn RenardElise ManaloSara TufaDouglas KeeneJulie De BackerLynn Sakai

TGFβ and aortic disease severity in MFS

Marjolijn RenardElise ManaloSara TufaDouglas KeeneJulie De BackerLynn Sakai

TGFβ and aortic disease severity in MFS

Marjolijn RenardElise ManaloSara TufaDouglas KeeneJulie De BackerLynn Sakai

2017

Cardiomyocyte cell junctions : unraveling the mechanobiology with 3-D volume electron microscopy

Bieke VanslembrouckMarjolijn RenardSaskia LippensAnna KremerJolanda van Hengel

FIB-SEM and SBF-SEM to unravel the cardiomyocyte cell junctions

Bieke VanslembrouckAnna KremerSaskia LippensMarjolijn RenardJolanda van Hengel

Nitric oxide mediates aortic disease in mice deficient in the metalloprotease Adamts1 and in a mouse model of Marfan syndrome

Jorge OllerNerea Méndez-BarberoE Josue RuizSilvia VillahozMarjolijn RenardLizet I CanelasAna M BrionesRut AlbercaNoelia Lozano-VidalMaría A Hurlé et al.

A1 Journal Article in NATURE MEDICINE

Sex, pregnancy and aortic disease in Marfan syndrome

Marjolijn RenardLaura Muiño MosqueraElise C ManaloSara TufaEric J CarlsonDouglas R KeeneJulie De BackerLynn Y Sakai

A1 Journal Article in PLOS ONE

Shallow whole genome sequencing on circulating cell-free DNA allows reliable non-invasive copy number profiling in neuroblastoma patients

Nadine Van RoyMalaïka Van der LindenPauline DepuydtBjörn MentenAnnelies DheedeneCharlotte VandeputteJo Van DorpeGenevieve LaureysMarjolijn RenardTom Sante et al.

Tailoring the ACMG and AMP recommendations for the interpretation of genetic variants in the FBN1 gene : a gene-specific guideline

Laura Muiño MosqueraFelke SteijnsMarjolijn RenardJulie De Backer

2016

FBN1: the disease-causing gene for Marfan syndrome and other genetic disorders

Lynn Y SakaiDouglas R KeeneMarjolijn RenardJulie De Backer

A1 Journal Article in GENE

2015

Gene panel sequencing in heritable thoracic aortic disorders and related entities: results of comprehensive testing in a cohort of 264 patients

Laurence CampensBert CallewaertLaura Muiño MosqueraMarjolijn RenardSofie SymoensAnne De PaepePaul CouckeJulie De Backer

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

Intrinsic cardiomyopathy in Marfan syndrome: results from in- and ex-vivo studies of the Fbn1C1039G/+ model and longitudinal findings in humans

Laurence CampensMarjolijn RenardBram TrachetPatrick SegersLaura Muiño MosqueraJohan De SutterLynn SakaiAnne De PaepeJulie De Backer

A1 Journal Article in PEDIATRIC RESEARCH

Marfan syndrome and related heritable thoracic aortic aneurysms and dissections

Julie De BackerMarjolijn Renard

Bookchapter in Arterial disorders : definition, clinical manifestations, mechanisms and therapeutic approaches

Marfan syndrome and related heritable thoracic aortic aneurysms and dissections

Julie De BackerMarjolijn RenardLaurence CampensLaura Muiño MosqueraAnne De PaepePaul CouckeBert CallewaertYskert von Kodolitsch

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

Mechanotransduction in cardiomyopathies : role of- and interaction between the areae compositae and extracellular matrix

Jolanda van HengelMarjolijn RenardJulie De Backer

2014

Absence of cardiovascular manifestations in a haploinsufficient TGFBR1 mouse model

Marjolijn RenardBram TrachetChristophe CasteleynLaurence CampensPieter CornillieBert CallewaertSteven DeleyeBert VandeghinstePaula van HeijningenHarry Dietz et al.

A1 Journal Article in PLOS ONE

Longitudinal follow-up of ascending versus abdominal aortic aneurysm formation in angiotensin II-infused ApoE -/- mice

Bram TrachetMarjolijn RenardCarole Van der DoncktSteven DeleyeJoris BolsGuido RY De MeyerSteven StaelensBart LoeysPatrick Segers

A2 Journal Article in ARTERY RESEARCH

Mutation detection rate and - characteristics in thoracic aortic aneurysm (TAA) related disorders: results from next generation sequencing (NGS) panel testing

Laurence CampensLaura Muiño MosqueraBert CallewaertMarjolijn RenardMachteld BaetensAnne De PaepePaul CouckeJulie De Backer

2013

Genes in thoracic aortic aneurysms and dissections : do they matter? Translation and integration of research and modern genetic techniques into daily clinical practice

Julie De BackerMarjolijn RenardLaurence CampensKatrien FrancoisBert CallewaertPaul CouckeAnne De Paepe

A2 Journal Article in AORTA

Marfan related cardiomyopathy: an in vivo and in vitro study of the fbn1C1039G/+ mouse model

Laurence CampensMarjolijn RenardBram TrachetPatrick SegersAnne De PaepeJulie De Backer

Multiple aneurysms in a patient with aneurysms-osteoarthritis syndrome

Thomas MartensIsabelle Van HerzeeleFrederic De RyckMarjolijn RenardAnne De PaepeKatrien FrancoisFrank VermassenJulie De Backer

Editorial material

New insights into the molecular diagnosis and management of heritable thoracic aortic aneurysms and dissections

Laurence CampensMarjolijn RenardBert CallewaertPaul CouckeJulie De BackerAnne De Paepe

A1 Journal Article in POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE

Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD

Marjolijn RenardBert CallewaertMachteld BaetensLaurence CampensKay MacDermotJean-Pierre FrynsMarise BonduelleHarry C DietzIsabel Mendes GasparDiogo Cavaco et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CARDIOLOGY

Study of the molecular pathogenesis of thoracic aortic aneurysms

Marjolijn RenardAnne De PaepeJulie De Backer

Thoracic aortic-aneurysm and dissection in association with significant mitral valve disease caused by mutations in TGFB2

Marjolijn RenardBert CallewaertFransiska MalfaitLaurence CampensSaba SharifMiguel del CampoIrene ValenzuelaCatherine McwilliamPaul CouckeAnne De Paepe et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CARDIOLOGY

Twenty patients including 7 probands with autosomal dominant cutis laxa confirm clinical and molecular homogeneity

Smail Hadj-RabiaBert CallewaertEmmanuelle BourratMarlies KempersAstrid S PlompValerie LayetDeborah BartholdiMarjolijn RenardJulie De BackerFransiska Malfait et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

2012

Characterization of a distinct lethal arteriopathy syndrome in twenty-two infants associated with an identical, novel mutation in FBLN4 gene, confirms fibulin-4 as a critical determinant of human vascular elastogenesis

Mahesh KappanayilSheela NampoothiriRajesh KannanMarjolijn RenardPaul CouckeFransiska MalfaitSwapna MenonHiran K RavindranRenu KurupMuhammad Faiyaz-Ul-Haque et al.

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

Development of a novel COL3A1 transgenic mouse model for vascular Ehlers Danlos Syndrome

Yike KangSofie SymoensFransiska MalfaitPaul CouckeMarjolijn RenardBrecht GuillemynJulie De BackerFilipe Branco MadeiraWendy ToussaintLeen Vanhoutte et al.

Erfelijke vormen van thoracale aorta-aneurysma's en -dissecties : diagnostiek en beleid

Anne De PaepeBert CallewaertLaurence CampensPaul CouckeFransiska MalfaitMarjolijn RenardOlivier VanakkerJulie De BackerLAURENT DEMULIERKatrien Francois et al.

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Hemodynamics in ascending and abdominal aorta aneurysm formation in the ApoE -/- angiotensin II mouse model

Bram TrachetMarjolijn RenardJoris BolsSteven StaelensBart LoeysPatrick Segers

In-frame mutations in exon 1 of SKI cause dominant Shprintzen-Goldberg syndrome

Virgini CarmignacJulien ThevenonLesly AdèsBert CallewaertSophie JuliaChristel Thauvin-RobinetLucie GueneauJean-Benoit CourcetEstelle LopezKatherine Holman et al.

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

The Ghent Marfan trial: a randomized, double-blind placebo controlled trial with losartan in Marfan patients treated with β-blockers

Katarina MöbergSylvia De NobeleDaniel DevosEls GoetghebeurPatrick SegersBram TrachetChris VervaetMarjolijn RenardPaul CouckeBart Loeys et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CARDIOLOGY

2011

A longitudinal study in ApoE mice comparing baseline hemodynamics to endstage aneurysm location in a mouse-specific way

Bram TrachetMarjolijn RenardGianluca De SantisSteven StaelensJulie De BackerLuca AntigaBart LoeysPatrick Segers

A quantitative comparison between baseline hemodynamics and endstage aneurysm formation in apoE -/- mice

Bram TrachetMarjolijn RenardGianluca De SantisSteven StaelensJulie De BackerBart LoeysPatrick Segers

An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiotensin II-infused ApoE -/- mice

Bram TrachetMarjolijn RenardGianluca De SantisSteven StaelensJulie De BackerLuca AntigaBart LoeysPatrick Segers

A1 Journal Article in ANNALS OF BIOMEDICAL ENGINEERING

Applying massive parallel sequencing to molecular diagnosis of Marfan and Loeys-Dietz syndromes

Machteld BaetensLut Van LaerKim De LeeneerJan HellemansJoachim De SchrijverHendrik Van de VoordeMarjolijn RenardHal DietzRonald V LacroBjörn Menten et al.

A1 Journal Article in HUMAN MUTATION

Identification of binding partners interacting with the α1-N-propeptide of type V collagen

Sofie SymoensMarjolijn RenardChristelle Bonod-BidaudDelfien SyxElisabeth VaganayFransiska MalfaitSylvie Ricard-BlumEfrat KesslerLut Van LaerPaul Coucke et al.

A1 Journal Article in BIOCHEMICAL JOURNAL

Is AAA formation influenced by abdominal aortic hemodynamics?: a follow-up study in mice

Bram TrachetMarjolijn RenardGianluca De SantisSteven StaelensJulie De BackerLuca AntigaBart LoeysPatrick Segers

Is there a role for hemodynamics in AAA formation? A longitudinal in-vivo study in ApoE -/- mice

Bram TrachetMarjolijn RenardGianluca De SantisSteven StaelensJulie De BackerBart LoeysPatrick Segers

Left ventricular dysfunction in a mouse model of Marfan syndrome

Laurence CampensMarjolijn RenardBram TrachetPatrick SegersAnne De PaepeJulie De Backer

New insights into the pathogenesis of autosomal-dominant cutis laxa with report of five ELN mutations

Bert CallewaertMarjolijn RenardVishwanathan HucthagowderBeate AlbrechtIngrid HausserEdward BlairCristina DiasAlice AlbinoHiroshi WachiFumiaki Sato et al.

A1 Journal Article in HUMAN MUTATION

Replacing vascular corrosion casting by in-vivo micro-CT imaging for building 3D cardiovascular models in mice

Bert VandeghinsteBram TrachetMarjolijn RenardChristophe CasteleynSteven StaelensBart LoeysPatrick SegersStefaan Vandenberghe

A1 Journal Article in MOLECULAR IMAGING AND BIOLOGY

2010

Altered TGFβ signaling and cardiovascular manifestations in patients with autosomal recessive cutis laxa type I caused by fibulin-4 deficiency

Marjolijn RenardTammy HolmRegan VeithBert CallewaertLesley C AdèsOsman BaspinarAngela PickartMajed DasoukiJuliane HoyerAnita Rauch et al.

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Comparative aspects of non-invasive assessment of cardiovascular function in human and mouse by high-frequency ultrasound

Bram TrachetMarjolijn RenardAbigail SwillensJulie De BackerBart LoeysPatrick Segers

Comparison between vascular corrosion casting and in vivo micro-CT imaging for wall shear stress calculations in the mouse aorta

Bram TrachetBert VandeghinsteMarjolijn RenardChristophe CasteleynSteven StaelensBart LoeysPatrick SegersStefaan Vandenberghe

Het Marfansyndroom : een paradigma voor de studie van aorta-aneurysma's

Julie De BackerMarjolijn RenardPaul CouckeLut Van LaerAnne De PaepeBart Loeys

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Investigating the role of hemodynamics in AAA formation through combined imaging and modelling: a longitudonal in vivo study in apoE mice

Bram TrachetMarjolijn RenardGianluca De SantisSteven StaelensJulie De BackerBart LoeysPatrick Segers

Investigating the role of hemodynamics in AAA formation using an apoe -/- mouse model

Bram TrachetMarjolijn RenardGianluca De SantisSteven StaelensJulie De BackerBart LoeysPatrick Segers

Resolving in-vivo flow fields in the systemic circulation of the mouse through combined ultrasound imaging and computational fluid dynamics

Bram TrachetAbigail SwillensMarjolijn RenardJulie De BackerSteven StaelensBart LoeysPatrick Segers

Short stature, severe aortic root dilation, skin hyperextensibility, extreme joint laxity and craniofacial dysmorphic features: a probable new syndrome

Elke VerstraetenSofie SymoensMarjolijn RenardBert CallewaertK VandekerckhoveJulie De BackerFransiska MalfaitL MarksPaul CouckeAnne De Paepe et al.

A1 Journal Article in CLINICAL DYSMORPHOLOGY

The Loeys-Dietz syndrome: an update for the clinician

CHRISTINE VAN HEMELRIJKMarjolijn RenardBart Loeys

A1 Journal Article in CURRENT OPINION IN CARDIOLOGY

Vascular corrosion casting vs in vivo micro-CT casting : what is the effect on wall shear stress calculations in the mouse aorta?

Bram TrachetBert VandeghinsteMarjolijn RenardChristophe CasteleynSteven StaelensBart LoeysStefaan VandenberghePatrick Segers

2009

COL5A1 signal peptide mutations interfere with protein secretion and cause classic Ehlers-Danlos syndrome

Sofie SymoensFransiska MalfaitMarjolijn RenardJosette AndréIngrid HausserBart LoeysPaul CouckeAnne De Paepe

A1 Journal Article in HUMAN MUTATION

Replacing vascular corrosion casting by in-vivo µCT imaging for building 3D cardiovascular models in mice

Bert VandeghinsteBram TrachetMarjolijn RenardChristophe CasteleynSteven DeleyePhilippe JoyeStefaan VandenbergheSteven StaelensPatrick SegersBart Loeys