Research Explorer

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Researcher

Maarten De Smet

Awards & Distinctions

37 Results

2023

Arrhythmogenic consequences of connexin 43 hemichannel opening in the heart : an experimental and computational study

Maarten De SmetLuc LeybaertKarin Sipido

Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments

Luc LeybaertMaarten De SmetAlessio LissoniRosalie AllewaertH. Llewelyn RoderickGeert BultynckMario DelmarKarin R. SipidoKatja Witschas

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Trends in diagnosis, referral, red flag onset, patient profiles and natural outcome of de novo cardiac amyloidosis and their multidisciplinary implications

Philippe DebonnaireMathias ClaeysMaarten De SmetSander TrensonMichelle LyckeCatherine DemeesterJan Van DroogenbroeckAn S. De VrieseKristof VerhoevenNikolaas Vantomme et al.

A1 Journal Article in ACTA CARDIOLOGICA

2022

An unexpected cause of constipation and abdominal distension in COPD

Maarten De SmetEric DeromGuy Joos

Editorial material

Atrial tachycardia occurring after a prior atrial fibrillation ablation procedure : does non-inducibility matter?

L O'NeillB De BeckerMaarten De SmetJB Le Polain De WarouxR TavernierMattias DuytschaeverS Knecht

A1 Journal Article in FRONTIERS IN CARDIOVASCULAR MEDICINE

Case report : hemorrhagic fever with renal syndrome presenting as hemophagocytic lymphohistiocytosis

Maarten De SmetSimon BogaertAlexander SchauwvliegheAmélie DendoovenPieter DepuydtPatrick Druwé

A1 Journal Article in FRONTIERS IN MEDICINE

SARS-CoV-2-related multisystem inflammatory syndrome in adult complicated by myocarditis and cardiogenic shock

Maarten De SmetJan FierensLander VanhulleYannick Vande WeygaerdeThomas MalfaitDaniel DevosFilomeen HaerynckSofie Gevaert

A1 Journal Article in ESC HEART FAILURE

Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis

Marijke De BockMaarten De SmetStijn VerwaerdeHanane TahiriSteffi SchumacherValérie Van HaverKatja WitschasChristian SteinhäuserNathalie RouachRoosmarijn Vandenbroucke et al.

A1 Journal Article in JCI INSIGHT

2021

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Maarten De SmetAlessio LissoniTimur NezlobinskiiNan WangEef DriesMarta Pérez-HernándezXianming LinMatthew AmoniTim VervlietKatja Witschas et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes

Alessio LissoniPaco HulpiauTânia Martins-MarquesNan WangGeert BultynckRainer SchulzKatja WitschasHenrique GiraoMaarten De SmetLuc Leybaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

2020

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

Delphine HoorelbekeElke DecrockMaarten De SmetMarijke De BockBenedicte DescampsValérie Van HaverTinneke DelvaeyeDmitri KryskoChristian VanhoveGeert Bultynck et al.

A1 Journal Article in CELL DEATH & DISEASE

Gap19, a Cx43 hemichannel inhibitor, acts as a gating modifier that decreases main state opening while increasing substate gating

Alessio LissoniNan WangTimur NezlobinskiiMaarten De SmetAlexander PanfilovNele VandersickelLuc LeybaertKatja Witschas

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2019

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

Tinneke DelvaeyeMaarten De SmetStijn VerwaerdeElke DecrockAleksandra CzekajRoosmarijn VandenbrouckeKelly LemeireAmanda GonçalvesWim DeclercqPeter Vandenabeele et al.

A1 Journal Article in SCIENTIFIC REPORTS

Intercalated discs : specialized cytoskeletal anchors in cardiac muscle

Jolanda van HengelMaarten De SmetAnna KremerSaskia LippensMarjolijn RenardChristophe AmpeBieke Vanslembrouck

2018

Activation of Cx43 hemichannels by TNFα in HeLa cells stably overexpressing Cx43 and in the endothelial cell line EA.hy926

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+

Alessio LissoniMaarten De SmetPaco HulpiauTania Martins-MarquesNan WangHenrique GiraoLuc Leybaert

Functional consequences of Cx43 hemichannels in adult cardiac myocytes

Luc LeybaertMaarten De Smet

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesNan WangHenrique GiraoPaco HulpiauLuc Leybaert

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesNan WangHenrique GiraoPaco HulpiauLuc Leybaert

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesHerique GiraoNan WangPaco HulpiauLuc Leybaert

2017

Activation, regulation and arrhythmogenic implications of Cx43 hemichannels in ventricular cardiomyocytes

Maarten De SmetAlessio LissoniNan WangEef DriesKarin SipidoLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+

Alessio LissoniMaarten De SmetTânia Martins-MarquesNan WangHenrique GirãoLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII and p38MAPK

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII and p38MAPK

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart

Ashish GadicherlaNan WangMarco BulicEsperanza Agullo-PascualAlessio LissoniMaarten De SmetMario DelmarGeert BultynckDmitri KryskoAmadou Camara et al.

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Modulation of Cx43 hemichannels by TNFα in HeLa cells overexpressing Cx43

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleDmitri KryskoLuc Leybaert

Role of Cx43 hemichannels in ventricular arrhythmia associated with abnormal Ca2+ homeostasis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Sex steroids in relation to cardiac structure and function in men

Maarten De SmetBruno LapauwTine De Backer

A1 Journal Article in ANDROLOGIA

2016

Activation, regulation and arrhythmogenic implications of Cx43 hemichannels in ventricular cardiomyocytes

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Whole-cell patch clamp recordings of unitary connexin 43 hemichannel currents

Nan WangAlessio LissoniMaarten De SmetKarin R SipidoLuc Leybaert

Bookchapter in Gap junction channels and hemichannels

2015

Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ and are a potential arrhythmogenic substrate in the heart

Luc LeybaertMaarten De Smet

2014

Een 75-jarige vrouw met inspanningsgebonden kortademigheid en desaturatie

Maarten De SmetEline NaertThomas MalfaitGuy BrusselleEric Derom

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2013

Short-term changes in serum sex steroid levels and cardiac function in healthy young men

Maarten De SmetBruno LapauwTine De BackerJohannes Ruige

2012

Enhancing information extraction from clinical practice guidelines to improve the transparency and efficiency of Clinical Decision Support development

Maarten De SmetTine De BackerRobert Vander Stichele