Research Explorer

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Researcher

Luc Leybaert

Publications & Research Data

Awards & Distinctions

318 Results

2025

Astrocyte-targeted connexin43 hemichannel inhibition prevents radiation-induced energy transporter decrease in neurons and astrocytic proBDNF transport to synapses

Steffi SchumacherSara NeytChristian VanhoveLien De SchaepmeesterRobrecht RaedtKatja WitschasLuc Leybaert

A1 Journal Article in GLIA

From IP3RPEP6 inhibition of IP3 receptor channels to insights : do channel subunits collaborate or cooperate?

Katja WitschasSiyu TaoLuc Leybaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Myelin sheaths can act as compact temporary oxygen storage units as modeled by an electrical RC circuit model

Wouter VervustSina SafaeiKatja WitschasLuc LeybaertAn Ghysels

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

2024

An improved F98 glioblastoma rat model to evaluate novel treatment strategies incorporating the standard of care

Velislava ZotevaValerie De MeulenaereMarthe De BoeckChristian VanhoveLuc LeybaertRobrecht RaedtLeen PietersAnne VralTom BoterbergKarel Deblaere

A1 Journal Article in PLOS ONE

Baselining physiological parameters in three muscles across three equine breeds : what can we learn from the horse?

Carmen Vidal Moreno de VegaConstance De meeûsBerit BoshuizenLorie De MaréYannick GansemansFilip Van NieuwerburghDieter DeforceKlara GoethalsWard De SpiegelaereLuc Leybaert et al.

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI

Arantxa Cardona BarberánRamesh Reddy GuggillaCora ColenbierEmma Van der VeldenAndrei RybouchkinDominic StoopLuc LeybaertPaul CouckeSofie SymoensAnnekatrien Boel et al.

A1 Journal Article in HUMAN REPRODUCTION OPEN

Inhibiting astrocyte connexin-43 hemichannels blocks radiation-induced vesicular VEGF-A release and blood-brain barrier dysfunction

Steffi SchumacherHanane TahiriPascal EzanNathalie RouachKatja WitschasLuc Leybaert

A1 Journal Article in GLIA

Integrating and optimizing tonabersat in standard glioblastoma therapy : a preclinical study

Velislava ZotevaValerie De MeulenaereChristian VanhoveLuc LeybaertRobrecht RaedtLeen PietersAnne VralTom BoterbergKarel Deblaere

A1 Journal Article in PLOS ONE

IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels

Siyu TaoPaco HulpiauLarry E. WagnerKatja WitschasDavid I. YuleGeert BultynckLuc Leybaert

A1 Journal Article in ACTA PHYSIOLOGICA

Novel peptide tools to inhibit the IP3 receptor/connexin-43 hemichannel calcium signaling axis

Siyu TaoLuc Leybaert

2023

A new look at osteoarthritis: threshold potentials and an analogy to hypocalcemia

Patrick Van GelderEmmanuel AudenaertPatrick CaldersLuc Leybaert

A2 Journal Article in FRONTIERS IN AGING

Arrhythmogenic consequences of connexin 43 hemichannel opening in the heart : an experimental and computational study

Maarten De SmetLuc LeybaertKarin Sipido

Assisted oocyte activation does not overcome recurrent embryo developmental problems

Arantxa Cardona BarberánDavina BonteAnnekatrien BoelVanessa ThysRuth ParedisFemke MachtelinckxPetra De SutterIlse De CrooLuc LeybaertDominic Stoop et al.

A1 Journal Article in HUMAN REPRODUCTION

Baselining physiological parameters in posture versus locomotion muscles across breeds towards tailored dietary and training management

Carmen Vidal Moreno de VegaConstance De meeûsBerit BoshuizenLorie De MaréYannick GansemansFilip Van NieuwerburghDieter DeforceKlara GoethalsWard De SpiegelaereElisabeth-Lidwien J.M.M. Verdegaal et al.

Connexin hemichannels as candidate targets for cardioprotective and anti-arrhythmic treatments

Luc LeybaertMaarten De SmetAlessio LissoniRosalie AllewaertH. Llewelyn RoderickGeert BultynckMario DelmarKarin R. SipidoKatja Witschas

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Cx43 can form functional channels at the nuclear envelope and modulate gene expression in cardiac cells

Tania Martins-MarquesKatja WitschasIlda RibeiroMónica ZuzarteSteve CatarinoTeresa Ribeiro-RodriguesFrancisco CarameloTrond AasenIsabel Marques CarreiraLino Goncalves et al.

A1 Journal Article in OPEN BIOLOGY

Cx43 hemichannel and Panx1 channel modulation by Gap19 and 10Panx1 peptides

Alessio LissoniSiyu TaoRosalie AllewaertKatja WitschasLuc Leybaert

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dynamic of training and acute exercised-induced shifts in muscular glucose transporter (GLUT) 4, 8 and 12 expression in locomotion versus posture muscles in healthy horses.

Carmen Vidal Moreno de VegaDiete LemmensConstance De meeûsBerit BoshuizenLorie De MaréLuc LeybaertKlara GoethalsJean Eduardo de OliveiraGuilherme HosotaniDieter Deforce et al.

Dynamics of training and acute exercise-induced shifts in muscular glucose transporter (GLUT) 4, 8, and 12 expression in locomotion versus posture muscles in healthy horses

Carmen Vidal Moreno de VegaDiete LemmensConstance de Meeus d'ArgenteuilBerit BoshuizenLorie De MaréLuc LeybaertKlara GoethalsJean Eduardo de OliveiraGuilherme HosotaniDieter Deforce et al.

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

2022

Connexin 43 in mitochondria : what do we really know about its function?

Kerstin BoenglerLuc LeybaertMarisol Ruiz-MeanaRainer Schulz

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Differential effect of exercise on bioenergetics and plasticity of the equine muscle

Constance De meeûsCatherine DelesalleLuc LeybaertWard De Spiegelaere

Novel modulators of connexin 43 hemichannel in the heart : from peptides to pathways

Alessio LissoniLuc LeybaertAlexander Panfilov

Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis

Marijke De BockMaarten De SmetStijn VerwaerdeHanane TahiriSteffi SchumacherValérie Van HaverKatja WitschasChristian SteinhäuserNathalie RouachRoosmarijn Vandenbroucke et al.

A1 Journal Article in JCI INSIGHT

2021

Comparison of shifts in skeletal muscle plasticity parameters in horses in three different muscles, in answer to 8 weeks of harness training

Constance De meeûsBerit BoshuizenCarmen Vidal Moreno de VegaLuc LeybaertLorie De MaréKlara GoethalsWard De SpiegelaereMaarten OosterlinckCatherine Delesalle

A1 Journal Article in FRONTIERS IN VETERINARY SCIENCE

Connexin 43 phosphorylation by casein kinase 1 is essential for the cardioprotection by ischemic preconditioning

Christine HirschhäuserAlessio LissoniPhilipp Maximilian GörgePaul D. LampeJacqueline HegerKlaus-Dieter SchlüterLuc LeybaertRainer SchulzKerstin Boengler

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability

Maarten De SmetAlessio LissoniTimur NezlobinskiiNan WangEef DriesMarta Pérez-HernándezXianming LinMatthew AmoniTim VervlietKatja Witschas et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Glial connexins and pannexins in the healthy and diseased brain

Christian BA GiaumeChristian C. NausJuan Carlos SaezLuc Leybaert

A1 Journal Article in PHYSIOLOGICAL REVIEWS

Intercellular communication in the heart : therapeutic opportunities for cardiac ischemia

Tania Martins-MarquesDerek J. HausenloyJoost P.G. SluijterLuc LeybaertHenrique Girao

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Preservation of connexin 43 and transzonal projections in isolated bovine pre-antral follicles before and following vitrification (Nov, 10.1007/s10815-020-01993-2, 2020)

Anniek BusKatarzyna Szymańska-VandendriesscheIsabel PintelonJo L. M. R. LeroyLuc LeybaertPeter E. J. Bols

RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes

Alessio LissoniPaco HulpiauTânia Martins-MarquesNan WangGeert BultynckRainer SchulzKatja WitschasHenrique GiraoMaarten De SmetLuc Leybaert

A1 Journal Article in CARDIOVASCULAR RESEARCH

Software for cardiac modelling and patch clamp experiments, and its application to study conduction in the presence of fibrosis

Timur NezlobinskiiAlexander PanfilovLuc Leybaert

The calcium dynamics of human dental pulp stem cells stimulated with tricalcium silicate-based cements determine their differentiation and mineralization outcome

Elanagai RathinamSrinath GovindarajanSivaprakash RajasekharanHeidi DeclercqDirk ElewautPeter De CosterLuc MartensLuc Leybaert

A1 Journal Article in SCIENTIFIC REPORTS

The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells

Dieter V. van de SandeIvan KopljarAlaerts MaaikeArd TeismanDavid J. GallacherLoeys BartDirk J. SnydersLuc LeybaertHua Rong LuAlain J Labro

A1 Journal Article in CHANNELS

The role of connexin proteins and their channels in radiation-induced atherosclerosis

Raghda RamadanSarah BaatoutAn AertsLuc Leybaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The role of connexin proteins and their channels in radiation-induced atherosclerosis (Jan, 10.1007/s00018-020-03716-3, 2021)

Raghda RamadanSarah BaatoutAn AertsLuc Leybaert

The spreading mechanisms and responsible messengers of the radiation induced bystander effect

Delphine HoorelbekeLuc Leybaert

X-irradiation induces acute and early term inflammatory responses in atherosclerosis-prone ApoE-/- mice and in endothelial cells

Raghda RamadanMichaël ClaessensEllen CocquytMohamed MysaraElke DecrockSarah BaatoutAn AertsLuc Leybaert

A1 Journal Article in MOLECULAR MEDICINE REPORTS

2020

Astrocytic Connexin43 channels as candidate targets in epilepsy treatment

Laura WalraveMathieu VinkenLuc LeybaertIlse Smolders

A1 Journal Article in BIOMOLECULES

Christian Giaume (November 1951–July 2019)

Arantxa TaberneroAnnette KoulakoffLisa RouxLaurent VenanceLuc LeybaertJuan C. SáezChristian C. Naus

Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysA HachemAnnekatrien BoelFilip Van NieuwerburghDieter DeforceLuc LeybaertPetra De SutterJ. Parrington et al.

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage

Raghda RamadanEls VromansDornatien Chuo AnangInes GoetschalckxDelphine HoorelbekeElke DecrockSarah BaatoutLuc LeybaertAn Aerts

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells

Delphine HoorelbekeElke DecrockMaarten De SmetMarijke De BockBenedicte DescampsValérie Van HaverTinneke DelvaeyeDmitri KryskoChristian VanhoveGeert Bultynck et al.

A1 Journal Article in CELL DEATH & DISEASE

Gap19, a Cx43 hemichannel inhibitor, acts as a gating modifier that decreases main state opening while increasing substate gating

Alessio LissoniNan WangTimur NezlobinskiiMaarten De SmetAlexander PanfilovNele VandersickelLuc LeybaertKatja Witschas

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting connexins with Gap27 during cold storage of the human donor uterus protects against cell death

Katarzyna Szymańska-VandendriesscheMenekse GOKERMélissa BolJo Van DorpeSteven WeyersLuc Leybaert

A1 Journal Article in PLOS ONE

Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes

Davina BonteVanessa ThysPetra De SutterAnnekatrien BoelLuc LeybaertBjörn Heindryckx

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

2019

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma : a preclinical F98 glioblastoma rat model study

Valerie De MeulenaereEllen BonteJeroen VerhoevenJean-Pierre Kalala OkitoLeen PietersAnne VralOlivier De WeverLuc LeybaertIngeborg GoethalsChristian Vanhove et al.

A1 Journal Article in PLOS ONE

Articulated instruments and 3D visualization : a synergy? : evaluation of execution time, errors, and visual fatigue

Frank DewaeleTim De PauwNicolaas LumenElke Van DaeleTjalina HamerlynckSteven WeyersIne StrubbeFilip Van Den BroeckThibaut Van ZeleDirk Van Roost et al.

A1 Journal Article in SURGICAL INNOVATION

Blocking connexin channels to protect the oocyte, embryo and uterus against biobanking stress

Katarzyna Szymańska-VandendriesscheLuc LeybaertEtienne Van den AbbeelAnn Van Soom

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock

Tinneke DelvaeyeMaarten De SmetStijn VerwaerdeElke DecrockAleksandra CzekajRoosmarijn VandenbrouckeKelly LemeireAmanda GonçalvesWim DeclercqPeter Vandenabeele et al.

A1 Journal Article in SCIENTIFIC REPORTS

Connexin hemichannels and cell death as measures of bovine COC vitrification success

Katarzyna Szymańska-VandendriesscheNerea Ortiz EscribanoEtienne Van den AbbeelAnn Van SoomLuc Leybaert

A1 Journal Article in REPRODUCTION

Connexins and pannexins in Alzheimer’s disease

Christian GiaumeJuan C SáezWeihong SongLuc LeybaertChristian C. Naus

A1 Journal Article in NEUROSCIENCE LETTERS

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity

Layal MaatoukChenju YiMaria-Angeles Carrillo-de SauvageAnne-Claire CompagnionStéphane HunotPascal EzanEtienne C HirschAnnette KoulakoffFrank W PfriegerFrançois Tronche et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Oocyte vitrification negatively affects the Ca2+-releasing pattern and oocyte activation potential of mouse oocytes

Davina BonteVanessa ThysAnnekatrien BoelLuc LeybaertPetra De SutterBjörn Heindryckx

Risico op cardiovasculaire aandoeningen bij radiotherapie in de thoraxregio : de rol van een dysfunctioneel endotheel

Raghda RamadanSarah BaatoutLuc LeybaertAn Aerts

A4 Journal Article in BLOEDVATEN, HART, LONGEN

Risques de maladies cardiovasculaires en cas de radiothérapie dans la région thoracique : le rôle d'un endothélium dysfonctionnel

Raghda RamadanSarah BaatoutLuc LeybaertAn Aerts

A4 Journal Article in VAISSEAUX, COEUR, POUMONS

Semen and oocyte cryopreservation in the domestic cat : the first steps in the establishment of a frozen zoo for wild felids

Féline SnoeckAnn Van SoomLuc Leybaert

Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function

Raghda RamadanEls VromansDornatien Chuo AnangElke DecrockMohamed MysaraPieter MonsieursSarah BaatoutLuc LeybaertAn Aerts

A1 Journal Article in SCIENTIFIC REPORTS

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke

Moises Freitas-AndradeNan WangJohn F BechbergerMarijke De BockPaul D LampeLuc LeybaertChristian C Naus

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The role of connexin-mediated intercellular communication in radiation-induced atherosclerosis

Raghda RamadanLuc LeybaertAn Aerts

2018

Activation of Cx43 hemichannels by TNFα in HeLa cells stably overexpressing Cx43 and in the endothelial cell line EA.hy926

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleLuc Leybaert

Blocking connexin channels during vitrification of immature cat oocytes improves maturation capacity after warming

Féline SnoeckKatarzyna Szymańska-VandendriesscheSteven SarrazinNerea Ortiz EscribanoLuc LeybaertAnn Van Soom

A1 Journal Article in THERIOGENOLOGY

Calcium, a pivotal player in photodynamic therapy?

Delphine HoorelbekeElke DecrockValérie Van HaverMarijke De BockLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Culture conditions affect Ca2+ release in artificially activated mouse and human oocytes

Yuechao LuDavina BonteMinerva Ferrer BuitragoMina PopovicJitesh NeupaneMargot Van der JeughtLuc LeybaertPetra De SutterBjörn Heindryckx

A1 Journal Article in REPRODUCTION FERTILITY AND DEVELOPMENT

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+

Alessio LissoniMaarten De SmetPaco HulpiauTania Martins-MarquesNan WangHenrique GiraoLuc Leybaert

Functional consequences of Cx43 hemichannels in adult cardiac myocytes

Luc LeybaertMaarten De Smet

Human oocyte calcium analysis predicts the response to assisted oocyte activation in patients experiencing fertilization failure after ICSI

Minerva Ferrer BuitragoLien DhaenensYuechao LuDavina BonteFrauke Vanden MeerschautPetra De SutterLuc LeybaertBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents

Laura WalraveAnouk PierreGiulia AlbertiniNajat AourzDimitri De BundelAnn Van EeckhautMathieu VinkenChristian GiaumeLuc LeybaertIlse Smolders

A1 Journal Article in GLIA

Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using 99mTc-duramycin during TNF-induced SIRS

Tinneke DelvaeyeLeonie wyffelsSteven DeleyeKelly LemeireAmanda GonçalvesElke DecrockSteven StaelensLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in JOURNAL OF NUCLEAR MEDICINE

PLCz knock-out sperm reveals the sole effect of altering calcium signals during assisted oocyte activation on later mouse embryogenesis

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysA HachemFilip Van NieuwerburghLuc LeybaertPetra De SutterDieter DeforceJ ParringtonBjörn Heindryckx

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesNan WangHenrique GiraoPaco HulpiauLuc Leybaert

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesNan WangHenrique GiraoPaco HulpiauLuc Leybaert

RyR2 regulates Cx43 hemichannel [Ca2+]i-dependent activation in cardiomyocytes

Alessio LissoniMaarten De SmetTania Martins-MarquesHerique GiraoNan WangPaco HulpiauLuc Leybaert

Safety & innovation in endoscopy

Frank DewaeleJacques CaemaertDirk Van RoostLuc LeybaertYves Van Nieuwenhove

Single Ca2+ transients vs oscillatory Ca2+ signaling for assisted oocyte activation : limitations and benefits

Minerva Ferrer BuitragoDavina BontePetra De SutterLuc LeybaertBjörn Heindryckx

A1 Journal Article in REPRODUCTION

Species-dependent extracranial manifestations of a brain seeking breast cancer cell line

Valerie De MeulenaereSara NeytBert VandeghinstePieter MolletOlivier De WeverElke DecrockLuc LeybaertIngeborg GoethalsChristian VanhoveBenedicte Descamps et al.

A1 Journal Article in PLOS ONE

TAT-Gap19 and carbenoxolone alleviate liver fibrosis in mice

Sara Crespo YanguasTereza da SilvaIsabel PereiraJoost WillebrordsMichaël MaesMarina Sayuri NogueiraInar Alves de CastroIsabelle LeclercqGuilherme RomualdoLuís Barbisan et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The pathological role of Cx43 and MLKL in TNF-induced systemic inflammatory response syndrome

Tinneke DelvaeyePeter VandenabeeleLuc LeybaertDmitri Krysko

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity

Jegan IyyathuraiNan WangCatheleyne D'hondtJean X. JiangLuc LeybaertGeert Bultynck

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

The use of vitrified-thawed mouse oocytes and lysolecithin to determine the oocyte activation potential of human sperm by Ca2+ pattern analysis

Davina BonteVanessa ThysLuc LeybaertPetra De SutterBjörn Heindryckx

Therapeutic targeting of connexin channels : new views and challenges

Tinneke DelvaeyePeter VandenabeeleGeert BultynckLuc LeybaertDmitri Krysko

A1 Journal Article in TRENDS IN MOLECULAR MEDICINE

Using vitrified mouse oocytes and lysolecithin to evaluate the oocyte-activating potential of human sperm by Ca2+ pattern analysis

Davina BonteVanessa ThysLuc LeybaertPetra De SutterBjörn Heindryckx

2017

Activation, regulation and arrhythmogenic implications of Cx43 hemichannels in ventricular cardiomyocytes

Maarten De SmetAlessio LissoniNan WangEef DriesKarin SipidoLuc Leybaert

Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex

Paolo BazzigaluppiIliya WeisspapirBojana StefanovicLuc LeybaertPeter L Carlen

A1 Journal Article in NEUROBIOLOGY OF DISEASE

At the cross-point of connexins, calcium, and ATP : blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries

Mélissa BolNan WangMarijke De BockBenjamin WacquierElke DecrockAshish GadicherlaKatrijn DecaluweBert VanheelHarold Victor Maria van RijenDmitri Krysko et al.

A1 Journal Article in CARDIOVASCULAR RESEARCH

Blocking connexin channels improves embryo development of vitrified bovine blastocysts

Nerea Ortiz EscribanoKatarzyna Szymańska-VandendriesscheMélissa BolLynn VandenbergheElke DecrockMario Van PouckeLuc PeelmanEtienne Van den AbbeelAnn Van SoomLuc Leybaert

A1 Journal Article in BIOLOGY OF REPRODUCTION

Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?

Elke DecrockDelphine HoorelbekeRaghda RamadanTinneke DelvaeyeMarijke De BockNan WangDmitri KryskoSarah BaatoutGeert BultynckAn Aerts et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Can vitrified-thawed mouse oocytes be efficiently used to determine the oocyte activation potential of human sperm?

Davina BonteMinerva Ferrer BuitragoVanessa ThysDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

Connexin channels at the glio-vascular interface : gatekeepers of the brain

Marijke De BockLuc LeybaertChristian Giaume

A1 Journal Article in NEUROCHEMICAL RESEARCH

Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice

Michaël MaesSara Crespo YanguasJoost WillebrordsJames L WeemhoffTereza Cristina da SilvaElke DecrockMargitta LebofskyIsabel Veloso Alves PereiraLuc LeybaertAnwar Farhood et al.

A1 Journal Article in TOXICOLOGY LETTERS

Connexin-dependent neuroglial networking as a new therapeutic target

Mathieu CharvériatChristian C NausLuc LeybaertJuan C SáezChristian Giaume

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

Connexins in cardiovascular and neurovascular health and disease : pharmacological implications

Luc LeybaertPaul D LampeStefan DheinBrenda R KwakPeter FerdinandyEric C BeyerDale W LairdChristian C NausColin R GreenRainer Schulz

A1 Journal Article in PHARMACOLOGICAL REVIEWS

Contribution of astroglial Cx43 hemichannels to the modulation of glutamatergic currents by D-serine in the mouse prefrontal cortex

Claire MeunierNan WangChenju YiGlenn DalleracPascal EzanAnnette KoulakoffLuc LeybaertChristian Giaume

A1 Journal Article in JOURNAL OF NEUROSCIENCE

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+

Alessio LissoniMaarten De SmetTânia Martins-MarquesNan WangHenrique GirãoLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII and p38MAPK

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII and p38MAPK

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice

Joost WillebrordsBruno CogliatiIsabel Veloso Alves PereiraTereza Cristina da SilvaSara Crespo YanguasMichaël MaesVeronica Mollica GovoniAndressa LimaDaniele Aparecida FelisbinoElke Decrock et al.

A1 Journal Article in SCIENTIFIC REPORTS

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart

Ashish GadicherlaNan WangMarco BulicEsperanza Agullo-PascualAlessio LissoniMaarten De SmetMario DelmarGeert BultynckDmitri KryskoAmadou Camara et al.

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Modulation of Cx43 hemichannels by TNFα in HeLa cells overexpressing Cx43

Stijn VerwaerdeMaarten De SmetTinneke DelvaeyeAlessio LissoniPeter VandenabeeleDmitri KryskoLuc Leybaert

Necroptotic cell death in anti-cancer therapy

Olga KryskoTania Love AaesValerian E KaganKatharina D'HerdeClaus BachertLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in IMMUNOLOGICAL REVIEWS

Pannexin1 as mediator of inflammation and cell death

Sara Crespo YanguasJoost WillebrordsScott R JohnstoneMichaël MaesElke DecrockMarijke De BockLuc LeybaertBruno CogliatiMathieu Vinken

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of Cx43 hemichannels in ventricular arrhythmia associated with abnormal Ca2+ homeostasis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

The BH4 domain of Bcl-2 orthologues from different classes of vertebrates can act as an evolutionary conserved inhibitor of IP3 receptor channels

Hristina IvanovaThomas LuytenElke DecrockTim VervlietLuc LeybaertJan B ParysGeert Bultynck

A1 Journal Article in CELL CALCIUM

Vitrified-thawed mouse oocytes can be efficiently used to determine the oocyte activation potential of human sperm

Davina BonteMinerva Ferrer BuitragoVanessa ThysDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

2016

Activation, regulation and arrhythmogenic implications of Cx43 hemichannels in ventricular cardiomyocytes

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Connexins : substrates and regulators of autophagy

Jegan IyyathuraiJean-Paul DecuypereLuc LeybaertCatheleyne D'hondtGeert Bultynck

A1 Journal Article in BMC CELL BIOLOGY

Connexins and their channels in inflammation

Joost WillebrordsSara Crespo YanguasMichael MaesElke DecrockNan WangLuc LeybaertBrenda R KwakColin R GreenBruno CogliatiMathieu Vinken

A1 Journal Article in CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Cx43 hemichannel opening in ventricular cardiomyocytes necessitates simultaneous ryanodine receptor activation and elevation of intracellular Ca2+, and is modulated by CaMKII

Alessio LissoniMaarten De SmetNan WangLuc Leybaert

Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ through a CaM-dependent signaling cascade and are a potent contributor to cardiac arrhythmogenesis

Maarten De SmetAlessio LissoniNan WangLuc Leybaert

Electroporation loading and dye transfer : a safe and robust method to probe gap junctional coupling

Elke DecrockMarijke De BockDiego De BaereDelphine HoorelbekeNan WangLuc Leybaert

Bookchapter in Gap junction protocols

Inhibition of Connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory

Laura WalraveMathieu VinkenGiulia AlbertiniDimitri De BundelLuc LeybaertIlse J. Smolders

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

Into rather unexplored terrain : transcellular transport across the blood-brain barrier

Marijke De BockValérie Van HaverRoosmarijn VandenbrouckeElke DecrockNan WangLuc Leybaert

A1 Journal Article in GLIA

IP3, still on the move but now in the slow lane

Editorial material

Nutrient starvation decreases Cx43 levels and limits intercellular communication in primary bovine corneal endothelial cells

Catheleyne D'hondtJegan IyyathuraiKirsten WelkenhuyzenBernard HimpensLuc LeybaertGeert Bultynck

A1 Journal Article in JOURNAL OF MEMBRANE BIOLOGY

Predictive value of human calcium pattern analysis on the benefit of assisted oocyte activation in cases of failed fertilization after ICSI

Minerva Ferrer BuitragoYuechao LuSylvie LiermanEtienne Van den AbbeelMargot Van der JeughtDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

Role and contribution of mitochondrial connexin43, complex I and calcium sensitive potassium channels in cardiac ischemia-reperfusion injury

Ashish GadicherlaLuc LeybaertAlexander PanfilovDmitri Krysko

Vaccination with necroptotic cancer cells induces efficient anti-tumor immunity

Tania Love AaesAgnieszka KaczmarekTinneke DelvaeyeBram De CraeneStefaan De KokerLiesbeth HeyndrickxIris DelrueJoachim TaminauBartosz WiernickiPhilippe De Groote et al.

A1 Journal Article in CELL REPORTS

Whole-cell patch clamp recordings of unitary connexin 43 hemichannel currents

Nan WangAlessio LissoniMaarten De SmetKarin R SipidoLuc Leybaert

Bookchapter in Gap junction channels and hemichannels

Zinc chelation promotes oocyte activation in human oocytes

Davina BonteMinerva Ferrer BuitragoEtienne Van den AbbeelMargot Van der JeughtDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

2015

18F-fluoromethylcholine (FCho), 18F-fluoroethyltyrosine (FET), and 18F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: a PET study

Julie BolcaenBenedicte DescampsKarel DeblaereTom BoterbergFilip De VosJean-Pierre Kalala OkitoCaroline Van den BroeckeElke DecrockLuc LeybaertChristian Vanhove et al.

A1 Journal Article in NUCLEAR MEDICINE AND BIOLOGY

Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection

Rainer SchulzPhilipp Maximilian GörgeAnikó GörbePéter FerdinandyPaul D LampeLuc Leybaert

A1 Journal Article in PHARMACOLOGY & THERAPEUTICS

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

Elke DecrockMarijke De BockNan WangGeert BultynckChristian GiaumeChristian C NausColin R GreenLuc Leybaert

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Cx43 hemichannels in ventricular cardiomyocytes can be activated by an elevation of cytoplasmic Ca2+ and are a potential arrhythmogenic substrate in the heart

Luc LeybaertMaarten De Smet

Electroporation loading and flash photolysis to investigate intra- and intercellular Ca2+ signaling

Elke DecrockMarijke De BockNan WangMélissa BolAshish GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Electroporation loading of membrane-impermeable molecules to investigate intra- and intercellular Ca2+ signaling

Elke DecrockMarijke De BockNan WangMélissa BolAshish GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Flash photolysis of caged IP3 to trigger intercellular Ca2+ waves

Elke DecrockMarijke De BockNan WangMélissa BolAshish GadicherlaLuc Leybaert

A2 Journal Article in COLD SPRING HARBOR PROTOCOLS

Fluoxetine suppresses calcium signaling in human T lymphocytes through depletion of intracellular calcium stores

Veerle GobinMarijke De BockBart BroeckxMaja KiselinovaWard De SpiegelaereLinos VandekerckhoveKatleen Van SteendamLuc LeybaertDieter Deforce

A1 Journal Article in CELL CALCIUM

Intracellular cleavage of the Cx43 C-terminal domain by matrix-metalloproteases : a novel contributor to inflammation?

Marijke De BockNan WangElke DecrockGeert BultynckLuc Leybaert

A1 Journal Article in MEDIATORS OF INFLAMMATION

Ryanodine receptors are targeted by anti-apoptotic Bcl-X-L involving its BH4 domain and Lys87 from its BH3 domain

Tim VervlietIrma LemmensElien VandermarliereElke DecrockHristina IvanovaGiovanni MonacoVincenzo SorrentinoNael Nadif KasriLudwig MissiaenLennart Martens et al.

A1 Journal Article in SCIENTIFIC REPORTS

Structure, regulation and function of gap junctions in liver

Joost WillebrordsSara Crespo YanguasMichaël MaesElke DecrockNan WangLuc LeybaertTereza Cristina da SilvaIsabel Veloso Alves PereiraHartmut JaeschkeBruno Cogliati et al.

A1 Journal Article in CELL COMMUNICATION AND ADHESION

The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria

Giovanni MonacoElke DecrockNir ArbelAlexander R van VlietRita M La RovereHumbert De SmedtJan B ParysPatrizia AgostinisLuc LeybaertVarda Shoshan-Barmatz et al.

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2014

A new angle on blood–CNS interfaces: a role for connexins?

Marijke De BockRoosmarijn VandenbrouckeElke DecrockMaxime CulotRomeo CecchelliLuc Leybaert

A1 Journal Article in FEBS LETTERS

A novel design for steerable instruments based on laser-cut nitinol

Frank DewaeleAlain KalmarFrederic De RyckNicolaas LumenLeonie WilliamsEdward BaertHUGO VEREECKEJean-Pierre Kalala OkitoCyriel MabildeBart Blanckaert et al.

A1 Journal Article in SURGICAL INNOVATION

Bcl-2 binds to and inhibits ryanodine receptors

Tim VervlietElke DecrockJordi MolgóVincenzo SorrentinoLudwig MissiaenLuc LeybaertHumbert De SmedtNael Nadif KasriJan B ParysGeert Bultynck

A1 Journal Article in JOURNAL OF CELL SCIENCE

Connexin and pannexin (hemi)channels in the liver

Michaël MaesElke DecrockBruno CogliatiAndré G OliveiraPedro E MarquesMaria LZ DagliGustavo B MenezesGregory MennecierLuc LeybaertTamara Vanhaecke et al.

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Cx43-hemichannel function and regulation in physiology and pathophysiology: insights from the bovine corneal endothelial cell system and beyond

Catheleyne D'hondtJegan IyyathuraiBernard HimpensLuc LeybaertGeert Bultynck

A1 Journal Article in FRONTIERS IN PHYSIOLOGY

Dysautonomia and its underlying mechanisms in the hypermobility type of Ehlers-Danlos syndrome

Inge De WandeleLies RombautLuc LeybaertPhilippe Van de BorneTine De BackerFransiska MalfaitAnne De PaepePatrick Calders

A1 Journal Article in SEMINARS IN ARTHRITIS AND RHEUMATISM

Efficacy of products to remove eggs of Pediculus humanus capitis (Phthiraptera: Pediculidae) from the human hair

Hilde LapeereLieve BrochezEvelien VerhaegheRobert Vander SticheleJean Paul RemonJo LambertLuc Leybaert

A1 Journal Article in JOURNAL OF MEDICAL ENTOMOLOGY

Hunting for connexin hemichannels

Juan C SáezLuc Leybaert

A1 Journal Article in FEBS LETTERS

MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP)

Julie BolcaenBenedicte DescampsKarel DeblaereTom BoterbergGiorgio HallaertCaroline Van den BroeckeElke DecrockAnne VralLuc LeybaertChristian Vanhove et al.

A1 Journal Article in JOURNAL OF NEURO-ONCOLOGY

Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons

Mauricio A RetamalJulio AlcayagaChristian A VerdugoGeert BultynckLuc LeybaertPablo J SáezRicardo FernándezLuis E LéonJuan C Sáez

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

Verónica AbudaraJohn BechbergerMoises Freitas-AndradeMarijke De BockNan WangGeert BultynckChristian C NausLuc LeybaertChristian Giaume

A1 Journal Article in FRONTIERS IN CELLULAR NEUROSCIENCE

The dual face of connexin-based astroglial Ca2+ communication: a key player in brain physiology and a prime target in pathology

Marijke De BockElke DecrockNan WangMélissa BolMathieu VinkenGeert BultynckLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

2013

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor

Giovanni MonacoElke DecrockKoen NuytsLarry E, II WagnerTomas LuytenSergei V StrelkovLudwig MissiaenWim M De BorggraeveLuc LeybaertDavid I Yule et al.

A1 Journal Article in PLOS ONE

Connexin 43 impacts on mitochondrial potassium uptake

Kerstin BoenglerElvira UngefugGerd HeuschLuc LeybaertRainer Schulz

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Connexin and pannexin hernichannels in brain glial cells : properties, pharmacology, and roles

Christian GiaumeLuc LeybaertChristian C NausJuan C Sáez

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Connexin targeting peptides as inhibitors of voltage- and intracellular Ca2+-triggered Cx43 hemichannel opening

Nan WangMarijke De BockElke DecrockMélissa BolAshish GadicherlaGeert BultynckLuc Leybaert

A1 Journal Article in NEUROPHARMACOLOGY

Diagnostic and prognostic value of calcium oscillatory pattern analysis for patients with ICSI fertilization failure

Frauke Vanden MeerschautLuc LeybaertDimitra NikiforakiChen QianBjörn HeindryckxPetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Endothelial calcium dynamics, connexin channels and blood-brain barrier function

Marijke De BockNan WangElke DecrockMélissa BolAshish GadicherlaMaxime CulotRomeo CecchelliGeert BultynckLuc Leybaert

A1 Journal Article in PROGRESS IN NEUROBIOLOGY

Inhibiting connexin channels protects against cryopreservation-induced cell death in human blood vessels

Mélissa BolCaroline Van GeytSaskia BaertElke DecrockNan WangMarijke De BockAshish GadicherlaCaren RandonWH EvansHilde Beele et al.

A1 Journal Article in EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

IP₃, a small molecule with a powerful message

Elke DecrockMarijke De BockNan WangAshish GadicherlaMélissa BolTinneke DelvaeyePeter VandenabeeleMathieu VinkenGeert BultynckDmitri Krysko et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Modulation of the vascular function by cannabinoids, calcitonin gene related peptide and connexin hemichannels

Mélissa BolLuc LeybaertBert Vanheel

Negatively charged residues (Asp378 and Asp379) in the last ten amino acids of the C-terminal tail of Cx43 hemichannels are essential for loop/tail interactions

Catheleyne D'HondtJegan IyyathuraiNan WangRobert G GourdieBernard HimpensLuc LeybaertGeert Bultynck

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neurological manifestations of oculodentodigital dysplasia: a Cx43 channelopathy of the central nervous system?

Marijke De BockMarianne KerrebrouckNan WangLuc Leybaert

A1 Journal Article in FRONTIERS IN PHARMACOLOGY

Peptides and peptide-derived molecules targeting the intracellular domains of Cx43: gap junctions versus hemichannels

Jegan IyyathuraiCatheleyne D'hondtNan WangMarijke De BockBernard HimpensMauricio A RetamalJimmy StehbergLuc LeybaertGeert Bultynck

A1 Journal Article in NEUROPHARMACOLOGY

Proteomic and metabolomic responses to connexin43 silencing in primary hepatocyte cultures

Mathieu VinkenMichaël MaesRachel CavillDirk ValkenborgJames K EllisElke DecrockLuc LeybaertAn StaesKris GevaertAndré G Oliveira et al.

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Regulation of connexin- and pannexin-based channels by post-translational modifications

Catheleyne D'hondtJegan IyyathuraiMathieu VinkenVera RogiersLuc LeybaertBernard HimpensGeert Bultynck

A1 Journal Article in BIOLOGY OF THE CELL

Regulation of inositol 1,4,5-trisphosphate receptor during human oocyte maturation and fertilization

Dimitra NikiforakiLiesbeth VossaertFrauke Vanden MeerschautChen QianYuechao LuJ ParysWinnok De VosDieter DeforceTom DerooEtienne Van den Abbeel et al.

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury

Nan WangElke De VuystRaf PonsaertsKerstin BoenglerNicolás Palacios-PradoJoris WaumanCharles P LaiMarijke De BockElke DecrockMélissa Bol et al.

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Single channel studies on the modulation of connexin hemichannels by Cx43 targeting peptides and cytoplasmic Ca2+ in the context of heart disease

Nan WangLuc Leybaert

TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation

Agnieszka KaczmarekOlga KryskoLiesbeth HeyndrickxTania Love AaesTinneke DelvaeyeClaus BachertLuc LeybaertPeter VandenabeeleDmitri Krysko

A1 Journal Article in CELL DEATH & DISEASE

2012

Connexin 43 hemichannels contribute to cytoplasmic Ca2+ oscillations by providing a bimodal Ca2+-dependent Ca2+ entry pathway

Marijke De BockNan WangMélissa BolElke DecrockRaf PonsaertsGeert BultynckGnenviève DupontLuc Leybaert

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Connexin channels provide a target to manipulate calcium dynamics and blood brain barrier permeability

Marijke De BockLuc Leybaert

Connexin mimetic peptides inhibit Cx43 hemichannel opening triggered by voltage and intracellular Ca2+ elevation

Nan WangMarijke De BockGudrun AntoonsAshish GadicherlaMélissa BolElke DecrockWilliam Howard EvansKarin R SipidoFeliksas F BukauskasLuc Leybaert

A1 Journal Article in BASIC RESEARCH IN CARDIOLOGY

Connexin-based intercellular signaling in cell death, to live or let die?

Elke DecrockLuc LeybaertKatharina D'Herde

Connexin43 signaling contributes to spontaneous apoptosis in cultures of primary hepatocytes

Mathieu VinkenElke DecrockTamara VanhaeckeLuc LeybaertVera Rogiers

A1 Journal Article in TOXICOLOGICAL SCIENCES

Diagnostic calcium pattern analysis in mouse oocytes for patients with previous fertilization failure following ICSI

Frauke Vanden MeerschautDimitra NikiforakiChen QianBjörn HeindryckxLuc LeybaertPetra De Sutter

Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels

T DesplantezV VermaLuc LeybaertWH EvansR Weingart

A1 Journal Article in PHARMACOLOGICAL RESEARCH

Influence of CGRP and methanandamide on membrane potential, K+ currents and calcium oscillations in mesenteric artery smooth muscle

Mélissa BolJoke BreyneLuc LeybaertBert Vanheel

Influence of methanandamide and CGRP on potassium currents in smooth muscle cells of small mesenteric arteries

Mélissa BolLuc LeybaertBert Vanheel

A1 Journal Article in PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Intercellular Ca2+ waves: mechanisms and functions

Luc LeybaertMichael J Sanderson

A1 Journal Article in PHYSIOLOGICAL REVIEWS

Is chronic exposure of the blood-brain barrier to relatively low L-β-ODAP concentrations a possible entry point of L-β-ODAP into the central nervous system?

Marijke Van MoorhemM CulotM KuntzElke DecrockMarijke De BockNan WangKatharina D'HerdeFernand LambeinLuc Leybaert

Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves

Marijke De BockMaxime CulotNan WangAnaelle da CostaElke DecrockMélissa BolGeert BultynckRomeo CecchelliLuc Leybaert

A1 Journal Article in BRAIN RESEARCH

Manipulating connexin communication channels: use of peptidomimetics and the translational outputs

W Howard EvansGeert BultynckLuc Leybaert

A1 Journal Article in JOURNAL OF MEMBRANE BIOLOGY

Non-channel functions of connexins in cell growth and cell death

Mathieu VinkenElke DecrockLuc LeybaertGeert BultynckBernard HimpensTamara VanhaeckeVera Rogiers

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pannexin 1 ohnologs in the teleost lineage

Steven R BondNan WangLuc LeybaertChristian C Naus

A1 Journal Article in JOURNAL OF MEMBRANE BIOLOGY

Paracrine signaling through plasma membrane hemichannels

Nan WangMarijke De BockElke DecrockMélissa BolAshish GadicherlaMathieu VinkenVera RogiersFeliksas F BukauskasGeert BultynckLuc Leybaert

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Quantifying hemodynamic refractory BOLD effects in normal subjects at the single-subject level using an inverse logit fitting procedure

Benedicte DescampsPieter VandemaeleHarmen ReyngoudtKarel DeblaereLuc LeybaertKoen PaemeleireEric Achten

A1 Journal Article in JOURNAL OF MAGNETIC RESONANCE IMAGING

Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

Jimmy StehbergRodrigo Moraga-AmaroChristian SalazarAlvaro BecerraCesar EcheverríaJuan A OrellanaGeert BultynckRaf PonsaertsLuc LeybaertFelipe Simon et al.

A1 Journal Article in FASEB JOURNAL

RhoA GTPase switch controls Cx43-hemichannel activity through the contractile system

Raf PonsaertsCatheleyne D'HondtFréderic HertensJan B ParysLuc LeybaertJohan VereeckeBernard HimpensGeert Bultynck

A1 Journal Article in PLOS ONE

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl

G MonacoElke DecrockH AklRaf PonsaertsT VervlietT LuytenM De MaeyerL MissiaenCW DistelhorstH De Smedt et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

The contractile system as a negative regulator of the connexin 43 hemichannel

Raf PonsaertsNan WangBernard HimpensLuc LeybaertGeert Bultynck

A1 Journal Article in BIOLOGY OF THE CELL

Transfer of IP3 through gap junctions is critical, but not sufficient, for the spread of apoptosis

Elke DecrockDmitri KryskoMathieu VinkenAgnieszka KaczmarekGiulia CrispinoMélissa BolNan WangMarijke De BockElke De VuystChristian C Naus et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

2011

Absence of haemodynamic refractory effects in patients with migraine without aura : an interictal fMRI study

Benedicte DescampsPieter VandemaeleHarmen ReyngoudtKarel DeblaereLuc LeybaertKoen PaemeleireEric Achten

A1 Journal Article in CEPHALALGIA

Calcium and connexin-based intercellular communication, a deadly catch?

Elke DecrockMathieu VinkenMélissa BolKatharina D'HerdeVera RogiersPeter VandenabeeleDmitri KryskoGeert BultynckLuc Leybaert

A1 Journal Article in CELL CALCIUM

Calcium releasing ability of human sperm with deficient oocyte activation capacity

Dimitra NikiforakiFrauke Vanden MeerschautChen QianDieter DeforceEsther Van den AbbeelK CowardJ ParringtonLuc LeybaertBjörn HeindryckxPetra De Sutter

Characterization of spontaneous cell death in monolayer cultures of primary hepatocytes

Mathieu VinkenElke DecrockTatyana DoktorovaEva RamboerElke De VuystTamara VanhaeckeLuc LeybaertVera Rogiers

A1 Journal Article in ARCHIVES OF TOXICOLOGY

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood brain barrier permeability

Marijke De BockMaxime CulotNan WangMélissa BolElke DecrockElke De VuystAnaelle Da CostaIne DauweMathieu VinkenAlexander Simon et al.

A1 Journal Article in JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Connexins: sensors and regulators of cell cycling

Mathieu VinkenElke DecrockElke De VuystRaf PonsaertsCatheleyne D'hondtGeert BultynckLiesbeth CeelenTamara VanhaeckeLuc LeybaertVera Rogiers

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Engaging neuroscience to advance translational research in brain barrier biology

Edward A NeuweltBjörn BauerChristoph FahlkeGert FrickerConstantino IadecolaDamir JanigroLuc LeybaertZoltan MolnarMartha O’DonnellJohn Povlishock et al.

A1 Journal Article in NATURE REVIEWS NEUROSCIENCE

Galactose modified iNKT cell agonists stabilised by a novel structural modification of CD1D lead to marked TH1 polarisation in vivo

SANDRINE ASPESLAGHYaLi LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardiTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

SANDRINE ASPESLAGHYali LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

A1 Journal Article in EMBO JOURNAL

L-β-N-oxalyl-α,β-diaminopropionic acid toxicity in motor neurons

Marijke Van MoorhemElke DecrockElke De VuystMarijke De BockNan WangFernand LambeinLudo Van Den BoschLuc Leybaert

A1 Journal Article in NEUROREPORT

Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplasmic reticulum

Catheleyne D'hondtRaf PonsaertsHumbert De SmedtMathieu VinkenElke De VuystMarijke De BockNan WangVera RogiersLuc LeybaertBernard Himpens et al.

A1 Journal Article in CELLULAR SIGNALLING

Pharmacological modulation of connexin-formed channels in cardiac pathophysiology

Elke De VuystKerstin BoenglerGudruun AntoonsKarin SipidoRainer SchulzLuc Leybaert

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

Phospholipase Cβ1 as a possible oocyte factor responsible for successful oocyte activation and embryo development

Frauke Vanden MeerschautBjörn HeindryckxChen QianDieter DeforceLuc LeybaertPetra De Sutter

Study of the etiology of neurolathyrism, a human neurodegenerative disease with nutritional causes

Marijke Van MoorhemLuc LeybaertFernand Lambein

Unraveling the mechanism of β-N-oxalyl-α,β-diaminopropionic acid (β-ODAP) induced excitotoxicity and oxidative stress, relevance for neurolathyrism prevention

Marijke Van MoorhemFernand LambeinLuc Leybaert

A1 Journal Article in FOOD AND CHEMICAL TOXICOLOGY

2010

Assisted oocyte activation: role of calcium and PLCzeta

Elke HeytensPetra De SutterLuc Leybaert

Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death

Mathieu VinkenElke DecrockElke De VuystMarijke De BockRoosmarijn VandenbrouckeBruno De GeestJo DemeesterNiek SandersTamara VanhaeckeLuc Leybaert et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes

Mathieu VinkenSarah SnykersJoanna FraczekElke DecrockLuc LeybaertVera RogiersTamara Vanhaecke

A1 Journal Article in TOXICOLOGY IN VITRO

Fitting interictal hemodynamic response functions to characterize anomalous refractory effects in patients with migraine without aura

Benedicte DescampsPieter VandemaeleHarmen ReyngoudtKarel DeblaereLuc LeybaertKoen PaemeleireEric Achten

Hemichannel involvement in CA2+ dynamics and contractility of smooth muscle cells in acutely isolated small mesenteric arteries

Mélissa BolMarijke De BockElke De VuystNan WangElke DecrockJhon Jairo Monsalvo CastaKelly DecaluwéBert VanheelJohan Van de VoordeLuc Leybaert

Interictal anomalies in patients with migraine without aura: absence of hemodynamic refractory effects

Benedicte DescampsPieter VandemaeleHarmen ReyngoudtKarel DeblaereLuc LeybaertKoen PaemeleireEric Achten

Intramolecular loop/tail interactions are essential for connexin 43-hemichannel activity

Raf PonsaertsElke De VuystMauricio RetamalCatheleyne D'hondtDieter VermeireNan WangHumbert De SmedtPascale ZimmermannBernard HimpensJohan Vereecke et al.

A1 Journal Article in FASEB JOURNAL

L-β-ODAP alters mitochondrial Ca2+ handling as an early event in excitotoxicity

Marijke Van MoorhemElke DecrockEvelyne CousseeLiesbeth FaesElke De VuystKatleen VranckxMarijke De BockNan WangKatharina D'HerdeFernand Lambein et al.

A1 Journal Article in CELL CALCIUM

Neurovascular dishabituation in patients with migraine without aura

Benedicte DescampsPieter VandemaeleHarmen ReyngoudtKarel DeblaereLuc LeybaertKoen PaemeleireEric Achten

Oscillatory Ca2+ dynamics and cell cycle resumption at fertilization in mammals: a modelling approach

Geneviève DupontElke HeytensLuc Leybaert

A1 Journal Article in INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

2009

A novel design for steerable endoscopic instruments

F DewaeleCyriel MabildeB BlanckaertG MeynsJan QuintelierJean-Pierre Kalala OkitoE BaertJ Van de VoordeLuc LeybaertDirk Van Roost et al.

Biochemical characterisation of an in vitro model of hepatocellular apoptotic cell death.

Mathieu VinkenElke DecrockElke De VuystLuc LeybaertTamara VanhaeckeVera Rogiers

A1 Journal Article in ATLA-ALTERNATIVES TO LABORATORY ANIMALS

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

Elke De VuystNan WangElke DecrockMarijke De BockMathieu VinkenMarijke Van MoorhemCharles LaiMaxime CulotVera RogiersRomeo Cecchelli et al.

A1 Journal Article in Cell Calcium

Calcium regulation of connexin-43 hemichannel-mediated ATP release in glial cells

Elke De VuystMarijke De BockNan WangElke DecrockMathieu VinkenMarijke Van MoorhemVera RogiersChristian NausHoward EvansLuc Leybaert

Cell death communication via connexin channels investigated in a C6 glioma cell model

Elke DecrockMarijke Van MoorhemElke De VuystNan WangMarijke De BockMathieu VinkenVera RogiersCC NausC ErneuxLuc Leybaert

Cell-cell communication of apoptosis via connexin channels in a C6 glioma cell model.

Elke DecrockMarijke Van MoorhemElke De VuystNan WangMarijke De BockMélissa BolKatharina D'HerdeC ErneuxLuc Leybaert

Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model.

Elke DecrockElke De VuystMathieu VinkenMarijke Van MoorhemKatleen VranckxNan WangLaura Van LaekenMarijke De BockKatharina D'HerdeCharles Lai et al.

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Connexin-related signaling in cell death: to live or let die?

Elke DecrockMathieu VinkenElke De VuystDmitri KryskoKatharina D'HerdeTamara VanhaeckePeter VandenabeeleVera RogiersLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet?

Mathieu VinkenEvelien De RopElke DecrockElke De VuystLuc LeybaertTamara VanhaeckeVera Rogiers

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Flow cytometric calcium flux assay: evaluation of cytoplasmic calcium kinetics in whole blood leukocytes

Eva SchepersGriet GlorieuxAnnemieke DhondtLuc LeybaertRaymond Vanholder

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity

Mathieu VinkenTatyana DoktorovaElke DecrockLuc LeybaertTamara VanhaeckeVera Rogiers

A1 Journal Article in CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Hemichannels contribute to Ca2+ dynamics in smooth muscle cells in acutely isolated small mesenteric arteries

Mélissa BolMarijke De BockElke De VuystNan WangElke DecrockMarijke Van MoorhemBert VanheelLuc Leybaert

Inhibition of connexin 43 hemichannel responses with high cytoplasmic calcium concentrations is mediated by mechanisms different from calcium activation of hemichannel responses

Nan WangElke De VuystMarijke De BockElke DecrockMarijke Van MoorhemLuc Leybaert

Involvement of connexin hemichannels in dynamic calcium changes and permeability of blood-brain barrier endothelial cells

Marijke De BockElke De VuystNan WangElke DecrockMarijke Van MoorhemMaxime CulotAM SimonRomeo CecchelliLuc Leybaert

Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical defence

Marijke Van MoorhemElke DecrockMarijke De BockNan WangElke De VuystGeert CallewaertLudo Van Den BoschFernand LambeinLuc Leybaert

Neuro- and gliotoxicity of the excitatory amino acid beta-ODAP involves impaired free radical difference

Marijke Van MoorhemElke DecrockMarijke De BockNan WangElke De VuystGeert CallewaertLudo Van den BoschFernand LambeinLuc Leybaert

Peroxisome proliferator-activated receptor gamma activation alleviates postoperative ileus in mice by inhibition of Egr-1 expression and its downstream target genes

Ole De BackerEllen ElinckEvelien PriemLuc LeybaertRomain Lefebvre

A1 Journal Article in JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins

Vandana VermaMaurice HallettLuc LeybaertPatricia MartinW Howard Evans

A1 Journal Article in EUROPEAN JOURNAL OF CELL BIOLOGY

Reduced amounts and abnormal forms of phospholipase C zeta (PLC zeta) in spermatozoa from infertile men

Elke HeytensJ ParringtonK CowardC YoungSTEFANIE LAMBRECHTSY YoonRA FissoreR. HamerCM DeaneM Ruas et al.

A1 Journal Article in HUMAN REPRODUCTION

Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytes

Eva SchepersGriet GlorieuxAnnemieke DhondtLuc LeybaertRaymond Vanholder

A1 Journal Article in NEPHROLOGY DIALYSIS TRANSPLANTATION

SYMMETRIC DIMETHYLARGININE (SDMA):A PRO-INFLAMMATORY UREMIC TOXIN ENHANCING CELLULAR CALCIUM INFLUX AND ACTIVATING NF kappa B

Eva SchepersGriet GlorieuxLuc LeybaertAnnemieke DhondtRaymond Vanholder

Unraveling the mechanism of beta-ODAP induced excitotoxicity and oxidative stress, relevance for neurolathyrism prevention

Marijke Van MoorhemFernand LambeinLuc Leybaert

Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress

Ole De BackerEllen ElinckBart BlanckaertLuc LeybaertR MotterliniRomain Lefebvre

A1 Journal Article in GUT

2008

A novel method for the evaluation of intestinal transit and contractility in mice using fluorescence imaging and spatiotemporal motility mapping

Ole De BackerBart BlanckaertLuc LeybaertRomain Lefebvre

A1 Journal Article in NEUROGASTROENTEROLOGY AND MOTILITY

Cx43 hemichannel regulation by intracellular calcium: involvement of different signaling pathways

Elke De VuystMarijke De BockElke DecrockMarijke Van MoorhemLuc Leybaert

In situ bipolar Electroporation for localized cell loading with reporter dyes and investigating gap junctional coupling

Elke De VuystMarijke De BockElke DecrockMarijke Van MoorhemC NAUSCyriel MabildeLuc Leybaert

A1 Journal Article in BIOPHYSICAL JOURNAL

Rapamycin prevents mesenteric neo-angiogenesis and reduces splanchnic blood flow in portal hypertensive mice

Anja GeertsEline VanheuleHans Van VlierbergheLuc LeybaertChristophe Van SteenkisteMartine De VosIsabelle Colle

A1 Journal Article in HEPATOLOGY RESEARCH

Role and regulation of connexin hemichannels in cellular ATP release

Elke De VuystLuc Leybaert

Single-subject hemodynamic refractory effects in healthy volunteers

Benedicte DescampsPieter VandemaeleLuc LeybaertKoen PaemeleireEric Achten

2007

Adult-derived neural stem cells differentiate mainly towards astrocytes upon transplantation in the sclerotic hippocampus of a model for temporal lobe epilepsy

Robrecht RaedtAnnelies Van DyckeTine WyckhuysKristl VonckWytse WadmanLuc LeybaertPaul Boon

ATP release through hemi-gap junction channels

Calcium dynamics : spatio-temporal organization from the subcellular to the organ level

Geneviève DupontLaurent CombettesLuc Leybaert

A1 Journal Article in International Review of Cytology : a Survey of Cell Biology

Connexin channels mediate propagation of apoptosis in a C6 glioma cell model

Elke DecrockMarijke Van MoorhemMarijke De BockElke De VuystKatharina D'HerdeLuc Leybaert

Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor

Elke De VuystElke DecrockMarijke De BockH YAMASAKICC NAUSWH EVANSLuc Leybaert

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

Contribution to the study of blood gas transport and acid-base and electrolyte balance in Rwandan students in Butare

Jean Bosco GahutuLuc LeybaertJustin Wane

High frequency deep brain stimulation in the hippocampus modifies seizure characteristics in kindled rats

Tine WyckhuysTim De SmedtPieter ClaeysRobrecht RaedtLiesbeth WaterschootKristl VonckCaroline Van den broeckeCyriel MabildeLuc LeybaertWytse Wadman et al.

A1 Journal Article in EPILEPSIA

Ionophore treatment of mouse oocytes injected with human round-headed sperm does not lead to subsequent normal calcium oscillation pattern

Elke HeytensLeen VanhoutteSylvie LiermanClaude CuvelierJan GerrisMarc DhontPetra De SutterLuc Leybaert

Mimetic peptides as blockers of connexin channel-facilitated intercellular communication

W Howard EvansLuc Leybaert

A1 Journal Article in CELL COMMUNICATION AND ADHESION

Neurobarrier coupling in the brain: Adjusting glucose entry with demand

Luc LeybaertMarijke De BockMarijke Van MoorhemElke DecrockElke De Vuyst

A1 Journal Article in JOURNAL OF NEUROSCIENCE RESEARCH

2006

Connexin channels, possible mediators in apoptosis spread in a glioma cell model

Elke DecrockMarijke Van MoorhemMarijke De BockElke De VuystKatharina D'HerdeLuc Leybaert

High frequency deep brain stimulation of the hippocampus in a rat model for temporal lobe epilepsy

Tine WyckhuysP CLAEYSRobrecht RaedtTim De SmedtLiesbeth WaterschootCaroline Van den broeckeCyriel MabildeLuc LeybaertWytse WadmanPaul Boon

Influence of the membrane potential on Ca2+ dynamics in smooth muscle cells of intact small mesenteric arteries of the rat

Joke BreyneLuc LeybaertBert Vanheel

Intracellular calcium changes trigger connexin 32 hemichannel opening

Elke De VuystElke DecrockL CABOOTERGR DUBYAKCC NAUSWH EVANSLuc Leybaert

A1 Journal Article in EMBO JOURNAL

Placental growth factor plays a role in the mesenteric neo-angiogenesis of portal hypertensive mice

Anja GeertsEline VanheuleP CARMELIETHans Van VlierbergheLuc LeybaertMartine De VosIsabelle Colle

Placental growth factor plays a role in the mesenteric neo-angiogenesis of portal hypertensive mice

Anja GeertsEline VanheuleP CARMELIETHans Van VlierbergheLuc LeybaertMartine De VosIsabelle Colle

The gap junction cellular internet: connexin hemichannels enter the signalling limelight

WH EVANSElke De VuystLuc Leybaert

A1 Journal Article in BIOCHEMICAL JOURNAL

2005

A Rwandan altitude blood gas, acid-base and hemoglobin study

JB GAHUTUJ WANEJD UWAMBAZIMANAD MIDONZIT TWAGIRUMUGABEJN MINEGALuc Leybaert

A1 Journal Article in CLINICA CHIMICA ACTA

A simple and practical method to acquire geometrically correct images with resonant scanning-based line scanning in a custom-built video-rate laser scanning microscope

Luc LeybaertAlexandre de MeyerCyriel MabildeMJ SANDERSON

A1 Journal Article in JOURNAL OF MICROSCOPY-OXFORD

Gap junctions and the propagation of cell survival and cell death signals

Dmitri KryskoLuc LeybaertPeter VandenabeeleKatharina D'Herde

A1 Journal Article in APOPTOSIS

Method to measure force required to remove Pediculus humanus capitis (Phthiraptera: Pediculidae) eggs from human hair

Hilde LapeereLieve BrochezYves Vander HaeghenCyriel MabildeRobert Vander SticheleLuc LeybaertJean Naeyaert

A1 Journal Article in JOURNAL OF MEDICAL ENTOMOLOGY

Neurobarrier coupling in the brain: a partner of neurovascular and neurometabolic coupling?

A1 Journal Article in JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Technical note: the design of a stereotactic frame for direct MRI-anatomical correlation of the brachial plexus

Tom Van HoofCyriel MabildeLuc LeybaertKoenraad VerstraeteKatharina D'Herde

A1 Journal Article in SURGICAL AND RADIOLOGIC ANATOMY

2004

Calcium signal communication between glial and vascular brain cells

Luc LeybaertL CABOOTERKatleen Braet

A1 Journal Article in ACTA NEUROLOGICA BELGICA

Calcium signal communication in the central nervous system

Katleen BraetL CABOOTERKoen PaemeleireLuc Leybaert

A1 Journal Article in BIOLOGY OF THE CELL

Electroporation loading and photoactivation of caged InsP(3): tools to investigate the relation between cellular ATP release in response to intracellular InsP(3) elevation

Katleen BraetCyriel MabildeL CABOOTERG RAPPLuc Leybaert

A1 Journal Article in JOURNAL OF NEUROSCIENCE METHODS

Gap junctional communication and connexin43 expression in relation to apoptotic cell death and survival of granulosa cells

Dmitri KryskoSylvie MusscheLuc LeybaertKatharina D'Herde

A1 Journal Article in JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Tumour necrosis factor alpha inhibits purinergic calcium signalling in blood-brain barrier endothelial cells

W VANDAMMEKatleen BraetL CABOOTERLuc Leybaert

A1 Journal Article in JOURNAL OF NEUROCHEMISTRY

2003

Calcium talk at the blood-brain barrier : in vitro studies on calcium signal communication

Katleen BraetLuc Leybaert

Connexin channels, connexin mimetic peptides and ATP release

Luc LeybaertKatleen BraetW VANDAMMEL CABOOTERPEM MARTINWH EVANS

A1 Journal Article in CELL COMMUNICATION AND ADHESION

Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells

Katleen BraetSANDRINE ASPESLAGHW VANDAMMEK WILLECKEPEM MARTINWH EVANSLuc Leybaert

A1 Journal Article in JOURNAL OF CELLULAR PHYSIOLOGY

Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26

Katleen BraetW VANDAMMEPEM MARTINWH EVANSLuc Leybaert

A1 Journal Article in CELL CALCIUM

2002

Calcium signaling in and between brain astrocytes and endothelial cells

Koen PaemeleireLuc LeybaertAlexandre De Hemptinne

Inositol 1,4,5-trisphosphate receptor function in human oocytes: calcium responses and oocyte activation-related phenomena induced by photolytic release of InsP(3) are blocked by a specific antibody to the type I receptor

Pravin T GoudAnuradha P GoudLuc LeybaertPatric Van OostveldtK MikoshibaMichael P DiamondMarc Dhont

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

2001

Astrocyte-endothelial cell calcium signals conveyed by two signalling pathways

Katleen BraetK PAEMELAIREKatharina D'HerdeLuc LeybaertKoen PaemeleireMJ SANDERSON

A1 Journal Article in EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial transmembrane potential changes support the concept of mitochondrial heterogeneity during apoptosis

Dmitri KryskoFrank RoelsLuc LeybaertKatharina D'Herde

A1 Journal Article in JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

2000

ATP-dependent astrocyte-endothelial calcium signalling following mechanical damage to a single astrocyte in astrocyte-endothelial co-cultures.

Koen PaemeleireLuc Leybaert

A1 Journal Article in JOURNAL OF NEUROTRAUMA

First and second messenger role of calcium - Survival versus apoptosis in serum-free cultured granulosa explants

Sylvie MusscheLuc LeybaertKatharina D'Herde

A1 Journal Article in MECHANISMS OF CELL DEATH II

Intercellular calcium signaling and flash photolysis of caged compounds : a sensitive method to evaluate gap junctional coupling

Luc LeybaertMichael J Sanderson

Bookchapter in Connexin methods and protocols

Intercellular calcium waves in HeLa cells expressing GFP-labeled connexin 43, 32, or 26.

Koen PaemeleireP MARTINSL COLEMANKE FOGARTYWA CARRINGTONLuc LeybaertRA TUFTWH EVANSMJ SANDERSON

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

Ionic changes accompanying astrocytic intercellular calcium waves triggered by mechanical cell damaging stimulation.

Koen PaemeleireLuc Leybaert

A1 Journal Article in BRAIN RESEARCH

1999

Chemically, mechanically, and hyperosmolarity-induced calcium responses of rat cortical capillary endothelial cells in culture.

Koen PaemeleireAlexandre De HemptinneLuc Leybaert

A1 Journal Article in EXPERIMENTAL BRAIN RESEARCH

1998

A simple method for high temporal resolution calcium imaging with dual excitation dyes

Luc LeybaertJ SNEYDMJ SANDERSON

A1 Journal Article in BIOPHYSICAL JOURNAL

Apoptotic granulosa cells have moderately increased intracellular free calcium during phosphatidylserine exposure and a normal resting calcium level during DNA fragmentation.

Katharina D'HerdeLuc Leybaert

A1 Journal Article in APOPTOSIS

ATP-dependent astrocyte-endothelial calcium signalling following single astrocyte trauma

Koen PaemeleireAlexandre De HemptinneLuc Leybaert

Heterogeneity of calcium responses to mechanical and chemical stimulation of rat brain capillary endothelial cells in culture

Koen PaemeleireAlexandre De HemptinneLuc Leybaert

Inositol trisphosphate-dependent calcium signaling and gap junctional coupling in and between astrocytes and endothelial cells in co-culture

Luc LeybaertKoen PaemeleireKatharina D'HerdeMJ SANDERSON

Inositol-trisphosphate-dependent intercellular calcium signaling in and between astrocytes and endothelial cells.

Luc LeybaertKoen PaemeleireA STRAHONJAMJ SANDERSON

A1 Journal Article in GLIA

Intercellular Ca2+ signaling between glial and endothelial cells

MJ SandersonKoen PaemeleireA StrahonjaLuc Leybaert

Traumatic single cell injury to astrocytes causes ATP-dependent astrocyte-endothelial Ca2+ signalling

Koen PaemeleireAlexandre De HemptinneLuc Leybaert

1997

Calcium signaling between astrocytes and endothelial cells in co-culture

Koen PaemeleireM SANDERSONLuc Leybaert

Calcium signaling between astrocytes and endothelial cells in co-culture

Luc LeybaertKoen PaemeleireM SANDERSON

Intracellular free calcium related to apoptotic cell death in quail granulosa cell sheets kept in serum-free culture

Katharina D'HerdeLuc Leybaert

A1 Journal Article in CELL DEATH AND DIFFERENTIATION

Ionic changes associated with a glial intercellular calcium wave

Koen PaemeleireLuc LeybaertAlexandre De Hemptinne

1996

A study of the correlation between agonist- or injury-induced changes of intracellular free calcium and in situ labeling with GFAP-antibodies in a ridged glial cell culture

Koen PaemeleireLuc Leybaert

A1 Journal Article in ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Changes of intracellular free calcium during intracytoplasmic sperm injection.

Luc LeybaertHerman DepypereMarc DhontA DEHEMPTINNE

A1 Journal Article in MOLECULAR REPRODUCTION AND DEVELOPMENT

Changes of intracellular free calcium following mechanical injury in a spinal cord slice preparation.

Luc LeybaertA DEHEMPTINNE

A1 Journal Article in EXPERIMENTAL BRAIN RESEARCH

Intracellular free calcium related to apoptotic cell death in serum-free culture of avian granulosa cell sheets

Katharina D'HerdeLuc LeybaertFrank Roels

Van ionenkanalen tot ziekten

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

1995

A study of intracellular free calcium in an in vivo model of apoptosis in avian granulosa cell sheets

Luc LeybaertKatharina D'Herde

Changes of intracellular free calcium following mechanical injury in a spinal cord slice preparation : effect of MK801, dantrolene and decreased extracellular clearance

Luc LeybaertAlexandre De Hemptinne

Delay of apoptosis in serum-free culture of avian granulosa cell sheets: role of intercellular communication

Katharina D'HerdeLuc LeybaertFrank Roels

Intracellulaire calciummetingen tijdens de penetratie van een eicel met een injectie-pipette voor intracytoplasmatische sperma-injectie bij de muis

Herman DepypereLuc LeybaertMarc DhontAlexandre De Hemptinne

A2 Journal Article in TIJDSCHRIFT VOOR FERTILITEITSONDERZOEK

Making the best of brain slices: comparing preparative methods

P LiptonPG AitkenFE DudekK EskessenMT EspanolPA FerchminJB KellyNR KreismanPW LandfieldPM Larkman et al.

Editorial material

1994

Changes of intracellular calcium in a slice model of spinal injury

Luc LeybaertJ DEPREITEREB BILLIET

A2 Journal Article in J. Neurose. Meth. A17

Interstitial and tissue cations and electrical potential after experimental spinal cord injury.

Luc LeybaertG DELEY

A1 Journal Article in EXPERIMENTAL BRAIN RESEARCH

INTRACELLULAR PH CHANGES DURING ZONA DRILLING.

Herman DepypereLuc Leybaert

A1 Journal Article in FERTILITY AND STERILITY

1993

A VOLTAGE-CLAMP STUDY OF CALCIUM CURRENTS IN NEURONS FRESHLY ISOLATED FROM THE DORSAL-ROOT GANGLION OF ADULT-RATS.

Luc LeybaertA DEHEMPTINNE

A1 Journal Article in ARCHIVES INTERNATIONALES DE PHYSIOLOGIE, DE BIOCHIMIE ET DE BIOPHYSIQUE

Effect of flunarizine and methylprednisolone on functional recovery after experimental spinal injury.

G DELEYLuc Leybaert

A1 Journal Article in JOURNAL OF NEUROTRAUMA

Effects of flunarizine on induced calcium transients as measured in fura-2 loaded neurons of the rat dorsal root ganglion

Luc LeybaertGaspard De LeyAlexandre De Hemptinne

A1 Journal Article in NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Mechanisms of ionic changes after experimental spinal injury.

Luc LeybaertGaspard De Ley

1992

Inlfuence of a combination of two antiarrhythmic agents (Flecainide and Mexiletine) on the upstroke of the cardiac ventricular action potential.

HT KINDTLuc LeybaertBert VanheelAlexandre De Hemptinne

Intracellular pH changes during zona pellucida drilling of human oocytes

Herman DepypereLuc LeybaertMarc Dhont

1991

Effects of two calcium entry blockers on calcium influx in rat dorsal root ganglion neurons

Luc LeybaertGaspard De Ley

Flunarizine improves functional recovery after acute experimental spinal injury in cats

Gaspard De LeyLuc Leybaert

1989

Simulated ischemia and intracellular pH in isolated ventricular muscle

Bert VanheelLuc LeybaertAlexandre De HemptinneIsidoor Leusen

A1 Journal Article in AMERICAN JOURNAL OF PHYSIOLOGY

1988

Effect of amiloride on action potential and contraction characteristics in acid loaded guinea pig papillary muscle

Bert VanheelLuc LeybaertJohan Van de VoordeAlexandre De Hemptinne

Effect of amiloride on intracellular sodium activity in acid loaded guinea pig papillary muscle

Luc LeybaertBert VanheelAlexandre De Hemptinne

1987

Microelectrode measurement of intracellular pH and its relation to the decrease in developed tension during simulated ischaemia in isolated ventricular muscle

Bert VanheelLuc LeybaertAlexandre De HemptinneIsidoor Leusen

Effects of flunarizine on induced calcium transients in rat DRG neurons. Proceedings of the XXXIIth Congress of the International Union of Physiological Sciences, Glasgow U.K., 1993, nr. 205.18/P.

Luc LeybaertAlexandre De Hemptinne

Mechanisms of ionic changes after experimental spinal injury in the cat. Proceedings of the XXXIIth Congress of the International Union of Physiological Sciences, Glasgow U.K., 1993, nr. 50.2/P.

Luc LeybaertGaspard De Ley