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Researcher
Koen Raemdonck
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
124
Results
2025
Driving CAR-T cell therapy forward: Optimizing lipid nanoparticle designs for non-viral T cell engineering
Laure Harinck
Koen Raemdonck
Kevin Braeckmans
Dissertation
2025
Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye
Weiran Li
Helena Vanluchene
Laura Raes
Karen Peynshaert
Liene Veys
Sofía González Hernández
Emily De Lombaerde
Bruno De Geest
Niek Sanders
Lieve Moons
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2025
Exploring the interface : the interaction between pulmonary surfactant and RNA therapeutics
Lore Herman
Koen Raemdonck
Stefaan De Smedt
Dissertation
2025
mRNA galsomes vaccine protects budgerigars against virulent Chlamydia psittaci challenge
Anne De Meyst
Joeri Van Mieghem
Koen Chiers
Koen Raemdonck
Rein Verbeke
Ine Lentacker
Daisy Vanrompay
A1
Journal Article
in
VACCINES
2025
Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation
Jana Ramon
Cláudio Pinheiro
Charysse Vandendriessche
Estefanía Lozano-Andrés
Herlinde De Keersmaecker
Deep Punj
Juan Fraire
Edward Geeurickx
Marca H. M. Wauben
Pieter Vader
et al.
A1
Journal Article
in
JOURNAL OF NANOBIOTECHNOLOGY
2025
Surfactant protein B-derived peptides as endosomal escape enhancers for pulmonary delivery of siRNA
Lore Herman
Roberta Guagliardo
Agata Zamborlin
Qiaoyu Liu
Jesús Pérez-Gil
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2025
Target, trigger, deliver : biochemical tools to modulate quadruplex nucleic acid structures
Lessandro De Paepe
Annemieke Madder
Koen Raemdonck
Enrico Cadoni
Dissertation
2025
2024
Beyond chloroquine : cationic amphiphilic drugs as endosomal escape enhancers for nucleic acid therapeutics
Aliona Debisschop
Bram Bogaert
Cristina Muntean
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
CURRENT OPINION IN CHEMICAL BIOLOGY
2024
Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy
Pieterjan Merckx
GRIET CONICKX
Evy Blomme
Tania Maes
Ken Bracke
Guy Brusselle
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2024
Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics
Jana Ramon
Yanou Engelen
Herlinde De Keersmaecker
Ilia Goemaere
Deep Punj
Julián Mejía Morales
Cédric Bonte
Geert Berx
Esther Hoste
Stephan Stremersch
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2024
Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells
Helena Vanluchene
Oriane Gillon
Karen Peynshaert
Stefaan De Smedt
Niek Sanders
Koen Raemdonck
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2024
Multicompartment polyion complex micelles based on triblock polypept(o)ides mediate efficient siRNA delivery to cancer‐associated fibroblasts for antistromal therapy of hepatocellular carcinoma
Paul Schneider
Heyang Zhang
Leon Simic
Zhuqing Dai
Barbara Schrörs
Özlem Akilli‐Öztürk
Jian Lin
Feyza Durak
Jenny Schunke
Vanessa Bolduan
et al.
A1
Journal Article
in
ADVANCED MATERIALS
2024
Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery
Bram Bogaert
Aliona Debisschop
Thomas Ehouarne
Hannelore Van Eeckhoutte
Joyceline De Volder
An Jacobs
Eline Pottie
Riet De Rycke
Aurélie Crabbé
Pieter Mestdagh
et al.
A1
Journal Article
in
NANO LETTERS
2024
2023
A lipid nanoparticle platform for RNA delivery with cationic amphiphilic drugs : merging the best of both worlds
Bram Bogaert
Koen Raemdonck
Stefaan De Smedt
Dissertation
2023
Capric acid and myristic acid permeability enhancers in curved liposome membranes
Samaneh Davoudi
Koen Raemdonck
Kevin Braeckmans
An Ghysels
A1
Journal Article
in
JOURNAL OF CHEMICAL INFORMATION AND MODELING
2023
Cationic amino-acid functionalized polymethacrylamide vectors for siRNA transfection based on modification of poly(2-isopropenyl-2-oxazoline)
Adriana Jerca
Cristina Muntean
Katrien Remaut
Valentin-Victor Jerca
Koen Raemdonck
Richard Hoogenboom
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
Immunogenicity versus efficacy of lipid nanoparticle-mediated delivery of mRNA and self-amplifying mRNA to the retina
Helena Vanluchene
Katrien Remaut
Niek Sanders
Koen Raemdonck
Dissertation
2023
mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells
Shanna Dewaele
Louis Delhaye
Boel De Paepe
Bram Bogaert
Ramiro Martinez
Jasper Anckaert
Nurten Yigit
Justine Nuytens
Rudy Van Coster
Sven Eyckerman
et al.
A1
Journal Article
in
NUCLEIC ACID THERAPEUTICS
2023
Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer
Cristina Muntean
Eva Blondeel
Laure Harinck
Kunal Pednekar
Jai Prakash
Olivier De Wever
Jeanne Leblond Chain
Stefaan De Smedt
Katrien Remaut
Koen Raemdonck
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Strategies to overcome the lysosomal entrapment of siRNA therapeutics and chemotherapeutic drugs
Cristina Muntean
Koen Raemdonck
Katrien Remaut
Dissertation
2023
The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments
Thijs Van de Vyver
Cristina Muntean
Iuliia Efimova
Dmitri Krysko
Lynn De Backer
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
Unfolding the versatility of laser-induced vapor nanobubbles : from balancing intracellular delivery with regulated cell death to loading of extracellular vesicles
Jana Ramon
Kevin Braeckmans
Koen Raemdonck
Stephan Stremersch
Dissertation
2023
2022
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs
Bram Bogaert
Felix Sauvage
Roberta Guagliardo
Cristina Muntean
[missing] Van Phuc Nguyen
Eline Pottie
Mike Wels
An-Katrien Minnaert
Riet De Rycke
Qiangbing Yang
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2022
Counting permeant crossings to assess the effect of membrane curvature and composition on the permeability rate
Samaneh Davoudi
Koen Raemdonck
Kevin Braeckmans
An Ghysels
C3
Conference
2022
Investigating membrane curvature and composition effect on membrane permeability by counting permeant crossings
Samaneh Davoudi
Koen Raemdonck
Kevin Braeckmans
An Ghysels
C3
Conference
2022
Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics
Thijs Van de Vyver
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2022
Non-invasive cell-tracking methods for adoptive T cell therapies
Jelter Van Hoeck
Christian Vanhove
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
DRUG DISCOVERY TODAY
2022
Non-viral siRNA delivery to T cells : challenges and opportunities in cancer immunotherapy
Jelter Van Hoeck
Kevin Braeckmans
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
BIOMATERIALS
2022
Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis
Elke De Schutter
Jana Ramon
Benjamin Pfeuty
Caroline De Tender
Stephan Stremersch
Koen Raemdonck
Ken Op de Beeck
Wim Declercq
Franck Riquet
Kevin Braeckmans
et al.
A1
Journal Article
in
CELLULAR AND MOLECULAR LIFE SCIENCES
2022
Understanding membrane permeability of drug releasing liposomes from molecular dynamics simulations : effect of curvature and composition
Samaneh Davoudi
Koen Raemdonck
Kevin Braeckmans
An Ghysels
C3
Conference
2022
2021
Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering
Laurens Raes
Melissa Pille
Aranit Harizaj
Glenn Goetgeluk
Jelter Van Hoeck
Stephan Stremersch
Juan Fraire
Toon Brans
Olivier Gerrit de Jong
Roel Maas-Bakker
et al.
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2021
Challenges and strategies for the delivery of biologics to the cornea
Mike Wels
D. Roels
Koen Raemdonck
Stefaan De Smedt
Félix Sauvage
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2021
Delivering on the promise of adoptive T cell therapy : assessment of non-viral methods for direct cytosolic delivery of membrane-impermeable cargo
Jelter Van Hoeck
Koen Raemdonck
Stefaan De Smedt
Dissertation
2021
Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo
Jelter Van Hoeck
Thijs Van de Vyver
Aranit Harizaj
Glenn Goetgeluk
Pieterjan Merckx
Jing Liu
Mike Wels
Félix Sauvage
Herlinde De Keersmaecker
Christian Vanhove
et al.
A1
Journal Article
in
ADVANCED MATERIALS
2021
Increasing angiogenesis factors in hypoxic diabetic wound conditions by siRNA delivery : additive effect of LbL-gold nanocarriers and desloratadine-induced lysosomal escape
Elnaz Shaabani Sichani
Maryam Sharifiaghdam
Joris Lammens
Herlinde De Keersmaecker
Chris Vervaet
Thomas De Beer
Elahe Motevaseli
Mohammad Hossein Ghahremani
Parvin Mansouri
Stefaan De Smedt
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2021
Intracellular delivery of mRNA and proteins by VNB photoporation for cancer immunotherapy
Laurens Raes
Kevin Braeckmans
Koen Raemdonck
Dissertation
2021
Non-viral transfection technologies for next-generation therapeutic T cell engineering
Laurens Raes
Stefaan De Smedt
Koen Raemdonck
Kevin Braeckmans
A1
Journal Article
in
BIOTECHNOLOGY ADVANCES
2021
Old drugs with new tricks : repurposing small molecules to promote lysosomal escape of small nucleic acid therapeutics
Thijs Van de Vyver
Koen Raemdonck
Stefaan De Smedt
Dissertation
2021
Photothermal nanofibres enable safe engineering of therapeutic cells
Ranhua Xiong
Dawei Hua
Jelter Van Hoeck
Dominika Berdecka
Laurens Léger
Stijn De Munter
Juan Fraire
Laurens Raes
Aranit Harizaj
Félix Sauvage
et al.
A1
Journal Article
in
NATURE NANOTECHNOLOGY
2021
Pulmonary surfactant as a versatile biomaterial to fight COVID-19
Lore Herman
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2021
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across
An-Katrien Minnaert
Helena Vanluchene
Rein Verbeke
Ine Lentacker
Stefaan De Smedt
Koen Raemdonck
Niek Sanders
Katrien Remaut
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2021
Surfactant protein B promotes cytosolic SiRNA delivery by adopting a virus-like mechanism of action
Roberta Guagliardo
Lore Herman
Jelle Penders
Agata Zamborlin
Herlinde De Keersmaecker
Thijs Van de Vyver
Sandrine Verstraeten
Pieterjan Merckx
Marie-Paule Mingeot-Leclercq
Mercedes Echaide
et al.
A1
Journal Article
in
ACS NANO
2021
Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology
Jana Ramon
Ranhua Xiong
Stefaan De Smedt
Koen Raemdonck
Kevin Braeckmans
A1
Journal Article
in
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
2021
2020
Beyond the surface : unraveling the intracellular mechanism behind surfactant protein B (SP-B) mediated siRNA delivery
Roberta Guagliardo
Koen Raemdonck
Stefaan De Smedt
Dissertation
2020
Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner
Thijs Van de Vyver
Bram Bogaert
Lynn De Backer
Freya Joris
Roberta Guagliardo
Jelter Van Hoeck
Pieterjan Merckx
Serge Van Calenbergh
Srinivas Ramishetti
Dan Peer
et al.
A1
Journal Article
in
ACS NANO
2020
Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation
Laurens Raes
Stephan Stremersch
Juan Fraire
Toon Brans
Glenn Goetgeluk
Stijn De Munter
Lien Van Hoecke
Rein Verbeke
Jelter Van Hoeck
Ranhua Xiong
et al.
A1
Journal Article
in
NANO-MICRO LETTERS
2020
Lung surfactant-hydrogel nanocomposites for pulmonary siRNA delivery : breaching barriers for nanomedicine-based inhalation therapy
Pieterjan Merckx
Koen Raemdonck
Stefaan De Smedt
Dissertation
2020
Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy
Pieterjan Merckx
Joris Lammens
Gust Nuytten
Bram Bogaert
Roberta Guagliardo
Tania Maes
Chris Vervaet
Thomas De Beer
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2020
Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis
Juan Fraire
Gaëlle Houthaeve
Jing Liu
Laurens Raes
Lotte Vermeulen
Stephan Stremersch
Toon Brans
Gerardo Garcia-Diaz Barriga
Sarah De Keulenaer
Filip Van Nieuwerburgh
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2020
2019
Challenges for labeling and longitudinal tracking of adoptively transferred autoreactive T lymphocytes in an experimental type-1 diabetes model
Shweta Saini
Hannelie Korf
Sayuan Liang
Rein Verbeke
Bella Manshian
Koen Raemdonck
Ine Lentacker
Conny Gysemans
Stefaan De Smedt
Uwe Himmelreich
A1
Journal Article
in
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2019
Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells
Lien Van Hoecke
Laurens Raes
Stephan Stremersch
Toon Brans
Juan Fraire
Ria Roelandt
Wim Declercq
Peter Vandenabeele
Koen Raemdonck
Kevin Braeckmans
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2019
Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells
Laurens Raes
Clarissa Van Hecke
Julie Michiels
Stephan Stremersch
Juan Fraire
Toon Brans
Ranhua Xiong
Stefaan De Smedt
Linos Vandekerckhove
Koen Raemdonck
et al.
A1
Journal Article
in
CRYSTALS
2019
Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate
Juan Fraire
Stephan Stremersch
Davinia Bouckaert
Tinne Monteyne
Thomas De Beer
Pieter Wuytens
Riet De Rycke
Andre Skirtach
Koen Raemdonck
Stefaan De Smedt
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2019
Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA
Roberta Guagliardo
Pieterjan Merckx
Agata Zamborlin
Lynn De Backer
Mercedes Echaide
Jesus Pérez-Gil
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
PHARMACEUTICS
2019
2018
Nucleic acid loading and fluorescent labeling of isolated extracellular vesicles requires adequate purification
Stephan Stremersch
Toon Brans
Kevin Braeckmans
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2018
Pulmonary surfactant and drug delivery : focusing on the role of surfactant proteins
Roberta Guagliardo
Jésus Pérez-Gil
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2018
Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells
Freya Joris
Lynn De Backer
Thijs Van de Vyver
Chiara Bastiancich
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2018
Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy
Pieterjan Merckx
Lynn De Backer
Lien Van Hoecke
Roberta Guagliardo
Mercedes Echaide
Pieter Baatsen
Bárbara Olmeda
Xavier Saelens
Jésus Pérez-Gil
Stefaan De Smedt
et al.
A1
Journal Article
in
ACTA BIOMATERIALIA
2018
2017
Choose your cell model wisely : the in vitro nanoneurotoxicity of differentially coated iron oxide nanoparticles for neural cell labeling
Freya Joris
Daniel Valdepérez
Beatriz Pelaz
Tianqiang Wang
Shareen H. Doak
Bella B. Manshian
Stefaan J. Soenen
Wolfgang J. Parak
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
ACTA BIOMATERIALIA
2017
Comparing photoporation and nucleofection for delivery of small interfering RNA to cytotoxic T cells
Laura Wayteck
Ranhua Xiong
Kevin Braeckmans
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2017
Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus
Rita Santos
George Dakwar
Elisa Zagato
Toon Brans
Céu Figueiredo
Koen Raemdonck
Nuno F Azevedo
Stefaan De Smedt
Kevin Braeckmans
A1
Journal Article
in
BIOMATERIALS
2017
Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress
Simon Devos
Wouter Van Putte
Jolien Vitse
Gonzalez Van Driessche
Stephan Stremersch
Wim Van Den Broeck
Koen Raemdonck
Kevin Braeckmans
Henning Stahlberg
Misha Kudryashev
et al.
A1
Journal Article
in
ENVIRONMENTAL MICROBIOLOGY
2017
Small molecules convey big messages : boosting non-viral nucleic acid delivery with low molecular weight drugs
Freya Joris
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
NANO TODAY
2017
The repurposing of low molecular weight drugs to induce lysosomal release of siRNA and in vitro approaches to probe the toxicity of inorganic nanoparticles
Freya Joris
Stefaan De Smedt
Koen Raemdonck
Dissertation
2017
2016
An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis
Eline Desmet
STEFANIE BRACKE
Katrien Forier
Lien Taevernier
Marc Stuart
Bart De Spiegeleer
Koen Raemdonck
Mireille Van Gele
Jo Lambert
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2016
Characterization data on the topical carrier DDC642
Eline Desmet
STEFANIE BRACKE
Katrien Forier
Lien Taevernier
Marc CA Stuart
Bart De Spiegeleer
Koen Raemdonck
Mireille Van Gele
Jo Lambert
A2
Journal Article
in
DATA IN BRIEF
2016
Combining the strengths of cytotoxic T cells and nanomedicines for cancer immunotherapy
Laura Wayteck
Stefaan De Smedt
Koen Raemdonck
Dissertation
2016
Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs
Stephan Stremersch
Roosmarijn Vandenbroucke
Elien Van Wonterghem
An Hendrix
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2016
Cytosolic delivery of nanolabels prevents their asymmetric inheritance and enables extended quantitative in vivo cell imaging
Ranhua Xiong
Freya Joris
Sayuan Liang
Riet De Rycke
Saskia Lippens
Jo Demeester
Andre Skirtach
Koen Raemdonck
Uwe Himmelreich
Stefaan De Smedt
et al.
A1
Journal Article
in
NANO LETTERS
2016
Exploring extracellular vesicles for siRNA delivery and Raman-based diagnostics
Stephan Stremersch
Stefaan De Smedt
Koen Raemdonck
Kevin Braeckmans
Dissertation
2016
Hitchhiking nanoparticles: reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes
Laura Wayteck
Heleen Dewitte
Lynn De Backer
Karine Breckpot
Jo Demeester
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
BIOMATERIALS
2016
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles
Sriram Balusu
Elien Van Wonterghem
Riet De Rycke
Koen Raemdonck
Stephan Stremersch
Kris Gevaert
Marjana Brkić
Delphine Demeestere
Valerie Vanhooren
An Hendrix
et al.
A1
Journal Article
in
EMBO MOLECULAR MEDICINE
2016
Identification of individual exosome-like vesicles by surface enhanced Raman spectroscopy
Stephan Stremersch
Monica Marro
Bat-El Pinchasik
Pieter Baatsen
An Hendrix
Stefaan De Smedt
Pablo Loza-Alvarez
Andre Skirtach
Koen Raemdonck
Kevin Braeckmans
A1
Journal Article
in
SMALL
2016
Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance
Simon Devos
Stephan Stremersch
Koen Raemdonck
Kevin Braeckmans
Bart Devreese
A1
Journal Article
in
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2016
The impact of species and cell type on the nanosafety profile of iron oxide nanoparticles in neural cells
Freya Joris
Daniel Valdepérez
Beatriz Pelaz
Stefaan J Soenen
Bella B Manshian
Wolfgang J Parak
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF NANOBIOTECHNOLOGY
2016
Therapeutic and diagnostic applications of extracellular vesicles
Stephan Stremersch
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2016
2015
Bio-inspired materials in drug delivery : exploring the role of pulmonary surfactant in siRNA inhalation therapy
Lynn De Backer
Alejandro Cerrada
Jesús Pérez-Gil
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2015
Bio-inspired pulmonary surfactant-modified nanogels : a promising siRNA delivery system
Lynn De Backer
Kevin Braeckmans
Marc CA Stuart
Jo Demeester
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2015
Exploring bio-inspired nanocomposites of nanogels and pulmonary surfactant for small interfering RNA delivery
Lynn De Backer
Stefaan De Smedt
Koen Raemdonck
Dissertation
2015
Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages
Lynn De Backer
Thomas Naessens
Stefaan De Koker
Elisa Zagato
Jo Demeester
Johan Grooten
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2015
Laser-induced vapor nanobubbles for efficient delivery of macromolecules in live cells
Ranhua Xiong
Koen Raemdonck
Karen Peynshaert
Ine Lentacker
Ine De Cock
Jo Demeester
Stefaan De Smedt
Andre Skirtach
Kevin Braeckmans
P1
Conference
2015
Lessons in simplicity that should shape the future of drug delivery
Koen Raemdonck
Stefaan De Smedt
A1
Journal Article
in
NATURE BIOTECHNOLOGY
2015
Reduction-sensitive dextran nanogels aimed for intracellular delivery of antigens
Dandan Li
Neda Kordalivand
Marieke F. Fransen
Ferry Ossendorp
Koen Raemdonck
Tina Vermonden
Wim E. Hennink
Cornelus F. van Nostrum
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2015
Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells
Ana CN Oliveira
Koen Raemdonck
Thomas Martens
Koen Rombouts
Rosana Simón-Vázquez
Cláudia Bothelho
Ivo Lopes
Marlene Lúcio
África González-Fernández
M Elisabete CD Real Oliveira
et al.
A1
Journal Article
in
ACTA BIOMATERIALIA
2015
The effect of imipenem and diffusible signaling factors on the secretion of outer membrane vesicles and associated Ax21 proteins in Stenotrophomonas maltophilia
Simon Devos
Laurence Van Oudenhove
Stephan Stremersch
Wouter Van Putte
Riet De Rycke
Gonzalez Van Driessche
Jolien Vitse
Koen Raemdonck
Bart Devreese
A1
Journal Article
in
FRONTIERS IN MICROBIOLOGY
2015
2014
A personalized view on cancer immunotherapy
Laura Wayteck
Karine Breckpot
Jo Demeester
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
CANCER LETTERS
2014
Comparison of gold nanoparticle mediated photoporation: vapor nanobubbles outperform direct heating for delivering macromolecules in live cells
Ranhua Xiong
Koen Raemdonck
Karen Peynshaert
Ine Lentacker
Ine De Cock
Jo Demeester
Stefaan De Smedt
Andre Skirtach
Kevin Braeckmans
A1
Journal Article
in
ACS NANO
2014
Dioctadecyldimethylammonium:monoolein nanocarriers for efficient in vitro gene silencing
Ana Cristina Norbert Oliveira
Thomas Martens
Koen Raemdonck
Renata Danielle Adati
Eloi Feitosae
Cláudia Botelho
Andreia Castro Gomes
Kevin Braeckmans
María Elisabete Cunha Dias Real Oliveira
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2014
FRAP in pharmaceutical research: practical guidelines and applications in drug delivery
Hendrik Deschout
Koen Raemdonck
Jo Demeester
Stefaan De Smedt
Kevin Braeckmans
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2014
Lipid and polymer nanoparticles for drug delivery to bacterial biofilms
Katrien Forier
Koen Raemdonck
Stefaan De Smedt
Jo Demeester
Tom Coenye
Kevin Braeckmans
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Merging the best of both worlds : hybrid lipid-enveloped matrix nanocomposites in drug delivery
Koen Raemdonck
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2014
On-chip light sheet illumination enables diagnostic size and concentration measurements of membrane vesicles in biofluids
Hendrik Deschout
Koen Raemdonck
Stephan Stremersch
Pietro Maoddi
Guillaume Mernier
Philippe Renaud
Sebastien Jiguet
An Hendrix
marc bracke
Rudy Van den Broecke
et al.
A1
Journal Article
in
NANOSCALE
2014
Overcoming biological barriers to nanomedicines for the treatment of pulmonary biofilm infections in cystic fibrosis
Katrien Forier
Kevin Braeckmans
Koen Raemdonck
Jo Demeester
Dissertation
2014
Probing the size limit for nanomedicine penetration into Burkholderia multivorans and Pseudomonas aeruginosa biofilms
Katrien Forier
Anne-Sophie Messiaen
Koen Raemdonck
Hans Nelis
Stefaan De Smedt
Jo Demeester
Tom Coenye
Kevin Braeckmans
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels
Stefaan Soenen
Lynn De Backer
Bella Manshian
Shareen Doak
Koen Raemdonck
Jo Demeester
Kevin Braeckmans
Stefaan De Smedt
A1
Journal Article
in
NANOMEDICINE
2014
2013
Development of nanomedicines for the treatment of pulmonary biofilm infections: Insights from advanced fluorescence microscopy studies
Katrien Forier
Anne-Sophie Messiaen
Martijn Risseeuw
Serge Van Calenbergh
Hendrik Deschout
Koen Raemdonck
Hans Nelis
Fabienne Danhier
Véronique Préat
Frans De Baets
et al.
C3
Conference
2013
Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles
Sander AA Kooijmans
Stephan Stremersch
Kevin Braeckmans
Stefaan De Smedt
An Hendrix
Matthew JA Wood
Raymond M Schiffelers
Koen Raemdonck
Pieter Vader
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2013
In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier
Broes Naeye
Hendrik Deschout
Vicky Caveliers
Benedicte Descamps
Kevin Braeckmans
Christian Vanhove
Jo Demeester
Tony Lahoutte
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
BIOMATERIALS
2013
Polysaccharide-based nucleic acid nanoformulations
Koen Raemdonck
Thomas F Martens
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2013
The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels
Lynn De Backer
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
NANOMEDICINE
2013
Transport of nanoparticles in cystic fibrosis sputum and bacterial biofilms by single-particle tracking microscopy
Katrien Forier
Anne-Sophie Messiaen
Koen Raemdonck
Hendrik Deschout
Joanna Rejman
Frans De Baets
Hans Nelis
Stefaan De Smedt
Jo Demeester
Tom Coenye
et al.
A1
Journal Article
in
NANOMEDICINE
2013
2012
Bio-inspired surfactant-modified dextran nanogels mediate enhanced intracellular siRNA delivery
Lynn De Backer
Jo Demeester
Stefaan De Smedt
Koen Raemdonck
C3
Conference
2012
Comparison of polymeric siRNA nanocarriers in a murine LPS-activated macrophage cell line: gene silencing, toxicity and off-target gene expression
Linda B Jensen
Joscha Griger
Broes Naeye
Amir K Varkouhi
Koen Raemdonck
Raymond Schiffelers
Twan Lammers
Gert Storm
Stefaan De Smedt
Brian S Sproat
et al.
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2012
Evaluation of small interfering RNA delivery by nanoparticle-loaded tumoritropic cells
Laura Wayteck
Stefaan De Smedt
Koen Raemdonck
C3
Conference
2012
Influence of CORM-A1 and resveratrol on TNF-a-induced oxidative stress and apoptosis in murine MODE-K intestinal epithelial cells
Dinesh Babu
Ole De Backer
Stefaan Soenen
Koen Raemdonck
Georges Leclercq
R Motterlini
Romain Lefebvre
C3
Conference
2012
Influence of CORM-A1 on TNF-alpha-induced oxidative stress and apoptosis in mode-K cells
Dinesh Babu
Ole De Backer
Stefaan Soenen
Koen Raemdonck
Georges Leclercq
Roberto Motterlini
Romain Lefebvre
C3
Conference
2012
Matrix systems for siRNA delivery
Broes Naeye
Koen Raemdonck
Katrien Remaut
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
CURRENT TOPICS IN MEDICINAL CHEMISTRY
2012
TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells
Dinesh Babu
Stefaan Soenen
Koen Raemdonck
Georges Leclercq
Ole De Backer
Roberto Motterlini
Romain Lefebvre
A1
Journal Article
in
CURRENT PHARMACEUTICAL DESIGN
2012
2011
Assessing dextran nanogels for intravenous small interfering RNA delivery
Broes Naeye
Stefaan De Smedt
Jo Demeester
Koen Raemdonck
Dissertation
2011
Hemocompatibility of siRNA loaded dextran nanogels
Broes Naeye
Hendrik Deschout
Magnus Roding
Mats Rudemo
Joris Delanghe
Katrien Devreese
Jo Demeester
Kevin Braeckmans
Stefaan De Smedt
Koen Raemdonck
A1
Journal Article
in
BIOMATERIALS
2011
2010
Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles
Kevin Braeckmans
Kevin Buyens
Broes Naeye
Dries Vercauteren
Hendrik Deschout
Koen Raemdonck
Katrien Remaut
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2010
Interactions of siRNA loaded dextran nanogel with blood cells
Broes Naeye
Koen Raemdonck
Jo Demeester
Stefaan De Smedt
C3
Conference
2010
PEGylation of biodegradable dextran nanogels for siRNA delivery
Broes Naeye
Koen Raemdonck
Katrien Remaut
B Sproat
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2010
Prolonged gene silencing by combining siRNA nanogels and photochemical internalization
Koen Raemdonck
Broes Naeye
A Hogset
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2010
2009
Advanced nanogel engineering for drug delivery
Koen Raemdonck
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
Soft Matter
2009
Biodegradable dextran nanogels as functional carriers for the intracellular delivery of small interfering RNA
Koen Raemdonck
Stefaan De Smedt
Jo Demeester
Dissertation
2009
Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery
Koen Raemdonck
Broes Naeye
Kevin Buyens
Roosmarijn Vandenbroucke
A Hogset
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
Advanced Functional Materials
2009
2008
A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum
Kevin Buyens
Bart Lucas
Koen Raemdonck
Kevin Braeckmans
J VERCAMMEN
J HENDRIX
Y ENGELBORGHS
Stefaan De Smedt
Niek Sanders
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2008
Dextran microgels for time-controlled delivery of siRNA
Koen Raemdonck
Tinneke Van Thienen
Roosmarijn Vandenbroucke
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
ADVANCED FUNCTIONAL MATERIALS
2008
Maintaining the silence: reflections on long-term RNAi
Koen Raemdonck
Roosmarijn Vandenbroucke
Jo Demeester
Niek Sanders
Stefaan De Smedt
A1
Journal Article
in
DRUG DISCOVERY TODAY
2008
2007
Can we better understand the intracellular behavior of DNA nanoparticles by fluorescence correlation spectroscopy?
Katrien Remaut
Bart Lucas
Koen Raemdonck
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2007
Protection of oligonucleotides against enzymatic degradation by pegylated and nonpegylated branched polyethyleneimine
Katrien Remaut
Bart Lucas
Koen Raemdonck
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
BIOMACROMOLECULES
2007
Protein release from biodegradable dextran nanogels
Tinneke Van Thienen
Koen Raemdonck
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
LANGMUIR
2007
2006
In situ analysis of single-stranded and duplex siRNA integrity in living cells
Koen Raemdonck
Katrien Remaut
Bart Lucas
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
BIOCHEMISTRY
2006