Research Explorer

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Researcher

Koen Raemdonck

Awards & Distinctions

115 Results

2024

Beyond chloroquine : cationic amphiphilic drugs as endosomal escape enhancers for nucleic acid therapeutics

Aliona DebisschopBram BogaertCristina MunteanStefaan De SmedtKoen Raemdonck

A1 Journal Article in CURRENT OPINION IN CHEMICAL BIOLOGY

Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy

Pieterjan MerckxGRIET CONICKXEvy BlommeTania MaesKen BrackeGuy BrusselleStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Laser-induced vapor nanobubbles for B16-F10 melanoma cell killing and intracellular delivery of chemotherapeutics

Jana RamonYanou EngelenHerlinde De KeersmaeckerIlia GoemaereDeep PunjJulián Mejía MoralesCédric BonteGeert BerxEsther HosteStephan Stremersch et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Selective replacement of cholesterol with cationic amphiphilic drugs enables the design of lipid nanoparticles with improved RNA delivery

Bram BogaertAliona DebisschopThomas EhouarneHannelore Van EeckhoutteJoyceline De VolderAn JacobsEline PottieRiet De RyckeAurélie CrabbéPieter Mestdagh et al.

A1 Journal Article in NANO LETTERS

2023

A lipid nanoparticle platform for RNA delivery with cationic amphiphilic drugs : merging the best of both worlds

Bram BogaertKoen RaemdonckStefaan De Smedt

Capric acid and myristic acid permeability enhancers in curved liposome membranes

Samaneh DavoudiKoen RaemdonckKevin BraeckmansAn Ghysels

A1 Journal Article in JOURNAL OF CHEMICAL INFORMATION AND MODELING

Cationic amino-acid functionalized polymethacrylamide vectors for siRNA transfection based on modification of poly(2-isopropenyl-2-oxazoline)

Adriana JercaCristina MunteanKatrien RemautValentin-Victor JercaKoen RaemdonckRichard Hoogenboom

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Immunogenicity versus efficacy of lipid nanoparticle-mediated delivery of mRNA and self-amplifying mRNA to the retina

Helena VanlucheneKatrien RemautNiek SandersKoen Raemdonck

Mammalian target of rapamycin inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells

Shanna DewaeleLouis DelhayeBoel De PaepeBram BogaertRamiro MartinezJasper AnckaertNurten YigitJustine NuytensRudy Van CosterSven Eyckerman et al.

A1 Journal Article in NUCLEIC ACID THERAPEUTICS

Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer

Cristina MunteanEva BlondeelLaure HarinckKunal PednekarJai PrakashOlivier De WeverJeanne Leblond ChainStefaan De SmedtKatrien RemautKoen Raemdonck

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Strategies to overcome the lysosomal entrapment of siRNA therapeutics and chemotherapeutic drugs

Cristina MunteanKoen RaemdonckKatrien Remaut

The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments

Thijs Van de VyverCristina MunteanIuliia EfimovaDmitri KryskoLynn De BackerStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Unfolding the versatility of laser-induced vapor nanobubbles : from balancing intracellular delivery with regulated cell death to loading of extracellular vesicles

Jana RamonKevin BraeckmansKoen RaemdonckStephan Stremersch

2022

A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs

Bram BogaertFelix SauvageRoberta GuagliardoCristina Muntean[missing] Van Phuc NguyenEline PottieMike WelsAn-Katrien MinnaertRiet De RyckeQiangbing Yang et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Counting permeant crossings to assess the effect of membrane curvature and composition on the permeability rate

Samaneh DavoudiKoen RaemdonckKevin BraeckmansAn Ghysels

Investigating membrane curvature and composition effect on membrane permeability by counting permeant crossings

Samaneh DavoudiKoen RaemdonckKevin BraeckmansAn Ghysels

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

Thijs Van de VyverStefaan De SmedtKoen Raemdonck

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Non-invasive cell-tracking methods for adoptive T cell therapies

Jelter Van HoeckChristian VanhoveStefaan De SmedtKoen Raemdonck

A1 Journal Article in DRUG DISCOVERY TODAY

Non-viral siRNA delivery to T cells : challenges and opportunities in cancer immunotherapy

Jelter Van HoeckKevin BraeckmansStefaan De SmedtKoen Raemdonck

A1 Journal Article in BIOMATERIALS

Plasma membrane perforation by GSDME during apoptosis-driven secondary necrosis

Elke De SchutterJana RamonBenjamin PfeutyCaroline De TenderStephan StremerschKoen RaemdonckKen Op de BeeckWim DeclercqFranck RiquetKevin Braeckmans et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Understanding membrane permeability of drug releasing liposomes from molecular dynamics simulations : effect of curvature and composition

Samaneh DavoudiKoen RaemdonckKevin BraeckmansAn Ghysels

2021

Cas9 RNP transfection by vapor nanobubble photoporation for ex vivo cell engineering

Laurens RaesMelissa PilleAranit HarizajGlenn GoetgelukJelter Van HoeckStephan StremerschJuan FraireToon BransOlivier Gerrit de JongRoel Maas-Bakker et al.

A1 Journal Article in MOLECULAR THERAPY-NUCLEIC ACIDS

Challenges and strategies for the delivery of biologics to the cornea

Mike WelsD. RoelsKoen RaemdonckStefaan De SmedtFélix Sauvage

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Delivering on the promise of adoptive T cell therapy : assessment of non-viral methods for direct cytosolic delivery of membrane-impermeable cargo

Jelter Van HoeckKoen RaemdonckStefaan De Smedt

Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo

Jelter Van HoeckThijs Van de VyverAranit HarizajGlenn GoetgelukPieterjan MerckxJing LiuMike WelsFélix SauvageHerlinde De KeersmaeckerChristian Vanhove et al.

A1 Journal Article in ADVANCED MATERIALS

Increasing angiogenesis factors in hypoxic diabetic wound conditions by siRNA delivery : additive effect of LbL-gold nanocarriers and desloratadine-induced lysosomal escape

Elnaz Shaabani SichaniMaryam SharifiaghdamJoris LammensHerlinde De KeersmaeckerChris VervaetThomas De BeerElahe MotevaseliMohammad Hossein GhahremaniParvin MansouriStefaan De Smedt et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intracellular delivery of mRNA and proteins by VNB photoporation for cancer immunotherapy

Laurens RaesKevin BraeckmansKoen Raemdonck

Non-viral transfection technologies for next-generation therapeutic T cell engineering

Laurens RaesStefaan De SmedtKoen RaemdonckKevin Braeckmans

A1 Journal Article in BIOTECHNOLOGY ADVANCES

Old drugs with new tricks : repurposing small molecules to promote lysosomal escape of small nucleic acid therapeutics

Thijs Van de VyverKoen RaemdonckStefaan De Smedt

Photothermal nanofibres enable safe engineering of therapeutic cells

Ranhua XiongDawei HuaJelter Van HoeckDominika BerdeckaLaurens LégerStijn De MunterJuan FraireLaurens RaesAranit HarizajFélix Sauvage et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Pulmonary surfactant as a versatile biomaterial to fight COVID-19

Lore HermanStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across

An-Katrien MinnaertHelena VanlucheneRein VerbekeIne LentackerStefaan De SmedtKoen RaemdonckNiek SandersKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Surfactant protein B promotes cytosolic SiRNA delivery by adopting a virus-like mechanism of action

Roberta GuagliardoLore HermanJelle PendersAgata ZamborlinHerlinde De KeersmaeckerThijs Van de VyverSandrine VerstraetenPieterjan MerckxMarie-Paule Mingeot-LeclercqMercedes Echaide et al.

A1 Journal Article in ACS NANO

Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology

Jana RamonRanhua XiongStefaan De SmedtKoen RaemdonckKevin Braeckmans

A1 Journal Article in CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

2020

Beyond the surface : unraveling the intracellular mechanism behind surfactant protein B (SP-B) mediated siRNA delivery

Roberta GuagliardoKoen RaemdonckStefaan De Smedt

Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner

Thijs Van de VyverBram BogaertLynn De BackerFreya JorisRoberta GuagliardoJelter Van HoeckPieterjan MerckxSerge Van CalenberghSrinivas RamishettiDan Peer et al.

A1 Journal Article in ACS NANO

Intracellular delivery of mRNA in adherent and suspension cells by vapor nanobubble photoporation

Laurens RaesStephan StremerschJuan FraireToon BransGlenn GoetgelukStijn De MunterLien Van HoeckeRein VerbekeJelter Van HoeckRanhua Xiong et al.

A1 Journal Article in NANO-MICRO LETTERS

Lung surfactant-hydrogel nanocomposites for pulmonary siRNA delivery : breaching barriers for nanomedicine-based inhalation therapy

Pieterjan MerckxKoen RaemdonckStefaan De Smedt

Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy

Pieterjan MerckxJoris LammensGust NuyttenBram BogaertRoberta GuagliardoTania MaesChris VervaetThomas De BeerStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Vapor nanobubble is the more reliable photothermal mechanism for inducing endosomal escape of siRNA without disturbing cell homeostasis

Juan FraireGaëlle HouthaeveJing LiuLaurens RaesLotte VermeulenStephan StremerschToon BransGerardo Garcia-Diaz BarrigaSarah De KeulenaerFilip Van Nieuwerburgh et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2019

Challenges for labeling and longitudinal tracking of adoptively transferred autoreactive T lymphocytes in an experimental type-1 diabetes model

Shweta SainiHannelie KorfSayuan LiangRein VerbekeBella ManshianKoen RaemdonckIne LentackerConny GysemansStefaan De SmedtUwe Himmelreich

A1 Journal Article in MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells

Lien Van HoeckeLaurens RaesStephan StremerschToon BransJuan FraireRia RoelandtWim DeclercqPeter VandenabeeleKoen RaemdonckKevin Braeckmans et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells

Laurens RaesClarissa Van HeckeJulie MichielsStephan StremerschJuan FraireToon BransRanhua XiongStefaan De SmedtLinos VandekerckhoveKoen Raemdonck et al.

A1 Journal Article in CRYSTALS

Improved label-free identification of individual exosome-like vesicles with Au@Ag nanoparticles as SERS substrate

Juan FraireStephan StremerschDavinia BouckaertTinne MonteyneThomas De BeerPieter WuytensRiet De RyckeAndre SkirtachKoen RaemdonckStefaan De Smedt et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA

Roberta GuagliardoPieterjan MerckxAgata ZamborlinLynn De BackerMercedes EchaideJesus Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in PHARMACEUTICS

2018

Nucleic acid loading and fluorescent labeling of isolated extracellular vesicles requires adequate purification

Stephan StremerschToon BransKevin BraeckmansStefaan De SmedtKoen Raemdonck

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pulmonary surfactant and drug delivery : focusing on the role of surfactant proteins

Roberta GuagliardoJésus Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells

Freya JorisLynn De BackerThijs Van de VyverChiara BastiancichStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy

Pieterjan MerckxLynn De BackerLien Van HoeckeRoberta GuagliardoMercedes EchaidePieter BaatsenBárbara OlmedaXavier SaelensJésus Pérez-GilStefaan De Smedt et al.

A1 Journal Article in ACTA BIOMATERIALIA

2017

Choose your cell model wisely : the in vitro nanoneurotoxicity of differentially coated iron oxide nanoparticles for neural cell labeling

Freya JorisDaniel ValdepérezBeatriz PelazTianqiang WangShareen H. DoakBella B. ManshianStefaan J. SoenenWolfgang J. ParakStefaan De SmedtKoen Raemdonck

A1 Journal Article in ACTA BIOMATERIALIA

Comparing photoporation and nucleofection for delivery of small interfering RNA to cytotoxic T cells

Laura WayteckRanhua XiongKevin BraeckmansStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Intracellular delivery of oligonucleotides in Helicobacter pylori by fusogenic liposomes in the presence of gastric mucus

Rita SantosGeorge DakwarElisa ZagatoToon BransCéu FigueiredoKoen RaemdonckNuno F AzevedoStefaan De SmedtKevin Braeckmans

A1 Journal Article in BIOMATERIALS

Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress

Simon DevosWouter Van PutteJolien VitseGonzalez Van DriesscheStephan StremerschWim Van Den BroeckKoen RaemdonckKevin BraeckmansHenning StahlbergMisha Kudryashev et al.

A1 Journal Article in ENVIRONMENTAL MICROBIOLOGY

Small molecules convey big messages : boosting non-viral nucleic acid delivery with low molecular weight drugs

Freya JorisStefaan De SmedtKoen Raemdonck

A1 Journal Article in NANO TODAY

The repurposing of low molecular weight drugs to induce lysosomal release of siRNA and in vitro approaches to probe the toxicity of inorganic nanoparticles

Freya JorisStefaan De SmedtKoen Raemdonck

2016

An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: proof-of-concept in the treatment of psoriasis

Eline DesmetSTEFANIE BRACKEKatrien ForierLien TaevernierMarc StuartBart De SpiegeleerKoen RaemdonckMireille Van GeleJo Lambert

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterization data on the topical carrier DDC642

Eline DesmetSTEFANIE BRACKEKatrien ForierLien TaevernierMarc CA StuartBart De SpiegeleerKoen RaemdonckMireille Van GeleJo Lambert

A2 Journal Article in DATA IN BRIEF

Combining the strengths of cytotoxic T cells and nanomedicines for cancer immunotherapy

Laura WayteckStefaan De SmedtKoen Raemdonck

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

Stephan StremerschRoosmarijn VandenbrouckeElien Van WonterghemAn HendrixStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Cytosolic delivery of nanolabels prevents their asymmetric inheritance and enables extended quantitative in vivo cell imaging

Ranhua XiongFreya JorisSayuan LiangRiet De RyckeSaskia LippensJo DemeesterAndre SkirtachKoen RaemdonckUwe HimmelreichStefaan De Smedt et al.

A1 Journal Article in NANO LETTERS

Exploring extracellular vesicles for siRNA delivery and Raman-based diagnostics

Stephan StremerschStefaan De SmedtKoen RaemdonckKevin Braeckmans

Hitchhiking nanoparticles: reversible coupling of lipid-based nanoparticles to cytotoxic T lymphocytes

Laura WayteckHeleen DewitteLynn De BackerKarine BreckpotJo DemeesterStefaan De SmedtKoen Raemdonck

A1 Journal Article in BIOMATERIALS

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles

Sriram BalusuElien Van WonterghemRiet De RyckeKoen RaemdonckStephan StremerschKris GevaertMarjana BrkićDelphine DemeestereValerie VanhoorenAn Hendrix et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Identification of individual exosome-like vesicles by surface enhanced Raman spectroscopy

Stephan StremerschMonica MarroBat-El PinchasikPieter BaatsenAn HendrixStefaan De SmedtPablo Loza-AlvarezAndre SkirtachKoen RaemdonckKevin Braeckmans

A1 Journal Article in SMALL

Intra- and interspecies effects of outer membrane vesicles from Stenotrophomonas maltophilia on β-lactam resistance

Simon DevosStephan StremerschKoen RaemdonckKevin BraeckmansBart Devreese

A1 Journal Article in ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The impact of species and cell type on the nanosafety profile of iron oxide nanoparticles in neural cells

Freya JorisDaniel ValdepérezBeatriz PelazStefaan J SoenenBella B ManshianWolfgang J ParakStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF NANOBIOTECHNOLOGY

Therapeutic and diagnostic applications of extracellular vesicles

Stephan StremerschStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2015

Bio-inspired materials in drug delivery : exploring the role of pulmonary surfactant in siRNA inhalation therapy

Lynn De BackerAlejandro CerradaJesús Pérez-GilStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Bio-inspired pulmonary surfactant-modified nanogels : a promising siRNA delivery system

Lynn De BackerKevin BraeckmansMarc CA StuartJo DemeesterStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Exploring bio-inspired nanocomposites of nanogels and pulmonary surfactant for small interfering RNA delivery

Lynn De BackerStefaan De SmedtKoen Raemdonck

Hybrid pulmonary surfactant-coated nanogels mediate efficient in vivo delivery of siRNA to murine alveolar macrophages

Lynn De BackerThomas NaessensStefaan De KokerElisa ZagatoJo DemeesterJohan GrootenStefaan De SmedtKoen Raemdonck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Laser-induced vapor nanobubbles for efficient delivery of macromolecules in live cells

Ranhua XiongKoen RaemdonckKaren PeynshaertIne LentackerIne De CockJo DemeesterStefaan De SmedtAndre SkirtachKevin Braeckmans

Lessons in simplicity that should shape the future of drug delivery

Koen RaemdonckStefaan De Smedt

A1 Journal Article in NATURE BIOTECHNOLOGY

Reduction-sensitive dextran nanogels aimed for intracellular delivery of antigens

Dandan LiNeda KordalivandMarieke F. FransenFerry OssendorpKoen RaemdonckTina VermondenWim E. HenninkCornelus F. van Nostrum

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Stealth monoolein-based nanocarriers for delivery of siRNA to cancer cells

Ana CN OliveiraKoen RaemdonckThomas MartensKoen RomboutsRosana Simón-VázquezCláudia BothelhoIvo LopesMarlene LúcioÁfrica González-FernándezM Elisabete CD Real Oliveira et al.

A1 Journal Article in ACTA BIOMATERIALIA

The effect of imipenem and diffusible signaling factors on the secretion of outer membrane vesicles and associated Ax21 proteins in Stenotrophomonas maltophilia

Simon DevosLaurence Van OudenhoveStephan StremerschWouter Van PutteRiet De RyckeGonzalez Van DriesscheJolien VitseKoen RaemdonckBart Devreese

A1 Journal Article in FRONTIERS IN MICROBIOLOGY

2014

A personalized view on cancer immunotherapy

Laura WayteckKarine BreckpotJo DemeesterStefaan De SmedtKoen Raemdonck

A1 Journal Article in CANCER LETTERS

Comparison of gold nanoparticle mediated photoporation: vapor nanobubbles outperform direct heating for delivering macromolecules in live cells

Ranhua XiongKoen RaemdonckKaren PeynshaertIne LentackerIne De CockJo DemeesterStefaan De SmedtAndre SkirtachKevin Braeckmans

A1 Journal Article in ACS NANO

Dioctadecyldimethylammonium:monoolein nanocarriers for efficient in vitro gene silencing

Ana Cristina Norbert OliveiraThomas MartensKoen RaemdonckRenata Danielle AdatiEloi FeitosaeCláudia BotelhoAndreia Castro GomesKevin BraeckmansMaría Elisabete Cunha Dias Real Oliveira

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

FRAP in pharmaceutical research: practical guidelines and applications in drug delivery

Hendrik DeschoutKoen RaemdonckJo DemeesterStefaan De SmedtKevin Braeckmans

A1 Journal Article in PHARMACEUTICAL RESEARCH

Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

Katrien ForierKoen RaemdonckStefaan De SmedtJo DemeesterTom CoenyeKevin Braeckmans

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Merging the best of both worlds : hybrid lipid-enveloped matrix nanocomposites in drug delivery

Koen RaemdonckKevin BraeckmansJo DemeesterStefaan De Smedt

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

On-chip light sheet illumination enables diagnostic size and concentration measurements of membrane vesicles in biofluids

Hendrik DeschoutKoen RaemdonckStephan StremerschPietro MaoddiGuillaume MernierPhilippe RenaudSebastien JiguetAn Hendrixmarc brackeRudy Van den Broecke et al.

A1 Journal Article in NANOSCALE

Overcoming biological barriers to nanomedicines for the treatment of pulmonary biofilm infections in cystic fibrosis

Katrien ForierKevin BraeckmansKoen RaemdonckJo Demeester

Probing the size limit for nanomedicine penetration into Burkholderia multivorans and Pseudomonas aeruginosa biofilms

Katrien ForierAnne-Sophie MessiaenKoen RaemdonckHans NelisStefaan De SmedtJo DemeesterTom CoenyeKevin Braeckmans

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Unraveling the effects of siRNA carrier systems on cell physiology: a multiparametric approach demonstrated on dextran nanogels

Stefaan SoenenLynn De BackerBella ManshianShareen DoakKoen RaemdonckJo DemeesterKevin BraeckmansStefaan De Smedt

A1 Journal Article in NANOMEDICINE

2013

Development of nanomedicines for the treatment of pulmonary biofilm infections: Insights from advanced fluorescence microscopy studies

Katrien ForierAnne-Sophie MessiaenMartijn RisseeuwSerge Van CalenberghHendrik DeschoutKoen RaemdonckHans NelisFabienne DanhierVéronique PréatFrans De Baets et al.

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

Sander AA KooijmansStephan StremerschKevin BraeckmansStefaan De SmedtAn HendrixMatthew JA WoodRaymond M SchiffelersKoen RaemdonckPieter Vader

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier

Broes NaeyeHendrik DeschoutVicky CaveliersBenedicte DescampsKevin BraeckmansChristian VanhoveJo DemeesterTony LahoutteStefaan De SmedtKoen Raemdonck

A1 Journal Article in BIOMATERIALS

Polysaccharide-based nucleic acid nanoformulations

Koen RaemdonckThomas F MartensKevin BraeckmansJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

The influence of natural pulmonary surfactant on the efficacy of siRNA-loaded dextran nanogels

Lynn De BackerKevin BraeckmansJo DemeesterStefaan De SmedtKoen Raemdonck

A1 Journal Article in NANOMEDICINE

Transport of nanoparticles in cystic fibrosis sputum and bacterial biofilms by single-particle tracking microscopy

Katrien ForierAnne-Sophie MessiaenKoen RaemdonckHendrik DeschoutJoanna RejmanFrans De BaetsHans NelisStefaan De SmedtJo DemeesterTom Coenye et al.

A1 Journal Article in NANOMEDICINE

2012

Bio-inspired surfactant-modified dextran nanogels mediate enhanced intracellular siRNA delivery

Lynn De BackerJo DemeesterStefaan De SmedtKoen Raemdonck

Comparison of polymeric siRNA nanocarriers in a murine LPS-activated macrophage cell line: gene silencing, toxicity and off-target gene expression

Linda B JensenJoscha GrigerBroes NaeyeAmir K VarkouhiKoen RaemdonckRaymond SchiffelersTwan LammersGert StormStefaan De SmedtBrian S Sproat et al.

A1 Journal Article in PHARMACEUTICAL RESEARCH

Evaluation of small interfering RNA delivery by nanoparticle-loaded tumoritropic cells

Laura WayteckStefaan De SmedtKoen Raemdonck

Influence of CORM-A1 and resveratrol on TNF-a-induced oxidative stress and apoptosis in murine MODE-K intestinal epithelial cells

Dinesh BabuOle De BackerStefaan SoenenKoen RaemdonckGeorges LeclercqR MotterliniRomain Lefebvre

Influence of CORM-A1 on TNF-alpha-induced oxidative stress and apoptosis in mode-K cells

Dinesh BabuOle De BackerStefaan SoenenKoen RaemdonckGeorges LeclercqRoberto MotterliniRomain Lefebvre

Matrix systems for siRNA delivery

Broes NaeyeKoen RaemdonckKatrien RemautJo DemeesterStefaan De Smedt

A1 Journal Article in CURRENT TOPICS IN MEDICINAL CHEMISTRY

TNF-α/cycloheximide-induced oxidative stress and apoptosis in murine intestinal epithelial MODE-K cells

Dinesh BabuStefaan SoenenKoen RaemdonckGeorges LeclercqOle De BackerRoberto MotterliniRomain Lefebvre

A1 Journal Article in CURRENT PHARMACEUTICAL DESIGN

2011

Assessing dextran nanogels for intravenous small interfering RNA delivery

Broes NaeyeStefaan De SmedtJo DemeesterKoen Raemdonck

Hemocompatibility of siRNA loaded dextran nanogels

Broes NaeyeHendrik DeschoutMagnus RodingMats RudemoJoris DelangheKatrien DevreeseJo DemeesterKevin BraeckmansStefaan De SmedtKoen Raemdonck

A1 Journal Article in BIOMATERIALS

2010

Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles

Kevin BraeckmansKevin BuyensBroes NaeyeDries VercauterenHendrik DeschoutKoen RaemdonckKatrien RemautNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Interactions of siRNA loaded dextran nanogel with blood cells

Broes NaeyeKoen RaemdonckJo DemeesterStefaan De Smedt

PEGylation of biodegradable dextran nanogels for siRNA delivery

Broes NaeyeKoen RaemdonckKatrien RemautB SproatJo DemeesterStefaan De Smedt

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Prolonged gene silencing by combining siRNA nanogels and photochemical internalization

Koen RaemdonckBroes NaeyeA HogsetJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2009

Advanced nanogel engineering for drug delivery

Koen RaemdonckJo DemeesterStefaan De Smedt

A1 Journal Article in Soft Matter

Biodegradable Dextran Nanogels for RNA Interference: Focusing on Endosomal Escape and Intracellular siRNA Delivery

Koen RaemdonckBroes NaeyeKevin BuyensRoosmarijn VandenbrouckeA HogsetJo DemeesterStefaan De Smedt

A1 Journal Article in Advanced Functional Materials

Biodegradable dextran nanogels as functional carriers for the intracellular delivery of small interfering RNA

Koen RaemdonckStefaan De SmedtJo Demeester

2008

A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum

Kevin BuyensBart LucasKoen RaemdonckKevin BraeckmansJ VERCAMMENJ HENDRIXY ENGELBORGHSStefaan De SmedtNiek Sanders

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Dextran microgels for time-controlled delivery of siRNA

Koen RaemdonckTinneke Van ThienenRoosmarijn VandenbrouckeNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED FUNCTIONAL MATERIALS

Maintaining the silence: reflections on long-term RNAi

Koen RaemdonckRoosmarijn VandenbrouckeJo DemeesterNiek SandersStefaan De Smedt

A1 Journal Article in DRUG DISCOVERY TODAY

2007

Can we better understand the intracellular behavior of DNA nanoparticles by fluorescence correlation spectroscopy?

Katrien RemautBart LucasKoen RaemdonckKevin BraeckmansJo DemeesterStefaan De Smedt

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Protection of oligonucleotides against enzymatic degradation by pegylated and nonpegylated branched polyethyleneimine

Katrien RemautBart LucasKoen RaemdonckKevin BraeckmansJo DemeesterStefaan De Smedt

A1 Journal Article in BIOMACROMOLECULES

Protein release from biodegradable dextran nanogels

Tinneke Van ThienenKoen RaemdonckJo DemeesterStefaan De Smedt

A1 Journal Article in LANGMUIR

2006

In situ analysis of single-stranded and duplex siRNA integrity in living cells

Koen RaemdonckKatrien RemautBart LucasNiek SandersJo DemeesterStefaan De Smedt

A1 Journal Article in BIOCHEMISTRY