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Researcher
Katrien Remaut
Profile
Projects
Publications & Research Data
Activities
Awards & Distinctions
Patents
144
Results
2026
Photothermal transport for guiding nanoparticles through the vitreous humor
Léa Guerassimoff
Yera Ussembayev
Louise De Clerck
Deep Punj
Martijn van den Broek
Filip Beunis
Katrien Remaut
Kevin Braeckmans
Stefaan De Smedt
Félix Sauvage
A1
Journal Article
in
ADVANCED SCIENCE
2026
2025
Advancing nanoparticle delivery studies: flow cytometry-based quantification of nanoparticle uptake and transfection in retinal tissue
Luca Paoletti
Kaat De Clerck
Emma De Coster
Pietro Matricardi
Katrien Remaut
Karen Peynshaert
U
Journal Article
in
Drug Delivery and Translational Research
2025
Breaking barriers : photodisruption of the inner limiting membrane to unlock retinal gene therapy after intravitreal injection
Kaat De Clerck
Karen Peynshaert
Katrien Remaut
Stefaan De Smedt
Dissertation
2025
Carriers, cargo, and consequences : analytical strategies to resolve heterogeneity in lipid nanoparticle delivery
Sarah Goddaer
Katrien Remaut
Jo Vandesompele
Kevin Braeckmans
Dissertation
2025
Cationic polyelectrolyte adsorption onto anionic nanoparticles analyzed with frequency-domain scanning fluorescence correlation spectroscopy
Lucas Oorlynck
Lenny Van Daele
Alina Myslovska
Sarah Goddaer
Sumit Sumit
Yera Ussembayev
Katrien Remaut
Iwan Moreels
Peter Dubruel
Filip Strubbe
A1
Journal Article
in
SMALL METHODS
2025
Cationic polyelectrolyte adsorption onto anionic nanoparticles analyzed with frequency‐domain scanning fluorescence correlation spectroscopy (Small Methods 9/2025)
Lucas Oorlynck
Lenny Van Daele
Alina Myslovska
Sarah Goddaer
Sumit Sumit
Yera Ussembayev
Katrien Remaut
Iwan Moreels
Peter Dubruel
Filip Strubbe
Other
2025
Collagenase-modified polydopamine nanoparticles for safe and effective vitreolysis
An-Katrien Minnaert
Van-Phuc Nguyen
Aranit Harizaj
Ilia Goemaere
Bart Van Puyvelde
Maarten Dhaenens
Félix Sauvage
Dieter Deforce
Stefano Salmaso
Paolo Caliceti
et al.
U
Journal Article
in
Journal of Controlled Release
2025
Design and evaluation of universal control antisense oligonucleotides across cellular models
Edith De Bruycker
Manon Bouckaert
Emma Delanote
Leander Meuris
Hanne Lenaerts
Lode Denolf
Katrien Remaut
An Staes
Kris Gevaert
Steve Lefever
et al.
C3
Conference
2025
Evaluation of a novel antisense oligonucleotide therapy targeting a 5’UTR variant in the RDH12 gene
Manon Bouckaert
Kyana Van Acker
Birthe Hilgen
Maria Georgiou
Filip Van Den Broeck
Edith De Bruycker
Alfredo Dueñas Rey
Emma Delanote
Hanne Lenaerts
Melita Kaltak
et al.
C3
Conference
2025
Feasibility and efficacy of electromotive intraperitoneal drug delivery : a hybrid study
Nidda Saeed
Hooman Salavati
Jolene Wong Si Min
Sarah Cosyns
Katrien Remaut
Charlotte Debbaut
Mieke Adriaens
Annelies Coene
Wim Ceelen
A1
Journal Article
in
BIOMEDICINE & PHARMACOTHERAPY
2025
From passive diffusion to active penetration : translating electromotive drug administration through experimental nanoparticle transport models for peritoneal metastasis
Nidda Saeed
Katrien Remaut
Sarah Cosyns
Hooman Salavati
Wim Ceelen
Annelies Coene
C3
Conference
2025
Strategic lipid nanoparticle design dictates retinal delivery post inner limiting membrane disruption
Kaat De Clerck
Emma De Coster
Luca Paoletti
Stefaan De Smedt
Katrien Remaut
Karen Peynshaert
A1
Journal Article
in
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
2025
2024
Evaluation of a novel antisense oligonucleotide therapy targeting a 5’UTR mutation in the RDH12 gene
Manon Bouckaert
Kyana Van Acker
Maria Georgiou
Filip Van Den Broeck
Margot De Moor
Edith De Bruycker
Alfredo Dueñas Rey
Emma Delanote
Hanne Lenaerts
Melita Kaltak
et al.
C3
Conference
2024
Evaluation of a novel antisense oligonucleotide therapy targeting a 5’UTR mutation in the RDH12 gene
Manon Bouckaert
Kyana Van Acker
Birthe Hilgen
Maria Georgiou
Filip Van Den Broeck
Margot De Moor
Edith De Bruycker
Alfredo Dueñas Rey
Emma Delanote
Hanne Lenaerts
et al.
C3
Conference
2024
Evaluation of a novel antisense oligonucleotide therapy targeting a 5’UTR mutation in the RDH12 gene
Manon Bouckaert
Kyana Van Acker
Maria Georgiou
Filip Van Den Broeck
Edith De Bruycker
Alfredo Dueñas Rey
Emma Delanote
Hanne Lenaerts
Melita Kaltak
Elfride De Baere
et al.
C3
Conference
2024
Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells
Helena Vanluchene
Oriane Gillon
Karen Peynshaert
Stefaan De Smedt
Niek Sanders
Koen Raemdonck
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2024
Nucleic acid degradation as barrier to gene delivery : a guide to understand and overcome nuclease activity
Heyang Zhang
Jo Vandesompele
Kevin Braeckmans
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
CHEMICAL SOCIETY REVIEWS
2024
2023
Cationic amino-acid functionalized polymethacrylamide vectors for siRNA transfection based on modification of poly(2-isopropenyl-2-oxazoline)
Adriana Jerca
Cristina Muntean
Katrien Remaut
Valentin-Victor Jerca
Koen Raemdonck
Richard Hoogenboom
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis
Helena Braet
Peter-Paul Fransen
Remco Mariën
Giovanna Lollo
Wim Ceelen
Chris Vervaet
Lieve Balcaen
Frank Vanhaecke
Christian Vanhove
Stefan van der Vegte
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2023
Dual-modality hafnium oxide nanocrystals for in vivo computed tomography and fluorescence imaging of sentinel lymph nodes
Loren Deblock
Benedicte Descamps
Ilia Goemaere
Eline Goossens
Glenn Vergauwen
Jens Debacker
Philippe Tummers
Katrien Remaut
Isabel Van Driessche
Klaartje De Buysser
et al.
A1
Journal Article
in
CHEMISTRY OF MATERIALS
2023
Every nano-step counts : a critical reflection on do’s and don’ts in researching nanomedicines for retinal gene therapy
Karen Peynshaert
Joke Devoldere
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
EXPERT OPINION ON DRUG DELIVERY
2023
High pressure nebulization of smart hydrogels : driving intraperitoneal drug delivery forward
Helena Braet
Katrien Remaut
Stefaan De Smedt
Dissertation
2023
Hybrid core-shell particles for mRNA systemic delivery
Valentina Andretto
Mathieu Repellin
Marine Pujol
Eyad Almouazen
Jacqueline Sidi-Boumedine
Thierry Granjon
Heyang Zhang
Katrien Remaut
Lars Petter Jordheim
Stéphanie Briançon
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
Immunogenicity versus efficacy of lipid nanoparticle-mediated delivery of mRNA and self-amplifying mRNA to the retina
Helena Vanluchene
Katrien Remaut
Niek Sanders
Koen Raemdonck
Dissertation
2023
Repositioning the antihistamine ebastine as an intracellular siRNA delivery enhancer
Cristina Muntean
Eva Blondeel
Laure Harinck
Kunal Pednekar
Jai Prakash
Olivier De Wever
Jeanne Leblond Chain
Stefaan De Smedt
Katrien Remaut
Koen Raemdonck
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2023
Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions
Helena Braet
Peter-Paul Fransen
Yong Chen
Simon Van Herck
Remco Mariën
Valérie Vanhoorne
Wim Ceelen
Annemieke Madder
Steven Ballet
Richard Hoogenboom
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2023
Strategies to overcome the lysosomal entrapment of siRNA therapeutics and chemotherapeutic drugs
Cristina Muntean
Koen Raemdonck
Katrien Remaut
Dissertation
2023
The effect of electrostatic high pressure nebulization on the stability, activity and ex vivo distribution of ionic self-assembled nanomedicines
Helena Braet
Valentina Andretto
Remco Mariën
Beyza Yücesan
Stefan van der Vegte
Ragna Haegebaert
Giovanna Lollo
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ACTA BIOMATERIALIA
2023
2022
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugs
Bram Bogaert
Felix Sauvage
Roberta Guagliardo
Cristina Muntean
[missing] Van Phuc Nguyen
Eline Pottie
Mike Wels
An-Katrien Minnaert
Riet De Rycke
Qiangbing Yang
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2022
ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery
Karen Peynshaert
Helena Vanluchene
Kaat De Clerck
An-Katrien Minnaert
Morgane Verhoeven
Noémie Gouspillou
Nezahat Bostan
Toshio Hisatomi
Geraldine Accou
Félix Sauvage
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2022
Laser-induced nanobubbles safely ablate vitreous opacities in vivo
Félix Sauvage
Van Phuc Nguyen
Yanxiu Li
Aranit Harizaj
J. Sebag
Dimitri Roels
Viktor Van Havere
Karen Peynshaert
Ranhua Xiong
Juan Fraire
et al.
A1
Journal Article
in
NATURE NANOTECHNOLOGY
2022
Nanoparticle mediated targeting of toll-like receptors to treat colorectal cancer
Ragna Haegebaert
Maxime Kempers
Wim Ceelen
Ine Lentacker
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2022
Ocular enzyme delivery and nanotechnology : expanding the therapeutic horizon for vitreoretinal diseases
An-Katrien Minnaert
Katrien Remaut
Stefaan De Smedt
Dissertation
2022
Photodisruption of the inner limiting membrane : exploring ICG loaded nanoparticles as photosensitizers
Kaat De Clerck
Geraldine Accou
Félix Sauvage
Kevin Braeckmans
Stefaan De Smedt
Katrien Remaut
Karen Peynshaert
A1
Journal Article
in
PHARMACEUTICS
2022
Yeast-produced fructosamine-3-kinase retains mobility after ex vivo intravitreal injection in human and bovine eyes as determined by Fluorescence Correlation Spectroscopy
An-Katrien Minnaert
Loes van Schie
Hendrik Grootaert
Jonas Himpe
Simon Devos
Wannes Weyts
Herlinde De Keersmaecker
Kevin Braeckmans
Elisabeth Van Aken
Joris Delanghe
et al.
A1
Journal Article
in
INTERNATIONAL JOURNAL OF PHARMACEUTICS
2022
2021
Aerosolization of thermosensitive hydrogels using pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Mohammad Rahimi Gorji
Helena Braet
Charlotte Debbaut
Ghader Ghorbaniasl
Sarah Cosyns
Wouter Willaert
Katrien Remaut
Wim Ceelen
C3
Conference
2021
Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery
Helena Braet
Mohammad Rahimi Gorji
Charlotte Debbaut
G Ghorbaniasl
Thibault Van Walleghem
Senne Cornelis
Sarah Cosyns
Chris Vervaet
Wouter Willaert
Wim Ceelen
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2021
Lipoplexes to deliver oligonucleotides in gram-positive and gram-negative bacteria : towards treatment of blood infections
Sara Pereira
Rita Sobral Santos
Luís Moreira
Nuno Guimarães
Mariana Gomes
Heyang Zhang
Katrien Remaut
Kevin Braeckmans
Stefaan De Smedt
Nuno Filipe Azevedo
A1
Journal Article
in
PHARMACEUTICS
2021
Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across
An-Katrien Minnaert
Helena Vanluchene
Rein Verbeke
Ine Lentacker
Stefaan De Smedt
Koen Raemdonck
Niek Sanders
Katrien Remaut
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2021
Together is better : mRNA co‐encapsulation in lipoplexes is required to obtain ratiometric co‐delivery and protein expression on the single cell level
Heyang Zhang
Jeroen Bussmann
Florian H. Huhnke
Joke Devoldere
An-Katrien Minnaert
Wim Jiskoot
Friedhelm Serwane
Joachim Spatz
Magnus Röding
Stefaan De Smedt
et al.
A1
Journal Article
in
ADVANCED SCIENCE
2021
Vaccinia virus protein B18R : influence on mRNA immunogenicity and translation upon non-viral delivery in different ocular cell types
An-Katrien Minnaert
Joke Devoldere
Karen Peynshaert
Laure Vercruysse
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
PHARMACEUTICS
2021
2020
Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner
Thijs Van de Vyver
Bram Bogaert
Lynn De Backer
Freya Joris
Roberta Guagliardo
Jelter Van Hoeck
Pieterjan Merckx
Serge Van Calenbergh
Srinivas Ramishetti
Dan Peer
et al.
A1
Journal Article
in
ACS NANO
2020
Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides
Chun Yin Jerry Lau
Federico Fontana
Laurens D. B. Mandemaker
Dennie Wezendonk
Benjamin Vermeer
Alexandre M. J. J. Bonvin
Renko de Vries
Heyang Zhang
Katrien Remaut
Joep van den Dikkenberg
et al.
A1
Journal Article
in
COMMUNICATIONS CHEMISTRY
2020
Electrostatic intraperitoneal aerosol delivery of nanoparticles : proof of concept and preclinical validation
Leen Van de Sande
Mohammad Rahimi Gorji
Silvia Giordano
Enrico Davoli
Cristina Matteo
Sonke Detlefsen
Katharina D'Herde
Helena Braet
Molood Shariati
Katrien Remaut
et al.
A1
Journal Article
in
ADVANCED HEALTHCARE MATERIALS
2020
Electrostatic precipitation is a valuable adjunct to pressurized intraperitoneal aerosol chemotherapy : an in vitro study
Leen Van de Sande
Melanie Coetsier
Azarie Victor
Sarah Cosyns
Wouter Willaert
Molood Shariati
Helena Braet
Katrien Remaut
Wim Ceelen
C3
Conference
2020
Exploring the interface between nanomedicines and aerosolization for intraperitoneal drug delivery
Molood Shariati
Katrien Remaut
Stefaan De Smedt
Wim Ceelen
Dissertation
2020
Fluorescence-based quantification of messenger RNA and plasmid DNA decay kinetics in extracellular biological fluids and cell extracts
Heyang Zhang
Koen Rombouts
Laurens Raes
Ranhua Xiong
Stefaan De Smedt
Kevin Braeckmans
Katrien Remaut
A1
Journal Article
in
ADVANCED BIOSYSTEMS
2020
Hyaluronic acid coating of gold nanoparticles for intraocular drug delivery : evaluation of the surface properties and effect on their distribution
P. S. Apaolaza
M. Busch
E. Asin-Prieto
Karen Peynshaert
R. Rathod
Katrien Remaut
N. Dünker
A. Göpferich
A1
Journal Article
in
EXPERIMENTAL EYE RESEARCH
2020
Influence of pathogenic stimuli on Müller cell transfection by lipoplexes
Karen Peynshaert
Joke Devoldere
Frederik Philips
Fauve Vergauwe
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2020
Intraperitoneal aerosolized drug delivery : technology, recent developments, and future outlook
Mohammad Rahimi Gorji
Leen Van de Sande
Charlotte Debbaut
Ghader Ghorbaniasl
Helena Braet
Sarah Cosyns
Katrien Remaut
Wouter Willaert
Wim Ceelen
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2020
Intraperitoneal chemotherapy for peritoneal metastases : an expert opinion
Wim Ceelen
Helena Braet
Gabrielle Van Ramshorst
Wouter Willaert
Katrien Remaut
A1
Journal Article
in
EXPERT OPINION ON DRUG DELIVERY
2020
Local release of siRNA using polyplex-loaded thermosensitive hydrogels
Lies A. L. Fliervoet
Heyang Zhang
Emma van Groesen
Kyra Fortuin
Naut J. C. B. Duin
Katrien Remaut
Raymond M. Schiffelers
Wim E. Hennink
Tina Vermonden
A1
Journal Article
in
NANOSCALE
2020
Materials and technologies to combat counterfeiting of pharmaceuticals : current and future problem tackling
Heyang Zhang
Dawei Hua
Chaobo Huang
Sangram Keshari Samal
Ranhua Xiong
Félix Sauvage
Kevin Braeckmans
Katrien Remaut
Stefaan De Smedt
A1
Journal Article
in
ADVANCED MATERIALS
2020
Nanomaterials to avoid and destroy protein aggregates
Félix Sauvage
Joost Schymkowitz
Frederic Rousseau
Bela Z. Schmidt
Katrien Remaut
Kevin Braeckmans
Stefaan De Smedt
A1
Journal Article
in
NANO TODAY
2020
Nebulization of thermosensitive hydrogels to treat peritoneal carcinomatosis
Helena Braet
Mohammad Rahimi Gorji
Charlotte Debbaut
Wim Ceelen
Stefaan De Smedt
Katrien Remaut
C3
Conference
2020
Ocular barriers to retinal delivery of intravitreal liposomes : impact of vitreoretinal interface
Shirin Tavakoli
Karen Peynshaert
Tatu Lajunen
Joke Devoldere
Eva M. del Amo
Marika Ruponen
Stefaan De Smedt
Katrien Remaut
Arto Urtti
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2020
Pressurized intraperitoneal aerosol chemotherapy for the treatment of irresectable peritoneal metastasis
Leen Van de Sande
Wim Ceelen
Wouter Willaert
Katrien Remaut
Dissertation
2020
Synergy between intraperitoneal aerosolization (PIPAC) and cancer nanomedicine : cisplatin-loaded polyarginine-hyaluronic acid nanocarriers efficiently eradicate peritoneal metastasis of advanced human ovarian cancer
Molood Shariati
Giovanna Lollo
Kevin Matha
Benedicte Descamps
Christian Vanhove
Leen Van de Sande
Wouter Willaert
Lieve Balcaen
Frank Vanhaecke
Jean-Pierre Benoit
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2020
The versatility of nucleic acids : a detailed view on mRNA therapeutics and the exploration of oligonucleotides for in-drug labeling
Heyang Zhang
Katrien Remaut
Stefaan De Smedt
Dissertation
2020
2019
Aerosolization of nanotherapeutics as a newly emerging treatment regimen for peritoneal carcinomatosis
Molood Shariati
Wouter Willaert
Wim Ceelen
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
CANCERS
2019
Establishment of a rat ovarian peritoneal metastasis model to study pressurized intraperitoneal aerosol chemotherapy (PIPAC)
Leen Van de Sande
Wouter Willaert
Sarah Cosyns
Kaat De Clercq
Molood Shariati
Katrien Remaut
Wim Ceelen
A1
Journal Article
in
BMC CANCER
2019
High pressure nebulization (PIPAC) versus injection for the intraperitoneal administration of mRNA complexes
Molood Shariati
Heyang Zhang
Leen Van de Sande
Benedicte Descamps
Christian Vanhove
Wouter Willaert
Wim Ceelen
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2019
Morphology and composition of the inner limiting membrane : species-specific variations and relevance toward drug delivery research
Karen Peynshaert
Joke Devoldere
An-Katrien Minnaert
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
CURRENT EYE RESEARCH
2019
Müller cells as a target for retinal therapy
Joke Devoldere
Karen Peynshaert
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
DRUG DISCOVERY TODAY
2019
Non-viral delivery of chemically modified mRNA to the retina : subretinal versus intravitreal administration
Joke Devoldere
Karen Peynshaert
Heleen Dewitte
Christian Vanhove
Lies De Groef
Lieve Moons
Sinem Yilmaz Özcan
Deniz Dalkara
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2019
Photoablation of human vitreous opacities by light-induced vapor nanobubbles
Félix Sauvage
Juan Fraire
Katrien Remaut
J Sebag
Karen Peynshaert
Michael Harrington
Frans J Van de Velde
Ranhua Xiong
Marie-Jose Tassignon
Toon Brans
et al.
A1
Journal Article
in
ACS NANO
2019
Potential and pitfalls of non-viral mRNA delivery for ocular therapies
Joke Devoldere
Katrien Remaut
Stefaan De Smedt
Dissertation
2019
The obstacle course to the inner retina : hyaluronic acid-coated lipoplexes cross the vitreous but fail to overcome the inner limiting membrane
Joke Devoldere
Mike Wels
Karen Peynshaert
Heleen Dewitte
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2019
2018
Endosomal size and membrane leakiness influence proton sponge-based rupture of endosomal vesicles
Lotte Vermeulen
Toon Brans
Sangram Keshari Samal
Peter Dubruel
Jo Demeester
Stefaan De Smedt
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
ACS NANO
2018
Fluorescence correlation spectroscopy to find the critical balance between extracellular association and intracellular dissociation of mRNA complexes
Heyang Zhang
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ACTA BIOMATERIALIA
2018
In vitro and ex vivo models to study drug delivery barriers in the posterior segment of the eye
Karen Peynshaert
Joke Devoldere
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2018
Investigating the intracellular delivery of non-viral gene therapeutics : a focus on the endosomal barrier
Lotte Vermeulen
Kevin Braeckmans
Katrien Remaut
Dissertation
2018
Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy
Lotte Vermeulen
Toon Brans
Stefaan De Smedt
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
NANO TODAY
2018
Photothermally triggered endosomal escape and its influence on transfection efficiency of gold-functionalized JetPEI/pDNA nanoparticles
Lotte Vermeulen
Juan Fraire
Laurens Raes
Ellen De Meester
Sarah De Keulenaer
Filip Van Nieuwerburgh
Stefaan De Smedt
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2018
Post-PEGylated and crosslinked polymeric ssRNA nanocomplexes as adjuvants targeting lymph nodes with increased cytolytic T cell inducing properties
Bo Lou
Ans De Beuckelaer
George Dakwar
Katrien Remaut
Johan Grooten
Kevin Braeckmans
Bruno De Geest
Enrico Mastrobattista
Stefaan De Koker
Wim E. Hennink
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2018
Quantifying the average number of nucleic acid therapeutics per nanocarrier by single particle tracking microscopy
Elisa Zagato
Lotte Vermeulen
Heleen Dewitte
Griet Van Imschoot
Roosmarijn Vandenbroucke
Jo Demeester
Stefaan De Smedt
Kristiaan Neyts
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2018
Search for the source of the retinal relaxing factor
Laura Vanden Daele
Charlotte Boydens
Joke Devoldere
Katrien Remaut
Johan Van de Voorde
A1
Journal Article
in
CURRENT EYE RESEARCH
2018
Technical implementations of light sheet microscopy
Elisa Zagato
Toon Brans
Stefaan De Smedt
Katrien Remaut
Kristiaan Neyts
Kevin Braeckmans
A1
Journal Article
in
MICROSCOPY RESEARCH AND TECHNIQUE
2018
The proton sponge hypothesis : fable or fact?
Lotte Vermeulen
Stefaan De Smedt
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
2018
Towards the development of a RNAi-based topical treatment for psoriasis : proof-of-concept in a 3D psoriasis skin model
Eline Desmet
Mireille Van Gele
Lynda Grine
Katrien Remaut
Jo Lambert
A1
Journal Article
in
EXPERIMENTAL DERMATOLOGY
2018
What you see is what you get : the physicochemistry of nanoparticles dictates how they cross ocular delivery barriers and alter autophagy
Karen Peynshaert
Katrien Remaut
Stefaan De Smedt
Dissertation
2018
2017
Coating of quantum dots strongly defines their effect on lysosomal health and autophagy
Karen Peynshaert
Stefaan J Soenen
Bella B Manshian
Shareen H Doak
Kevin Braeckmans
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ACTA BIOMATERIALIA
2017
Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy
Thomas Martens
Karen Peynshaert
Thaís Leite Nascimento
Elias Fattal
Marcus Karlstetter
Thomas Langmann
Serge Picaud
Jo Demeester
Stefaan De Smedt
Katrien Remaut
et al.
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2017
Expanding the biologist's toolbox with microfabricated sample holders for single objective SPIM and Single Particle Tracking for the characterization of nanomedicines
Elisa Zagato
Kevin Braeckmans
Katrien Remaut
Kristiaan Neyts
Dissertation
2017
Exploring the HYDRAtion method for loading siRNA on liposomes : the interplay between stability and biological activity in human undiluted ascites fluid
George Dakwar
Kevin Braeckmans
Wim Ceelen
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
2017
High-pressure nebulization as application route for the peritoneal administration of siRNA complexes
An-Katrien Minnaert
George Dakwar
Juan M Benito
José M García Fernández
Wim Ceelen
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
MACROMOLECULAR BIOSCIENCE
2017
Microfabricated devices for single objective single plane illumination microscopy (SoSPIM)
Elisa Zagato
Toon Brans
Steven Verstuyft
Dries Van Thourhout
Jeroen Missinne
Geert Van Steenberge
Jo Demeester
Stefaan De Smedt
Katrien Remaut
Kristiaan Neyts
et al.
A1
Journal Article
in
OPTICS EXPRESS
2017
Nanomedicine-based intraperitoneal therapy for the treatment of peritoneal carcinomatosis : mission possible?
George Dakwar
Molood Shariati
Wouter Willaert
Wim Ceelen
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2017
PEGylated and functionalized aliphatic polycarbonate polyplex nanoparticles for intravenous administration of HDAC5 siRNA in cancer therapy
Antoine Frère
Alexandra Baroni
Elodie Hendrick
Anne-Sophie Delvigne
François Orange
Olivier Peulen
George Dakwar
Jérôme Diricq
Philippe Dubois
Brigitte Evrard
et al.
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2017
Toward smart design of retinal drug carriers : a novel bovine retinal explant model to study the barrier role of the vitreoretinal interface
Karen Peynshaert
Joke Devoldere
Valérie Forster
Serge Picaud
Christian Vanhove
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
DRUG DELIVERY
2017
2016
Aerosolized non-viral nucleic acid delivery in the vaginal tract of pigs
Katrien Remaut
Evelien De Clercq
Oliwia Andries
Koen Rombouts
Matthias Van Gils
Laetitia Cicchelero
Ian Vandenbussche
Sarah Van Praet
Juan Manuel Benito
José Manuel Garcia Fernandéz
et al.
A1
Journal Article
in
PHARMACEUTICAL RESEARCH
2016
Approximate Bayesian computation for estimating number concentrations of monodisperse nanoparticles in suspension by optical microscopy
Magnus Röding
Elisa Zagato
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
PHYSICAL REVIEW E
2016
Evading innate immunity in nonviral mRNA delivery : don't shoot the messenger
Joke Devoldere
Heleen Dewitte
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
DRUG DISCOVERY TODAY
2016
Exploring the intraperitoneal route of administration for siRNA delivery in the treatment of pertitoneal carcinomatosis
George Dakwar
Katrien Remaut
Stefaan De Smedt
Wim Ceelen
Dissertation
2016
Fluorescent labeling of DNA : strategies, pitfalls and necessity for fluorescence microscopy investigations of gene therapy
Koen Rombouts
Katrien Remaut
Kevin Braeckmans
Dissertation
2016
Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies
Koen Rombouts
Kevin Braeckmans
Katrien Remaut
A1
Journal Article
in
BIOCONJUGATE CHEMISTRY
2016
Freeze-dried mucoadhesive polymeric system containing pegylated lipoplexes : towards a vaginal sustained released system for siRNA
Tania Furst
George Dakwar
Elisa Zagato
Anna Lechanteur
Katrien Remaut
Brigitte Evrard
Kevin Braeckmans
Geraldine Piel
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2016
2015
Coating nanocarriers with hyaluronic acid facilitates intravitreal drug delivery for retinal gene therapy
Thomas Martens
Katrien Remaut
Hendrik Deschout
Johan FJ Engbersen
Wim E Hennink
Mies J van Steenbergen
Jo Demeester
Stefaan De Smedt
Kevin Braeckmans
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2015
Disregarded effect of biological fluids in siRNA delivery : human ascites fluid severely restricts cellular uptake of nanoparticles
George Dakwar
Kevin Braeckmans
Jo Demeester
Wim Ceelen
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ACS APPLIED MATERIALS & INTERFACES
2015
Effect of native gastric mucus on in vivo hybridization therapies directed at Helicobacter pylori
Rita Santos
George Dakwar
Ranhua Xiong
Katrien Forier
Katrien Remaut
Stephan Stremersch
Nuno Guimarães
Silvia Fontenete
Jesper Wengel
Marina Leite
et al.
A1
Journal Article
in
MOLECULAR THERAPY-NUCLEIC ACIDS
2015
Intraperitoneal nonviral nucleic acid delivery in the treatment of peritoneal cancer
George Dakwar
Stefaan De Smedt
Katrien Remaut
Bookchapter
in
Intraperitoneal cancer therapy : principles and practice
2015
Mechanistic profiling of the siRNA delivery dynamics of lipid-polymer hybrid nanoparticles
Stefano Colombo
Dongmei Cun
Katrien Remaut
Matt Bunker
Jianxin Zhang
Birte Martin-Bertelsen
Anan Yaghmur
Kevin Braeckmans
Hanne M. Nielsen
Camilla Foged
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2015
Targeted decationized polyplexes for siRNA delivery
Luis Novo
Kaori M Takeda
Tamara Petteta
George Dakwar
Joep B van den Dikkenberg
Katrien Remaut
Kevin Braeckmans
Cornelus F van Nostrum
Enrico Mastrobattista
Wim E Hennink
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2015
2014
Cell division responsive peptides for optimized plasmid DNA delivery : the mitotic window of opportunity?
Katrien Remaut
Nathalie Symens
Bart Lucas
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Colloidal stability of nano-sized particles in the peritoneal fluid : towards optimizing drug delivery systems for intraperitoneal therapy
George Dakwar
Elisa Zagato
Joris Delanghe
Sabina Hobel
Achim Aigner
Hannelore Denys
Kevin Braeckmans
Wim Ceelen
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ACTA BIOMATERIALIA
2014
Decationized polyplexes as stable and safe carrier systems for improved biodistribution in systemic gene therapy
Luís Novo
Larissa Y Rizzo
Suzanne K Golombek
George Dakwar
Bo Lou
Katrien Remaut
Enrico Mastrobattista
Cornelus F van Nostrum
Wilhelm Jahnen-Dechent
Fabian Kiessling
et al.
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Effect of covalent fluorescence labeling of plasmid DNA on its intracellular processing and transfection with lipid-based carriers
Koen Rombouts
Thomas Martens
Elisa Zagato
Jo Demeester
Stefaan De Smedt
Kevin Braeckmans
Katrien Remaut
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2014
Intracellular delivery of nanomaterials: how to catch endosomal escape in the act
Thomas Martens
Katrien Remaut
Jo Demeester
Stefaan De Smedt
Kevin Braeckmans
A1
Journal Article
in
NANO TODAY
2014
Lysosomal capturing of cytoplasmic injected nanoparticles by autophagy: an additional barrier to non viral gene delivery
Katrien Remaut
Viola Oorschot
Kevin Braeckmans
Judith Klumperman
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2014
Optimizing delivery of gene nanomedicines towards the retina via intravitreal administration
Thomas Martens
Kevin Braeckmans
Stefaan De Smedt
Katrien Remaut
Dissertation
2014
Single-particle tracking for studying nanomaterial dynamics: applications and fundamentals in drug delivery
Elisa Zagato
Katrien Forier
Thomas Martens
Kristiaan Neyts
Jo Demeester
Stefaan De Smedt
Katrien Remaut
Kevin Braeckmans
A1
Journal Article
in
NANOMEDICINE
2014
2013
Correlation of dual colour single particle trajectories for improved detection and analysis of interactions in living cells
Hendrik Deschout
Thomas Martens
Dries Vercauteren
Katrien Remaut
Jo Demeester
Stefaan De Smedt
Kristiaan Neyts
Kevin Braeckmans
A1
Journal Article
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2013
Measuring the intravitreal mobility of nanomedicines with single-particle tracking microscopy
Thomas Martens
Dries Vercauteren
Katrien Forier
Hendrik Deschout
Katrien Remaut
Rik Paesen
Marcel Ameloot
Johan FJ Engbersen
Jo Demeester
Stefaan De Smedt
et al.
A1
Journal Article
in
NANOMEDICINE
2013
Noncoding DNA in lipofection of HeLa cells: a few insights
Nathalie Symens
Joanna Rejman
Bart Lucas
Jo Demeester
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2013
2012
An ex vivo assay to measure the mobility inside the eye of nanomedicines for retinal gene therapy
Thomas Martens
Dries Vercauteren
Katrien Forier
Hendrik Deschout
Katrien Remaut
Jo Demeester
Stefaan De Smedt
Kevin Braeckmans
C3
Conference
2012
Efficient transfection of hepatocytes mediated by mRNA complexed to galactosylated cyclodextrins
Nathalie Symens
Alejandro Méndez-Ardoy
Alejandro Diaz-Moscoso
Elena Sánchez-Fernéndez
Katrien Remaut
Jo Demeester
José M García Fernández
Stefaan De Smedt
Joanna Rejman
A1
Journal Article
in
BIOCONJUGATE CHEMISTRY
2012
Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis
Nathalie Symens
Stefaan Soenen
Joanna Rejman
Kevin Braeckmans
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2012
Matrix systems for siRNA delivery
Broes Naeye
Koen Raemdonck
Katrien Remaut
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
CURRENT TOPICS IN MEDICINAL CHEMISTRY
2012
Overcoming intracellular barriers in non-viral gene delivery : chromatin targeting, messenger RNA and non-coding DNA
Nathalie Symens
Stefaan De Smedt
Katrien Remaut
Joanna Rejman
Dissertation
2012
2011
Dynamic colocalization microscopy to characterize intracellular trafficking of nanomedicines
Dries Vercauteren
Hendrik Deschout
Katrien Remaut
Johan FJ Engbersen
Arwyn T Jones
Jo Demeester
Stefaan De Smedt
Kevin Braeckmans
A1
Journal Article
in
ACS NANO
2011
Nuclear inclusion of nontargeted and chromatin-targeted polystyrene beads and plasmid DNA containing nanoparticles
Nathalie Symens
Rudolf Walczak
Jo Demeester
Iain Mattaj
Stefaan De Smedt
Katrien Remaut
A1
Journal Article
in
MOLECULAR PHARMACEUTICS
2011
2010
Advanced fluorescence microscopy methods illuminate the transfection pathway of nucleic acid nanoparticles
Kevin Braeckmans
Kevin Buyens
Broes Naeye
Dries Vercauteren
Hendrik Deschout
Koen Raemdonck
Katrien Remaut
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2010
Efficient delivery of intact phosphodiester oligonucleotides by poly-β-amino esters
Katrien Remaut
Nathalie Symens
Bart Lucas
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2010
PEGylation of biodegradable dextran nanogels for siRNA delivery
Broes Naeye
Koen Raemdonck
Katrien Remaut
B Sproat
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
2010
2007
Can we better understand the intracellular behavior of DNA nanoparticles by fluorescence correlation spectroscopy?
Katrien Remaut
Bart Lucas
Koen Raemdonck
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2007
Exploring the relation between the intracellular fate and biological activity of nucleic acid nanoparticles
Katrien Remaut
S De Smedt
J Demeester
Dissertation
2007
Line FRAP with the confocal laser scanning microscope for diffusion measurements in small regions of 3-D samples
Kevin Braeckmans
Katrien Remaut
Roosmarijn Vandenbroucke
Bart Lucas
Stefaan De Smedt
Jo Demeester
A1
Journal Article
in
BIOPHYSICAL JOURNAL
2007
Nucleic acid delivery: Where material sciences and bio-sciences meet
Katrien Remaut
Niek Sanders
Bruno De Geest
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
MATERIALS SCIENCE & ENGINEERING R-REPORTS
2007
Pegylation of liposomes favours the endosornal degradation of the delivered phosphodiester oligonucleotides
Katrien Remaut
Bart Lucas
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2007
Protection of oligonucleotides against enzymatic degradation by pegylated and nonpegylated branched polyethyleneimine
Katrien Remaut
Bart Lucas
Koen Raemdonck
Kevin Braeckmans
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
BIOMACROMOLECULES
2007
2006
Anomalous photobleaching in fluorescence recovery after photobleaching measurements due to excitation saturation- a case study for fluorescein
Kevin Braeckmans
Barbara Stubbe
Katrien Remaut
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF BIOMEDICAL OPTICS
2006
Characterization of the mode of incorporation of lipophilic compounds in solid dispersions at the nanoscale using fluorescence resonance energy transfer (FRET)
DJ VAN DROOGE
Kevin Braeckmans
WLJ HINRICHS
Katrien Remaut
Stefaan De Smedt
HW FRIJLINK
A1
Journal Article
in
MACROMOLECULAR RAPID COMMUNICATIONS
2006
Delivery of phosphodiester oligonucleotides: Can DOTAP/DOPE liposomes do the trick?
Katrien Remaut
Bart Lucas
Kevin Braeckmans
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
BIOCHEMISTRY
2006
In situ analysis of single-stranded and duplex siRNA integrity in living cells
Koen Raemdonck
Katrien Remaut
Bart Lucas
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
BIOCHEMISTRY
2006
Influence of plasmid DNA topology on the transfection properties of DOTAP/DOPE lipoplexes
Katrien Remaut
Niek Sanders
Farzaneh Fayazpour
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2006
2005
Fluorescence energy transfer to study the degradation of double-labeled oligonucleotides
Katrien Remaut
Bart Lucas
Kevin Braeckmans
Niek Sanders
Stefaan De Smedt
Jo Demeester
C3
Conference
2005
FRET-FCS as a tool to evaluate the stability of oligonucleotide drugs after intracellular delivery
Katrien Remaut
Bart Lucas
Kevin Braeckmans
Niek Sanders
Stefaan De Smedt
Jo Demeester
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2005
Protection of oligonucleotides against nucleases by pegylated and non-pegylated liposomes as studied by fluorescence correlation spectroscopy
Katrien Remaut
Bart Lucas
Kevin Braeckmans
Niek Sanders
Jo Demeester
Stefaan De Smedt
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2005
Studying biophysical barriers to DNA delivery by advanced light microscopy
Stefaan De Smedt
Katrien Remaut
Bart Lucas
Kevin Braeckmans
Niek Sanders
Jo Demeester
A1
Journal Article
in
ADVANCED DRUG DELIVERY REVIEWS
2005
Studying the intracellular dissociation of polymer-oligonucleotide complexes by dual color fluorescence fluctuation spectroscopy and confocal imaging
Bart Lucas
Katrien Remaut
Niek Sanders
Kevin Braeckmans
Stefaan De Smedt
Jo Demeester
A1
Journal Article
in
BIOCHEMISTRY
2005
Towards a better understanding of the dissociation behavior of liposome-oligonucleotide complexes in the cytosol of cells
Bart Lucas
Katrien Remaut
Niek Sanders
Kevin Braeckmans
Stefaan De Smedt
Jo Demeester
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2005
2004
123I-EGF internalisation in tumour cells in vitro is inhibited by farnesyltransferase inhibitor therapy: possible target for early therapy response prediction
Bart Cornelissen
Katrien Remaut
Veerle Kersemans
Ruth Oltenfreiter
Ingrid Burvenich
Guido Slegers
C3
Conference
2004
On the biological activity of anti-ICAM-1 oligonucleotides complexed to non-viral carriers
Bart Lucas
Elsa Van Rompaey
Katrien Remaut
Niek Sanders
Stefaan De Smedt
Jo Demeester
A1
Journal Article
in
JOURNAL OF CONTROLLED RELEASE
2004
Studying pegylated DNA complexes by dual color fluorescence fluctuation spectroscopy
Bart Lucas
Katrien Remaut
Kevin Braeckmans
Jurgen Haustraete
Stefaan De Smedt
Jo Demeester
A1
Journal Article
in
MACROMOLECULES
2004