Research Explorer

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Jonas Steenbrugge

Prijzen & Erkenningen

35 Resultaten

2025

Canine mammary carcinomas are associated with an immunosuppressed, vascularized and proliferative microenvironment

Caro De HaesHilde De RoosterKristel DemeyereHilde De CockEvelyne MeyerJonas Steenbrugge

Feline mammary carcinomas are associated with an immunosuppressed vascularized and proliferative microenvironment

Caro De HaesHilde De RoosterKristel DemeyereHilde De CockEvelyne MeyerJonas Steenbrugge

Transcriptomic heterogeneity of nine complementary mouse TNBC models based on their comparative in vitro and in vivo characterization

Robbe SalembierCaro De HaesBo WylinKristel DemeyereSteven Van LaereNiek SandersEvelyne MeyerJonas Steenbrugge

2024

Chitin-mediated blockade of chitinase-like proteins reduces tumor immunosuppression, inhibits lymphatic metastasis and enhances anti-PD-1 efficacy in complementary TNBC models

Robbe SalembierCaro De HaesJulie BellemansKristel DemeyereWim Van Den BroeckNiek SandersSteven Van LaereTraci R. LyonsEvelyne MeyerJonas Steenbrugge

A1 Artikel in een tijdschrift in BREAST CANCER RESEARCH

Comparative profiling of mouse TNBC models with differential TME states that mimic clinical heterogeneity

Robbe SalembierCaro De HaesBo WylinKristel DemeyereEvelyne MeyerJonas Steenbrugge

Lipocalin-2 blockade enhances anti-PD-1 efficacy in an immunosuppressed mouse TNBC model

Caro De HaesRobbe SalembierBo WylinKristel DemeyereEvelyne MeyerJonas Steenbrugge

Lipocalin-2 blockade reduces tumor growth and neutrophil infiltration in a mouse model for TNBC

Caro De HaesRobbe SalembierBo WylinKristel DemeyereNiek SandersEvelyne MeyerJonas Steenbrugge

2023

Characterization of the immune landscape of canine and feline mammary tumors as a basis for candidate biomarker, drug and toxicity studies

Jonas SteenbruggeCaro De HaesJulie BellemansKristel DemeyereHilde De RoosterEvelyne Meyer

Chitinase 3-like 1 stimulates macrophage-mediated lymphatic remodeling in triple-negative breast cancer

Jonas SteenbruggeRobbe SalembierAlan M. ElderEvelyne MeyerTraci R. Lyons

Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis : a proof-of-concept study

Niels Vander ElstJulie BellemansJonas SteenbruggeChloë GeeromsKoen BreyneSofie PiepersBruno Toledo-SilvaFernando Nogueira De SouzaFreddy HaesebrouckSarne De Vliegher et al.

A1 Artikel in een tijdschrift in VETERINARY RESEARCH

Xenogeneic equine stem cells activate anti-tumor adaptive immunity in a 4T1-based intraductal mouse model for triple-negative breast cancer : proof-of-principle

Jonas SteenbruggeGlenn PauwelynKristel DemeyereNausikaa DevriendtHilde De RoosterNiek SandersJan H. SpaasEvelyne Meyer

A1 Artikel in een tijdschrift in FRONTIERS IN IMMUNOLOGY

2022

Chitin immunomodulation stimulates anti-PD-1 therapy in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeJulie BellemansKristel DemeyereNiek SandersEvelyne Meyer

One cisplatin dose provides durable stimulation of anti-tumor immunity and alleviates anti-PD-1 resistance in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeJulie BellemansNiels Vander ElstKristel DemeyereJosephine De VliegherTimothy PereraOlivier De WeverWim Van Den BroeckWard De SpiegelaereNiek Sanders et al.

A1 Artikel in een tijdschrift in ONCOIMMUNOLOGY

One cisplatin dose suffices to maintain anti-tumor immunity and enhances anti-PD-1 efficacy in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeJulie BellemansNiels Vander ElstKristel DemeyereNiek SandersEvelyne Meyer

Progression of canine mammary tumors is associated with an immunosuppressed microenvironment

Jonas SteenbruggeJulie BellemansLennert HeirmanAurelie De RooverKristel DemeyereHilde De RoosterEvelyne Meyer

2021

Immunomodulation by cisplatin chemotherapy in an immunocompetent intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereJosephine De VliegherAnnegret Van der AaEric CiamporceroTimothy PereraEvelyne Meyer

OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckEric CiamporceroTimothy PereraEvelyne Meyer

A1 Artikel in een tijdschrift in NPJ BREAST CANCER

Splenic immunomodulatory effects of cisplatin in an immunocompetent intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereJosephine De VliegherAnnegret Van der AaEric CiamporceroTimothy PereraEvelyne Meyer

Unexpected effects of a selective and potent c-MET inhibitor in an immunocompetent intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckAnnegret Van der AaEric CiamporceroTimothy PereraEvelyne Meyer

2020

Enterobactin deficiency in a coliform mastitis isolate decreases its fitness in a murine model : a preliminary host-pathogen interaction study

Niels Vander ElstKoen BreyneJonas SteenbruggeAmanda Jane GibsonDavid George Emslie SmithPierre GermonDirk WerlingEvelyne Meyer

A1 Artikel in een tijdschrift in FRONTIERS IN VETERINARY SCIENCE

Splenic hematopoietic and stromal cells in cancer progression

Jonas SteenbruggeEmiel De JaeghereEvelyne MeyerHannelore DenysOlivier De Wever

A1 Artikel in een tijdschrift in CANCER RESEARCH

2019

Characterization of an immunocompetent intraductal mouse model for triple-negative breast cancer

Jonas SteenbruggeEvelyne MeyerSteven Van Laere

Comparative immune profiling of an aggressive 4T1-based versus a non-aggressive Py230-based intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverSteven Van LaereEvelyne Meyer

Comparative profiling of metastatic 4T1- vs. non-metastatic Py230-based mammary tumors in an intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckLuc DirixSteven Van LaereEvelyne Meyer

A1 Artikel in een tijdschrift in FRONTIERS IN IMMUNOLOGY

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

Yves DepetterSilke GeursRob De VreeseSophie GoethalsElien VandoornAlien LaevensJonas SteenbruggeEvelyne MeyerPascal de TullioMarc Bracke et al.

A1 Artikel in een tijdschrift in INTERNATIONAL JOURNAL OF CANCER

2018

Anti-inflammatory signaling by mammary tumor cells mediates prometastatic macrophage polarization in an innovative intraductal mouse model for triple-negative breast cancer

Jonas SteenbruggeKoen BreyneKristel DemeyereOlivier De WeverNiek SandersWim Van Den BroeckCecile ColpaertPeter VermeulenSteven Van LaereEvelyne Meyer

A1 Artikel in een tijdschrift in JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Immunomodulation of host chitinase 3-like 1 during a mammary pathogenic Escherichia coli infection

Koen BreyneJonas SteenbruggeKristel DemeyereChun Geun LeeJack A EliasWolfram PetzlDavid GE SmithPierre GermonEvelyne Meyer

A1 Artikel in een tijdschrift in FRONTIERS IN IMMUNOLOGY

Transparent reporting of experimental parameters in assays measuring phenotypic steps in metastasis

Robin BoiyJonas SteenbruggeJan Van DeunAn HendrixEvelyne MeyerOlivier De Wever

A1 Artikel in een tijdschrift in CLINICAL & EXPERIMENTAL METASTASIS

Tumor immune profiling and host NF-kappaB activity assessment in a novel Py230-based intraductal model for triple-negative breast cancer

Jonas SteenbruggeNiels Vander ElstKristel DemeyereNiek SandersOlivier De WeverSteven Van LaereEvelyne Meyer

2017

Efficacy and safety of a bovine-associated Staphylococcus aureus phage cocktail in a murine model of mastitis

Koen BreyneRyan W HonakerZachary HobbsManuela RichterMaciej ZaczekTaylor SpanglerJonas SteenbruggeRebecca LuAnika KinkhabwalaBruno Marchon et al.

A1 Artikel in een tijdschrift in FRONTIERS IN MICROBIOLOGY

Preconditioning with lipopolysaccharide or lipoteichoic acid protects against Staphylococcus aureus mammary infection in mice

Koen BreyneJonas SteenbruggeKristel DemeyereTom Vanden BergheEvelyne Meyer

A1 Artikel in een tijdschrift in FRONTIERS IN IMMUNOLOGY

The crosstalk between macrophages and 4T1 mammary tumor cells promotes metastasis in a novel intraductal model for breast cancer

Jonas SteenbruggeKoen BreyneLore Vander PlanckenKristel DemeyereNiek SandersCecile ColpaertSteven Van LaereEvelyne Meyer

2016

Chitinase 3-like 1 as breast cancer metastasis biomarker for differential tumor progression in the intraductal versus the fat pad preclinical model

Jonas SteenbruggeKoen BreyneSofie DeniesMelissa DekimpeKristel DemeyereOlivier De WeverNiek SandersEvelyne Meyer

Comparison of the adipose and luminal mammary gland compartment as orthotopic inoculation sites in a 4T1-based immunocompetent preclinical model for triple-negative breast cancer

Jonas SteenbruggeKoen BreyneSofie DeniesMelissa DekimpeKristel DemeyereOlivier De WeverPeter VermeulenSteven Van LaereNiek SandersEvelyne Meyer

A1 Artikel in een tijdschrift in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

2015

Is intraductal inoculation of tumour cells a more relevant in vivo model for immune-competent breast cancer metastasis than the classical fat pad model?

Koen BreyneSofie DeniesJonas SteenbruggeMelissa DekimpeKristel DemeyereOlivier De WeverNiek SandersEvelyne Meyer