Research Explorer

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Researcher

Jimmy Van den Eynden

Awards & Distinctions

45 Results

2024

ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition

Marcus BorenäsGanesh UmapathyDan E. LindWei-Yun LaiJikui GuanJoel JohanssonEva JennischeAlexander SchmidtYeshwant KurheJonatan Linus Gabre et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of hyperthermia on cisplatin tissue penetration and gene expression in peritoneal metastases : results from a randomized trial in ovarian cancer

Jesse DemuytereCharlotte CarlierTom Van HeldenJoke BelzaFrank VanhaeckeFeifan XieAn VermeulenJoseph WeertsJürgen ThomaleHannelore Denys et al.

A1 Journal Article in BRITISH JOURNAL OF SURGERY

MHC class II genotypes are independent predictors of anti-PD1 immunotherapy response in melanoma

Arne ClaeysJimmy Van den Eynden

U Journal Article in Communications Medicine

Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN

Jonatan Linus GabrePeter MerseburgerArne ClaeysJoachim SiawSarah-Lee BekaertFranki SpelemanBengt HallbergRuth H PalmerJimmy Van den Eynden

A2 Journal Article in NAR CANCER

2023

A computational exploration of MHC-based immune selection signals in large cancer genome sequencing datasets

Arne ClaeysJimmy Van den EyndenKathleen Marchal

A systematic analysis of immune escape signals in the primary and metastatic tumor genome

Jimmy Van den Eynden

Editorial material

ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via SERPINB4 expression

Tzu-Po ChuangWei-Yun LaiJonatan Linus GabreDan E. LindGanesh UmapathyAbdulmalik A. BokhariBengt BergmanLinnea KristensonFredrik B. ThorénAnh Le et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data

Arne ClaeysPeter MerseburgerJasper StautKathleen MarchalJimmy Van den Eynden

A1 Journal Article in BMC GENOMICS

Quantification of neoantigen-mediated immunoediting in cancer evolution : letter

Arne ClaeysJimmy Van den Eynden

A1 Journal Article in CANCER RESEARCH

2022

A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues

Tom LuijtsKerryn ElliottJoachim SiawJoris Van de VeldeElien BeylsArne ClaeysTim LammensErik LarssonWouter WillaertAnne Vral et al.

A1 Journal Article in SCIENTIFIC REPORTS

Benchmark of tools for in silico prediction of MHC class I and class II genotypes from NGS data

Arne ClaeysJasper StautPeter MerseburgerKathleen MarchalJimmy Van den Eynden

Novel human-derived EML4-ALK fusion cell lines identify ribonucleotide reductase RRM2 as a target of activated ALK in NSCLC

A.A. BokhariW-Y. LaiA.T. LeJ.L. GabreT-P. ChuangS. FranssonB. BergmanA. DjosN. ChenT. Martinsson et al.

A1 Journal Article in LUNG CANCER

2021

ALK ligand ALKAL2 potentiates MYCN‐driven neuroblastoma in the absence of ALK mutation

Marcus BorenäsGanesh UmapathyWei‐Yun LaiDan E LindBarbara WitekJikui GuanPatricia Mendoza‐GarciaTafheem MasudiArne ClaeysTzu‐Po Chuang et al.

A1 Journal Article in EMBO JOURNAL

ATR inhibition enables complete tumour regression in ALK-driven NB mouse models

Joanna SzydzikDan E. LindBadrul ArefinYeshwant KurheGanesh UmapathyJoachim Tetteh SiawArne ClaeysJonatan Linus GabreJimmy Van den EyndenBengt Hallberg et al.

A1 Journal Article in NATURE COMMUNICATIONS

Loss of RET promotes mesenchymal identity in neuroblastoma cells

Joachim T. SiawJonatan Linus GabreEzgi UçkunMarc VignyWancun ZhangJimmy Van den EyndenBengt HallbergRuth H. PalmerJikui Guan

A1 Journal Article in CANCERS

Low immunogenicity of common cancer hot spot mutations resulting in false immunogenic selection signals

Arne ClaeysTom LuijtsKathleen MarchalJimmy Van den Eynden

A1 Journal Article in PLOS Genetics

Network-based analysis to identify drivers of metastatic prostate cancer using GoNetic

Louise de Schaetzen van BrienenGiles MiclotteMaarten LarmuseauJimmy Van den EyndenKathleen Marchal

A1 Journal Article in CANCERS

Pharmacologic RNA splicing modulation : a novel mechanism to enhance neoantigen-directed anti-tumor immunity and immunotherapy response

Kerryn ElliottJonas NilssonJimmy Van den Eynden

Editorial material

2020

11q deletion or ALK activity curbs DLG2 expression to maintain an undifferentiated state in neuroblastoma

Joachim Tetteh SiawNiloufar JavanmardiJimmy Van den EyndenDan Emil LindSusanne FranssonAngela Martinez-MonleonAnna DjosRose-Marie SjöbergMalin ÖstenssonHelena Carén et al.

A1 Journal Article in CELL REPORTS

Separating positional noise from neutral alignment in multicomponent statistical shape models

Emmanuel AudenaertJimmy Van den EyndenDF de AlmeidaG SteenackersD VandermeulenP Claes

A2 Journal Article in BONE REPORTS

2019

Lack of detectable neoantigen depletion signals in the untreated cancer genome

Jimmy Van den EyndenAlejandro Jiménez-SánchezMartin L MillerErik Larsson

A1 Journal Article in NATURE GENETICS

Targeting filamin A reduces macrophage activity and atherosclerosis

Sashidar BandaruChandu AlaReza SalimiMurali K AkulaMatias EkstrandSravani DevarakondaJoakim KarlssonJimmy Van den EyndenGoran BergströmErik Larsson et al.

A1 Journal Article in CIRCULATION

2018

An antisense RNA capable of modulating the expression of the tumor suppressor microRNA-34a

Jason T ServissNathanael AndrewsJimmy Van den EyndenFelix Clemens RichterMiranda HoutmanMattias VesterlundLaura SchwarzmuellerPer JohnssonErik LarssonDan Grandér et al.

A1 Journal Article in CELL DEATH & DISEASE

Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib

Jikui GuanSusanne FranssonJoachim Tetteh SiawDiana TreisJimmy Van den EyndenDamini ChandGanesh UmapathyKristina RuuthPetter SvenbergSandra Wessman et al.

A2 Journal Article in COLD SPRING HARBOR MOLECULAR CASE STUDIES

Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers

Kerryn ElliottMartin BoströmStefan FilgesMarkus LindbergJimmy Van den EyndenAnders StåhlbergAnders R ClausenErik Larsson

A1 Journal Article in PLOS GENETICS

Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways

Jimmy Van den EyndenGanesh UmapathyArghavan AshouriDiana Cervantes-MadridJoanna SzydzikKristina RuuthJan KosterErik LarssonJikui GuanRuth H Palmer et al.

A1 Journal Article in SCIENCE SIGNALING

The genetic structure of the Belgian population

Jimmy Van den EyndenTine DescampsEls DelporteNancy HC RoosensSigrid CJ De KeersmaeckerVanessa De WitJoris Robert VermeeschEls GoetghebeurJean TafforeauStefaan Demarest et al.

A1 Journal Article in HUMAN GENOMICS

2017

Mutational signatures are critical for proper estimation of purifying selection pressures in cancer somatic mutation data when using the dN/dS metric

Jimmy Van den EyndenErik Larsson

A1 Journal Article in FRONTIERS IN GENETICS

Recurrent promoter mutations in melanoma are defined by an extended context-specific mutational signature

Nils Johan FredrikssonKerryn ElliottStefan FilgesJimmy Van den EyndenAnders StåhlbergErik Larsson

A1 Journal Article in PLOS GENETICS

2016

Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events

Arghavan AshouriVolkan I SayinJimmy Van den EyndenSimranjit X SinghThales PapagiannakopoulosErik Larsson

A1 Journal Article in NATURE COMMUNICATIONS

Simultaneous discovery of cancer subtypes and subtype features by molecular data integration

Thanh Le VanMatthijs van LeeuwenAna Carolina Elisa Fierro GutierrezDries De MaeyerJimmy Van den EyndenLieven VerbekeLuc De RaedtKathleen MarchalSiegfries Nijssen

A1 Journal Article in BIOINFORMATICS

Somatic mutation patterns in hemizygous genomic regions unveil purifying selection during tumor evolution

Jimmy Van den EyndenSwaraj BasuErik Larsson

A1 Journal Article in PLOS GENETICS

2015

Pathway relevance ranking for tumor samples through network-based data integration

Lieven VerbekeJimmy Van den EyndenAna Carolina Elisa Fierro GutierrezPiet DemeesterJan FostierKathleen Marchal

A1 Journal Article in PLOS ONE

Pathway relevance ranking for tumor samples through network-based data integration (award for Outstanding Oral Poster Presentation )

Lieven VerbekeJimmy Van den EyndenPiet DemeesterKathleen MarchalJan Fostier

SomInaClust: detection of cancer genes based on somatic mutation patterns of inactivation and clustering

Jimmy Van den EyndenAna Carolina Elisa Fierro GutierrezLieven VerbekeKathleen Marchal

A1 Journal Article in BMC BIOINFORMATICS

2013

Identifying relevant pathways for different breast cancer subtypes using network based data integration

Lieven VerbekeAC FierroJimmy Van den EyndenPiet DemeesterJan FostierKathleen Marchal

2011

Glycine enhances microglial intracellular calcium signaling : a role for sodium-coupled neutral amino acid transporters

Jimmy Van den EyndenKristof NotelaersBert BrôneDaniel JanssenKatherine NelissenSheen SahebAliInge SmoldersNiels HellingsPaul SteelsJean-Michel Rigo

A1 Journal Article in PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

2010

The inhibitory neurotransmitter glycine modulates macrophage activity by activation of neutral amino acid transporters

Sofie CarmansJerome JA HendriksKristof ThewissenJimmy Van den EyndenPiet StinissenJean-Michel RigoNiels Hellings

A1 Journal Article in JOURNAL OF NEUROSCIENCE RESEARCH

2009

Glycine and glycine receptor signalling in non-neuronal cells

Jimmy Van den EyndenSheen Saheb AliNikki HorwoodSofie CarmansBert BrôneNiels HellingPaul SteelsRobert J HarveyJean-Michel Rigo

A1 Journal Article in FRONTIERS IN MOLECULAR NEUROSCIENCE

2007

A highly reliable and budget-friendly Peltier-cooled camera for biological fluorescence imaging microscopy

Koen JollingMartin VandevenJimmy Van den EyndenMarcel AmelootEmmy Van Kerkhove

A1 Journal Article in JOURNAL OF MICROSCOPY-OXFORD

Dorsal unpaired median neurons of Locusta migratoria express ivermectin- and fipronil-sensitive glutamate-gated chloride channels

Daniel JanssenChristian DerstRoeland BuckinxJimmy Van den EyndenJean-Michel RigoEmmy Van Kerkhove

A1 Journal Article in JOURNAL OF NEUROPHYSIOLOGY

2004

Axillaire stagering met de schildwachtklier bij borstkanner : onze leercurve

E LannoeyP NevenF AmantJimmy Van den EyndenS StroobantA Van SteenC Van OngevalR DrijkoningenI VergoteMR Christiaens

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Dopamine transporter SPECT using fast kinetic ligands : 123I-FP-β-CIT versus 99mTc-TRODAT-1

K Van LaereL De CeuninckR DomJimmy Van den EyndenH VanbilloenJ CleynhensP DupontG BormansA VerbruggenL Mortelmans

A1 Journal Article in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Evaluation of anatomy based reconstruction for partial volume correction in brain FDG-PET

Kristof BaeteJohan NuytsKoen Van LaereWim Van PaesschenSarah CeyssensLiesbet De CeuninckOlivier GheysensAnnemarie KellesJimmy Van den EyndenPaul Suetens et al.

A1 Journal Article in NEUROIMAGE

2003

De schildwachtklierprocedure bij de behandeling van het vulvacarcinoom : eerste resultaten bij een reeks van 32 patiënten

Jimmy Van den EyndenL LannooF AmantS StroobantsI Vergote

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE