Research Explorer

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Researcher

Isabel Leroux-Roels

Publications & Research Data

Awards & Distinctions

83 Results

2025

A novel carbohydrate fatty-acid monosulphate ester, squalane-in-water adjuvant is safe and enhances inactivated influenza vaccine immunogenicity in older adults

Valentino D'OnofrioBart JacobsAzhar AlhatemiSimon De GussemMarjolein VerstraeteSharon PorrezAnthony WillemsFien De BoeverGwenn WaerlopGeert Leroux-Roels et al.

A1 Journal Article in VACCINES

AS04 drives superior cross-protective antibody response by increased NOTCH signaling of dendritic cells and proliferation of memory B cells

Valentino D'OnofrioAna Carolina SantanaMarthe PauwelsGwenn WaerlopAnthony WillemsFien De BoeverMartin MüllerPeter SehrTim WaterboerIsabel Leroux-Roels et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Effectiveness of the XBB.1.5 COVID-19 vaccines against SARS-CoV-2 hospitalisation among adults aged ≥ 65 years during the BA.2.86/JN.1 predominant period, VEBIS Hospital Study, Europe, November 2023 to May 2024

Liliana AntunesMadelyn Rojas-CastroMarcos LozanoIván Martínez-BazIsabel Leroux-RoelsMaria-Louise BorgBeatrix OrosziMargaret FitzgeraldRalf DürrwaldLigita Jancoriene et al.

A1 Journal Article in INFLUENZA AND OTHER RESPIRATORY VIRUSES

Safety and immunogenicity of an adjuvanted clostridioides difficile vaccine candidate in healthy adults : a randomized placebo-controlled phase 1 study

Isabel Leroux-RoelsAzhar AlhatemiMagalie CaubetFien De BoeverBertrand de WergifosseMohamed El IdrissiGuilherme S FerreiraBart JacobsAxel LambertSandra Morel et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2024

Efficacy and safety of respiratory syncytial virus (RSV) prefusion F protein vaccine (RSVPreF3 OA) in older adults over 2 RSV seasons

Michael G IsonAlberto PapiEugene AthanRobert G FeldmanJoanne M LangleyDong-Gun LeeIsabel Leroux-RoelsFederico Martinon-TorresTino F SchwarzRichard N van Zyl-Smit et al.

A1 Journal Article in CLINICAL INFECTIOUS DISEASES

Environmental sustainability and antimicrobials : an underestimated problem with far-reaching consequences

Jan De WaeleIsabel Leroux-RoelsAndrew Conway-Morris

A1 Journal Article in INTENSIVE CARE MEDICINE

Epidemiology and molecular typing of multidrug-resistant bacteria in tertiary hospitals and nursing homes in Flanders, Belgium

Stefanie van Kleef-van KoeveringeVeerle MatheeussenAnnette SchuermansSien De KosterNatascha Perales SelvaHilde JansensDieter De ConinckKatrien De BruyneKlaas MensaertMarjolein Kluytmans-van den Bergh et al.

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Evaluation of safety, immunogenicity and cross-reactive immunity of OVX836, a nucleoprotein-based universal influenza vaccine, in older adults

Bart JacobsIsabel Leroux-RoelsJacques BruhwylerNicola GrothGwenn WaerlopYorick JanssensJessika TourneurFien De BoeverAzhar AlhatemiPhilippe Moris et al.

A1 Journal Article in VACCINES

Microbiological evaluation of ultraviolet C light-emitting diodes for disinfection of medical instruments

Hannah SiweAnnelies AerssensMieke V. FlourSilke TernestLeen Van SimaeyDuncan VerstraetenAlain KalmarIsabel Leroux-RoelsPhilip MeulemanPiet Cools

A1 Journal Article in HELIYON

One Health surveillance of colistin-resistant Enterobacterales in Belgium and the Netherlands between 2017 and 2019

Sien De KosterBasil Britto XavierChristine LammensNatascha Perales SelvaStefanie van Kleef-van KoeveringeSamuel CoenenYouri GlupczynskiIsabel Leroux-RoelsWouter DhaezeChristian J. P. A. Hoebe et al.

A1 Journal Article in PLOS ONE

Safety and immunogenicity of a 4-component generalized modules for membrane antigens Shigella vaccine in healthy European adults : randomized, phase 1/2 study

Isabel Leroux-RoelsCathy MaesFrancesca ManciniBart JacobsEleanna SarakinouAzhar AlhatemiJasper JoyeSilvia GrappiGiulia Luna CilioAlimamy Serry-Bangura et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of a carbohydrate fatty acid monosulphate ester adjuvant combined with a low-dose quadrivalent split-virion inactivated influenza vaccine : a randomised, observer-blind, active-controlled, first-in-human, phase 1 study

Valentino D'OnofrioSharon PorrezBart JacobsAzhar AlhatemiFien De BoeverGwenn WaerlopEls MichelsFrancesca VanniAlessandro ManentiGeert Leroux-Roels et al.

A1 Journal Article in VACCINES

Safety and immunogenicity of a revaccination with a respiratory syncytial virus prefusion F vaccine in older adults : a phase 2b study

Isabel Leroux-RoelsMarc Van RanstCorinne VandermeulenCarline Vanden AbeeleNathalie De SchrevelBruno SalaunCéline VerheustMarie-Pierre DavidShady KotbVeronica Hulstrøm

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of the live-attenuated hRVFV-4s vaccine against Rift Valley fever in healthy adults : a dose-escalation, placebo-controlled, first-in-human, phase 1 randomised clinical trial

Isabel Leroux-RoelsChittappen Kandiyil PrajeethAmare AregayNiranjana NairGuus F RimmelzwaanAlbert D M E OsterhausSimone KardinahlSabrina PelzStephan BauerValentino D'Onofrio et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

2023

Double-blind, placebo-controlled, dose-escalating study evaluating the safety and immunogenicity of an epitope-specific chemically defined nanoparticle RSV vaccine

Isabel Leroux-RoelsJacques BruhwylerLilli StergiouMark SumerayJasper JoyeCathy MaesPaul-Henri LambertGeert Leroux-Roels

A1 Journal Article in VACCINES

Harmonization of cellular immunoassays for the evaluation of influenza vaccine immunogenicity

Gwenn WaerlopIsabel Leroux-RoelsGeert Leroux-Roels

Human immunity and susceptibility to influenza A(H3) viruses of avian, equine, and swine origin

Elien VandoornWojciech StadejekIsabel Leroux-RoelsGeert Leroux-RoelsAnna ParysKristien Van Reeth

A1 Journal Article in EMERGING INFECTIOUS DISEASES

Immune responses in healthy adults elicited by a bivalent norovirus vaccine candidate composed of GI.4 and GII.4 VLPs without adjuvant

Gwenn WaerlopYorick JanssensBart JacobsFranziska JarczowskiAndré DiessnerGeert Leroux-RoelsVictor KlimyukIsabel Leroux-RoelsFrank Thieme

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate : a randomised, double-blind, placebo-controlled, phase 2a trial

Isabel Leroux-RoelsPaul WillemsGwenn WaerlopYorick JanssensJessika TourneurFien De BoeverJacques BruhwylerAzhar AlhatemiBart JacobsFlorence Nicolas et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

Respiratory syncytial virus prefusion F protein vaccine in older adults

Alberto PapiMichael G. IsonJoanne M. LangleyDong-Gun LeeIsabel Leroux-RoelsFederico Martinon-TorresTino F. SchwarzRichard N. van Zyl-SmitLaura CamporaNancy Dezutter et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Safety and immunogenicity of a respiratory syncytial virus prefusion F (RSVPreF3) candidate vaccine in older adults : phase 1/2 randomized clinical trial

Isabel Leroux-RoelsMatthew G DavisKatie SteenackersBrandon EssinkCorinne VandermeulenCharles FogartyCharles P AndrewsEdward KerwinMarie Pierre DavidLaurence Fissette et al.

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of respiratory syncytial virus prefusion maternal vaccine coadministered with diphtheria-tetanus-pertussis vaccine : a phase 2 study

Nerea HermidaMurdo FergusonIsabel Leroux-RoelsSandra PagnussatDeborah YapleeNancy HuaPeter van den SteenBruno AnspachIlse DieussaertJoon Hyung Kim

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Sanitary installations and wastewater plumbing as reservoir for the long-term circulation and transmission of carbapenemase producing Citrobacter freundii clones in a hospital setting

Hannelore HamerlinckAnnelies AerssensJerina BoelensAndrea DehaeneMichael McMahonAnne-Sophie MessiaenStien VandendriesscheAnja VelgheIsabel Leroux-RoelsBruno Verhasselt

A1 Journal Article in ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL

Selective digestive decontamination-Pro

Jan De WaeleIsabel Leroux-RoelsPieter Depuydt

Editorial material

2022

A randomized, double-blind, placebo-controlled, dose-escalating phase I trial to evaluate safety and immunogenicity of a plant-produced, bivalent, recombinant norovirus-like particle vaccine

Isabel Leroux-RoelsCathy MaesJasper JoyeBart JacobsFranziska JarczowskiAndré DiessnerYorick JanssensGwenn WaerlopKirsi TamminenSuvi Heinimäki et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Efficacy and safety of the CVnCoV SARS-CoV-2 mRNA vaccine candidate in ten countries in Europe and Latin America (HERALD) : a randomised, observer-blinded, placebo-controlled, phase 2b/3 trial

Peter G. KremsnerRodolfo Andres Ahuad GuerreroEunate Arana-ArriGustavo Jose Aroca MartinezMarc BontenReynaldo ChandlerGonzalo CorralEddie Jan Louis De BlockLucie EckerJulian Justin Gabor et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

Efficacy, safety, and immunogenicity of a booster regimen of Ad26.COV2.S vaccine against COVID-19 (ENSEMBLE2) : results of a randomised, double-blind, placebo-controlled, phase 3 trial

Karin HardtAn VandeboschJerald SadoffMathieu Le GarsCarla TruyersDavid LowsonIlse Van DrommeJohan VingerhoetsTobias KamphuisGert Scheper et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

Implementation of the Infection Risk Scan (IRIS) in nine hospitals in the Belgian-Dutch border region (i-4-1-Health project)

M VerelstI WillemsenV WeteringsPascal De WaegemaekerIsabel Leroux-RoelsE NieuwkoopV SaegemanL van AlphenS van Kleef-van KoeveringeM Kluytmans-van den Bergh et al.

A1 Journal Article in ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL

In vitro comparison of 3 different brushes for manual cleaning of endoscopes

Sofie ColmanThomas VanzieleghemIsabel Leroux-Roels

A1 Journal Article in INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Practice testing of generic quality indicators for responsible antibiotic use in nine hospitals in the Dutch–Belgian border area

A.A. MonnierValentino D'OnofrioI. WillemsenM.F.Q. Kluytmans-van den BerghJ.A.J.W. KluytmansA. SchuermansIsabel Leroux-RoelsI.C. Gyssens

A1 Journal Article in JOURNAL OF HOSPITAL INFECTION

Randomized, double-blind, reference-controlled, phase 2a study evaluating the immunogenicity and safety of OVX836, a nucleoprotein-based influenza vaccine

Isabel Leroux-RoelsGwenn WaerlopJessika TourneurFien De BoeverCatherine MaesJacques BruhwylerDelphine Guyon-GellinPhilippe MorisJudith Del CampoPaul Willems et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

The role of cell-mediated immunity against influenza and its implications for vaccine evaluation

Yorick JanssensJasper JoyeGwenn WaerlopFrédéric ClementGeert Leroux-RoelsIsabel Leroux-Roels

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

2021

A new fully liquid presentation of MenACWY-CRM conjugate vaccine : results from a multicentre, randomised, controlled, observer-blind study

C VandermeulenIsabel Leroux-RoelsJ VandeleurT StanisciaG GirardM FergusonG IcardiTF SchwarzAM NevilleT Nolan et al.

A1 Journal Article in VACCINE

Combined oropharyngeal/nasal swab is equivalent to nasopharyngeal sampling for SARS-CoV-2 diagnostic PCR

Tania DesmetPeter De PaepeJerina BoelensLiselotte CoorevitsElizaveta PadalkoStien VandendriesscheIsabel Leroux-RoelsAnnelies AerssensSteven CallensEva Van Braeckel et al.

A1 Journal Article in BMC MICROBIOLOGY

Comparison of five SARS-CoV-2 rapid antigen detection tests in a hospital setting and performance of one antigen assay in routine practice : a useful tool to guide isolation precautions?

E Van HonackerK Van VaerenberghA BoelH De BeenhouwerIsabel Leroux-RoelsL Cattoir

A1 Journal Article in JOURNAL OF HOSPITAL INFECTION

ESBL-producing, carbapenem- and ciprofloxacin-resistant Escherichia coli in Belgian and Dutch broiler and pig farms : a cross-sectional and cross-border study

Sien De KosterMoniek RingenierChristine LammensArjan StegemanTijs TobiasFrancisca VelkersHans VernooijMarjolein Kluytmans-van den BerghJan KluytmansJeroen Dewulf et al.

A1 Journal Article in ANTIBIOTICS-BASEL

Feedback of ATP measurement as a tool for reducing environmental contamination in hospitals in the Dutch/Belgian border area

A Van ArkelI WillemsenL Kilsdonk-BodeS Vlamings-WagenaarsA Van OudheusdenPascal De WaegemaekerIsabel Leroux-RoelsM VerelstE MaasA Van Oosten et al.

A1 Journal Article in INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE

Immunogenicity and safety of a 3-antigen hepatitis B vaccine vs a single-antigen hepatitis B vaccine : a phase 3 randomized clinical trial

T VesikariA FinnP van DammeIsabel Leroux-RoelsGeert Leroux-RoelsN SegallA TomaG VallieresR AronsonD Reich et al.

A1 Journal Article in JAMA NETWORK OPEN

Immunogenicity and safety of a quadrivalent high-dose inactivated influenza vaccine compared with a standard-dose quadrivalent influenza vaccine in healthy people aged 60 years or older : a randomized Phase III trial

S PepinJF NicolasH SzymanskiIsabel Leroux-RoelsT SchaumM BontenG IcardiA ShresthaC TabarQHD00011 study team

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Immunogenicity and safety of a tri-antigenic versus a mono-antigenic hepatitis B vaccine in adults (PROTECT) : a randomised, double-blind, phase 3 trial

T VesikariJM LangleyN SegallBJ WardC CooperG PoliquinB SmithS GanttJE McElhaneyM Dionne et al.

A1 Journal Article in LANCET INFECTIOUS DISEASES

Interim results of a phase 1-2a trial of Ad26.COV2.S Covid-19 vaccine

J SadoffM Le GarsG ShukarevD HeerweghC TruyersAM de GrootJ StoopS TeteW Van DammeIsabel Leroux-Roels et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Proof-of-concept of a low-dose unmodified mRNA-based rabies vaccine formulated with lipid nanoparticles in human volunteers : a phase 1 trial

Cassandra AldrichIsabel Leroux-RoelsKatell Bidet HuangMihai Alexandru BicaEdde LoeligerOliver Schoenborn-KellenbergerLisa WalzGeert Leroux-RoelsFrank von SonnenburgLidia Oostvogels

A1 Journal Article in VACCINE

Safety and immunogenicity of a new Sabin inactivated poliovirus vaccine candidate produced on the PER.C6 (R) cell-line : a phase 1 randomized controlled trial in adults

Isabel Leroux-RoelsGeert Leroux-RoelsGeorgi ShukarevHanneke SchuitemakerConor CahillRichard de RooijMartin StruijsHester van ZeeburgJeanne-Marie Jacquet

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2 : a phase 1 randomized clinical trial

PG KremsnerP MannA KroidlIsabel Leroux-RoelsC SchindlerJJ GaborM SchunkGeert Leroux-RoelsJJ BoschR Fendel et al.

A1 Journal Article in WIENER KLINISCHE WOCHENSCHRIFT

Safety and immunogenicity of two novel type 2 oral poliovirus vaccine candidates compared with a monovalent type 2 oral poliovirus vaccine in healthy adults : two clinical trials

Ilse De CosterIsabel Leroux-RoelsAnanda S. BandyopadhyayChristopher GastKanchanamala WithanageKatie SteenackersPhilippe De SmedtAnnelies AerssensGeert Leroux-RoelsM. Steven Oberste et al.

A1 Journal Article in LANCET

2020

ATP measurement as an objective method to measure environmental contamination in 9 hospitals in the Dutch/Belgian border area

A van ArkelI WillemsenL Kilsdonk-BodeS Vlamings-WagenaarsA van OudheusdenPascal De WaegemaekerIsabel Leroux-RoelsM VerelstE MaasA van Oosten et al.

A1 Journal Article in ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL

Detection of H1 swine influenza a virus antibodies in human serum samples by age group

Elien VandoornIsabel Leroux-RoelsGeert Leroux-RoelsAnna ParysAmy VincentKristien Van Reeth

A1 Journal Article in EMERGING INFECTIOUS DISEASES

Infection prevention and control challenges in Flemish homecare nursing : a pilot study

Karel MaelegheerI DumitrescuN VerpaelstH MassonC BrouckeP BraekeveldD BackaertC MensaertIsabel Leroux-RoelsK Floré

A2 Journal Article in BRITISH JOURNAL OF COMMUNITY NURSING

Multidrug-resistant bacteria in ICU : fact or myth

Jan De WaeleJerina BoelensIsabel Leroux-Roels

A1 Journal Article in CURRENT OPINION IN ANESTHESIOLOGY

Persistence of vaccine-elicited immune response up to 14 years post-HIV gp120-NefTat/AS01(B) vaccination

Olivier Van Der MeerenErik JongertKelly E. SeatonMarguerite KoutsoukosAnnelies AerssensCaroline BrackettMuriel DeboisMichel JanssensGeert Leroux-RoelsDoris Mesia Vela et al.

A1 Journal Article in VACCINE

Toilet drain water as a potential source of hospital room-to-room transmission of carbapenemase-producing Klebsiella pneumoniae

Laura HeiremanHannelore HamerlinckStien VandendriesscheJerina BoelensLiselotte CoorevitsEls De BrabanderePascal De WaegemaekerSaskia VerhofstedeK. ClausM. A. Chlebowicz-Flissikowska et al.

A1 Journal Article in JOURNAL OF HOSPITAL INFECTION

2019

A recurrent and transesophageal echocardiography-associated outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae complex in cardiac surgery patients

Tom Van MaerkenEls De BrabandereAudrey NoëlLiselotte CoorevitsPascal De WaegemaekerRaina AblorhStefaan BouchezINGRID HERCKHarlinde PeperstraetePierre Bogaerts et al.

A1 Journal Article in ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL

Nosocomial outbreak of extended-spectrum β-lactamase-producing Enterobacter cloacae among cardiothoracic surgical patients : causes and consequences

A NoëlC VastradeS DupontM de BarsyTD HuangTom Van MaerkenIsabel Leroux-RoelsB DelaereL MellyB Rondelet et al.

A1 Journal Article in JOURNAL OF HOSPITAL INFECTION

2018

Impact of an antimicrobial stewardship programme on the quality of care indicators for Staphylococcus aureus bacteraemia

Franky BuyleSteven CallensJerina BoelensLinos VandekerckhoveDiana Huis in 't VeldGeert ClaeysKaren VermisSabine DeryckereJulie De KeulenaerIsabel Leroux-Roels et al.

Improving timelines in reporting results from positive blood cultures : simulation of impact of rapid identification on therapy on a real-life cohort

Lien CattoirLiselotte CoorevitsIsabel Leroux-RoelsGeert ClaeysBruno VerhasseltJerina Boelens

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

2017

Surveillance of endoscopes : comparison of different sampling techniques

Lien CattoirThomas VanzieleghemLISA FLORINTania HelleputteMartine De VosBruno VerhasseltJerina BoelensIsabel Leroux-Roels

A1 Journal Article in INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

2016

Antibody persistence and booster responses to split-virion H5N1 avian influenza vaccine in young and elderly adults

Rajeka LazarusSarah KellyMatthew D SnapeCorinne VandermeulenMerryn VoyseyKarel HoppenbrouwersAnnick HensPierre Van DammeStephanie PepinIsabel Leroux-Roels et al.

A1 Journal Article in PLOS ONE

LISBETH VANDENABEELEGeertrui CoppensIsabel Leroux-RoelsPieter Hindryckx

Editorial material

2015

Adjuvant system AS02V enhances humoral and cellular immune responses to pneumococcal protein PhtD vaccine in healthy young and older adults: randomised, controlled trials

Isabel Leroux-RoelsJeanne-Marie DevasterGeert Leroux-RoelsVincent VerlantIsabelle HenckaertsPhilippe MorisPhilippe HermandPascale Van BelleJan T PoolmanPierre Vandepapeliére et al.

A1 Journal Article in VACCINE

Influenza vaccines: where do we stand? Where do we go? A bumpy but steady road upwards

Guus RimmelzwaanIsabel Leroux-RoelsS GilbertA Thomson

Editorial material

2014

Bordetella pertussis seroprevalence in Belgian adults aged 20-39 years, 2012

K HuygenC RodeghieroD GovaertsIsabel Leroux-RoelsP MelinM ReyndersS Van der MeerenS Van den WijngaertD Pierard

A1 Journal Article in EPIDEMIOLOGY AND INFECTION

Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines : randomized, double-blind study in malaria-naïve adults

Geert Leroux-RoelsIsabel Leroux-RoelsFrédéric ClementOpokua Ofori-AnyinamMarc LievensErik JongertPhilippe MorisW Ripley BallouJoe Cohen

A1 Journal Article in HUMAN VACCINES & IMMUNOTHERAPEUTICS

Implementation of a multidisciplinary infectious diseases team in a tertiary hospital within an Antimicrobial Stewardship Program

Franky BuyleMATTHIAS WALLAERTNATHALIE BECKJerina BoelensSteven CallensGeert ClaeysSABINE DERYCKEREEVELIEN HAEGEMANIsabel Leroux-RoelsERICA SERMIJN et al.

A1 Journal Article in ACTA CLINICA BELGICA

Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial

Jan De WaeleSofie CarretteMieke CarlierVeronique StoveJerina BoelensGeert ClaeysIsabel Leroux-RoelsEric HostePieter DepuydtJohan Decruyenaere et al.

A1 Journal Article in INTENSIVE CARE MEDICINE

Validity analysis of a unique infection surveillance system in the intensive care unit by analysis of a data warehouse built through a workflow-integrated software application

Liesbet De BusGUNTER DIETBram GadeyneIsabel Leroux-RoelsGeert ClaeysKristof SteurbautDominique BenoitFilip De TurckJohan DecruyenaerePieter Depuydt

A1 Journal Article in JOURNAL OF HOSPITAL INFECTION

2013

Characeteristics and outcome of neonates with a healthcare-associated bloodstream infection in a NICU over a 10-year period (2002-2011)

Evelien VerstraeteGeert ClaeysIsabel Leroux-RoelsDirk VogelaersPiet VanhaesebrouckStijn Blot

Clinical evaluation to confirm the manufacturing consistency of three lots of an adjuvanted glycoprotein D genital herpes vaccine in healthy seronegative pre-teen and adolescent girls: a phase III multi-center double-blind randomized trial

Geert Leroux-RoelsSimon DobsonDavid I BernsteinSandra FowlerBarbara RomanowskiIsabel Leroux-RoelsBrigitte CheuvartThomas HeinemanGary Dubin

A2 Journal Article in TRIALS IN VACCINOLOGY

Edwardsiella tarda sepsis in a live-stranded sperm whale (Physeter macrocephalus)

Piet CoolsJan HaeltersGuido Lopes dos Santos SantiagoGeert ClaeysJerina BoelensIsabel Leroux-RoelsMario VaneechouttePieter Deschaght

A1 Journal Article in VETERINARY MICROBIOLOGY

Improved CD4⁺ T cell responses to Mycobacterium tuberculosis in PPD-negative adults by M72/AS01 as compared to the M72/AS02 and Mtb72F/AS02 tuberculosis candidate vaccine formulations: a randomized trial

Isabel Leroux-RoelsSheron ForgusFIEN DE BOEVERFrédéric ClementMarie-Ange DemoitiéPascal MettensPhilippe MorisEdouard LedentGeert Leroux-RoelsOpokua Ofori-Anyinam

A1 Journal Article in VACCINE

Safety and immunogenicity of a glycoprotein D genital herpes vaccine in healthy girls 10-17 years of age: results from a randomised, controlled, double-blind trial

The HSV-040 Study groupJH RichardusRR Abu-ElyazeedT HeinemanG DubinM FourneauIsabel Leroux-RoelsGeert Leroux-RoelsL OstergaardJ Diez-Domingo et al.

A1 Journal Article in VACCINE

2012

A phase 1/2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein E subunit vaccine candidate in young and older adults

Isabel Leroux-RoelsGeert Leroux-RoelsFrédéric ClementPierre VandepapelièreVentzislav VassilevEdouard LedentThomas C Heineman

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

2011

H5N1 influenza vaccine formulated with AS03A induces strong cross-reactive and polyfunctional CD4 T-cell responses

Philippe MorisRobbert van der MostIsabel Leroux-RoelsFrédéric ClementMamadou DraméEmmanuel HanonGeert Leroux-RoelsMarcelle Van Mechelen

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Head-to-head comparison of pandemic influenza vaccines

Geert Leroux-RoelsIsabel Leroux-Roels

Editorial material

2010

Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02A candidate tuberculosis vaccine in purified protein derivative-negative adults

Isabel Leroux-RoelsGeert Leroux-RoelsOpokua Ofori-AnyinamPhilippe MorisEls De KockFrédéric ClementMarie-Claude DuboisMarguerite KoutsoukosMarie-Ange DemoitieJoe Cohen et al.

A1 Journal Article in CLINICAL AND VACCINE IMMUNOLOGY

Inactivated split-virion seasonal influenza vaccine (Fluarix®) : a review of its use in the prevention of seasonal influenza in adults and the elderly

Monique P CurranIsabel Leroux-Roels

A1 Journal Article in DRUGS

Priming with AS03A-adjuvanted H5N1 influenza vaccine improves the kinetics, magnitude and durability of the immune response after a heterologous booster vaccination: an open non-randomised extension of a double-blind randomised primary study

Isabel Leroux-RoelsFlorian RomanSheron ForgusCathy MaesFIEN DE BOEVERMamadou DramePaul GillardRobbert van der MostMarcelle Van MechelenEmmanuel Hanon et al.

A1 Journal Article in VACCINE

Strong and persistent CD4+ T-cell response in healthy adults immunized with a candidate HIV-1 vaccine containing gp120, Nef and Tat antigens formulated in three Adjuvant Systems

Isabel Leroux-RoelsMarguerite KoutsoukosFrédéric ClementSophia SteyaertMichel JanssensPatricia BourguignonKristen CohenMarcus AltfeldPierre VandepapelièreLouise Pedneault et al.

A1 Journal Article in VACCINE

2009

Current status and progress of prepandemic and pandemic influenza vaccine development

Isabel Leroux-RoelsGeert Leroux-Roels

A1 Journal Article in EXPERT REVIEW OF VACCINES

Humoral and cellular immune responses to split-virion H5N1 influenza vaccine in young and elderly adults

Isabel Leroux-RoelsMarie Van der WielenFroukje KafejaCorinne VandermeulenRajeka LazarusMatthew D SnapeTessa JohnChristophe CarreNolwenn NougaredeStephanie Pepin et al.

A1 Journal Article in VACCINE

2008

An adjuvanted, low-dose, pandemic influenza a (H5N1) vaccine candidate is safe, immunogenic, and induces cross-reactive immune responses in healthy adults

Karin LevieIsabel Leroux-RoelsKarel HoppenbrouwersAnne-Diane KervynCorinne VandermeulenSheron ForgusGeert Leroux-RoelsSylvie PichonInca Kusters

A1 Journal Article in JOURNAL OF INFECTIOUS DISEASES

Broad clade 2 cross-reactive immunity induced by an adjuvanted clade 1 rH5N1 pandemic influenza vaccine

Isabel Leroux-RoelsRoger BernhardPascal GérardMamadou DraméEmmanuel HanonGeert Leroux-Roels

A1 Journal Article in PLOS ONE

Seasonal influenza vaccine delivered by intradermal microinjection: A randomised controlled safety and immunogenicity trial in adults

Isabel Leroux-RoelsEva VetsRalf FreeseMichael SeiberlingFrancoise WeberCamille SalamandGeert Leroux-Roels

A1 Journal Article in VACCINE

2007

Antigen sparing and cross-reactive immunity with an adjuvanted rH5N1 prototype pandemic influenza vaccine: a randomised controlled trial

Isabel Leroux-RoelsAstrid BorkowskiTHOMAS VANWOLLEGHEMMamadou DrameFrédéric ClementEliane HonsJeanne-Marie DevasterGeert Leroux-Roels

A1 Journal Article in LANCET