Research Explorer

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Researcher

Hetty Helsmoortel

Awards & Distinctions

43 Results

2025

Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

U Journal Article in NATURE COMMUNICATIONS

2024

Subpar reporting of pre-analytical variables in RNA-focused blood plasma studies

Céleste Van Der SchuerenPhilippe DecruyenaereFrancisco Avila CobosJohanna BultJill DeleuLydia DipaloHetty HelsmoortelEva HulstaertAnnelien MorlionElena Ramos Varas et al.

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Céleste Van Der SchuerenPhilippe DecruyenaereFrancisco Avila CobosJohanna BultJill DeleuLydia DipaloHetty HelsmoortelEva HulstaertAnnelien MorlionElena Ramos Varas et al.

A1 Journal Article in MOLECULAR ONCOLOGY

2023

Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Reporting of pre-analytical variables in RNA-focused blood plasma studies : a prerequisite for quality assessment and replication

Céleste Van Der SchuerenPhilippe DecruyenaereFrancisco Avila CobosJill DeleuHetty HelsmoortelEva HulstaertAnnelien MorlionKathleen SchoofsEveline Vanden EyndeKimberly Verniers et al.

2022

Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Jasper AnckaertFrancisco Avila CobosAnneleen DecockPhilippe DecruyenaereJill DeleuKatleen De PreterOlivier De WeverJilke De WildeBert DhondtThibaut D'huyvetter et al.

2021

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study

Anneleen DecockOlivier De WeverCeline EveraertHetty HelsmoortelAn HendrixPieter MestdaghAnnelien MorlionJo VandesompeleRuben Van PaemelFrancisco Avila Cobos et al.

2020

Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles

Celine EveraertHetty HelsmoortelAnneleen DecockEva HulstaertRuben Van PaemelKimberly VerniersJustine NuytensJasper AnckaertNele NijsJoeri Tulkens et al.

Substantial performance differences among RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control study-important considerations for liquid biopsies

Anneleen DecockJasper AnckaertCeline EveraertJustine NuytensScott KuerstenAn HendrixJo VandesompelePieter MestdaghBert DhondtRuben Van Paemel et al.

2019

Dramatic differences in RNA purification kit performance in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

Dramatic differences in RNA purification kit performance in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

Evaluating the impact of RNA purification kit and blood collection tube in the extracellular RNA quality control study : important considerations for liquid biopsies

Annelien MorlionJasper AnckaertFrancisco Avila CobosAnneleen DecockJill DeleuOlivier De WeverBert DhondtCeline EveraertCarolina FierroHetty Helsmoortel et al.

Lack of adequate reporting of pre-analytical variables in RNA based liquid biopsies studies hampers quality assessment and replication

Pieter MestdaghJo VandesompeleCéleste Van Der SchuerenAnneleen DecockHetty HelsmoortelEva Hulstaert

Long noncoding RNA expression profiling in cancer : challenges and opportunities

Lucia LorenziFrancisco Avila CobosAnneleen DecockCeline EveraertHetty HelsmoortelSteve LefeverKaren VerboomPieter-Jan VoldersFranki SpelemanJo Vandesompele et al.

A1 Journal Article in GENES CHROMOSOMES & CANCER

Performance assessment of total RNA sequencing of human biofluids and extracellular vesicles

Celine EveraertHetty HelsmoortelAnneleen DecockEva HulstaertRuben Van PaemelKimberly VerniersJustine NuytensJasper AnckaertNele NijsJoeri Tulkens et al.

A1 Journal Article in SCIENTIFIC REPORTS

2018

Circulating microRNA biomarkers for metastatic disease in neuroblastoma patients

Fjoralba ZekaAnneleen DecockAlan Van GoethemKatrien VanderheydenFleur DemuynckTim LammensHetty HelsmoortelJoëlle VermeulenRosa NogueraAna P. Berbegall et al.

A1 Journal Article in JCI INSIGHT

Circulating microRNA biomarkers for metastatic neuroblastoma

Fjoralba ZekaAlan Van GoethemTim LammensAnneleen DecockHetty HelsmoortelGenevieve LaureysMichael HogartyEveline BarbieriJason ShohetFrank Berthold et al.

Detecting long non-coding RNA biomarkers in prostate cancer liquid biopsies : hype or hope?

Hetty HelsmoortelCeline EveraertNicolaas LumenPiet OstJo Vandesompele

A2 Journal Article in NON-CODING RNA RESEARCH

Exploring the long non-coding RNA landscape in juvenile myelomonocytic leukemia

Mattias HofmansTim LammensS BresolinH CavéC FlothoH HasleHetty HelsmoortelM Van den Heuvel-EibrinkC NiemeyerJ Stary et al.

The extracellular RNA quality control (exRNAQC) study : controlling pre-analytical variables of RNA sequencing in blood-based precision medicine

Francisco Avila CobosAnneleen DecockKatleen De PreterBert DhondtOlivier De WeverBram De WildeCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

The extracellular RNA quality control (exRNAQC) study : controlling pre-analytical variables of RNA sequencing in blood-based precision medicine

Francisco Avila CobosAnneleen DecockKatleen De PreterOlivier De WeverBram De WildeBert DhondtCeline EveraertCarolina FierroHetty HelsmoortelAn Hendrix et al.

The long non-coding RNA landscape in juvenile myelomonocytic leukemia

Mattias HofmansTim LammensHetty HelsmoortelSilvia BresolinHélène CavéChristian FlothoHenrik HasleMarry M van den Heuvel-EibrinkCharlotte NiemeyerJan Stary et al.

A1 Journal Article in HAEMATOLOGICA

2017

EV-TRACK : transparent reporting and centralizing knowledge in extracellular vesicle research

Jan Van DeunPieter MestdaghPatrizia AgostinisÖzden AkaySushma AnandJasper AnckaertZoraida Andreu MartinezTine BaetensEls BegheinLaurence Bertier et al.

A1 Journal Article in NATURE METHODS

The extracellular RNA quality control (exRNAQC) study : testing and controlling pre-analytical variables of RNA sequencing on liquid biopsies

Anneleen DecockOlivier De WeverBert DhondtThibaut D'huyvetterHetty HelsmoortelAn HendrixAnnouck PhilippronKimberly VerniersPieter MestdaghJo Vandesompele

Unravelling the biology of juvenile myelomonocytic leukaemia using transcriptomics

Hetty HelsmoortelTim LammensPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

mRNA capture sequencing enabled liquid biopsy screening

Anneleen DecockOlivier De WeverBert DhondtCarolina FierroAn HendrixHetty HelsmoortelScott KuerstenPieter MestdaghNele NijsPiet Ost et al.

2016

LIN28B is over-expressed in specific subtypes of pediatric leukemia and regulates lncRNA H19

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviSilvia BresolinHelene CaveAndrica de VriesValerie de HaasChristian FlothoVeerle Labarque et al.

A1 Journal Article in HAEMATOLOGICA

LIN28B is overexpressed in pediatric leukemia and regulates LNCRNA H19

Hetty HelsmoortelBarbara De MoerlooseSilvia BresolinHélèe CavéChristian FlothoCharlotte NiemeyerJan StaryMarry van den Heuvel-EibrinkPieter Van VlierbergheTim Lammens

LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia

Hetty HelsmoortelSilvia BresolinTim LammensHélène CavéPeter NoellkeAurélie CayeFarzaneh GhazaviAndrica de VriesHenrik HasleVeerle Labarque et al.

A1 Journal Article in BLOOD

Unique long non-coding RNA expression signature in ETV6/RUNX1-driven B-cell precursor acute lymphoblastic leukemia

Farzaneh GhazaviBarbara De MoerlooseWouter Van LoockeAnnelynn WallaertHetty HelsmoortelAlina FersterMarleen BakkusGeneviève PlatEric DelabesseAnne Uyttebroeck et al.

A1 Journal Article in ONCOTARGET

Unraveling the biology of juvenile myelomonocytic leukemia using transcriptomics

Hetty HelsmoortelBarbara De MoerlooseTim LammensPieter Van Vlierberghe

2015

CD200/BTLA deletions in pediatric precursor B-cell acute lymphoblastic leukemia treated according to the EORTC-CLG 58951 protocol

Farzaneh GhazaviEmmanuelle ClappierTim LammensStefan SuciuAurélie CayeSamira ZegrariMarleen BakkusNathalie GrardelYves BenoitOdile Minckes et al.

A1 Journal Article in HAEMATOLOGICA

MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

Anneleen BeckersGert Van PeerDaniel R CarterMoritz GartlgruberCarl HerrmannSaurabh AgarwalHetty HelsmoortelKristina AlthoffJan J MolenaarBelamy B Cheung et al.

A1 Journal Article in CANCER LETTERS

The long non-coding RNA H19 is regulated by LIN28B

Hetty HelsmoortelBarbara De MoerlooseTim PietersFarzaneh GhazaviS BresolinH CavéA CayeACH de VriesC FlothoV Labarque et al.

2014

Juvenile myelomonocytic leukaemia: the quest for more specific therapies

Hetty HelsmoortelTim LammensNadine Van RoyJan PhilippéPascale De PaepeYves BenoitFranki SpelemanPieter Van VlierbergheBarbara De Moerloose

A2 Journal Article in BELGIAN JOURNAL OF HEMATOLOGY

LIN28B defines an aggressive subtype of juvenile myelomonocytic leukemia

Hetty HelsmoortelTim LammensFarzaneh GhazaviAurelie CayeHélène CavéChristian FlothoCharlotte NiemeyerJan StarySilvia BresolinRiccardo Masetti et al.

Prognostic relevance of CD200/BTLA deletions in pediatric precursor-B cell acute lymphoblastic leukemia treated according to the EORTD-CLG 58951 protocol

Farzaneh GhazaviTim LammensEmmanuelle ClappierStefan SuciuAurélie CayeSamira ZegrariMarleen BakkusNathalie GrardelYves BenoitYves Bertrand et al.

2013

miRNAs distinguish children with myelodysplastic syndrome from healthy donors

Hetty HelsmoortelTim LammensPieter MestdaghNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitJo VandesompeleFranki SpelemanPieter Van Vlierberghe et al.

miRNAs distinguish children with myelodysplastic syndrome from healthy donors

Hetty HelsmoortelTim LammensPieter MestdaghNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitJo VandesompeleFranki SpelemanPieter Van Vlierberghe et al.

2012

Study of the miRNome of childhood myelodysplastic syndrome

Hetty HelsmoortelTim LammensNadine Van RoyAnne UyttebroeckAlina FersterYves BenoitFranki SpelemanBarbara De Moerloose