Research Explorer

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Researcher

Helena Vanluchene

Publications & Research Data

Awards & Distinctions

5 Results

2025

Efficacy versus immunogenicity of LNP-mediated delivery of mRNA and self-amplifying RNA upon intravitreal injection in the mouse eye

Weiran LiHelena VanlucheneLaura RaesKaren PeynshaertLiene VeysSofía González HernándezEmily De LombaerdeBruno De GeestNiek SandersLieve Moons et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2024

Less is more : self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells

Helena VanlucheneOriane GillonKaren PeynshaertStefaan De SmedtNiek SandersKoen RaemdonckKatrien Remaut

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2023

Immunogenicity versus efficacy of lipid nanoparticle-mediated delivery of mRNA and self-amplifying mRNA to the retina

Helena VanlucheneKatrien RemautNiek SandersKoen Raemdonck

2022

ICG-mediated photodisruption of the inner limiting membrane enhances retinal drug delivery

Karen PeynshaertHelena VanlucheneKaat De ClerckAn-Katrien MinnaertMorgane VerhoevenNoémie GouspillouNezahat BostanToshio HisatomiGeraldine AccouFélix Sauvage et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

2021

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics : getting the message across

An-Katrien MinnaertHelena VanlucheneRein VerbekeIne LentackerStefaan De SmedtKoen RaemdonckNiek SandersKatrien Remaut

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS