Research Explorer

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Researcher

Guy Haegeman

Awards & Distinctions

213 Results

2015

Anakoinosis : communicative reprogramming of tumor systems : for rescuing chemorefractory neoplasia

Christina HartMartin VogelhuberDaniel WolffSebastian KlobuchLina GhibelliJürgen FoellSelim CorbaciogluKlaus ReheGuy HaegemanSimone Thomas et al.

A2 Journal Article in CANCER MICROENVIRONMENT

Anakoinosis: communicative reprogramming of tumor systems: for rescuing chemorefractory neoplasia

Christina HartMartin VogelhuberDaniel WolffSebastian KlobuchLina GhibelliJürgen FoellSelim CorbaciogluKlaus ReheGuy HaegemanSimone Thomas et al.

Discovery of Compound A: a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity

Ekaterina LesovayaAlexander YemelyanovAmanda C SwartPieter SwartGuy HaegemanIrina Budunova

A1 Journal Article in ONCOTARGET

Inhibition of the NF-κB signaling pathway by a novel heterocyclic curcumin analogue

Anna-Maria KatsoriAjay PalaganiNadia BougarneDimitra Hadjipavlou-LitinaGuy HaegemanWim Vanden Berghe

A1 Journal Article in MOLECULES

NF-κB is required for dengue virus NS5-induced RANTES expression

Sasiprapa KhunchaiMutita JunkingAroonroong SuttitheptumrongSuwattanee KooptiwutGuy HaegemanThawornchai LimjindapornPa-thai Yenchitsomanus

A1 Journal Article in VIRUS RESEARCH

2014

Cancer chemoprevention by dietary polyphenols

Karen HeyninckGuy HaegemanAjay Goel

Bookchapter in Polyphenols in human health and disease

Compound A, a selective glucocorticoid receptor agonist, inhibits immunoinflammatory diabetes, induced by multiple low doses of streptozotocin in mice

T SaksidaM VujicicI NikolicI StojanovicGuy HaegemanS Stosic-Grujicic

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

Dietary flavanols modulate the transcription of genes associated with cardiovascular pathology without changes in their DNA methylation state

Dragan MilenkovicWim Vanden BergheCéline BobyChristine LerouxKen DeclerckKatarzyna Szarc vel SzicKaren HeyninckKris LaukensMartin BizetMatthieu Defrance et al.

A1 Journal Article in PLOS ONE

Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells

Myung-Hoon ChungDo-Hee KimHye-Kyung NaJung-Hwan KimHa-Na KimGuy HaegemanYoung-Joon Surh

A1 Journal Article in MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

How the venom from the ectoparasitoid wasp Nasonia vitripennis exhibits anti-inflammatory properties on mammalian cell lines

Ellen DanneelsSarah GerloKaren HeyninckKathleen Van CraenenbroeckKarolien De BosscherGuy HaegemanDirk de Graaf

A1 Journal Article in PLOS ONE

Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs : involvement of MAPK and NF-κB pathways

Mouna AchouiKaren HeyninckChung Yeng LooiAli Mohd MustafaGuy HaegemanMohd Rais Mustafa

A1 Journal Article in DRUG DESIGN DEVELOPMENT AND THERAPY

In vitro inhibition of the transcription factor NF-κB and cyclooxygenase by bamboo extracts

Laura Van HoyweghenKarolien De BosscherGuy HaegemanDieter DeforceArne Heyerick

A1 Journal Article in PHYTOTHERAPY RESEARCH

Inhibition of corticosteroid-binding globulin gene expression by glucocorticoids involves C/EBPβ

Nicolette VerhoogFatima Allie-ReidWim Vanden BergheCarine SmithGuy HaegemanJanet HapgoodAnn Louw

A1 Journal Article in PLOS ONE

Selective modulation of the glucocorticoid receptor can distinguish between transrepression of NF-κB and AP-1

Karolien De BosscherIlse BeckLien DejagerNadia BougarneAnthoula GaigneauxSebastien ChateauvieuxDariusz RatmanMarc BrackeJan TavernierWim Vanden Berghe et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ

Karen HeyninckMaija Lahtela-KakkonenPieter Van der VekenGuy HaegemanWim Vanden Berghe

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

β-Agonists selectively modulate proinflammatory gene expression in skeletal muscle cells via non-canonical nuclear crosstalk mechanisms

Krzysztof KolmusMarleen Van TroysKarlien Van WesemaelChristophe AmpeGuy HaegemanJan TavernierSarah Gerlo

A1 Journal Article in PLOS ONE

2013

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation

Ilse BeckZuzanna DrebertRuben Hoya-AriasAli A BaharMichael DevosDorien ClarisseSofie DesmetNadia BougarneBart RuttensValerie Gossye et al.

A1 Journal Article in PLOS ONE

Mitogen- and stress-activated protein kinase 1 (MSK1) regulates glucocorticoid response element (GRE) promoter activity in a glucocorticoid concentration-dependent manner

Ilse BeckDorien ClarisseNadia BougarneSam OkretGuy HaegemanKarolien De Bosscher

Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner

Ilse BeckDorien ClarisseNadia BougarneSam OkretGuy HaegemanKarolien De Bosscher

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

Modulation of Nrf2-KEAP1 signaling by the natural compound Withaferin A: potential therapeutic effect in cardiovascular diseases?

Linde SabbeWim Vanden BergheKaren HeyninckGuy Haegeman

Role of MSKs in regulating NF‑κB activation

Laurent ReberGuy Haegeman

Bookchapter in MSKs

Selective modulation through the glucocorticoid receptor ameliorates muscle pathology in mdx mice

Tony HuynhKitipong UaesoontrachoonJames L QuinnKathleen S TatemChristopher R HeierJack H Van Der MeulenQing YuMark HarrisChristopher J NolanGuy Haegeman et al.

A1 Journal Article in JOURNAL OF PATHOLOGY

The serotonin 5-HT₇ receptors: two decades of research

Evelien GellynckKaren HeyninckKjetil W AndressenGuy HaegemanFinn Olav LevyPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in EXPERIMENTAL BRAIN RESEARCH

2012

A dissociated glucocorticoid receptor modulator reduces airway hyperresponsiveness and inflammation in a mouse model of asthma

Laurent L ReberFrançois DaubeufMaud PlantingaLode De CauwerSarah GerloWim WaelputSerge Van CalenberghJan TavernierGuy HaegemanBart Lambrecht et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT7(a) receptor

Evelien GellynckKjetil W AndressenBéatrice LintermansGuy HaegemanFinn O LevyPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in FEBS JOURNAL

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells

Ana C LibermanMaria Antunica-NoguerolViviane Ferraz-de-PaulaJoao Palermo-NetoCarla N CastroJimena DrukerFlorian HolsboerMarcelo J PeroneSarah GerloKarolien De Bosscher et al.

A1 Journal Article in PLOS ONE

Flavanols modulate the transcription of genes involved in cardiovascular pathology with heterogenic changes of their DNA methylation state: FLAVIOLA associated

Antje R WeselerDragan MilenkovicWim Vanden BergheErik JB RuijtersKaren HeyninckFrançois FuksGuy HaegemanGuido RMM HaenenAalt Bast

Flavanols: what do we know about their mechanisms of action?

Aalt BastSylvain ClaudeGuy HaegemanGuido RMM HaenenChristian HeissKaren HeyninckMarc MerxDragan MilenkovicChristine MorandErik JB Ruijters et al.

Functional relevance of the KLHL12-mediated D4 dopamine receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

Gel-free proteomic analysis of enhanceosome composition at the IL-6 promoter upon β2-adrenergic/TNF-α receptor co-activation

Krzysztof KolmusAnneleen SpoorenKarlien Van WesemaelGuy HaegemanSarah Gerlo

Importance of N- and C-terminus in localization and function of the 5-HT7 serotonin receptor

Evelien GellynckGuy HaegemanPeter VanhoenackerKathleen Van Craenenbroeck

Molecular insight in the multifunctional activities of Withaferin A

Wim Vanden BergheLinde SabbeMary KailehGuy HaegemanKaren Heyninck

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

On the track of function of KLHL12-mediated dopamine D4 receptor ubiquitination

Kamila SkieterskaPieter RondouDasiel Oscar Borroto-EscuelaDorien ClarisseBéatrice LintermansGuy HaegemanKjell FuxeKathleen Van Craenenbroeck

RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation

Anne MatthysKathleen Van CraenenbroeckBéatrice LintermansGuy HaegemanPeter Van Hoenacker

A1 Journal Article in CELLULAR SIGNALLING

2011

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

Alexander RauchValerie GossyeDebby BrackeElien GevaertPeggy JacquesKatrien Van BenedenBernard VandoorenMartina RaunerLorenz C HofbauerGuy Haegeman et al.

A1 Journal Article in FASEB JOURNAL

Criticizable claims for the validity of communication acts in biological systems: therapeutic implications in cancer

A ReichleC GernerGuy Haegeman

Cyclic AMP: a selective modulator of NF-κB action

Sarah GerloRon KooijmanIlse BeckKrzysztof KolmusAnneleen SpoorenGuy Haegeman

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Dissociation of osteogenic and immunological effects by the selective glucocorticoid receptor agonist, compound A, in human bone marrow stromal cells

Martina RaunerClaudia GoettschNicola SteinSylvia ThieleMartin BornhaeuserKarolien De BosscherGuy HaegemanJan TuckermannLorenz C Hofbauer

A1 Journal Article in ENDOCRINOLOGY

Dopamine D-4 receptor oligomerization: contribution to receptor biogenesis

Kathleen Van CraenenbroeckDasiel O Borroto-EscuelaWilber Romero-FernandezKamila SkieterskaPieter RondouBéatrice LintermansPeter VanhoenackerKjell FuxeFrancisco CiruelaGuy Haegeman

A1 Journal Article in FEBS JOURNAL

Dopamine D2 and D4 receptor heteromerization and its allosteric receptor-receptor interactions

Dasiel O Borroto-EscuelaKathleen Van CraenenbroeckWilber Romero-FernandezDiego GuidolinAmina S WoodsAlicia RiveraGuy HaegemanLuigi F AgnatiAlexander O TarakanovKjell Fuxe

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Dual effects of β2-adrenergic receptor on NF-κB-dependent genes: synergy versus inhibition

G LaureysAnneleen SpoorenR ClinckersJ De KeyserGuy HaegemanSarah Gerlo

Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells

Dagmar Garcia-RiveraRene DelgadoNadia BougarneGuy HaegemanWim Vanden Berghe

A1 Journal Article in CANCER LETTERS

Glucocorticoid receptor mutants: man-made tools for functional research

Ilse BeckKarolien De BosscherGuy Haegeman

A1 Journal Article in TRENDS IN ENDOCRINOLOGY AND METABOLISM

IL-1 beta potently stabilizes IL-6 mRNA in human astrocytes

Anneleen SpoorenPieter MestdaghPieter RondouKrzysztof KolmusGuy HaegemanSarah Gerlo

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Inducible production of recombinant human Flt3 ectodomain variants in mammalian cells and preliminary crystallographic analysis of Flt3 ligand-receptor complexes

Kenneth VerstraeteBert RemmerieJonathan ElegheertBéatrice LintermansGuy HaegemanPeter VanhoenackerKathleen Van CraenenbroeckSavvas Savvides

A1 Journal Article in ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS

Interleukin-6, a mental cytokine

Anneleen SpoorenKrzysztof KolmusGuy LaureysRalph ClinckersJacques De KeyserGuy HaegemanSarah Gerlo

A1 Journal Article in BRAIN RESEARCH REVIEWS

Phytochemicals and cancer chemoprevention: epigenetic friends or foe?

Katarzina Szarc vel SzicAjay PalaganiBehrouz HassanniaLinde SabbeKaren HeyninckGuy HaegemanWim Vanden Berghe

Bookchapter in Phytochemicals : bioactivities and impact on health

Regulation of IL-6 expression in astrocytes

Anneleen SpoorenGuy Haegeman

Role of the 5-HT7 receptor in the central nervous system : from current status to future perspectives

Anne MatthysGuy HaegemanKathleen Van CraenenbroeckPeter Vanhoenacker

A1 Journal Article in MOLECULAR NEUROBIOLOGY

Study of the interaction of the 5-HT7a receptor with RhoBTB3

Anne MatthysGuy HaegemanPeter Vanhoenacker

2010

A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance

Valerie GossyeDirk ElewautKatrien Van BenedenPieter DewintGuy HaegemanKarolien De Bosscher

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis

Geert van LooMozes SzeNadia BougarneJelle PraetConor Mc GuireAndrea UllrichGuy HaegemanMarco PrinzRudi BeyaertKarolien De Bosscher

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Classic glucocorticoids versus non-steroidal glucocorticoid receptor modulators: survival of the fittest regulator of the immune system?

Karolien De BosscherIlse BeckGuy Haegeman

A1 Journal Article in BRAIN BEHAVIOR AND IMMUNITY

Cooperation of NF kappa B and CREB to induce synergistic IL-6 expression in astrocytes

Anneleen SpoorenRon KooijmanBéatrice LintermansKathleen Van CraenenbroeckLinda VermeulenGuy HaegemanSarah Gerlo

A1 Journal Article in CELLULAR SIGNALLING

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols

Wipob SuttanaSamlee MankhetkornWilart PoompimonAjay PalaganiSergey ZhokhovSarah GerloGuy HaegemanWim Vanden Berghe

A1 Journal Article in MOLECULAR CANCER

Epicatechin induces NF-kappa B, activator rotein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells

Ana Belen Granado-SerranoMaria Anegeles MartinGuy HaegemanLuis GoyaLaura BravoSonia Ramos

A1 Journal Article in BRITISH JOURNAL OF NUTRITION

Epigenetic remedies by dietary phytochemicals against inflammatory skin disorders: myth or reality?

Wim Vanden BergheGuy Haegeman

A1 Journal Article in CURRENT DRUG METABOLISM

Hunting for serine 276-phosphorylated p65

Anneleen SpoorenKrzysztof KolmusLinda VermeulenKarlien Van WesemaelGuy HaegemanSarah Gerlo

A1 Journal Article in JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

IL-1 beta stabilizes IL-6 mRNA in human astrocytoma cells

Anneleen SpoorenGuy HaegemanSarah Gerlo

KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation

Pieter RondouKamila SkieterskaAnn PackeuBéatrice LintermansPeter VanhoenackerGeorges VauquelinGuy HaegemanKathleen Van Craenenbroeck

A1 Journal Article in CELLULAR SIGNALLING

Molecular cross-talk between nuclear receptors and nuclear factor-kB

Ilse BeckGuy HaegemanKarolien De Bosscher

Bookchapter in From molecular to modular tumor therapy : tumors are reconstructible communicatively evolving systems

Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders

Katarzyna Szarc Vel SzicMatladi N NdlovuGuy HaegemanWim Vanden Berghe

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Proinflammatory stimuli and β2-adrenoreceptor agonists synergistically induce IL-6 expression in myotubes

Krzysztof KolmusAnneleen SpoorenKarlien Van WesemaelGuy HaegemanSarah Gerlo

Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation

Anneleen SpoorenPieter RondouKatarzyna DebowskaBéatrice LintermansLinda VermeulenBart SamynKamila SkieterskaGriet DebyserBart DevreesePeter Vanhoenacker et al.

A1 Journal Article in CELLULAR SIGNALLING

Targeting inflammation using selective glucocorticoid receptor modulators

Karolien De BosscherGuy HaegemanDirk Elewaut

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

The dopamine D4 receptor: biochemical and signalling properties

Pieter RondouGuy HaegemanKathleen Van Craenenbroeck

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

2009

A selective glucocorticoid receptor modulator improves muscle function in a mouse model for Duchenne muscular dystrophy

Tony HuynhAndrea TrebbinDavid CowleyFrancis BowlingGary M LeongAndrew M CotterillMark HarrisKarolien De BosscherGuy HaegemanAndrew J Hoey

Circumventing glucocorticoid-mediated hyperinsulinemia via the activation of PPAR alpha

Nadia BougarneRejane PaumelleGuy HaegemanBart StaelsKarolien De Bosscher

Editorial material

Cooperation of NF-κB and CREB to induce synergistic IL-6 transcription upon combined triggering of β2-adrenergic and TNF-receptors in astrocytes

Anneleen SpoorenRon KooijmanKathleen Van CraenenbroeckLinda VermeulenGuy HaegemanSarah Gerlo

Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases

Ilse BeckWim Vanden BergheLinda VermeulenKeith R YamamotoGuy HaegemanKarolien De Bosscher

A1 Journal Article in ENDOCRINE REVIEWS

Differential mechanism of NF-κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

Valerie GossyeDirk ElewautNadia BougarneDebby BrackeSerge Van CalenberghGuy HaegemanKarolien De Bosscher

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Exploring TNF-α and cAMP-induced signaling pathways regulating IL-6 expression in skeletal muscle cells

Krzysztof KolmusGuy HaegemanSarah Gerlo

Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: Possible partners in the combat against inflammation

Ilse BeckWim Vanden BergheSarah GerloNadia BougarneLinda VermeulenKarolien De BosscherGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds

Marjan Van CleemputKo CattoorKarolien De BosscherGuy HaegemanDenis De KeukeleireArne Heyerick

A1 Journal Article in Journal of Natural Products

Hop bitter acids efficiently block inflammation independent of GRα, PPARα, or PPARγ

Marjan Van CleemputArne HeyerickClaude LibertKatrien SwertsJan PhilippéDenis De KeukeleireGuy HaegemanKarolien De Bosscher

A1 Journal Article in MOLECULAR NUTRITION & FOOD RESEARCH

Hyperactivated NF-κB and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells

Matladi N NdlovuCarine Van LintKarlien Van WesemaelPieter CallebertDany ChalbosGuy HaegemanWim Vanden Berghe

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Minireview: Latest Perspectives on Antiinflammatory Actions of Glucocorticoids

Karolien De BosscherGuy Haegeman

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

PPAR alpha blocks glucocorticoid receptor alpha-mediated transactivation but cooperates with the activated glucocorticoid receptor alpha for transrepression on NF-kappa B

Nadia BougarneRejane PaumelleSandrine CaronNathalie HennuyerRoxane MansouriPhilippe GervoisBart StaelsGuy HaegemanKarolien De Bosscher

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ser276 phosphorylation of NF-kB p65 by MSK1 controls SCF expression in inflammation

Laurent ReberLinda VermeulenGuy HaegemanNelly Frossard

A1 Journal Article in PLOS ONE

TLR4-mediated IL-6 gene expression in macrophages : who does the job?

Sarah GerloAnneleen SpoorenAgatha KoreckaGuy HaegemanWim Vanden Berghe

The astrocytic β2-adrenergic receptor : a novel target for treatment of neuro-inflammation?

Sarah GerloAnneleen SpoorenRon KooijmanBéatrice LintermansKathleen Van CraenenbroeckGuy Haegeman

The intracellular targets and anticancer mechanisms of Siamois® polyphenols

Wipob SuttanaSamlee MankhetkornGuy HaegemanWim Vanden BergheManuel Garrigos

The versatile role of MSKs in transcriptional regulation

Linda VermeulenWim Vanden BergheIlse BeckKarolien De BosscherGuy Haegeman

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Xanthohumol activates the proapoptotic arm of the unfolded protein response in chronic lymphocytic leukemia

Sofie LustBarbara VanhoeckeMireille Van GeleJerina BoelensHeleen Van MelckebekeMary KailehWim Vanden BergheGuy HaegemanJan PhilippéMarc Bracke et al.

A1 Journal Article in ANTICANCER RESEARCH

2008

A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis

Pieter DewintValerie GossyeKarolien De BosscherWim Vanden BergheKatrien Van BenedenDieter DeforceSerge Van CalenberghU MULLER-LADNERBert Vander CruyssenAugust Verbruggen et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Altered subcellular distribution of MSK1 induced by glucocorticoids contributes to NF-kappa B inhibition

Ilse BeckWim Vanden BergheLinda VermeulenNadia BougarneBERT VANDER CRUYSSENGuy HaegemanKarolien De Bosscher

A1 Journal Article in EMBO JOURNAL

BTB protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase

Pieter RondouGuy HaegemanPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Beneficial effects of soy isoflavones Focus on epigenetic and anti-inflammatory effects

Wim Vanden BergheGuy Haegeman

A1 Journal Article in AGRO FOOD INDUSTRY HI-TECH

Cloning, genomic organization and functionality of 5-HT7 receptor splice variants from mouse brain

Evelien GellynckKoen LAENENKW ANDRESSENBéatrice LintermansKim De MartelaereAnne MatthysFO LEVYGuy HaegemanPeter VanhoenackerKathleen Van Craenenbroeck

A1 Journal Article in GENE

In-vitro and in-vivo evidence for the anti-inflammatory activity of hop bitter acids in mouse

Marjan Van CleemputArne HeyerickClaude LibertDenis De KeukeleireGuy HaegemanKarolien De Bosscher

Selective transrepression versus transactivation mechanisms by glucocorticoid receptor modulators in stress and immune systems

Karolien De BosscherKathleen Van CraenenbroeckOnno C. MeijerGuy Haegeman

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACOLOGY

Therapeutic implications of the nuclear factor-kappaB/nuclear receptor cross-talk

Valerie GossyeGuy HaegemanKarolien De Bosscher

A1 Journal Article in FRONTIERS IN BIOSCIENCE

Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells

Sarah GerloGuy HaegemanWim Vanden Berghe

A1 Journal Article in CELLULAR SIGNALLING

2007

A critical role for p53 in the control of NF-kappa B-dependent gene expression in TLR4-stimulated dendritic cells exposed to genistein

Nathalie DijsselbloemS GORIELYV ALBARANISarah GerloSarah FrancozJean-Christophe MarineM GOLDMANGuy HaegemanWim Vanden Berghe

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Chemopreventive principles from Pueararia lobata flowers: In Vitro Evaluation of the Inhibition of the NF kappa B activating signaling pathway

L BEBREVSKAKarolien De BosscherGuy HaegemanI MERFORTS APERSL PIETERSA VLIETINCK

Contribution of IKK and PKA pathways to TLR4-triggered chromatin relaxation and transcription of the IL-6 gene

Sarah GerloWim Vanden BergheGuy Haegeman

Estrogen receptor signaling is an unstable feature of the gonadotropic LβT2 cell line

F EertmansWillem DhoogeOlivier De WeverWim Vanden BergheVeerle BogaertMarc BrackeGuy HaegemanFrank ComhaireJean Kaufman

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappa B activation by delaying I kappa B alpha mRNA resynthesis - Comparison with tumor necrosis factor alpha

J HORIONG GLOIREN EL MJIYADV QUIVYLinda VermeulenWim Vanden BergheGuy HaegemanC VAN LINTJ PIETTEY HABRAKEN

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Methylglyoxal suppresses TNF-alpha-induced NF-kappa B activation by inhibiting NF-kappa B DNA-binding

Mathias LagaAnneleen CottynFranky Van HerrewegheWim Vanden BergheGuy HaegemanPatric Van OostveldtJoël VandekerckhoveKatia Vancompernolle

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Novel interaction between the human 5-HT7 receptor isoforms and PLAC-24/eIF3k

Kim De MartelaereBéatrice LintermansGuy HaegemanPeter Vanhoenacker

A1 Journal Article in CELLULAR SIGNALLING

Preclinical study of a novel, non-steroidal, plant-derived, anti-inflammatory compound for the treatment of airway disease

Philippe GevaertJoke PatouThibaut Van ZeleGabriële HoltappelsKarolien De BosscherWim Vanden BergheGuy HaegemanClaus Bachert

Recurrent mutation in the first zinc finger of the orphan nuclear receptor NR2E3 causes autosomal dominant retinitis pigmentosa

Frauke CoppietersBart LeroyDiane BeysenJan HellemansKarolien De BosscherGuy HaegemanKIRSTEN ROBBERECHTWim WuytsPaul CouckeElfride De Baere

A1 Journal Article in AMERICAN JOURNAL OF HUMAN GENETICS

Screening of indigenous Palestinian medicinal plants for potential anti-inflammatory and cytotoxic activity

Mary KailehWim Vanden BergheElke BooneT ESSAWIGuy Haegeman

A1 Journal Article in JOURNAL OF ETHNOPHARMACOLOGY

Structure of the human 5-HT7 receptor gene and characterization of its promoter region

Koen LAENENGuy HaegemanPeter Vanhoenacker

A1 Journal Article in GENE

Withaferin A strongly elicits I kappa B kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity

Mary KailehWim Vanden BergheArne HeyerickJ HORIONJ PIETTEClaude LibertDenis De KeukeleireT ESSAWIGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

2006

Attenuation of mitogen- and stress-activated protein kinase-1-driven nuclear factor-kappa B gene expression by soy isoflavones does not require estrogenic activity

Wim Vanden BergheNathalie DijsselbloemLinda VermeulenMatladi NdlovuElke BooneGuy Haegeman

A1 Journal Article in CANCER RESEARCH

Cross-talk between nuclear receptors and nuclear factor kappa B

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in ONCOGENE

Influence of the antipsychotic drug pipamperone on the expression of the dopamine D4 receptor

Kathleen Van CraenenbroeckEvelien GellynckBéatrice LintermansJE LEYSENHHM VAN TOLGuy HaegemanPeter Vanhoenacker

A1 Journal Article in LIFE SCIENCES

Keeping up NF-kappa B appearances: Epigenetic control of immunity or inflammation-triggered epigenetics

Wim Vanden BergheMatladi NdlovuR. HOYA-ARIASNathalie DijsselbloemSarah GerloGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Regulation of NF-kappaB transcriptional activity

Linda VermeulenWim Vanden BergheGuy Haegeman

Bookchapter in The Link Between Inflammation and Cancer: Wounds that do not heal

2005

A fully dissociated compound of plant origin for inflammatory gene repression

Karolien De BosscherWim Vanden BergheIlse BeckWim Van MolleN HENNUYERJ HAPGOODClaude LibertB STAELSA LOUWGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Baseline nucleophosmin status in mutated(M) versus unmutated (U) immunoglobulin B-CLL is a nuclear reflection of different signal transduction physiology

JENS BOELENSW. Van den BergheGuy HaegemanAnne JanssensJan PhilippéFritz Offner

Baseline nucleophosmin status in mutated(M) versus unmutated(U) immunoglobulin B-CLL is a nuclear reflection of different signal transduction physiology

Jerina BoelensWim Vanden BergheGuy HaegemanAnne JanssensJan PhilippéFritz Offner

Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-kappa B activation and IFN-beta synthesis downstream of Toll-like receptor 3 and 4

E AKSOYWim Vanden BergheS DETIENNEZ AMRAOUIKA FITZGERALDGuy HaegemanM GOLDMANF WILLEMS

A1 Journal Article in EUROPEAN JOURNAL OF IMMUNOLOGY

NF-kappa B mediated IL-6 production by renal epithelial cells is regulated by C-Jun NH2-terminal kinase

S DE HAIJAC BAKKERRN VAN DER GEESTGuy HaegemanWim Vanden BergheJ AARBIOUMR DAHAC VAN KOOTEN

A1 Journal Article in JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Phytoestrogens in Cancer Prevention: Characterization and Beneficial Effects of Kurarinone, a New Flavanone and a Major Phytoestrogen Constituent of Sophora flavescens Ait., Chapter 25 in: Phytopharmaceuticals in Cancer Chemoprevention, Debasis Bagchi & Harry G. Preuss (eds), CRC Press, Boca Raton, Florida, USA, 2005 (ISBN: 0-8493-1560-3)

Ann DE NAEYERWim VANDEN BERGHEDenis De KeukeleireGuy Haegeman

Bookchapter in Phytopharmaceuticals in Cancer Chemoprevention

Potent anti-inflammatory, fully dissociative compound for glucocorticoid receptor-mediated gene regulation

Pieter DewintKarolien De BosscherValerie GossyeWim Vanden BergheBert Vander CruyssenEric VeysGuy HaegemanDirk Elewaut

Regulation of NF-kappaB-driven inflammatory genes by phytoestrogens

Wim Vanden BergheN. DIJSSELBLOEMAn De NaeyerLinda VermeulenGuy Haegeman

Bookchapter in Oxidative stress, Inflammation and Health

Role of CREB1 and NF kappa B-p65 in the down-regulation of renin gene expression by tumor necrosis factor alpha

VT TODOROVS VOLKLR FRIEDRICHLA KUNZ-SCHUGHARTT HEHLGANSLinda VermeulenGuy HaegemanML SCHMITZA KURTZ

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Role of glucocorticoids in dopamine-related neuropsychiatric disorders

Kathleen Van CraenenbroeckKarolien De BosscherWim Vanden BerghePeter VanhoenackerGuy Haegeman

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

2004

Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens

An De NaeyerWim Vanden BergheV POCOCKS MILLIGANGuy HaegemanDenis De Keukeleire

A1 Journal Article in JOURNAL OF NATURAL PRODUCTS

Involvement of GSK-3 beta in TWEAK-mediated NF-kappa B activation

Adelheid De KetelaereLinda VermeulenJ VIALARDI VAN DE WEYERJ VAN WAUWEGuy HaegemanI MOELANS

A1 Journal Article in FEBS LETTERS

Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells

D KOUBOVECWim Vanden BergheLinda VermeulenGuy HaegemanJP HAPGOOD

A1 Journal Article in MOLECULAR AND CELLULAR ENDOCRINOLOGY

Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production

Greet BrouckaertMichaël KalaiDmitri KryskoXavier SaelensDominique VercammenMatladi NdlovuGuy HaegemanKatharina D'HerdePeter Vandenabeele

A1 Journal Article in MOLECULAR BIOLOGY OF THE CELL

Recruitment of I kappa B alpha to the hes1 promoter is associated with transcriptional repression

C AGUILERAR HOYA-ARIASGuy HaegemanL ESPINOSAA BIGAS

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soy isoflavone phyto-pharmaceuticals in interleukin-6 affections multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy

Nathalie DijsselbloemWim Vanden BergheAn De NaeyerGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2003

A paradigm for gene regulation: Inflammation, NF-kappa B and PPAR

Wim Vanden BergheLinda VermeulenP DELERIVEKarolien De BosscherB STAELSGuy Haegeman

A1 Journal Article in PEROXISOMAL DISORDERS AND REGULATION OF GENES

DNA viral vectors in gene therapy

Kathleen Van CraenenbroeckPeter VanhoenackerGuy Haegeman

Bookchapter in Nature Encyclopedia of the human genome

Inhibition of cytokine production by the herbicide atrazine - Search for nuclear receptor targets

S DEVOSKarolien De BosscherB STAELSE BAUERFrank RoelsWim Vanden BergheGuy HaegemanR HOOGHEEL HOOGHE-PETERS

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Inhibition of signal transduction pathways involved in inflammation

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Orientation-dependent gene expression with Epstein-Barr virus-derived vectors

Kathleen Van CraenenbroeckPeter VanhoenackerInge RomanGuy Haegeman

A1 Journal Article in FEBS LETTERS

Regulation of NF-kB by glucocorticoids

Karolien De BosscherWim Vanden BergheGuy Haegeman

Bookchapter in Nuclear Factor kB: Regulation and role in disease

The interplay between the glucocorticoid receptor and nuclear factor-kappa B or activator protein-1: Molecular mechanisms for gene repression

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in ENDOCRINE REVIEWS

Transcriptional activation of the NF-kappa B p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)

Linda VermeulenGert De WildePetra Van DammeWim Vanden BergheGuy Haegeman

A1 Journal Article in EMBO JOURNAL

2002

DNA binding-independent induction of I kappa B alpha gene transcription by PPAR alpha

P DeleriveKarolien De BosscherWim Vanden BergheJC FruchartGuy HaegemanB Staels

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Induction and repression of NF-kappaB-driven inflammatory genes.

Wim Vanden BergheKarolien De BosscherLinda VermeulenGert De WildeGuy Haegeman

Bookchapter in Recent Advances in Glucocorticoid Receptor Action

Regulation of the transcriptional activity of the nuclear factor-kappa B p65 subunit.

Linda VermeulenGert De WildeSofie NotebaertWim Vanden BergheGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

2001

Evaluation of the tetracycline- and ecdysone-inducible systems for expression of neurotransmitter receptors in mammalian cells.

Kathleen Van CraenenbroeckPeter VanhoenackerJE LEYSENGuy Haegeman

A1 Journal Article in EUROPEAN JOURNAL OF NEUROSCIENCE

Expression in Escherichia coli of the death domain of the human p55 tumor necrosis factor receptor.

Gert De WildeNico MertensElke BooneB DE VREESEJozef Van BeeumenWalther FiersGuy Haegeman

A1 Journal Article in PROTEIN EXPRESSION AND PURIFICATION

Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators.

Karolien De BosscherWim Vanden BergheGuy Haegeman

A1 Journal Article in MOLECULAR ENDOCRINOLOGY

Structure-activity relationship of the p55 TNF receptor death domain and its lymphoproliferation mutants.

Gert De WildeJ MURRAY-RUSTElke BooneD OLERENSHAWNQ MCDONALDC IBANEZGuy HaegemanA WOLLMERM FEDERWISCH

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

2000

5-HT7 receptors: current knowledge and future prospects.

Peter VanhoenackerGuy HaegemanJE LEYSEN

A1 Journal Article in TRENDS IN PHARMACOLOGICAL SCIENCES

Episomal vectors for gene expression in mammalian cells.

Kathleen Van CraenenbroeckPeter VanhoenackerGuy Haegeman

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Glucocorticoids repress NF-kappa B-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell.

Karolien De BosscherW VANDEN BERGHELinda VermeulenS PLAISANCEElke BooneGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-level expression of neurotransmitter receptors: Comparison of the usefulness of four different inducible expression systems

Peter VanhoenackerKathleen Van CraenenbroeckJ LEYSENGuy Haegeman

Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors.

Karolien De BosscherW VANDEN BERGHEGuy Haegeman

A1 Journal Article in JOURNAL OF NEUROIMMUNOLOGY

Molecular integrity and usefulness of episomal expression vectors derived from BK and Epstein-Barr virus.

Kathleen Van CraenenbroeckPeter VanhoenackerHilde DUCHAUGuy Haegeman

A1 Journal Article in GENE

Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6.

Wim Vanden BergheLinda VermeulenGert De WildeKarolien De BosscherElke BooneGuy Haegeman

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Structure/function analysis of p55 tumor necrosis factor receptor and Fas-associated death domain : effect on necrosis in L929sA cells.

Elke BooneTom Vanden BergheGeert van LooGert De WildeN DE WAELD VERCAMMENWalther FiersGuy HaegemanPeter Vandenabeele

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1999

Agonist-induced GTP & # 61543 ;[S-35] binding appears to be a more sensitive tool to assess group II/III mGluR expression as compared to adenylyl cyclase inhibition

ASJ LESAGEE LE POULL PEETERSP VAN GOMPELPeter VanhoenackerGuy HaegemanJE LEYSEN

Antagonist-mediated potentiation of glutamate-induced intracellular calcium mobilization in mGluR1a expressing cells

E LE POULA LESAGEP VAN GOMPELPeter VanhoenackerGuy HaegemanJ LEYSEN

Dissociated glucocorticoids with anti-inflammatory potential repress interleukin-6 gene expression by a nuclear factor-kappa B-dependent mechanism.

Wim Vanden BergheE FRANCESCONIKarolien De BosscherM RESCHE-RIGONGuy Haegeman

A1 Journal Article in MOLECULAR PHARMACOLOGY

In search of the molecular mechanism of gene repression by glucocorticoids

Karolien De BosscherWim Vanden BergheElke BooneGuy Haegeman

In search of the molecular mechanism of gene repression by glucocorticoids.

Karolien De BosscherWim Vanden BergheElke BooneGuy Haegeman

Multiple signal transduction pathways regulate TNF-induced actin reorganization in macrophages: Inhibition of Cdc42-mediated filopodium formation by TNF.

M PEPPELENBOSCHElke BooneGE JONESSJH VAN DEVENTERGuy HaegemanWalther FiersJohan GrootenAJ RIDLEY

A1 Journal Article in JOURNAL OF IMMUNOLOGY

N-acetyl-L-cysteine inhibits primary human T cell responses at the dendritic cell level: Association with NF-kappa B inhibition.

V VERHASSELTWim Vanden BergheN VANDERHEYDEFrans WillemsGuy HaegemanM GOLDMAN

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Optimized expression of serotonin receptors in mammalian cells using inducible expression systems

Peter VanhoenackerW GommerenW LuytenJE LeysenGuy Haegeman

Bookchapter in Gene therapy & molecular biology : from basic mechanisms to clinical applications, vol. 3

Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappa B and AP-1.

P DELERIVEKarolien De BosscherS BESNARDWim Vanden BergheJM PETERSFJ GONZALEZJC FRUCHARTA TEDGUIGuy HaegemanB STAELS

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

TNF-signalisatie leidend tot geninductie en celdood in de muis fibrosarcoma cellijn L929 : rol van de 55 kDa TNF-receptor

Veronique VandevoordeGuy HaegemanWalther Fiers

The nuclear factor-kappa B engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.

Wim Vanden BergheKarolien De BosscherElke BooneS PLAISANCEGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The zinc finger protein A20 inhibits TNF-induced NF-kappa B-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappa B-inhibiting protein ABIN.

Karen HeyninckDirk De ValckWim Vanden BergheWim Van CriekingeRoland ContrerasWalther FiersGuy HaegemanRudi Beyaert

A1 Journal Article in JOURNAL OF CELL BIOLOGY

1998

Activation of p42/p44 mitogen-activated protein kinases (MAPK) and p38 MAPK by tumor necrosis factor (TNF) is mediated through the death domain of the 55-kDa TNF receptor.

Elke BooneVeronique VandevoordeGert De WildeGuy Haegeman

A1 Journal Article in FEBS LETTERS

Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines.

AS LESAGER WOUTERSP VAN GOMPELL HEYLENPeter VanhoenackerGuy HaegemanWHML LUYTENJE LEYSEN

A1 Journal Article in BRITISH JOURNAL OF PHARMACOLOGY

Cloning and expression of a fused gene encoding TNFRI death domain and chloramphenicol acetyltransferase.

LZ LINCB LISY ZHAOG DE WILDEGuy HaegemanWalther Fiers

A1 Journal Article in ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Cross-talk between steroids and NF-kappa B: what language?

A DUMONTSP HEHNERML SCHMITZJA GUSTAFSSONJ LIDENS OKRETPT VAN DER SAAGS WISSINKB VAN DER BURGP HERRLICH et al.

A1 Journal Article in TRENDS IN BIOCHEMICAL SCIENCES

Efficient expression of neurotransmitter receptors in mammalian cells: Use of inducible expression systems

Peter VanhoenackerI VAN DEN BOGERDW GOMMERENWHML LUYTENJE LEYSENGuy Haegeman

Induction of unresponsiveness to tumor necrosis factor (TNF) after autocrine TNF expression requires TNF membrane retention.

Els DecosterB VANHAESEBROECKElke BooneS PLAISANCEKurt De VosGuy HaegemanJohan GrootenWalther Fiers

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

The 55-kDa tumor necrosis factor receptor induces clustering of mitochondria through its membrane-proximal region.

Kurt De VosVera GoossensElke BooneDominique VercammenK VANCOMPERNOLLEPeter VandenabeeleGuy HaegemanWalther FiersJohan Grooten

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor kappa B p65 transactivation mediated by tumor necrosis factor.

Wim Vanden BergheS PLAISANCEElke BooneKarolien De BosscherML SCHMITZWalther FiersGuy Haegeman

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1997

Effects of antioxidant enzyme modulations on interleukin-1-induced nuclear factor kappa B activation.

P RENARDMD ZACHARYC BOUGELETME MIRAULTGuy HaegemanJ REMACLEM RAES

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation

Karolien De BosscherM Lienhard SchmitzWim Vanden BergheStéphane PlaisanceWalther FiersGuy Haegeman

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced expression of trimerized intracellular domains of the human tumor necrosis factor (TNF) p55 receptor elicits TNF effects.

Veronique VandevoordeGuy HaegemanWalther Fiers

A1 Journal Article in JOURNAL OF CELL BIOLOGY

Recombination signal sequence binding protein J kappa is constitutively bound to the NF-kappa B site of the interleukin-6 promoter and acts as a negative regulatory factor.

S PLAISANCEW VANDENBERGHEElke BooneWalther FiersGuy Haegeman

A1 Journal Article in MOLECULAR AND CELLULAR BIOLOGY

Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways.

Els DecosterVeronique VandevoordeRudi BeyaertGuy HaegemanWalther Fiers

A1 Journal Article in FEBS LETTERS

Stable, high-level expression of human serotonin receptors in L929 cells using an inducible expression system.

Peter VanhoenackerW GOMMERENWHML LUYTENJE LEYSENGuy Haegeman

A1 Journal Article in RECEPTORS & CHANNELS

Tumour necrosis factor: intracellular mechanism of action

Walther FiersRudi BeyaertElke BooneWim DeclercqEls DecosterDirk De ValckVera GoossensJohan GrootenGuy HaegemanKaren Heyninck et al.

Bookchapter in HIV and cytokines

1996

Alniditan, a new 5-hydroxytryptamine(1D) agonist and migraine-abortive agent: Ligand-binding properties of human 5-hydroxytryptamine(1D alpha), human 5-hydroxytryptamine(1D beta), and calf 5-hydroxytryptamine(1D) receptors investigated with [H-3]5-hydroxytryptamine and [H-3]Alniditan.

JE LEYSENW GOMMERENL HEYLENWHML LUYTENI VANDEWEYERPeter VanhoenackerGuy HaegemanA SCHOTTEP VANGOMPELR WOUTERS et al.

A1 Journal Article in MOLECULAR PHARMACOLOGY

TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.

Walther FiersRudi BeyaertElke BooneSigrid CornelisWim DeclercqEls DecosterGeertrui DeneckerBart DepuydtDirk De ValckG DEWILDE et al.

A1 Journal Article in JOURNAL OF INFLAMMATION

The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor.

Rudi BeyaertA CUENDAW VANDENBERGHES PLAISANCEJC LEEGuy HaegemanP COHENWalther Fiers

A1 Journal Article in EMBO JOURNAL

1995

TNF-induced mechanisms for IL6 gene induction

Guy HaegemanWalther Fiers

1994

Studies on the induction of the interleukin-6 promoter in cell lines of human and simian origin.

Peter VanhoenackerWalther FiersGuy Haegeman

A1 Journal Article in EUROPEAN CYTOKINE NETWORK

1993

ACTIVATION OF THE NUCLEAR FACTOR-KAPPA-B IS NOT SUFFICIENT FOR REGULATION OF TUMOR NECROSIS FACTOR-INDUCED INTERLEUKIN-6 GENE-EXPRESSION.

NP PATESTOSGuy HaegemanVeronique VandevoordeWalther Fiers

A1 Journal Article in BIOCHIMIE

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

K SCHULZEOSTHOFFRudi BeyaertVeronique VandevoordeGuy HaegemanWalther Fiers

A1 Journal Article in EMBO JOURNAL

Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine

Rudi BeyaertBart VanhaesebroeckKaren HeyninckElke BooneDirk De ValckKlaus Schulze-OsthoffGuy HaegemanFrans Van RoyWalther Fiers

A1 Journal Article in CANCER RESEARCH

Studies on the inducibility of the IL6 promoter using a reporter gene construction.

Wim Vanden BergheGuy HaegemanWalther Fiers

Two pathways of tumor necrosis factor signal transduction: in vitro and in vivo implications

Walther FiersRudi BeyaertPeter BrouckaertAnje CauwelsWim DeclercqDirk De ValckB EveraerdtVera GoossensJohan GrootenGuy Haegeman et al.

1992

TNF-mediated IL6 gene expression and cytotoxicity are co-inducible in TNF resistant L929 cells

Veronique VandevoordeGuy HaegemanWalther Fiers

A1 Journal Article in FEBS LETTERS

TUMOR-NECROSIS-FACTOR STIMULATES MULTIPLE SERINE THREONINE PROTEIN-KINASES IN SWISS 3T3 AND L929 CELLS - IMPLICATION OF CASEIN KINASE-2 AND EXTRACELLULAR SIGNAL-REGULATED KINASES IN THE TUMOR-NECROSIS-FACTOR SIGNAL TRANSDUCTION PATHWAY.

J VANLINTP AGOSTINISVeronique VandevoordeGuy HaegemanWalther FiersW MERLEVEDEJR VANDENHEEDE

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

1991

Production and purification of recombinant human interleukin-6 secreted by the yeast Saccharomyces cerevisiae

Yves GuisezBernard TisonJoël VandekerckhoveJan DemolderGuy BauwGuy HaegemanWalther FiersRoland Contreras

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

Tumor necrosis factor-induced interleukin-6 expression and cytotoxicity follow a common signal transduction pathway in L929 cells

Veronique VandevoordeGuy HaegemanWalther Fiers

A1 Journal Article in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

1990

In vitro and in vivo action of tumor necrosis factor

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanClaude LibertPhilip SuffysNozomi TakahashiJan TavernierSigrid Van Bladel et al.

1987

B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-β2, HPGF)

P PoupartPeter VandenabeeleS CayphasJ Van SnickGuy HaegemanV KruysWalther FiersJ Content

A1 Journal Article in EMBO JOURNAL

Gene cloning and structure: function relationship of cytokines such as TNF and interleukins

Walther FiersRudi BeyaertPeter BrouckaertBart EveraerdtGuy HaegemanPhilip SuffysJan TavernierPeter VandenabeeleBart VanhaesebroeckXaveer Van Ostade et al.

A1 Journal Article in IMMUNOLOGY LETTERS

1986

Structural analysis of the sequence coding for an inducible 26-kDa protein in human fibroblasts

Guy HaegemanJean ContentGuido VolckaertRik DerynckJan TavernierWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1981

Nucleotide sequence of the chromosomal gene for human fibroblast (β1) interferon and of the flanking regions

Wim DegraveRik DerynckJan TavernierGuy HaegemanWalther Fiers

A1 Journal Article in GENE

1980

Characterization of the 5'-terminal cap structures of early simian virus 40 mRNA

Guy HaegemanWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

1979

Characterization of the major altered leader sequence of late mRNA induced by SV40 deletion mutant d1-1811

Guy HaegemanDirk IserentantDirk GheysenWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

Heterogeneity of the 5' terminus of late mRNA induced by a viable simian virus 40 deletion mutant

Guy HaegemanHugo Van HeuverswynDirk GheysenWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

1978

Characterization of the 5'-terminal capped structures of late simian virus 40-specific mRNA

Guy HaegemanWalther Fiers

A1 Journal Article in JOURNAL OF VIROLOGY

Complete nucleotide sequence of SV40 DNA

Walther FiersRoland ContrerasGuy HaegemanRaphaël RogiersAndré Van De VoordeHugo Van HeuverswynJacqueline Van HerrewegheGuido VolckaertMarc Ysebaert

A1 Journal Article in NATURE

Evidence for 'splicing' of SV40 16S mRNA

Guy HaegemanWalther Fiers

A1 Journal Article in NATURE

Localization of 5' terminus of late SV40 mRNA

Guy HaegemanWalther Fiers

A1 Journal Article in NUCLEIC ACIDS RESEARCH

1976

Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene

Walther FiersRoland ContrerasFred DuerinckGuy HaegemanDirk IserentantJozef MerregaertWilly Min JouFrancis MolemansAlex RaeymaekersA Van den Berghe et al.

A1 Journal Article in NATURE

1975

A-Protein gene of bacteriophage MS2

Walther FiersRoland ContrerasFred DuerinckGuy HaegemanJozef MerregaertWilly Min JouAlex RaeymakersGuido VolckaertMarc YsebaertJoël Vandekerckhove et al.

A1 Journal Article in NATURE

1973

Studies on the bacteriophage MS2: an internal nucleotide fragment resembling some ribosomal binding sites

Guy HaegemanWalther Fiers

A1 Journal Article in EUROPEAN JOURNAL OF BIOCHEMISTRY

1972

Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein

Willy Min JouMarc YsebaertWalther FiersGuy Haegeman

A1 Journal Article in NATURE

1971

Recent progress in the sequence determination of bacteriophage MS2 RNA

Walther FiersRoland ContrerasRupert De WachterGuy HaegemanJozef MerregaertWilly Min JouAntoon Vandenberghe

A1 Journal Article in BIOCHIMIE

Studies on the bacteriophage MS2, IX: the heptanucleotide sequences present in the pancreatic ribonuclease digest of the viral RNA

Guy HaegemanWilly Min JouWalther Fiers

A1 Journal Article in JOURNAL OF MOLECULAR BIOLOGY

Studies on the bacteriophage MS2: nucleotide fragments from the coat protein cistron

Willy Min JouGuy HaegemanWalther Fiers

A1 Journal Article in FEBS LETTERS

1970

The heptanucleotide sequences present in the pancreatic ribonuclease digest of bacteriophage MS2 RNA

Guy HaegemanWilly Min JouWalther Fiers

1969

Studies on the primary structure and the replication mechanism of bacteriophage RNA

Walther FiersMarc Van MontaguRupert De WachterGuy HaegemanWilly Min JouEric MessensErik RemautAntoon VandenbergheBenoni Van Styvendaele

A1 Journal Article in COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY

TNF-induced, cytotoxicity-linked IL6 gene expression in L929 cells may require factors other than NF-kB. Biochem. Soc. Trans., 1991, 20, 80S.

N PATESTOSGuy HaegemanW HERS

A2 Journal Article