Research Explorer

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Researcher

Dirk Elewaut

Publications & Research Data

Awards & Distinctions

563 Results

2026

Barrier breakdown : insights into the skin–gut axis in psoriatic arthritis

Wannes Van HoosteCaitlin Elizabeth GraySara ParsaDirk ElewautErik LubbertsLeonie S TaamsKoen Venken

A1 Journal Article in TRENDS IN IMMUNOLOGY

Cross-species cellular mapping and humanization of Fcγ receptors to advance antibody modeling

Karel Van DammeDorine SichienKatrien Van Der BorghtJustine Van MoorleghemSofie Van GassenJoseph JorssenSeppe De WinterElisabeth De LeeuwCaihong WangQingqing Chai et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

HIF1α gates tendon response to overload and drives tendinopathy independently of vascular recruitment

Greta MoschiniArchana G. MohananIzabella S. NiewczasDiane E. TaylorPatrick K. JaegerGuillermo TurielAmro A. HussienStefania L. WunderliOlivia BaumbergerMaja Wolleb et al.

A1 Journal Article in SCIENCE TRANSLATIONAL MEDICINE

In vivo modeling of human γS T cell ontogeny reveals terminal deoxynucleotidyl transferase as a key regulator of type 3 VS2 T cell development

Celine LaAurelie DetavernierMaria PapadopoulouGuillem Sanchez SanchezVincent MartensSeverine ThomasMuriel NguyenValerie AcoltyMaxime MelchiorDesiree Venturoli et al.

A1 Journal Article in CELL REPORTS

Ocular graft-versus-host disease in allogeneic stem cell transplant recipients : a longitudinal cohort study evaluating ocular surface parameters before and after transplantation

Dimitri RoelsAnke DelieDominiek MazureKatrien De GroveIneke van GrembergheJoke DeprezIsabelle PeeneDirk ElewautBart LeroyIlse Claerhout et al.

A1 Journal Article in CORNEA

Work participation and work disability in Belgian patients with systemic sclerosis

Ine DesimpeleAnn-Sophie De CraemerSaskia DecumanAnnick ViaenePiet MorteleLauren DelmezPhilippe CarronDirk ElewautFilip Van den BoschVanessa Smith

A1 Journal Article in RHEUMATOLOGY

Your FLORA Matters: Microbiome Modulation in Psoriatic Arthritis

Emilie DumasDirk Elewaut

Editorial material

2025

AI-driven histologic analysis of human Achilles tendinopathy provides a roadmap to unravel pathogenesis

Guillaume PlanckaertArne BurssensFlore StappersJulie CoudenysSofia DemolderIrem KayaMalaïka Van der LindenAmanda GonçalvesKelly LemeireBenjamin Pavie et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Artificial intelligence algorithm for detection of erosions and ankylosis on CT scans including the sacroiliac joints : multicentre development and validation of real-world detection performance

Thomas Van Den BergheDanilo BabinMin ChenVictor MylleAxel VlaminckRuben VerhackLarsen D'hietMartijn CallensDenim BrackHelena Maes et al.

BonAIr : an AI-driven histological validation of human Achilles tendinopathy provides a roadmap to unravel pathogenesis

Guillaume PlanckaertArne BurssensFlore StappersIrem KayaMalaïka Van der LindenAmanda GonçalvesBenjamin PavieAmber VanhaeckeJo Van DorpeJan Victor et al.

Development of extramusculoskeletal manifestations in upadacitinib-treated patients with psoriatic arthritis or axial spondyloarthritis

Denis PoddubnyyBhumik ParikhDirk ElewautVictoria Navarro-CompanStefan SiebertMichael PaleyDerek CoombsIvan LagunesAna BiljanPriscila Nakasato et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Disconnect to connect : towards clinically meaningful stratification tools in Sjögren's disease

Helena AchtenIsabelle PeeneDirk Elewaut

Efficacy of golimumab in early axial spondyloarthritis in relation to gut inflammation (GO‐GUT) : an early remission induction study

Zuzanna ŁukasikAnn-Sophie De CraemerThomas RensonLiselotte DerooGaëlle VarkasManouk de HoogeJan LenaertsAnne HoorensClaude CuvelierTriana Lobatón Ortega et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Endogenous lipoid pneumonia in adult autoinflammatory disease

Katrien SlabbynckJo Van DorpeIsabelle PeeneKarin MelsensCedric BosteelsRik JoosDirk ElewautPeggy JacquesHans SlabbynckGaëlle Varkas

A1 Journal Article in ARTHRITIS CARE & RESEARCH

Impact of IgG Fc glycosylation on disease dynamics in patients with primary Sjögren disease

Helena AchtenLeander MeurisLiselotte DerooMatthias JarlborgTine DecruyJoke DeprezEmilie DumasKristel De BoeckEva GenbruggeWouter Bauters et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Impressions of erosive hand osteoarthritis : the physical handprint and molecular fingerprint

Tine VanhaverbekeRuth WittoekDirk ElewautKoen Venken

Intestinal epithelial expression of human TNF is sufficient to induce small bowel inflammation and sacroiliitis, mimicking human spondyloarthritis

Karlijn DebusschereDonald SouzaGerald H. NaboznyEmilie DumasEveline VerheugenJulie CoudenysTeddy ManuelloFlore StappersTine DecruyMargaux Maelegheer et al.

A1 Journal Article in RHEUMATOLOGY

Long-term evolution of postpartum sacroiliac bone marrow oedema : a 5-year longitudinal follow-up study

Gaëlle VarkasLiesbet De MeesterManouk de HoogeAnn-Sophie De CraemerNele HerregodsLennart JansPhilippe CarronDirk ElewautFilip Van den Bosch

A1 Journal Article in RMD OPEN

Microbial contributions to gut and joint disease

Alexandra ThiranLars VereeckeDirk Elewaut

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

Muralikrishna AkulaElisabeth GilisPieter HertensLieselotte Vande WalleMozes SzeJulie CoudenysYunus IncikOmar KhanMartin O. BergoDirk Elewaut et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Roken : een trigger voor T-cel-autoreactiviteit bij reumatoïde artritis?

Koen VenkenDirk Elewaut

A4 Journal Article in ORTHO RHUMATO (NEDERLANDSE ED.)

Single cell analysis reveals fibroblast dysregulation in human Achilles tendinopathy

Sofia DemolderGuillaume PlanckaertFlore StappersCarolien VliegheArne BurssensJan VictorJess SnedekerEric GraceyDirk Elewaut

The force on tendinopathy : deep cellular profiling reveals potential therapeutic targets in achilles tendinopathy

Guillaume PlanckaertDirk ElewautJan VictorEric Gracey

The glucocorticoid receptor is affected by its target ZBTB16 in a dissociated manner

Sekar GaluhErin FaughtIngeborg KlaassenLisa KoorneefJoost BrinksElon H. C. van DijkDirk ElewautReinier O. SchlingemannMarcel J. M. SchaafCamiel J. F. Boon et al.

A1 Journal Article in JOURNAL OF ENDOCRINOLOGY

The lung-joint axis : impact of cigarette smoking on T cell reactivity in rheumatoid arthritis development

Matthias JarlborgDirk ElewautKoen Venken

Ultrasound-guided core needle biopsy of the parotid gland in Sjögren's disease : a promising tool towards precision medicine

Helena AchtenEva GenbruggeLiselotte DerooDavid CreytensAmber VanhaeckeJoke DeprezEmilie DumasSophie VanhoofKristel De BoeckWouter Bauters et al.

A1 Journal Article in RMD OPEN

Vascular occlusion for optimising the functional improvement in patients with knee osteoarthritis : a randomised controlled trial

Ewoud JacobsLenka StroobantJan VictorDirk ElewautThomas TampereSteven WallaertErik WitvrouwJoke SchuermansEvi Wezenbeek

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2024

Association of anatomical variants of the sacroiliac joint with bone marrow edema in patients with axial spondyloarthritis

Elke VereeckeLennart JansNele HerregodsMin ChenJacob L. JaremkoFrederiek LalooPhilippe CarronGaëlle VarkasManouk de HoogeFilip Van den Bosch et al.

A1 Journal Article in SKELETAL RADIOLOGY

Beyond inflammation : GDF15's influence on bone remodeling in arthritis

Renée Van der CruyssenDirk ElewautLars Vereecke

Improvement of antioxidant capability by dietary N-acetyl cysteine supplementation alleviates bone loss induced by chronic heat stress in finisher broilers

Huaiyong ZhangHerinda PertiwiJoris MichielsDjoere GaublommeMaryam MajdeddinYuhuang HouMatthieu BooneDirk ElewautIván JosipovicJeroen Degroote

A1 Journal Article in JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY

Levamisole-adulterated cocaine-induced mucous membrane pemphigoid : case reports and literature review

Elke ThijsDaire HurleyBrendan CummingsDirk ElewautNick VerougstraeteIlse ClaerhoutConor C. MurphyWilliam PowerDimitri Roels

A1 Journal Article in CORNEA

Lipidomic scanning of self-lipids identifies headless antigens for natural killer T cells

Tan-Yun ChengT PraveenaSrinath GovindarajanCatarina F AlmeidaDaniel G PellicciWellington C ArkinsIldiko Van RhijnKoen VenkenDirk ElewautDale I Godfrey et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maximal exercise tolerance, objective trunk strength, and mobility measurements in axial spondyloarthritis

Sophie De MitsTine WillemsPatrick CaldersLieven DanneelsGaëlle VarkasFilip Van den BoschDirk ElewautPhilippe Carron

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

Myeloid A20 is critical for alternative macrophage polarization and type-2 immune-mediated helminth resistance

Ioanna PettaMarie ThorpMaarten CiersGillian BlanckeLouis BoonTim MeeseFilip Van NieuwerburghAndy WullaertRichard GrencisDirk Elewaut et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

RANKL blockade for erosive hand osteoarthritis : a randomized placebo-controlled phase 2a trial

Ruth WittoekGust VerbruggenTine VanhaverbekeRoos ColmanDirk Elewaut

A1 Journal Article in NATURE MEDICINE

Shared lung and joint T cell repertoire in early rheumatoid arthritis driven by cigarette smoking

Koen VenkenMatthias JarlborgFrederik StevenaertThomas MalfaitCarolien VliegheYann AbrahamTeddy ManuelloTine DecruyStijn VanheeHans Wils et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Specific descriptions of axial involvement are associated with radiographic damage development after 2 years in psoriatic arthritis patients

Manouk de HoogeAlla IschenkoSerge SteinfeldAdrien NzeusseuDirk ElewautRik LoriesFilip Van den BoschKurt De Vlam

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Streptococcal quorum sensing peptide CSP-7 contributes to muscle inflammation and wasting

Anton De SpiegeleerAmélie DescampsEvelien WynendaelePetar NaumovskiLiesbeth CrombezMarta PlanasLidia FeliuDaniel KnappeVincent MoulyAnne Bigot et al.

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Saliva and Muscle Study (SaMu) : rationale and protocol for associations between salivary microbiome and accelerated muscle ageing

Liesbeth CrombezAmélie DescampsHannah HirmzMartijn LambertJonas CalewaertD. SilukM. MarkuszewskiM. BiesemansG. PetrellaD. Cicero et al.

A2 Journal Article in JOURNAL OF FRAILTY & AGING

Tregs protect against invariant NKT cell-mediated autoimmune colitis and hepatitis

Koen VenkenTine DecruyTim SparwasserDirk Elewaut

A1 Journal Article in IMMUNOLOGY

2023

Advances in primary Sjögren’s syndrome diagnosis and patient stratification : first results from the BeSSTT cohort

Liselotte DerooDirk ElewautIsabelle PeeneFilip Van den Bosch

Anti-CD74 IgA antibodies show diagnostic potential for axial spondyloarthritis but are not associated with microscopic gut inflammation

Ann-Sophie De CraemerTorsten WitteTriana Lobatón OrtegaAnne HoorensMartine De VosClaude CuvelierSebastiaan J. VastertXenofon BaraliakosFilip Van den BoschDirk Elewaut

A1 Journal Article in RHEUMATOLOGY

Bacterial quorum-sensing peptides as immune modulators present in systemic circulation

Anton De SpiegeleerAmélie DescampsSrinath GovindarajanJulie CoudenysKevin Van der borghtHannah HirmzNele Van Den NoortgateDirk ElewautBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOMOLECULES

Cell behavior changes and enzymatic biodegradation of hybrid electrospun poly(3-hydroxybutyrate)-based scaffolds with an enhanced piezoresponse after the addition of reduced graphene oxide

Roman ChernozemIgor PariyMaria A. A. SurmenevaVladimir V. V. ShvartsmanGuillaume PlanckaertJoost VerduijnStef GhyselsAnatolii AbalymovBogdan ParakhonskiyEric Gracey et al.

A1 Journal Article in ADVANCED HEALTHCARE MATERIALS

Challenges of the unifying spondyloarthritis concept : insights from the clinical observational Be-GIANT cohort study

Ann-Sophie De CraemerDirk ElewautFilip Van den Bosch

Distinct immune modulatory roles of regulatory T cells in gut versus joint inflammation in TNF-driven spondyloarthritis

Koen VenkenMatthias JarlborgTine DecruyCéline MortierCarolien VliegheElisabeth GilisAnn-Sophie De CraemerJulie CoudenysIsabelle CambréDevan Fleury et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Efficacy and safety of bimekizumab in axial spondyloarthritis : results of two parallel phase 3 randomised controlled trials

Desiree van der HeijdeAtul DeodharXenofon BaraliakosMatthew A. BrownHiroaki DobashiMaxime DougadosDirk ElewautAlicia M. EllisCarmen FleurinckKarl Gaffney et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Extent of axial damage in psoriatic arthritis and spondyloarthritis : comparative data from the BEPAS and (Be-)GIANT multicentre cohorts

Manouk de HoogeAlla IshchenkoAnn-Sophie De CraemerSerge SteinfeldAdrien NzeusseuDirk ElewautRik LoriesKurt de VlamFilip Van den Bosch

A1 Journal Article in RMD OPEN

Gut inflammation in axial spondyloarthritis patients is characterized by a marked type 17 skewed mucosal innate‐like T cell signature

Céline MortierKatrien QuintelierAnn-Sophie De CraemerThomas RensonLiselotte DerooEmilie DumasEveline VerheugenJulie CoudenysTine DecruyZuzanna Łukasik et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Innate-like T cells and type 17 immune responses in the gut-joint axis in Spondyloarthritis

Céline MortierDirk ElewautKoen VenkenTom Van de Wiele

Machine learning pipeline for predicting bone marrow edema along the sacroiliac joints on magnetic resonance imaging

Joris RoelsAnn-Sophie De CraemerThomas RensonManouk de HoogeArne GevaertThomas Van Den BergheLennart JansNele HerregodsPhilippe CarronFilip Van den Bosch et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Neural network algorithm for detection of erosions and ankylosis on CT of the sacroiliac joints : multicentre development and validation of diagnostic accuracy

Thomas Van Den BergheDanilo BabinMin ChenMartijn CallensDenim BrackHelena MaesJan LievensMarie LammensMaxime Van SumereLieve Morbée et al.

A1 Journal Article in EUROPEAN RADIOLOGY

Neural network algorithm for detection of erosions and ankylosis on CT of the sacroiliac joints : multicentre development and validation of diagnostic accuracy

Thomas Van Den BergheDanilo BabinMin ChenMartijn CallensDenim BrackHelena MaesJan LievensMarie LammensMaxime Van SumereLieve Morbée et al.

Osteomodulin downregulation is associated with osteoarthritis development

Jeremie ZappiaQiao TongRenée Van der CruyssenFrederique M. F. CornelisCecile LambertTiago Pinto CoelhoJuliane GrisartErika KagueRik J. LoriesMarc Muller et al.

A1 Journal Article in BONE RESEARCH

Pathophysiology and immunolgical basis of axial spondyloarthritis

Marleen Van de SandeDirk Elewaut

A1 Journal Article in BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA : post-hoc analysis of the CRESPA trial

Simon KrabbeThomas RensonLennart JansDirk ElewautFilip Van den BoschPhilippe CarronMikkel Østergaard

A1 Journal Article in RHEUMATOLOGY

Potential role of statins in treatment of acute sarcopenia

Anton De SpiegeleerHasan KahyaLiesbeth CrombezAmélie DescampsRoland RösslerReto W. KressigBruno LapauwEvelien WynendaeleDirk ElewautBart De Spiegeleer et al.

A1 Journal Article in MEDICAL HYPOTHESES

Protein citrullination and NET formation do not contribute to the pathology of A20/TNFAIP3 mutant mice

Karel Van DammePieter HertensArne MartensElisabeth GilisDario PriemInge BruggemanAmelie FossoulJozefien DeclercqHelena Catharine AegerterAndy Wullaert et al.

A1 Journal Article in SCIENTIFIC REPORTS

ROR gamma t inhibition ameliorates IL-23 driven experimental psoriatic arthritis by predominantly modulating gamma delta-T cells

Céline MortierEric GraceyJulie CoudenysTeddy ManuelloTine DecruyMargaux MaelegheerFlore StappersElisabeth GilisDjoere GaublommeLuc Van Hoorebeke et al.

A1 Journal Article in RHEUMATOLOGY

Sacroiliac bone marrow oedema on postpartum MRI does not result in significant SpA-like structural lesions : results of a 5-year follow-up study

Liesbet De MeesterGaëlle VarkasManouk de HoogeAnn-Sophie De CraemerNele HerregodsLennart JansPhilippe CarronDirk ElewautFilip Van den Bosch

Sterile triggers drive joint inflammation in TNF‐ and IL-1β‐dependent mouse arthritis models

Alexandra ThiranIoanna PettaGillian BlanckeMarie ThorpGuillaume PlanckaertMaude JansVanessa AndriesKorneel BarbryElisabeth GilisJulie Coudenys et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

Joke DeprezRein VerbekeSofie MeulewaeterIlke AernoutHeleen DewitteTine DecruyJulie CoudenysJulie Van DuyseGert Van IsterdaelDan Peer et al.

A1 Journal Article in NATURE NANOTECHNOLOGY

Ultrasound-guided core needle biopsy and incisional biopsy of the parotid gland are comparable in diagnosis of primary Sjögren’s syndrome

Liselotte DerooEva GenbruggeFrederick DochyDavid CreytensHelena AchtenKristel De BoeckWouter BautersDimitri RoelsJoke DeprezFilip Van den Bosch et al.

A1 Journal Article in RHEUMATOLOGY

Work participation is unaffected in Belgian spondyloarthritis patients : data from the Belgian Inflammatory Arthritis and Spondylitis Cohort

Ann-Sophie De CraemerLiselotte DerooThomas RensonIne DesimpeleLauren DelmezSaskia DecumanXavier JanssensAnnelies BoonenDirk ElewautPhilippe Carron et al.

A1 Journal Article in RHEUMATOLOGY

2022

A machine learning pipeline for prediction of bone marrow oedema along the sacroiliac joints on magnetic resonance imaging

Joris RoelsAnn-Sophie De CraemerThomas RensonManouk de HoogeArne GevaertLennart JansNele HerregodsThomas Van Den BerghePhilippe CarronFilip Van den Bosch et al.

A20 controls RANK-dependent osteoclast formation and bone physiology

Arne MartensPieter HertensDario PriemVagelis RinotasTheodore MeletakosMeropi GennadiLisette Van HoveEls LouagieJulie CoudenysAmélie De Muynck et al.

A1 Journal Article in EMBO REPORTS

An AI-based algorithm for automatic detection of erosion and ankylosis on CT images of the sacroiliac joints : multicentre development and validation

Thomas Van Den BergheMin ChenDanilo BabinNele HerregodsWouter HuysseJacob JaremkoFrederiek LalooAnn-Sophie De CraemerPhilippe CarronFilip Van den Bosch et al.

An AI-based algorithm for automatic detection of erosion and ankylosis on CT images of the sacroiliac joints : multicentre development and validation

Thomas Van Den BergheMin ChenDanilo BabinNele HerregodsWouter HuysseJacob JaremkoFrederiek LalooAnn-Sophie De CraemerPhilippe CarronFilip Van den Bosch et al.

Cluster analysis in early axial spondyloarthritis predicts poor outcome in the presence of peripheral articular manifestations

Felicie CostantinoPhilippe AegerterGeorg SchettAnn-Sophie De CraemerAnna MoltoFilip Van den BoschDirk ElewautMaxime BrebanMaria-Antonietta D'agostino

A1 Journal Article in RHEUMATOLOGY

Discriminative power of salivary gland ultrasound in relation to symptom-based endotypes in suspected and definite primary Sjögren's Syndrome

Liselotte DerooHelena AchtenKristel De BoeckEva GenbruggeWOUTER BAUTERSDimitri RoelsFrederick DochyDavid CreytensAnn-Sophie De CraemerFilip Van den Bosch et al.

A1 Journal Article in SEMINARS IN ARTHRITIS AND RHEUMATISM

Effect of impaired T cell receptor signaling on the gut microbiota in a mouse model of systemic autoimmunity

Mirei ShirakashiMikako MaruyaKeiji HirotaTatsuaki TsuruyamaTakashi MatsuoRyu WatanabeKoichi MurataMasao TanakaHiromu ItoHajime Yoshifuji et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Evaluation of liposome-loaded microbubbles as a theranostic tool in a murine collagen-induced arthritis model

Joke DeprezSilke RooversGuillaume LajoinieHeleen DewitteTine DecruyJulie CoudenysBenedicte DescampsChristian VanhoveMichel VersluisDirk Elewaut et al.

A2 Journal Article in SCIENTIA PHARMACEUTICA

In vitro triple coculture with gut microbiota from spondyloarthritis patients is characterized by inter-individual differences in inflammatory responses

Annelore BeteramsMarta Calatayud ArroyoKim De PaepeAnn-Sophie De CraemerDirk ElewautKoen VenkenTom Van de Wiele

A1 Journal Article in SCIENTIFIC REPORTS

Levelling the playing field of RMD research across Europe to address patients' needs : the emerging EULAR Research Centre

Katja ReuterCarina HauptAnna MoltoAndrew CopeRonald F. van VollenhovenDirk ElewautRik LoriesIain B. McInnes

Editorial material

Neural network based algorithm pipeline for automatic detection of erosions and ankylosis of the sacroiliac joints : development and validation using multicentre CT images

Thomas Van Den BergheMin ChenDanilo BabinNele HerregodsWouter HuysseJacob JaremkoFrederiek LalooAnn-Sophie De CraemerPhilippe CarronFilip Van den Bosch et al.

Omics and multi-omics analysis for the early identification and improved outcome of patients with psoriatic arthritis

Robert GurkeAnnika BendesJohn BowesMichaela KoehmRichard M. TwymanAnne BartonDirk ElewautCarl GoodyearLisa HahnefeldRainer Hillenbrand et al.

A1 Journal Article in BIOMEDICINES

Peripheral manifestations are major determinants of disease phenotype and outcome in new onset spondyloarthritis

Ann-Sophie De CraemerThomas RensonLiselotte DerooLiesbet Van PraetHeleen CypersGaëlle VarkasRik JoosMieke DevinckLieve GyselbrechtIsabelle Peene et al.

A1 Journal Article in RHEUMATOLOGY

Progressive increase in sacroiliac joint and spinal lesions detected on magnetic resonance imaging in healthy individuals in relation to age

Thomas RensonManouk de HoogeAnn-Sophie De CraemerLiselotte DerooZuzanna ŁukasikPhilippe CarronNele HerregodsLennart JansRoos ColmanFilip Van den Bosch et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Psoriatic arthritis from a mechanistic perspective

Georg SchettProton RahmanChristopher RitchlinIain B. McInnesDirk ElewautJose U. Scher

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Regulatory T cells and immunoglobulin E : a new therapeutic link for autoimmunity?

Oscar PalomaresDirk ElewautPeter M. IrvingXavier JaumontPaolo Tassinari

A1 Journal Article in ALLERGY

Response to : ‘Finding the right one’ by Zanwar

Thomas RensonFilip Van den BoschDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Sarcopenia : a gut-feeling for quorum sensing peptides and natural killer T cells

Anton De SpiegeleerNele Van Den NoortgateDirk ElewautEvelien Wynendaele

Selection of study endpoints and patients for clinical trials in primary Sjögren's syndrome

S ArendsL de WolffLiselotte DerooGM VerstappenA VissinkFGM KroeseDirk ElewautIsabelle PeeneH Bootsma

Editorial material

Spondyloarthritis : how far are we from precision medicine?

Jacqueline SoAnn-Sophie De CraemerDirk ElewautLai-Shan Tam

A1 Journal Article in FRONTIERS IN MEDICINE

Statin intake and all-cause mortality among older nursing home residents

Anton De SpiegeleerJordi Van MigerodeAntoon BronselaerEvelien WynendaeleMilan PeelmanFilip VandaeleGeert ByttebierGuy De TréLuc BelmansChristophe Van De Wiele et al.

A1 Journal Article in GERONTOLOGY

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

Sophia MaschalidiParul MehrotraBurcu Nur KeçeliHannah De CleeneKim LecomteRenée Van der CruyssenPauline JanssenJonathan PinneyGeert van LooDirk Elewaut et al.

A1 Journal Article in NATURE

The bacterial quorum sensing peptide iAM373 is a novel inducer of sarcopenia

Anton De SpiegeleerEvelien WynendaeleAmélie DescampsNathan DebunneBart BraeckmanMarjan De MeyJulie CoudenysLiesbeth CrombezFrederick VerbekeYorick Janssens et al.

A1 Journal Article in CLINICAL AND TRANSLATIONAL MEDICINE

The value of separate detection of anti-Ro52, anti-Ro60 and anti-SSB/La reactivities in relation to diagnosis and phenotypes in primary Sjögren's syndrome

Liselotte DerooHelena AchtenKristel De BoeckEva GenbruggeWouter BautersDimitri RoelsFrederick DochyDavid CreytensJoke DeprezFilip Van den Bosch et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Work status in patients with inflammatory rheumatic musculoskeletal diseases : results of a Belgian comparative study

Ann-Sophie De CraemerIne DesimpeleLauren DelmezLiselotte DerooThomas RensonSophie De MitsVanessa SmithPeggy JacquesDirk ElewautPhilippe Carron et al.

2021

25-hydroxycholecalciferol reverses heat induced alterations in bone quality in finisher broilers associated with effects on intestinal integrity and inflammation

Huaiyong ZhangMaryam MajdeddinDjoere GaublommeBernard TaminiauMatthieu BooneDirk ElewautGeorge DaubeIván JosipovicKeying ZhangJoris Michiels

A1 Journal Article in JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY

Acute sarcopenia changes following hospitalization : influence of pre-admission care dependency level

Anton De SpiegeleerHasan KahyaDolores Sanchez-RodriguezKarolina PiotrowiczMurielle SurquinEster MarcoCeline DetremerieDhurgham HusseinSuzy HopeDhayana Dallmeier et al.

A1 Journal Article in AGE AND AGEING

Axial involvement in patients with early peripheral spondyloarthritis : a prospective MRI study of sacroiliac joints and spine

Thomas RensonPhilippe CarronAnn-Sophie De CraemerLiselotte DerooManouk de HoogeSimon KrabbeLennart JansMin ChenMikkel OstergaardFilip Van den Bosch et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Crossing the boundaries : IL-23 and its role in linking inflammation of the skin, gut and joints

Zuzanna ŁukasikEric GraceyKoen VenkenChristopher RitchlinDirk Elewaut

A1 Journal Article in RHEUMATOLOGY

ELMO1 signaling is a promoter of osteoclast function and bone loss

Sanja ArandjelovicJustin S. A. PerryMing ZhouAdam CeroiIgor SmirnovScott F. WalkLaura S. ShankmanIsabelle CambréSuna Onengut-GumuscuDirk Elewaut et al.

A1 Journal Article in NATURE COMMUNICATIONS

FRI0312 anti-CD74 IGA antibodies are most sensitive and specific to identify young male axial spondyloarthritis patients

Ann-Sophie De CraemerT. WitteLiselotte DerooThomas RensonPhilippe CarronFilip Van den BoschX. BaraliakosDirk Elewaut

From science to success? Targeting tyrosine kinase 2 in spondyloarthritis and related chronic inflammatory diseases

Dominika HromadovaDirk ElewautRobert D. InmanBirgit StroblEric Gracey

A1 Journal Article in FRONTIERS IN GENETICS

Identifying pitfalls and opportunities of magnetic resonance imaging in spondyloarthritis

Thomas RensonDirk ElewautFilip Van den BoschJoke Dehoorne

Inflammasome activation in ankylosing spondylitis is associated with gut dysbiosis

Giuliana GugginoDaniele MauroAroldo RizzoRiccardo AlessandroStefania RaimondoAnne‐Sophie BergotM. Arifur RahmanJonathan J. EllisSimon MillingRik Lories et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Inflammatory foot involvement in spondyloarthritis : from tarsitis to ankylosing tarsitis

Jose Pablo Romero-LopezDirk ElewautCesar Pacheco-TenaRuben Burgos-Vargas

A1 Journal Article in FRONTIERS IN MEDICINE

Low incidence of inflammatory bowel disease adverse events in adalimumab clinical trials across nine different diseases

Dirk ElewautJürgen BraunJaclyn K. AndersonDilek ArikanSu ChenMaja HojnikAnn-Sophie De CraemerJeffrey R. Curtis

A1 Journal Article in ARTHRITIS CARE & RESEARCH

Mechanical stress in the hindfoot : quantification of inflammatory responses and structural deformity

Arne BurssensJan VictorDirk Elewaut

Monocyte transcriptomes from patients with axial spondyloarthritis reveal dysregulated monocytopoiesis and a distinct inflammatory imprint

Fabian KarowBiljana SmiljanovicJoachim R. GruenDenis PoddubnyyFabian ProftAlice TalpinChristophe HueAnne BolandJean-Francois DeleuzeHenri-Jean Garchon et al.

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

MRI-based synthetic CT in the detection of structural lesions in patients with suspected sacroiliitis : comparison with MRI

Lennart JansMin ChenDirk ElewautFilip Van den BoschPhilippe CarronPeggy JacquesRuth WittoekJacob L. JaremkoNele Herregods

A1 Journal Article in RADIOLOGY

New paradigm in NKT cell antigens : MCS-0208 (2-(hydroxymethyl)phenylthio-phytoceramide) - an aryl-phytoceramide compound with a single hydroxyl group stimulates NKT cells

Roser Borras-TuduriAnna AlcaideSANDRINE ASPESLAGHLorena UseroCarmen SerraCarme Roura-MirDirk ElewautAmadeu Llebaria

A1 Journal Article in CHEMMEDCHEM

SAT0549 a semi-quantitative MRI scoring system for inflammation in joints and entheses in the lower extremities demonstrates good reliability and validity : post-hoc analysis of data from the crespa trial

S. KrabbeThomas RensonLennart JansDirk ElewautFilip Van den BoschPhilippe CarronM. Ǿstergaard

The calcium dynamics of human dental pulp stem cells stimulated with tricalcium silicate-based cements determine their differentiation and mineralization outcome

Elanagai RathinamSrinath GovindarajanSivaprakash RajasekharanHeidi DeclercqDirk ElewautPeter De CosterLuc MartensLuc Leybaert

A1 Journal Article in SCIENTIFIC REPORTS

The value of magnetic resonance imaging for assessing disease extent and prediction of relapse in early peripheral spondyloarthritis

Thomas RensonPhilippe CarronAnn-Sophie De CraemerLiselotte DerooManouk de HoogeSimon KrabbeLennart JansMikkel ØstergaardDirk ElewautFilip Van den Bosch

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

TNFi-induced sustained clinical remission in peripheral spondyloarthritis patients cannot be maintained with a step-down strategy based on methotrexate

Philippe CarronAnn-Sophie De CraemerThomas RensonRoos ColmanDirk ElewautFilip Van den Bosch

A1 Journal Article in RHEUMATOLOGY

Transcriptomic profiling of human dental pulp cells treated with tricalcium silicate-based cements by RNA sequencing

Elanagai RathinamSrinath GovindarajanSivaprakash RajasekharanHeidi DeclercqDirk ElewautPeter De CosterLuc Martens

A1 Journal Article in CLINICAL ORAL INVESTIGATIONS

Unexpected impact of COVID-19 lockdown on spinal mobility and health perception in spondyloarthritis

Sophie De MitsAnn-Sophie De CraemerLiselotte DerooThomas RensonFilip Van den BoschPhilippe CarronDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2020

A role for iNKT cells in sarcopenia

Anton De SpiegeleerHasan KahyaNele Van Den NoortgateEvelien WynendaeleTine DecruySrinath GovindarajanDirk Elewaut

An unexpected role for iNKT cells in skeletal muscle homeostasis

Anton De SpiegeleerHasan KahyaNele Van Den NoortgateEvelien WynendaeleTine DecruySrinath GovindarajanDirk Elewaut

B cell tetherin : a flow‐cytometric cell‐specific assay for response to Type‐I interferon predicts clinical features and flares in SLE

Yasser M El‐SherbinyMd Yuzaiful Md YusofAntonios PsarrasElizabeth MA HensorKumba Z KabbaKatherine DuttonAlaa AA MohamedDirk ElewautDennis McGonagleReuben Tooze et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Bone marrow edema detection using dual-energy CT : application in sacroiliitis

Min ChenJacob JaremkoFilip Van den BoschNele HerregodsPhilippe CarronDirk ElewautLennart Jans

Bone marrow edema in sacroiliitis : detection with dual-energy CT

Min ChenNele HerregodsJacob JaremkoPhilippe CarronDirk ElewautFilip Van den BoschLennart Jans

A1 Journal Article in EUROPEAN RADIOLOGY

Diagnostic performance for erosion detection in sacroiliac joints on MR T1-weighted images : comparison between different slice thicknesses

Min ChenNele HerregodsJacob L. JaremkoPhilippe CarronDirk ElewautFilip Van den BoschLennart Jans

A1 Journal Article in EUROPEAN JOURNAL OF RADIOLOGY

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids

Srinath GovindarajanEveline VerheugenKoen VenkenDjoere GaublommeMargaux MaelegheerEva ClootsFien GysensBruno De GeestTan‐Yun ChengD Branch Moody et al.

A1 Journal Article in EMBO REPORTS

High prevalence of spondyloarthritis-like MRI lesions in postpartum women : a prospective analysis in relation to maternal, child and birth characteristics

Thomas RensonAnaïs DepickerAnn-Sophie De CraemerLiselotte DerooGaëlle VarkasManouk de HoogePhilippe CarronLennart JansNele HerregodsIsabelle Dehaene et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Immunoscintigraphy in axial spondyloarthritis : a new imaging modality for sacroiliac inflammation

Philippe CarronThomas RensonManouk de HoogeBieke LambertKathia De ManLennart JansDirk ElewautFilip Van den Bosch

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Intestinal microbiota, HLA-B27, and spondyloarthritis dangerous liaisons

Emilie DumasKoen VenkenJames T. RosenbaumDirk Elewaut

A1 Journal Article in RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Long-term MALT1 inhibition in adult mice without severe systemic autoimmunity

Annelies DemeyerYasmine DriegeIoannis SkordosJulie CoudenysKelly LemeireDirk ElewautJens StaalRudi Beyaert

A1 Journal Article in ISCIENCE

Long-term outcomes in patients with polyarticular juvenile idiopathic arthritis receiving adalimumab with or without methotrexate

Daniel J. LovellI Brunner, HermineAndreas O. ReiffLawrence JungKaterina JarosovaDana NemcovaRichard MouyChristy SandborgJohn F. BohnsackDirk Elewaut et al.

A1 Journal Article in RMD OPEN

MAIT cells come to the rescue in cancer immunotherapy?

Zuzanna ŁukasikDirk ElewautKoen Venken

A1 Journal Article in CANCERS

Nailfold capillaroscopy in Sjogren's syndrome : a systematic literature review and standardised interpretation

Karin MelsensMaria Comasia LeoneS. PaolinoDirk ElewautR. GerliAmber VanhaeckeIsabelle PeeneM. CutoloVanessa Smith

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Quorum sensing molecules as a novel microbial factor impacting muscle cells

Anton De SpiegeleerDirk ElewautNele Van Den NoortgateYorick JanssensNathan DebunneSelien Van LangenhoveSrinath GovindarajanBart De SpiegeleerEvelien Wynendaele

A1 Journal Article in BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Revisiting the gut-joint axis : links between gut inflammation and spondyloarthritis

Eric GraceyLars VereeckeDermot McGovernMareike FröhlingGeorg SchettSilvio DaneseMartine De VosFilip Van den BoschDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Serum IGG-undergalactosylation profiles reflect cumulative exposure to systemic inflammation in spondyloarthritis patients

Ann-Sophie De CraemerZ. LukasikLeander MeurisLiselotte DerooThomas RensonManouk de HoogePhilippe CarronAnnelies Van HeckeNico CallewaertFilip Van den Bosch et al.

Small-molecule inhibitors get pro-inflammatory TNF into shape

Savvas SavvidesDirk Elewaut

Editorial material

Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis

Eric GraceyArne BurssensIsabelle CambréGeorg SchettRik LoriesIain B McInnesHiroshi AsaharaDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

The impact of vedolizumab on extra-intestinal manifestations in inflammatory bowel disease patients : a real-life experience of a single-centre cohort

Marie TruyensJeroen GeldofG. DewitteElien GlorieusGaëlle VarkasDirk ElewautTriana Lobatón Ortega

The role of MALT1 in rheumatic diseases

Elisabeth GilisDirk ElewautStijn Lambrecht

2019

4''-O-Alkylated α-galactosylceramide analogues as iNKT-cell antigens : synthetic, biological, and structural studies

Jonas JanssensAruna BitraJing WangTine DecruyKoen VenkenJohan Van der EyckenDirk ElewautDirk ZajoncSerge Van Calenbergh

A1 Journal Article in CHEMMEDCHEM

A natural killer T-cell subset that protects against airway hyperreactivity

Ya-Ting ChuangKrystle LeungYa-Jen ChangRosemarie H DeKruyffPaul B SavageRichard CruseChristophe BenoitDirk ElewautNicole BaumgarthDale T Umetsu

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A practical guide to interpret MRI features of new bone formation in axial spondyloarthritis

Frederiek LalooNele HerregodsJacob JaremkoPhilippe CarronDirk ElewautFilip Van den BoschKoenraad VerstraeteLennart Jans

AxSpA patients with symptom onset < 30 years have more structural lesions on MRI of the sacroiliac joints when fulfilling the modified new york criteria

Manouk de HoogeAnn-Sophie De CraemerThomas RensonPhilippe CarronLiselotte DerooDirk ElewautFilip Van den Bosch

Changing the wolf from outside : how microbiota trigger systemic lupus erythematosus

Isabelle PeeneDirk Elewaut

Editorial material

Clinical features of axial spondyloarthritis patients diagnosed in peripheral versus an academic hospital

Ann-Sophie De CraemerThomas RensonPhilippe CarronPeggy JacquesJan LenaertsLieve GyselbrechtRik JoosFilip Van den BoschDirk Elewaut[missing] Be-Giant consortium

Deletion of mucosa-associated lymphoid tissue lymphoma translocation protein 1 in mouse T cells protects against development of autoimmune arthritis but leads to spontaneous osteoporosis

Elisabeth GilisDjoere GaublommeJens StaalKoen VenkenMaarten DhaenensStijn LambrechtJulie CoudenysTine DecruyNadia SchryversYasmine Driege et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Erosions are the most often reported structural lesion on MRI of the sacroiliac joints in axspa patients with IBP

Manouk de HoogeAnn-Sophie De CraemerThomas RensonPhilippe CarronLiselotte DerooDirk ElewautFilip Van den Bosch

Expert consensus : practical algorithms for management of inflammatory bowel disease patients presenting with back pain or peripheral arthropathies

Gaëlle VarkasClio RibbensEdouard LouisFilip Van den BoschRik LoriesSeverine VermeireDirk ElewautMartine De Vos

A1 Journal Article in ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Gender contrasts in patient reported outcomes don’t alter the disease activity score in axial spondyloarthritis patients

Ann-Sophie De CraemerThomas RensonLiselotte DerooManouk de HoogePhilippe CarronFilip Van den BoschDirk Elewaut[missing] Be-Giant consortium

High prevalence of sacroiliac bone marrow edema on MRI in post partum women : a temporary phenomenom

Thomas RensonAnn-Sophie De CraemerLiselotte DerooAnaïs DepickerManouk de HoogeNele HerregodsLennart JansKristien RoelensIsabelle DehaenePhilippe Carron et al.

High prevalence of sacroiliac bone marrow edema on MRI in postpartum women : a temporary phenomenon

Thomas RensonAnn-Sophie De CraemerAnaïs DepickerLiselotte DerooManouk de HoogeNele HerregodsLennart JansGaëlle VarkasKristien RoelensIsabelle Dehaene et al.

Ileal but not colonic inflammation is linked to fatty lesions on MRI of the sacroiliac joints in spondyloarthritis patients

Ann-Sophie De CraemerManouk de HoogeThomas RensonLiselotte DerooTriana Lobatón OrtegaAnne HoorensPhilippe CarronFilip Van den BoschDirk Elewaut[missing] Be-Giant consortium

Low specificity but high sensitivity of inflammatory back pain criteria in rheumatology settings in Europe : confirmation of findings from a German cohort study

Manouk de HoogeFloris A van GaalenThomas RensonAnn-Sophie De CraemerMarleen G van de SandeRoberta RamondaKaren Minde FagerliLennart TH JacobssonDesiree van der HeijdeDirk Elewaut et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Mechanical strain and its implications for mouse and human rheumatic diseases

Isabelle CambréDirk ElewautStijn Lambrecht

MRI of the axial skeleton in spondyloarthritis : the many faces of new bone formation

Frederiek LalooNele HerregodsJacob L JaremkoPhilippe CarronDirk ElewautFilip Van den BoschKoenraad VerstraeteLennart Jans

A1 Journal Article in INSIGHTS INTO IMAGING

Response to: 'The use of dual-energy CT to detect and depict bone marrow oedema in rheumatoid arthritis: is it ready to substitute MRI?' by Wu et al.

Lennart JansIsabelle De KockNele HerregodsKoenraad VerstraeteFilip Van den BoschPhilippe CarronEdwin H OeiDirk ElewautPeggy Jacques

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Risks and benefits of corticosteroids in arthritic diseases in the clinic

Ioanna PettaIsabelle PeeneDirk ElewautLars VereeckeKarolien De Bosscher

A1 Journal Article in BIOCHEMICAL PHARMACOLOGY

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen VenkenPeggy JacquesCéline MortierMark E. LabadiaTine DecruyJulie CoudenysKathleen HoytAnita L. WayneRobert HughesMichael Turner et al.

A1 Journal Article in NATURE COMMUNICATIONS

Running promotes chronicity of arthritis by local modulation of complement activators and impairing T regulatory feedback loops

Isabelle CambréDjoere GaublommeNadia SchryversStijn LambrechtRik LoriesKoen VenkenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Spinal mobility in spondyloarthritis patients : do the BASMI-measurements correlate with the David Back devices-measurements?

Sophie De MitsLiselotte DerooAnn-Sophie De CraemerThomas RensonTine WillemsLieven DanneelsPhilippe CarronFilip Van den BoschDirk Elewaut

Stellate cells, hepatocytes, and endothelial cells imprint the Kupffer cell identity on monocytes colonizing the liver macrophage niche

Johnny BonnardelWouter T'JonckDjoere GaublommeRobin BrowaeysCharlotte ScottLiesbet MartensBavo VannesteSofie De PrijckSergei A NedospasovAnna Kremer et al.

A1 Journal Article in IMMUNITY

The course of aberrant findings on MRI of the sacroiliac joints over 6 months in postpartum women

Anaïs DepickerThomas RensonAnn-Sophie De CraemerManouk de HoogeLiselotte DerooGaëlle VarkasNele HerregodsLennart JansKristien RoelensIsabelle Dehaene et al.

The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis

Douglas J VealeDennis McGonagleIain B McInnesJames G KruegerChristopher T RitchlinDirk ElewautKeith S KanikThijs HendrikxGabriel BersteinJennifer Hodge et al.

A1 Journal Article in RHEUMATOLOGY

The ties that bind : skin, gut and spondyloarthritis

Eric GraceyEmilie DumasMeital YerushalmiZoya QaiyumRobert D InmanDirk Elewaut

A1 Journal Article in CURRENT OPINION IN RHEUMATOLOGY

Trunk strength and spinal mobility in spondyloarthritis patients

Tine WillemsLieven DanneelsPhilippe CarronFilip Van den BoschDirk ElewautSophie De Mits

Trunk strength and spinal mobility in spondyloarthritis patients

Sophie De MitsLiselotte DerooAnn-Sophie De CraemerThomas RensonTine WillemsLieven DanneelsPhilippe CarronFilip Van den BoschDirk Elewaut

2018

4"-O-alkylated α-galactosylceramide analogues as iNKT cell antigens : synthetic, biological and structural studies

Jonas JanssensJing WangAruna BitraTine DecruyKoen VenkenJohan Van der EyckenDirk ElewautDirk ZajoncSerge Van Calenbergh

A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity

Marieke De BruyneDelfien BogaertKoen VenkenLien Van den BosscheCarolien BonroyLisa RoelsSimon TavernierEls van de VijverAnn DriessenMarielle van Gijn et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Meng ZhaoMattias ND SvenssonKoen VenkenAshu ChawlaShu LiangIsaac EngelPiotr MydelJeremy DayDirk ElewautNunzio Bottini et al.

A1 Journal Article in NATURE COMMUNICATIONS

Association of inflammatory bowel disease and acute anterior uveitis, but not psoriasis, with disease duration in patients with axial spondyloarthritis : results from two Belgian nationwide axial spondyloarthritis cohorts

Gaëlle VarkasNathan VastesaegerHeleen CypersRoos ColmanThomas RensonLiesbet Van PraetPhilippe CarronFrank RaemanMieke DevinckLieve Gyselbrecht et al.

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Axial spondyloarthritis : new insights in diagnosis and patient stratification

Gaëlle VarkasDirk ElewautFilip Van den Bosch

CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis

Jeroen FJ BogieEllen BoelenEls LouagiePeter DelputteDirk ElewautJack van HorssenJerome JA HendriksNiels Hellings

A1 Journal Article in MULTIPLE SCLEROSIS JOURNAL

Checkpoint inhibition in the treatment of multiple myeloma : a way to boost innate-like T cell anti-tumor function?

Koen VenkenMérédis FavreauDjoere GaublommeEline MenuKarin VanderkerkenDirk Elewaut

A1 Journal Article in MOLECULAR IMMUNOLOGY

Dual-energy CT : a new imaging modality for bone marrow oedema in rheumatoid arthritis

Lennart JansIsabelle De KockNele HerregodsKoenraad VerstraeteFilip Van den BoschPhilippe CarronEdwin H OeiDirk ElewautPeggy Jacques

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Dysregulation of NF-kB in glandular epithelial cells results in Sjögren's-like features

Xiaoyan WangAbeer ShaalanSilvia LiefersJulie CoudenysDirk ElewautGordon B ProctorHendrika BootsmaFrans GM KroeseSarah Pringle

A1 Journal Article in PLOS ONE

Effect of mechanical stress on magnetic resonance imaging of the sacroiliac joints : assessment of military recruits by magnetic resonance imaging study

Gaëlle VarkasManouk de HoogeThomas RensonSophie De MitsPhilippe CarronPeggy JacquesMuriel MorisGeert SouverijnsLennart JansDirk Elewaut et al.

A1 Journal Article in RHEUMATOLOGY

Etanercept in patients with inflammatory hand osteoarthritis (EHOA) : a multicentre, randomised, double-blind, placebo-controlled trial

Margreet KloppenburgRoberta RamondaKlaus BobaczWing-Yee KwokDirk ElewautTom WJ HuizingaFeline PB KroonLeonardo PunziJosef S SmolenBert Vander Cruyssen et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Exploration of the lymphocyte population in midportion Achilles tendinopathy

Nando De VulderArne BurssensIsabelle CambréK. VenkenWillem BongaertsP. BurssensDirk Elewaut

High rate of drug-free remission after induction therapy with golimumab in early peripheral spondyloarthritis

Philippe CarronGaëlle VarkasThomas RensonRoos ColmanDirk ElewautFilip Van den Bosch

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Immunoscintigraphic detection of tumour necrosis factor by radiolabelled certolizumab pegol in patients with erosive hand osteoarthritis : a proof-of-concept study

Ruth WittoekPhilippe CarronBieke LambertPaulien MeerssemanAugust VerbruggenFilip Van den BoschDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

It takes 'guts' to cause joint inflammation : role of innate-like T cells

Céline MortierSrinath GovindarajanKoen VenkenDirk Elewaut

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Mechanical strain determines the site-specific direction of inflammation and tissue damage in arthritis

Isabelle CambréDorien GaublommeArne BurssensPeggy JacquesLeander MeurisStijn LambrechtShea CarterAmélie De MuynckNico CallewaertGeorge Kollias et al.

Mechanical strain determines the site-specific direction of inflammation and tissue damage in arthritis

Isabelle CambréDjoere GaublommeArne BurssensPeggy JacquesDirk ElewautR LoriesG SchettG KolliasAmélie De MuynckLeander Meuris et al.

Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis

Isabelle CambréDjoere GaublommeArne BurssensPeggy JacquesNadia SchryversAmélie De MuynckLeander MeurisStijn LambrechtShea CarterPieter De Bleser et al.

A1 Journal Article in NATURE COMMUNICATIONS

New bone formation in the intervertebral joint space in spondyloarthritis : an MRI study

Frederiek LalooNele HerregodsJacob L JaremkoPhilippe CarronDirk ElewautFilip Van den BoschKoenraad VerstraeteLennart Jans

A1 Journal Article in EUROPEAN JOURNAL OF RADIOLOGY

New imaging modalities and treatment strategies in spondyloarthritis

Philippe CarronFilip Van den BoschDirk Elewaut

Response to: 'Simultaneous inhibition of α4/β7 integrin and tumor necrosis factor-α in concomitant spondyloarthritis and inflammatory bowel disease' by Richard et al

Gaëlle VarkasDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha

Srinath GovindarajanDjoere GaublommeRenée Van der CruyssenEveline VerheugenSofie Van GassenYvan SaeysSimon TavernierTakao IwawakiYehudi BlochSavvas Savvides et al.

A1 Journal Article in NATURE COMMUNICATIONS

Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1

Yehudi BlochLaura BouchareychasRomain MerceronKatarzyna SkladanowskaLien Van den BosscheSammy DetrySrinath GovindarajanDirk ElewautFilomeen HaerynckMelissa Dullaers et al.

A1 Journal Article in IMMUNITY

The role of the microbiome in gut and joint inflammation in psoriatic arthritis and spondyloarthritis

Elisabeth GilisCéline MortierKoen VenkenKarlijn DebusschereLars VereeckeDirk Elewaut

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

Tumour necrosis factor : out of my heart!

Lars VereeckeDirk Elewaut

Editorial material

2017

A20 inhibition of STAT1 expression in myeloid cells : a novel endogenous regulatory mechanism preventing development of enthesitis

Katelijne De WildeArne MartensStijn LambrechtPeggy JacquesMichael DrennanKarlijn DebusschereSrinath GovindarajanJulie CoudenysEveline VerheugenFien Windels et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

An induction or flare of arthritis and/or sacroiliitis by vedolizumab in inflammatory bowel disease : a case series

Gaëlle VarkasKristof ThevissenG De BrabanterLiesbet Van PraetF Czul-gurdianHeleen CypersJORIS DE KOCKPhilippe CarronMartine De VosPieter Hindryckx et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Anti-TNF-induced remission in very early peripheral spondyloarthritis : the CRESPA study

Philippe CarronGaëlle VarkasHeleen CypersLiesbet Van PraetDirk ElewautFilip Van den Bosch

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

ASAS definition for sacroiliitis on MRI in SpA : applicable to children?

Nele HerregodsJo DehoorneFilip Van den BoschJacob Lester JaremkoJoke Van VlaenderenRik JoosXenofon BaraliakosGaëlle VarkasKoenraad VerstraeteDirk Elewaut et al.

A1 Journal Article in PEDIATRIC RHEUMATOLOGY

Born to run : the paradox of biomechanical force in spondyloarthritis from an evolutionary perspective

Karlijn DebusschereIsabelle CambréEric GraceyDirk Elewaut

A1 Journal Article in BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Both mucosal-associated invariant and natural killer T-cell deficiency in multiple myeloma can be countered by PD-1 inhibition

Mérédis FavreauKoen VenkenSylvia FaictKen MaesKim De VeirmanElke De BruyneXavier LeleuLouis BoonDirk ElewautKarin Vanderkerken et al.

A1 Journal Article in HAEMATOLOGICA

Burden of hepatitis E virus infection in patients with rheumatic diseases

Peggy JacquesElizaveta PadalkoEveline VerheugenLien CattoirXavier VerhelstE NysS Van GuchtV HutseV SuinDirk Elewaut

Dialister as a microbial marker of disease activity in spondyloarthritis

Raul Y. TitoHeleen CypersMarie JOOSSENSGaëlle VarkasLiesbet Van PraetELIEN GLORIEUSFilip Van den BoschMartine De VosJeroen RaesDirk Elewaut

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis

Francesco CicciaGiuliana GugginoAroldo RizzoRiccardo AlessandroMichele Maria LuchettiSimon MillingLaura SaievaHeleen CypersTommaso StamponePaola Di Benedetto et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Efficient divergent synthesis of new immunostimulant 4″-modified α-galactosylceramide analogues

Jonas JanssensTine DecruyKoen VenkenToshiyuki SekiSimon KrolsJohan Van der EyckenMoriya TsujiDirk ElewautSerge Van Calenbergh

A1 Journal Article in ACS MEDICINAL CHEMISTRY LETTERS

Elevated GDF-15 contributes to pulmonary inflammation upon cigarette smoke exposure

Fien VerhammeLeen SeysElise De SmetSharen ProvoostW JanssensDirk ElewautGuy JoosGuy BrusselleKen Bracke

A1 Journal Article in MUCOSAL IMMUNOLOGY

Enthesitis : from pathophysiology to treatment

Georg SchettRik J LoriesMaria-Antonietta D'AgostinoDirk ElewautBruce KirkhamEnrique R SorianoDennis McGonagle

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d

Joren GuillaumeJing WangJonas JanssensSoumya G RemeshMartijn RisseeuwTine DecruyMathy FroeyenDirk ElewautDirk M ZajoncSerge Van Calenbergh

A1 Journal Article in SCIENTIFIC REPORTS

Haematopoietic prolyl hydroxylase-1 deficiency promotes M2 macrophage polarization and is both necessary and sufficient to protect against experimental colitis

Sophie Van WeldenMartine De VosBen WielockxSimon TavernierMelissa DullaersSara NeytBenedicte DescampsLindsey DevisscherSarah DevrieseLien Van den Bossche et al.

A1 Journal Article in JOURNAL OF PATHOLOGY

Immune therapy in multiple myeloma : can iNKT cells be targeted?

Mérédis FavreauEline MenuKarin VanderkerkenDirk ElewautKoen Venken

Leptin receptor antagonism of iNKT cell function : a novel strategy to combat multiple myeloma

Mérédis FavreauE MenuDjoere GaublommeK VanderkerkenS FaictK MaesE De BruyneSrinath GovindarajanMichael DrennanSerge Van Calenbergh et al.

A1 Journal Article in LEUKEMIA

Mechanistic insights into the regulation of iNKT development and cytokine production

Srinath GovindarajanDirk ElewautMichael Drennan

Monoclonal antibody binding to the macrophage-specific receptor sialoadhesin alters the phagocytic properties of human and mouse macrophages

Marjorie De SchryverDavie CappoenDirk ElewautHans NauwynckLouis MaesGuy CaljonPaul CosPeter L Delputte

A1 Journal Article in CELLULAR IMMUNOLOGY

MR signal in the sacroiliac joint space in spondyloarthritis : a new sign

Frederiek LalooNele HerregodsGaëlle VarkasJL JaremkoX BaraliakosDirk ElewautFilip Van den BoschKoenraad VerstraeteLennart Jans

A1 Journal Article in EUROPEAN RADIOLOGY

Novel myeloid regulators of rheumatic diseases

Katelijne De WildeDirk ElewautStijn Lambrecht

Presence of bone marrow edema and structural lesions on magnetic resonance imaging of the sacroiliac joints in young military recruits before and after 6 weeks of intensive physical training

Gaëlle VarkasManouk de HoogeThomas RensonSophie De MitsPhilippe CarronPeggy JacquesMuriel MorisGeert SouverijnsLennart JansDirk Elewaut et al.

Presence of bone marrow edema on magnetic resonance imaging of the sacroiliac joints in military recruits before and after 6 weeks of intensive physical training

Gaëlle VarkasManouk de HoogeThomas RensonPhilippe CarronSophie De MitsG SouverijnsDirk ElewautFilip Van den Bosch

Prevalence of structural lesions typical for axial spondyloarthritis in young military recruits before and after mechanical stress

Gaëlle VarkasManouk deHoogeThomas RensonPhilippe CarronSophie De MitsG SouverijnsDirk ElewautFilip Van den Bosch

Response to: 'Clinical benefit of vedolizumab on articular manifestations in patients with active spondyloarthritis associated with inflammatory bowel disease' by Orlando et al

Gaëlle VarkasFilip Van den BoschDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Ruminococcus on the horizon in arthritic disease

Lars VereeckeDirk Elewaut

Editorial material

Synthesis of C6′′-modified α-C-GalCer analogues as mouse and human iNKT cell agonists

Joren GuillaumeToshiyuki SekiTine DecruyKoen VenkenDirk ElewautMoriya TsujiSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

The influence of pitting on comparative X-ray µCT studies

Amélie De MuynckMatthieu BooneManuel DierickJelle DhaeneDjoere GaublommeDirk ElewautLuc Van Hoorebeke

The paracaspase MALT1 plays a central role in the pathogenesis of rheumatoid arthritis

Elisabeth GilisJens StaalRudi BeyaertDirk Elewaut

The role of intestinal inflammation in initiation, monitoring and outcome of spondyloarthritis

Heleen CypersDirk ElewautFilip Van den Bosch

2016

99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients : a biodistribution and dosimetry study

Bieke LambertPhilippe CarronYves D'AsselerKlaus BacherFilip Van den BoschDirk ElewautAugust VerbruggenRudi BeyaertCaroline DumolynFilip De Vos

A1 Journal Article in EJNMMI RESEARCH

A nationwide survey on patient's versus physician's evaluation of biological therapy in rheumatoid arthritis in relation to disease activity and route of administration : the Be-Raise study

Sophie De MitsJan LenaertsBert Vander CruyssenHerman MielantsRené WesthovensPatrick DurezDirk Elewaut

A1 Journal Article in PLOS ONE

Assessment of sensitivity to change of the European Scleroderma Study Group activity index

Karin MelsensFilip De KeyserSaskia DecumanGuy BrusselleMichel De PauwEllen DeschepperKatelijne De WildeDirk ElewautYVES PIETTEEls Vandecasteele et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Does an NKT-cell-based immunotherapeutic approach have a future in multiple myeloma?

Mérédis FavreauKarin VanderkerkenDirk ElewautKoen VenkenEline Menu

A1 Journal Article in ONCOTARGET

Elevated calprotectin levels reveal bowel inflammation in spondyloarthritis

Heleen CypersGaëlle VarkasSam BeeckmanKarlijn DebusschereT VoglJ RothMichael DrennanM LavricD FoellClaude Cuvelier et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

How the microbiota shapes rheumatic diseases

Tom Van de WieleJens Van PraetMassimo MarzoratiMichael DrennanDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

MAIT cells : not just another brick in the wall

Karlijn DebusschereRik J LoriesDirk Elewaut

Editorial material

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNF AIP3/A20

Michael DrennanSrinath GovindarajanEveline VerheugenJonathan CoquetJens StaalConor Mc GuireTom TaghonGeorges LeclercqRudi BeyaertGeert van Loo et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Scintigraphic detection of TNF-driven inflammation by radiolabelled certolizumab pegol in patients with rheumatoid arthritis and spondyloarthritis

Philippe CarronBieke LambertLiesbet Van PraetFilip De VosGaëlle VarkasLennart JansDirk ElewautFilip Van den Bosch

A2 Journal Article in RMD OPEN

Six-week treatment of axial spondyloarthritis patients with an optimal dose of nonsteroidal antiinflammatory drugs : early response to treatment in signal intensity on magnetic resonance imaging of the sacroiliac joints

Gaëlle VarkasLennart JansHeleen CypersLiesbet Van PraetPhilippe CarronDirk ElewautFilip Van den Bosch

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

The quest for autoreactive antibodies in nasal polyps

Els De SchryverLien CalusHenryk BonteNatalie De RuyckHannah GouldErin DonovanDirk ElewautRudolf ValentaIrene MittermannJan Gutermuth et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The role of Ly49E receptor expression on murine intraepithelial lymphocytes in intestinal cancer development and progression

Aline Van AckerEls LouagieJessica FiltjensSylvie TaveirneEls Van AmmelTessa KerreDirk ElewautTom TaghonBart VandekerckhoveJean Plum et al.

A1 Journal Article in CANCER IMMUNOLOGY IMMUNOTHERAPY

The role of stress related proteins in osteoarthritis

Nele JuchtmansDirk ElewautStijn Lambrecht

What rheumatologists need to know about innate lymphocytes

Mark A ExleyGeorge C TsokosKingston HG MillsDirk ElewautBen Mulhearn

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

2015

An optimized method for isolating and expanding invariant natural killer T cells from mouse spleen

Srinath GovindarajanDirk ElewautMichael Drennan

A1 Journal Article in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Application of µCT in arthritis and osteoporosis research

Els LouagieIsabelle CambréAmélie De MuynckDjoere GaublommeElin PauwelsPieter VanderniepenFien WindelsJulie CoudenysNadia SchryversEveline Verheugen et al.

Automated processing of series of micro-CT scans

Amélie De MuynckMatthieu BooneManuel DierickIsabelle CambréEls LouagieDirk ElewautLuc Van Hoorebeke

Clinical and radiological factors associated with erosive radiographic progression in hand osteoarthritis

Paulien MeerssemanCeline Van de VyverAugust VerbruggenDirk ElewautRuth Wittoek

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Commensal microbiota influence systemic autoimmune responses

Jens Van PraetErin DonovanInge VanasscheMichael DrennanFien WindelsAmélie DendoovenLiesbeth AllaisClaude CuvelierFons van de LooPaula S Norris et al.

A1 Journal Article in EMBO JOURNAL

Diagnositic value of pelvic enthesitis on MRI of the sacroiliac joints in enthesitis related arthritis

Nele HerregodsJo DehoorneEVA PATTYNJ. L. JaremkoX. BaraliakosDirk ElewautJ Van VlaenderenFilip Van den BoschR JoosKoenraad Verstraete et al.

A1 Journal Article in PEDIATRIC RHEUMATOLOGY

Distinct dysregulation of the small leucine-rich repeat protein family in osteoarthritic acetabular labrum compared to articular cartilage

Nele JuchtmansAad DhollanderJulie CoudenysEmmanuel AudenaertChristophe PattynStijn LambrechtDirk Elewaut

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients

Philip C RobinsonMary-Ellen CostelloPaul LeoLinda A BradburyKelly HollisAdrian CortesSeunghun LeeKyung Bin JooSeung-Cheol ShimMichael Weisman et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Heterogeneity of synovial molecular patterns in patients with arthritis

Bernard R LauwerysDaniel Hernández-LobatoPierre GrammeJulie DucreuxAdrien DessyIsabelle FocantJérôme AmbroiseBertrand BearzattoAdrien Nzeusseu ToukapBenoît J Van den Eynde et al.

A1 Journal Article in PLOS ONE

IL-23 Responsive innate-like T cells in spondyloarthritis: the less frequent they are, the more vital they appear

Koen VenkenDirk Elewaut

A1 Journal Article in CURRENT RHEUMATOLOGY REPORTS

Integrating the pathogenesis of spondyloarthritis: gut and joint united?

Katelijne De WildeKarlijn DebusschereSam BeeckmanPeggy JacquesDirk Elewaut

A1 Journal Article in CURRENT OPINION IN RHEUMATOLOGY

Leptin's metabolic and immune functions can be uncoupled at the ligand/receptor interaction level

Lennart ZabeauCathy J JensenSylvie SeeuwsKoen VenkenAnnick VerheeDominiek CatteeuwGeert van LooHui ChenKen WalderJacob Hollis et al.

A1 Journal Article in CELLULAR AND MOLECULAR LIFE SCIENCES

Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1

Adrian CortesSara L PulitPaul J LeoJenny J PointonPhilip C RobinsonMichael H WeismanMichael WardLianne S GenslerXiaodong ZhouHenri-Jean Garchon et al.

A1 Journal Article in NATURE COMMUNICATIONS

New immune cells in spondyloarthritis: key players or innocent bystanders?

Koen VenkenDirk Elewaut

A1 Journal Article in BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Outcome-based anti-TNFα treatment decisions in rheumatoid arthritis and axial spondyloarthritis : facilitating physician's and payer's choices

Nathan VastesaegerFilip Van den BoschDirk Elewaut

Spreading spondyloarthritis: are ILCs cytokine shuttles from base camp gut?

Barbara NeerinckxDirk ElewautRik J Lories

Editorial material

Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists

Joren GuillaumeNora PauwelsSANDRINE ASPESLAGHDirk ZajoncDirk ElewautSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

The effect of cigarette smoke exposure on the development of inflammation in lungs, gut and joints of TNFΔARE mice

Liesbeth AllaisSmitha KumarKarlijn DebusschereStephanie VERSCHUERETania MaesRebecca De SmetGriet ConickxMartine De VosDebby LaukensGuy Joos et al.

A1 Journal Article in PLOS ONE

Tofacitinib inhibits inflammation and new bone formation in murine spondyloarthritis but does not adversely inhibit normal human MSC function

Rik LoriesKatelijne De WildeKerri HeritageRichard CuthbertElena JonesKarlijn DebusschereDennis McGonagleDirk Elewaut

2014

A bidirectional crosstalk between iNKT cells and adipocytes mediated by leptin modulates susceptibility for T cell mediated hepatitis

Koen VenkenSylvie SeeuwsLennart ZabeauPeggy JacquesTine DecruyJulie CoudenysEveline VerheugenFien WindelsDominiek CatteeuwMichael Drennan et al.

A1 Journal Article in JOURNAL OF HEPATOLOGY

An in silico approach for modelling T-helper polarizing iNKT cell agonists

Anton De SpiegeleerEvelien WynendaeleMatthias VandekerckhoveSofie StalmansMaxime BoucartNele Van Den NoortgateKoen VenkenSerge Van CalenberghSANDRINE ASPESLAGHDirk Elewaut

A1 Journal Article in PLOS ONE

Baseline scintigraphic detection of TNFa as a predictor of therapy response after treatment with certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients

Philippe CarronBieke LambertFilip De VosAugust VerbruggenDirk ElewautFilip Van den Bosch

Calgranulin levels are elevated in spondyloarthritis and reflect the presence of acute microscopic gut inflammation

Heleen CypersGaëlle VarkasLiesbet Van PraetJohannes RothThomas VoglClaude CuvelierDirk FöllMiha LavricFilip Van den BoschDirk Elewaut

Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort

Liesbet Van PraetLennart JansPhilippe CarronPeggy JacquesELIEN GLORIEUSRoos ColmanHeleen CypersHerman MielantsMartine De VosClaude Cuvelier et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Diagnostic value of pelvic enthesitis on MRI of the sacroiliac joints in spondyloarthritis

Lennart JansCharlotte Van LangenhoveLiesbet Van PraetPhilippe CarronDirk ElewautFilip Van den BoschVALERIE LAMBRECHTJacob L JaremkoKoenraad Verstraete

A1 Journal Article in EUROPEAN RADIOLOGY

Etanercept versus monoclonal antibodies in axial spondyloarthritis: game over?

Gaëlle VarkasDirk Elewaut

Editorial material

Gebruik van een 'foot digitizer' om de voetstructuur van patiënten met reumatoïde artritis te beoordelen

Sophie De MitsHerman MielantsDirk De ClercqJim (James) WoodburnPhilip RoosenDirk Elewaut

A2 Journal Article in ORTHO-RHEUMATO

Growth differentiation factor 15, a marker of lung involvement in systemic sclerosis, is involved in fibrosis development but is not indispensable for fibrosis development

Stijn LambrechtVanessa SmithKatelijne De WildeJulie CoudenysSaskia DecumanDieter DeforceFilip De KeyserDirk Elewaut

A1 Journal Article in ARTHRITIS & RHEUMATOLOGY

Gut inflammation in SpA: flagellin joins the dance?

Peggy JacquesDirk Elewaut

Editorial material

Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins?

Stijn LambrechtNele JuchtmansDirk Elewaut

A1 Journal Article in RHEUMATOLOGY

How sensitive and specific are MRI features of sacroiliitis for diagnosis of spondyloarthritis in patients with inflammatory back pain?

Lennart JansLaurent CoemanLiesbet Van PraetPhilippe CarronDirk ElewautFilip Van den BoschJacob L JaremkoWouter HuysseKoenraad Verstraete

A1 Journal Article in JBR-BTR

MRI of the SI joints commonly shows non-inflammatory disease in patients clinically suspected of sacroiliitis

Lennart JansLiesbet Van PraetDirk ElewautFilip Van den BoschPhilippe CarronJacob L JaremkoMaxim BehaegheAlexander DenisWouter HuysseVALERIE LAMBRECHT et al.

A1 Journal Article in EUROPEAN JOURNAL OF RADIOLOGY

Multinational evidence-based recommendations for the diagnosis and management of gout : integrating systematic literature review and expert opinion of a broad panel of rheumatologists in the 3e initiative

Francisca SiveraMariano AndrésLoreto CarmonaAlison SR KyddJohn MoiRakhi SethMelonie SriranganathanCaroline van DurmeIrene van EchteldOphir Vinik et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

Lieselotte Vande WalleNina Van OpdenboschPeggy JacquesAmelie FossoulEveline VerheugenPeter VogelRudi BeyaertDirk ElewautThirumala-Devi KannegantiGeert van Loo et al.

A1 Journal Article in NATURE

Neutrophil elastase in the capacity of the 'H2A-specific protease'

Maarten DhaenensPieter GlibertStijn LambrechtLiesbeth VossaertKatleen Van SteendamDirk ElewautDieter Deforce

A1 Journal Article in INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

No evidence of autoreactivity in nasal polyposis

Els De SchryverLIEN CALUSHenryk BonteE DonovanDirk ElewautR ValentaI MittermanThibaut Van ZelePhilippe Gevaert

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells

Peggy JacquesStijn LambrechtEveline VerheugenElin PauwelsGeorge KolliasMaria ArmakaMarleen VerhoyeAnnemie Van der LindenEric AchtenRik J Lories et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Referral patterns, diagnosis, and disease management of patients with axial spondyloarthritis: results of an international survey

Désirée van der HeijdeJoachim SieperDirk ElewautAtul DeodharAileen L PanganAlexander P Dorr

A1 Journal Article in JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Relevance of the gut/joint axis for the management of spondyloarthritis in daily clinical practice

Heleen CypersLiesbet Van PraetGaëlle VarkasDirk Elewaut

A1 Journal Article in CURRENT OPINION IN RHEUMATOLOGY

Senescence marker killer cell lectin-like receptor G1 (KLRG1) contributes to TNF-α production by interaction with its soluble E-cadherin ligand in chronically inflamed joints

Lode MelisLiesbet Van PraetHanspeter PircherKoen VenkenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

The Ghent Inflammatory Arthritis and spoNdylitis cohorT: first results

Liesbet Van PraetDirk Elewaut

The role of the gut and microbes in the pathogenesis of spondyloarthritis

Mark AsquithDirk ElewautPhoebe LinJames T Rosenbaum

A1 Journal Article in BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The Thymic Microenvironment Differentially Regulates Development and Trafficking of Invariant Natural Killer T Cell Sublineages

Michael DrennanSrinath GovindarajanKatelijne De WildeSusan SchlennerCarl WareSergei NedospasovHans-Reimer RodewaldDirk Elewaut

The thymic microenvironment differentially regulates development and trafficking of invariant NKT cell sublineages

Michael DrennanSrinath GovindarajanKatelijne De WildeSusan M SchlennerCarl WareSergei NedospasovHans-Reimer RodewaldDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force

Josef S SmolenJürgen BraunMaxime DougadosPaul EmeryOliver FitzGeraldPhilip HelliwellArthur KavanaughTore K KvienRobert LandewéThomas Luger et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2013

99mTc labelled S-HYNIC certolizumab pegol for selecting patients for anti-TNF alpha treatment: a biodistribution and dosimetric study

Bieke LambertPhilippe CarronYves D'AsselerKlaus BacherFilip Van den BoschLennart JansDirk ElewautAugust VerbruggenFilip De Vos

A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands

Anton De SpiegeleerEvelien WynendaeleSofie StalmansNele Van Den NoortgateMatthias VandekerckhoveSerge Van CalenberghSANDRINE ASPESLAGHKoen VenkenDirk Elewaut

Active and structural lesions of the sacroiliac joints in spondyloarthritis

Laurent CoemanLennart JansLiesbet Van PraetPhilippe CarronDirk Elewaut

Editorial material

Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells

Koen VenkenTine DecruySANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Enhanced TCR footprint by a novel glycolipid increases NKT-dependent tumor protection

SANDRINE ASPESLAGHMarek NemčovičNora PauwelsKoen VenkenJing WangSerge Van CalenberghDirk M ZajoncDirk Elewaut

A1 Journal Article in JOURNAL OF IMMUNOLOGY

From immune senescence and insulin resistance to obesity and sarcopenia: iNKT cell as bridge?

Anton De SpiegeleerDirk ElewautPeggy JacquesGertjan De FlouNele Van Den Noortgate

Identification of multiple risk variants for ankylosing spondylitis through high-density genotyping of immune-related loci

Adrian CortesJohanna HadlerJenny P PointonPhilip C RobinsonTugce KaraderiPaul LeoKatie CreminKarena PryceJessica HarrisSeunghun Lee et al.

A1 Journal Article in NATURE GENETICS

Investigating the genetic association between ERAP1 and spondyloarthritis

Amir KadiBrigitte IzacRoula Said-NahalAriane LeboimeLiesbet Van PraetKurt de VlamDirk ElewautGilles ChiocchiaMaxime Breban

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Microbes, the gut and ankylosing spondylitis

Mary-Ellen CostelloDirk ElewautTony J KennaMatthew A Brown

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model

Liesbet Van PraetFilip Van den BoschPeggy JacquesPhilippe CarronLennart JansRoos ColmanELIEN GLORIEUSHarald PeetersHerman MielantsMartine De Vos et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Osteoarticular manifestations: specific treatments and/or treating intestinal disease?

Martine De VosLiesbet Van PraetDirk Elewaut

A1 Journal Article in DIGESTIVE DISEASES

Preclinical evaluation of invariant natural killer T cells in the 5T33 multiple myeloma model

Haneen NurKarel FostierSANDRINE ASPESLAGHWim RenmansElisabeth BertrandXavier LeleuMérédis FavreauKarine BreckpotRik SchotsMarc De Waele et al.

A1 Journal Article in PLOS ONE

Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients

Katleen Van SteendamMarlies De CeuleneerKelly TillemanDirk ElewautFilip De KeyserDieter Deforce

A1 Journal Article in RHEUMATOLOGY INTERNATIONAL

Scintigraphic detection of TNF alpha with a radiolabeled anti-TNF alpha in patients with active peripheral spondyloarthritis and rheumatoid arthritis

Philippe CarronBieke LambertFilip De VosAugust VerbruggenDirk ElewautFilip Van den Bosch

Selecting patients with spondyloarthritis (SpA) or rheumatoid arthritis (RA) for antiTNF-alfa treatment: first scintigraphic data with Tc99m-labelled certolizumab pegol

Philippe CarronBieke LambertFilip Van den BoschDirk ElewautAugust VerbruggenLennart JansYves D'AsselerFilip De Vos

Should we be morbid about comorbidities in the rheumatic diseases?: understanding the impact of comorbidity on rheumatic disease

Dirk ElewautNicola GoodsonRoy Fleischmann

Editorial material

Spondyloarthritis and inflammatory bowel disease: comorbidity and treatment implications

Gaëlle VarkasLiesbet Van PraetHeleen CypersDirk Elewaut

A1 Journal Article in ZEITSCHRIFT FUR RHEUMATOLOGIE

Toward a cytokine-based disease taxonomy

Georg SchettDirk ElewautIain B McInnesJean-Michel DayerMarkus F Neurath

Editorial material

Two-year results of an open pilot study of a 2-treatment course with rituximab in patients with early systemic sclerosis with diffuse skin involvement

Vanessa SmithYVES PIETTEJens Van PraetSaskia DecumanEllen DeschepperDirk ElewautFilip De Keyser

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

2012

A clinically applicable six-segmented foot model

Sophie De MitsVeerle SegersJim WoodburnDirk ElewautDirk De ClercqPhilip Roosen

A1 Journal Article in JOURNAL OF ORTHOPAEDIC RESEARCH

A conundrum: classifying patients with SpA in daily practice

Filip Van den BoschDirk Elewaut

Editorial material

A pilot study of the use of an osteochondral scaffold plug for cartilage repair in the knee and how to deal with early clinical failures

Aad DhollanderKOEN LIEKENSKarl AlmqvistRené VerdonkStijn LambrechtDirk ElewautAugust VerbruggenPeter Verdonk

A1 Journal Article in ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Adjuvantia of de queeste naar het ultieme vaccin

Anton De SpiegeleerMatthias VandekerckhoveSANDRINE ASPESLAGHDirk Elewaut

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Elevated soluble E-cadherin levels in chronically inflamed joints favour TNF production by KLRG1 expressing T cells

Lode MelisKoen VenkenLiesbet Van PraetDirk Elewaut

Elevated soluble E-cadherin levels in chronically inflamed joints favour TNF production by KLRG1 expressing T cells

Lode MelisKoen VenkenLiesbet Van PraetDirk Elewaut

First insights into human acetabular labrum cell metabolism

Aad DhollanderStijn LambrechtPeter VerdonkEmmanuel AudenaertKarl AlmqvistChristophe PattynRené VerdonkDirk ElewautAugust Verbruggen

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Midterm results of the treatment of cartilage defects in the knee using alginate beads containing human mature allogenic chondrocytes

Aad DhollanderPeter VerdonkStijn LambrechtRené VerdonkDirk ElewautAugust VerbruggenKarl Almqvist

A1 Journal Article in AMERICAN JOURNAL OF SPORTS MEDICINE

Motion for debate: The development of ankylosis in ankylosing spondylitis is largely dependent on inflammation

Walter P MaksymowychDirk ElewautGeorg Schett

Editorial material

Natural killer T cells in adipose tissue prevent insulin resistance

Henk S SchipperMaryam RakhshandehrooStan FJ van de GraafKoen VenkenArjen KoppenRinke StienstraSerge PropJenny MeerdingNicole HamersGurdyal Besra et al.

A1 Journal Article in JOURNAL OF CLINICAL INVESTIGATION

Natural killer T cells: born in the thymus, raised in the gut

Ken CoppietersDirk Elewaut

Editorial material

Pathophysiology and role of the gastrointestinal system in spondyloarthritides

Peggy JacquesLiesbet Van PraetPhilippe CarronFilip Van den BoschDirk Elewaut

A1 Journal Article in RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Quantification of citrullination by means of skewed isotope distribution pattern

Marlies De CeuleneerKatleen Van SteendamMaarten DhaenensDirk ElewautDieter Deforce

A1 Journal Article in JOURNAL OF PROTEOME RESEARCH

Quantitative assessment of foot structure in rheumatoid arthritis by a foot digitizer: detection of deformities even in the absence of erosions

Sophie De MitsHerman MielantsDirk De ClercqJames WoodburnPhilip RoosenDirk Elewaut

A1 Journal Article in ARTHRITIS CARE & RESEARCH

Repair of cartilage and fibrocartilage in large synovial joints

Aad DhollanderAugust VerbruggenDirk Elewaut

Second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee

Aad DhollanderPeter VerdonkStijn LambrechtRené VerdonkDirk ElewautAugust VerbruggenKarl Almqvist

Selection of non-competitive leptin antagonists using a random nanobody-based approach

Lennart ZabeauAnnick VerheeDominiek CatteeuwLiesbeth FaesSylvie SeeuwsTine DecruyDirk ElewautFrank PeelmanJan Tavernier

A1 Journal Article in BIOCHEMICAL JOURNAL

Short-term outcome of the second generation characterized chondrocyte implantation for the treatment of cartilage lesions in the knee

Aad DhollanderPeter VerdonkStijn LambrechtRené VerdonkDirk ElewautAugust VerbruggenKarl Almqvist

A1 Journal Article in KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Soluble contributors to systemic inflammation and local peripheral synovitis in chronic arthritides

Lode MelisDirk ElewautKoen Venken

Static and dynamic analysis of the rheumatoid arthritis foot

Sophie De MitsDirk ElewautPhilip Roosen

Synovial fluid derived iNKT cells in chronic arthritides show an increased PROGRAMMED DEATH-1 expression and anergic phenotype

Koen VenkenLode MelisPeggy JacquesLiesbet Van PraetFilip Van den BoschDirk Elewaut

Synthesis of 6”-triazole-substituted α-GalCer analogues as potent iNKT cell stimulating ligands

Nora PauwelsSANDRINE ASPESLAGHDirk ElewautSerge Van Calenbergh

A1 Journal Article in BIOORGANIC & MEDICINAL CHEMISTRY

The combination of microfracture and a cell-free polymer-based implant immersed with autologous serum for cartilage defect coverage

Aad DhollanderPeter VerdonkStijn LambrechtKarl AlmqvistDirk ElewautAugust VerbruggenRené Verdonk

A1 Journal Article in KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

The transition of acute to chronic bowel inflammation in spondyloarthritis

Liesbet Van PraetPeggy JacquesFilip Van den BoschDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Therapy for spondyloarthritis : the role of extra-articular manifestations (eye, skin)

Philippe CarronLiesbet Van PraetPeggy JacquesDirk ElewautFilip Van den Bosch

A1 Journal Article in RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Tumor necrosis factor α-induced proteins: natural brakes on inflammation

Peggy JacquesDirk Elewaut

Editorial material

Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints : a double blind, randomised trial on structure modification

August VerbruggenRuth WittoekBert Vander CruyssenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Versatile synthesis of C-5" and C-6"-modified α-GalCer analogues as new iNKT cell ligands

Nora PauwelsSANDRINE ASPESLAGHDirk ElewautSerge Van Calenbergh

2011

6''-Modified alpha-GalCer analogs capable of establishing an extra interaction with Cd1d leading to a polarized Th1 response and superior tumor protection

Serge Van CalenberghNora PauwelsSANDRINE ASPESLAGHYaLi LiMatthias TrappeniersDirk ZajoncDirk Elewaut

A nationwide survey on patient's versus physician's evaluation of biological therapy in rheumatoid arthritis in relation to disease activity and route of administration: the Be-Raise study

Jan LenaertsBert Vander CruyssenHerman MielantsRene WesthovensPatrick DurezDirk Elewaut

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

Mourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc GuireLars Vereecke et al.

A1 Journal Article in NATURE GENETICS

A20 (TNFAIP3) deficiency in myeloid cells triggers rheumatoid arthritis

Dirk ElewautMourad MatmatiPeggy JacquesJonathan MaelfaitEveline VerheugenMirjam KoolMozes SzeLies GeboesEls LouagieConor Mc Guire et al.

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

Alexander RauchValerie GossyeDebby BrackeElien GevaertPeggy JacquesKatrien Van BenedenBERNARD VANDOORENMartina RaunerLorenz C HofbauerGuy Haegeman et al.

A1 Journal Article in FASEB JOURNAL

Assessment of foot structure in rheumatoid arthritis by a foot digitizer reveals marked deformities, even in the absence of radiographic erosions

Sophie De MitsDirk De ClercqJim WoodburnPhilip RoosenDirk Elewaut

Autologous matrix-induced chondrogenesis combined with platelet-rich plasma gel: technical description and a five pilot patients report

Aad DhollanderFrancis De NeveKarl AlmqvistRené VerdonkStijn LambrechtDirk ElewautAugust VerbruggenPeter Verdonk

A1 Journal Article in KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Disruption of the SapM locus in Mycobacterium bovis BCG improves its protective efficacy as a vaccine against M. tuberculosis

Nele FestjensPieter BogaertAnjana BatniErica HouthuysEvelyn PletsDieter VanderschaegheBram LaukensBob AsselberghEef ParthoensRiet De Rycke et al.

A1 Journal Article in EMBO MOLECULAR MEDICINE

Divergent synthetic approach to 6''-modified α-GalCer analogues

Nora PauwelsSANDRINE ASPESLAGHGerd VanhoenackerKoen SandraEsther D. YuDirk M. ZajoncDirk ElewautBruno LinclauSerge Van Calenbergh

A1 Journal Article in ORGANIC & BIOMOLECULAR CHEMISTRY

Dysregulated adaptive immunity in two models of immune mediated inflammatory diseases: rheumatoid arthritis and systemic sclerosis

Katleen Van SteendamDieter DeforceFilip De KeyserDirk Elewaut

Feasibility of a molecular diagnosis of arthritis based on the identification of specific transcriptomic profiles in knee synovial biopsies

Isabelle FocantDaniel Hernandez-LobatoJulie DucreuxPatrick DurezAdrien Nzeusseu ToukapDirk ElewautFrédéric A HoussiauPierre DupontBernard Lauwerys

Galactose modified iNKT cell agonists stabilised by a novel structural modification of CD1D lead to marked TH1 polarisation in vivo

SANDRINE ASPESLAGHYaLi LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardiTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis

SANDRINE ASPESLAGHYali LiEsther Dawen YuNora PauwelsMatthias TrappeniersEnrico GirardTine DecruyKatrien Van BenedenKoen VenkenMichael Drennan et al.

A1 Journal Article in EMBO JOURNAL

GDF15, a distinct TGFb family member, is differentially regulated in spondyloarthritides compared to other rheumatic diseases

Stijn LambrechtJulie CoudenysFilip De KeyserAugust VerbruggenDieter DeforceDirk Elewaut

Histopathological cutaneous alterations in systemic sclerosis : a clinicopathological study

Jens Van PraetVanessa SmithMarc HaspeslaghNele DegryseDirk ElewautFilip De Keyser

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Involvement of endoplasmic reticulum stress in inflammatory bowel disease : a different implication for colonic and ileal disease?

Sara BogaertMartine De VosKim OlievierHarald PeetersDirk ElewautBart LambrechtPhilippe PouliotDebby Laukens

A1 Journal Article in PLOS ONE

Mechanisms regulating combined gut and joint inflammation in spondyloarthritis

Mechanisms regulating TNF-driven gut and joint inflammation

Dirk ElewautPeggy JacquesLode MelisKoen Venken

A1 Journal Article in Advances in Experimental Medicine and Biology

Mucosal inflammation in spondylarthritides : past, present, and future

Liesbet Van PraetFilip Van den BoschHerman MielantsDirk Elewaut

A1 Journal Article in CURRENT RHEUMATOLOGY REPORTS

Neutrophil elastase is the 'histone H2A-specific protease'

Pieter GlibertMaarten DhaenensStijn LambrechtDirk ElewautFritz OffnerTJ KippsDieter Deforce

New insights in the involvement of leptin and NKT cells in autoimmune responses

Sylvie SeeuwsDirk ElewautJan Tavernier

Novel autoantibody markers for early and seronegative rheumatoid arthritis

Klaartje SomersPiet GeusensDirk ElewautFilip De KeyserJean-Luc RummensMarieke CoenenMarlies BlomPiet StinissenVeerle Somers

A1 Journal Article in JOURNAL OF AUTOIMMUNITY

Optimized alkylated cyclodextrin polysulphates with reduced risks on thromboembolic accidents improve osteoarthritic chondrocyte metabolism

Sara GroeneboerStijn LambrechtAad DhollanderPeggy JacquesBert Vander CruyssenRik J LoriesKatrien DevreeseKoen ChiersDirk ElewautAugust Verbruggen

A1 Journal Article in RHEUMATOLOGY

Reduced levels of the TGFB family member GDF15 in spondyloarthritis versus other rheumatic diseases

Stijn LambrechtJulie CoudenysFilip De KeyserAugust VerbruggenDieter DeforceDirk Elewaut

Regulating the regulators: SOCS3 joins the dance

Michael DrennanDirk Elewaut

Editorial material

Reliability and validity of the INFOOT three-dimensional foot digitizer for patients with rheumatoid arthritis

Sophie De MitsPascal CoorevitsDirk De ClercqDirk ElewautJames WoodburnPhilip Roosen

A1 Journal Article in JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION

Safe and well tolerated: call for papers on comorbidities in rheumatic diseases

Roy FleischmannNicola GoodsonDirk Elewaut

Editorial material

Specific anti-nuclear antibodies in systemic sclerosis patients with and without skin involvement : an extended methodological approach

Jens Van PraetKatleen Van SteendamVanessa SmithGeorges De BruyneTsuneyo MimoriCarolien BonroyDirk ElewautDieter DeforceFilip De Keyser

A1 Journal Article in RHEUMATOLOGY

Subclinical gut inflammation in spondyloarthritis is associated with a pro-angiogenic intestinal mucosal phenotype

Pieter HindryckxDebby LaukensGerlinde SerryLiesbet Van PraetClaude CuvelierHerman MielantsHarald PeetersDirk ElewautMartine De Vos

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Systematic candidate gene investigations in the SPA2 locus (9q32) show an association between TNFSF8 and susceptibility to spondylarthritis

Elena ZinovievaAmir KadiFranck LetourneurNicolas CagnardBrigitte IzacAgathe VigierRoula Said-NahalDirk ElewautKurt de VlamFernando Pimentel-Santos et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity

Mirjam KoolGeert van LooWim WaelputSofie De PrijckFemke MuskensMozes SzeJens Van PraetFilipe Branco MadeiraSophie JanssensBoris Reizis et al.

A1 Journal Article in IMMUNITY

TNF driven activation of invariant NKT cells regulates combined gut and joint inflammation

Peggy JacquesSylvie SeeuwsHamida HammadBart LambrechtGeorge KolliasMartine De VosDirk Elewaut

2010

A multiparameter approach to monitor disease activity in collagen-induced arthritis

Sylvie SeeuwsPeggy JacquesJens Van PraetMichael DrennanNicky VandeghinsteReginald BrysDirk Elewaut

A multiparameter approach to monitor disease activity in collagen-induced arthritis

Sylvie SeeuwsPeggy JacquesJens Van PraetMichael DrennanJulie CoudenysTine DecruyEllen DeschepperLien LepescheuxPhilippe PujuguetLine Oste et al.

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

A plant-derived glucocorticoid receptor modulator attenuates inflammation without provoking ligand-induced resistance

Valerie GossyeDirk ElewautKatrien Van BenedenPieter DewintGuy HaegemanKarolien De Bosscher

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Beyond the scope of erosive osteoarthritis of the interphalangeal finger joints: new insights from epidemiological, clinical and imaging based studies

Ruth WittoekAugust VerbruggenDirk Elewaut

Biomechanical stretch is a key initiating event in the development of enthesitis in murine spondyloarthritis

Peggy JacquesStijn LambrechtEveline VerheugenRJ LoriesG KolliasAugust VerbruggenDirk Elewaut

Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins

Katleen Van SteendamKelly TillemanMarlies De CeuleneerFilip De KeyserDirk ElewautDieter Deforce

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Different mucosal expression of Th17 related genes in the small and large bowel of IBD patients

Sarah BogaertDebby LaukensHarald PeetersLode MelisKim OlievierNico BoonJo VandesompeleDirk ElewautMartine De Vos

Differential mucosal expression of Th17-related genes between the inflamed colon and ileum of patients with inflammatory bowel disease

Sara BogaertDebby LaukensHarald PeetersLode MelisKim OlievierNico BoonAugust VerbruggenJo VandesompeleDirk ElewautMartine De Vos

A1 Journal Article in BMC IMMUNOLOGY

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis

Debby LaukensMichel GeorgesCécile LibioulleCynthia SandorMyriam MniBert Vander CruyssenHarald PeetersDirk ElewautMartine De Vos

A1 Journal Article in PLOS ONE

Hydroxylase inhibition abrogates TNF-α-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD

Pieter HindryckxMartine De VosPeggy JacquesLiesbeth FerdinandeHarald PeetersKim OlievierSara BogaertBrigitta BrinkmanPeter VandenabeeleDirk Elewaut et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Interactions between gut inflammation and arthritis/spondylitis

Peggy JacquesDirk ElewautHerman Mielants

A1 Journal Article in CURRENT OPINION IN RHEUMATOLOGY

Invariant natural killer T cells are natural regulators of murine spondylarthritis

Peggy JacquesKoen VenkenKatrien Van BenedenHamida HammadSylvie SeeuwsMichael DrennanDieter DeforceAugust VerbruggenMaria ApostolakiGeorge Kollias et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Invariant natural killer T cells in rheumatic disease : a joint dilemma

Michael DrennanSANDRINE ASPESLAGHDirk Elewaut

A1 Journal Article in NATURE REVIEWS RHEUMATOLOGY

Linking Crohn's disease and ankylosing spondylitis: it's all about genes!

Editorial material

Morbid anatomy of 'erosive osteoarthritis' of the interphalangeal finger joints : an optimised scoring system to monitor disease progression in affected joints

August VerbruggenRuth WittoekBert Vander CruyssenDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Mucosal inflammation in spondyloarthritis: past, present and future

Optimized alkylated cyclodextrin polysulphates restore osteoarthritic chondrocyte extracellular matrix metabolism

Sara GroeneboerStijn LambrechtAad DhollanderPeggy JacquesBert VandercruyssenKatrien DevreeseDirk ElewautAugust Verbruggen

Optimized alkylated cyclodextrin polysulphates restore osteoarthritic chondrocyte extracellular matrix metabolism

Sara GroeneboerStijn LambrechtAad DhollanderPeggy JacquesBert VandercruyssenKatrien DevreeseDirk ElewautAugust Verbruggen

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

SANDRINE ASPESLAGHYali LiTine DecruyKatrien Van BenedenMichael DrennanKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Optimizing the iNKT cell dependent antitumor effect using an altered glycolipid

SANDRINE ASPESLAGHYali LiTine DecruyKatrien Van BenedenKoen VenkenMatthias TrappeniersSerge Van CalenberghDirk ZajoncDirk Elewaut

Oxygen sensor inhibition attenuates TNF-α induced intestinal epithelial damage by hypoxia inducible factor (HIF) 1-dependent repression of fas-associated death domain protein (Fadd)

Pieter HindryckxMartine De VosPeggy JacquesLiesbeth FerdinandeHarald PeetersBrigitta BrinkmanPeter VandenabeeleDirk ElewautDebby Laukens

Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability

Timothy C CheungKen CoppietersHideki SanjoLisa M ObornePaula S NorrisAmy CoddingtonSteven W GrangerDirk ElewautCarl F Ware

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability (vol 185, pg 1949, 2010)

Timothy C CheungKen CoppietersHideki SanjoLisa M ObornePaula S NorrisAmy CoddingtonSteven W GrangerDirk ElewautCarl F Ware

Proteome characterization of human articular chondrocytes leads to novel insights in the function of small heat-shock proteins in chondrocyte homeostasis

Stijn LambrechtMaarten DhaenensKarl AlmqvistPeter VerdonkAugust VerbruggenDieter DeforceDirk Elewaut

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Reduced levels of the TGFB family member GDF15 in spondyloarthritis versus other rheumatic diseases

Stijn LambrechtFilip Van den BoschBert Vander CruyssenFilip De KeyserAugust VerbruggenDieter DeforceDirk Elewaut

Reliability and validity of the Infoot 3D foot digitizer for normal healthy adults

Sophie De MitsPascal CoorevitsDirk De ClercqDirk ElewautJim WoodburnPhilip Roosen

A2 Journal Article in FOOTWEAR SCIENCE

Rituximab in diffuse cutaneous systemic sclerosis: an open-label clinical and histopathological study

Vanessa SmithJens Van PraetBERNARD VANDOORENBert Van der CruyssenJ.-M. NaeyaertSaskia DecumanDirk ElewautFilip De Keyser

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Suppression of human natural killer T cell function by CD4(+)CD25(+)FOXP3(+) regulatory T cells

Koen VenkenTine DecruyKim DeswarteSANDRINE ASPESLAGHSerge Van CalenberghBart LambrechtDirk Elewaut

Synthesis and evaluation of amino-modified α-GalCer analogues

Matthias TrappeniersRené ChoforSANDRINE ASPESLAGHYali LiBruno LinclauDirk M ZajoncDirk ElewautSerge Van Calenbergh

A1 Journal Article in ORGANIC LETTERS

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

Lode MelisBERNARD VANDOORENElli KruithofPeggy JacquesMartine De VosHerman MielantsAugust VerbruggenFilip De KeyserDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Targeting inflammation using selective glucocorticoid receptor modulators

Karolien De BosscherGuy HaegemanDirk Elewaut

A1 Journal Article in CURRENT OPINION IN PHARMACOLOGY

The small heat-shock protein HSP27 shows a decreased abundance in OA and mediates IL-1B induced IL-6 secretion in human articular chondrocytes

Stijn LambrechtKarl AlmqvistPeter VerdonkAugust VerbruggenDieter DeforceDirk Elewaut

The small heat-shock protein HSP27 shows decreased expression in OA-chondrocytes and mediates IL-6 secretion in human articular chondrocytes

Stijn LambrechtKarl AlmqvistPeter VerdonkAugust VerbruggenDieter DeforceDirk Elewaut

2009

Application of a new anti-zearalenone monoclonal antibody in different immunoassay formats

Natalia BurmistrovaIrina GoryachevaEvgenia BasovaAnn-Sophie FrankiDirk ElewautKatrien Van BenedenDieter DeforceCarlos Van PeteghemSarah De Saeger

A1 Journal Article in ANALYTICAL AND BIOANALYTICAL CHEMISTRY

ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis

D. van der HeijdeE. LieT. K. KvienJ. SieperFilip Van den BoschJ. ListingJ. BraunR. LandewePhilippe CarronManouk de Hooge et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Citrullination breaks T-cell tolerance in patients with inflammatory arthritides and in healthy persons

Katleen Van SteendamMarlies De CeuleneerFilip De KeyserDirk ElewautKelly TillemanDieter Deforce

Clinical Observations programme in SpA: disease parameters, treatment options and practical management issues

Dirk ElewautFilip Van den BoschAugust VerbruggenFilip De KeyserBert Vander CruyssenHerman Mielants

A1 Journal Article in Rheumatology International

Cutting Edge: The Chemokine Receptor CXCR3 Retains Invariant NK T Cells in the Thymus

Michael DrennanAnn-Sophie FrankiPieter DewintKatrien Van BenedenSylvie SeeuwsSerge van de PavertEmma ReillyGust VerbruggenThomas LaneReina Mebius et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Dendritic cells are crucial for maintenance of tertiary lymphoid structures in the lung of influenza virus-infected mice

Corine H GeurtsvanKesselMonique WillartIngrid M BergenLeonie S van RijtFemke MuskensDirk ElewautAlbert DLE OsterhausRudi HendriksGuus F RimmelzwaanBart Lambrecht

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

Dendritic cells from spondylarthritis-prone HLA-B27-transgenic rats display altered cytoskeletal dynamics, class II major histocompatibility complex expression, and viability

Maarten DhaenensIngrid FertSimon GlatignySaskia HaerinckCécile PoulainEmmanuel DonnadieuCécile Hacquard-BouderClaudine AndréDirk ElewautDieter Deforce et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Differential expression of alpha B-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis

Stijn LambrechtAugust VerbruggenDirk ElewautDieter Deforce

A1 Journal Article in Arthritis and rheumatism

Differential mechanism of NF-κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

Valerie GossyeDirk ElewautNadia BougarneDebby BrackeSerge Van CalenberghGuy HaegemanKarolien De Bosscher

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Een 55-jarige vrouw met persisterende stijging van creatininekinase

CAROLINE VERBISTV SmithGui De BackerDirk Elewaut

A2 Journal Article in Tijdschrift voor Geneeskunde

Evidence for significant overlap between common risk variants for Crohn's disease and ankylosing spondylitis

M GeorgesDebby LaukensC LibioulleC SandorM MniBert Vander CruyssenHarald PeetersDirk ElewautMartine De Vos

Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus

IEA HoffmanBR LauwerysFilip De KeyserTWJ HuizingaD IsenbergL CebecauerJoke DehoorneRik JoosG HendrickxF Houssiau et al.

A1 Journal Article in Annals of the Rheumatic Diseases

LT beta R Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen

MF VondenhoffM GreuterG GoverseDirk ElewautPieter DewintCF WareK HoorwegG KraalRE Mebius

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Progress in spondylarthritis immunopathogenesis of spondyloarthritis: which cells drive disease?

Lode MelisDirk Elewaut

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

Reversible changes in serum immunoglobulin galactosylation during the immune response and treatment of inflammatory autoimmune arthritis

Katrien Van BenedenKen CoppietersW LaroyFilip De KeyserIlse HoffmanFilip Van den BoschBert Vander CruyssenMichael DrennanPeggy JacquesP Rottiers et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Role of Lymphotoxin (alpha) in Cigarette Smoke-Induced Inflammation and Lymphoid Neogenesis

Tine DemoorKen BrackeTania MaesBERNARD VANDOORENDirk ElewautCharles PiletteGuy JoosGuy Brusselle

A1 Journal Article in EUROPEAN RESPIRATORY JOURNAL

Sensitivity and specificity of criteria for spondyloarthritis in children with late onset pauciarticular juvenile chronic arthritis as well as their characteristics

Rik JoosJo DehoorneIlse HoffmanHerman MielantsAugust VerbruggenDirk Elewaut

A1 Journal Article in Clinical and experimental rheumatology

Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

Lode MelisBERNARD VANDOORENElli KruithofPeggy JacquesMartine De VosHerman MielantsAugust VerbruggenFilip De KeyserDirk Elewaut

T cell reactivity against citrullinated proteins does not differ between healthy persons and patients with inflammatory arthritis

Katleen Van SteendamMarlies De CeuleneerFilip De KeyserDirk ElewautKelly TillemanDieter Deforce

The small heat-shock protein HSP27 shows a decreased abundance in OA and mediates IL-1B induced IL-6 secretion in human articular chondrocytes

Stijn LambrechtAugust VerbruggenDieter DeforceDirk Elewaut

The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000

Leo LeungCyrille TomassiKatrien Van BenedenTine DecruyMatthias TrappeniersDirk ElewautYifang GaoTim ElliottAymen Al-ShamkhaniChristian Ottensmeier et al.

A1 Journal Article in CHEMMEDCHEM

Thymic emigration: Sphingosine-1-phosphate receptor-1-dependent models and beyond

Michael DrennanDirk ElewautKristin Hogquist

A1 Journal Article in European Journal of immunology

Treatment of ankylosing spondylitis and extra-articular manifestations in everyday rheumatology practice

Dirk ElewautMarco Matucci-Cerinic

A1 Journal Article in Rheumatology

2008

6'-Derivatised α-GalCer analogues capable of inducing strong CD1d-mediated Th1-biased NKT cell responses in mice

Matthias TrappeniersKatrien Van BenedenTine DecruyBruno LinclauDirk ElewautSerge Van Calenbergh

A1 Journal Article in JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis

Pieter DewintValerie GossyeKarolien De BosscherWim Vanden BergheKatrien Van BenedenDieter DeforceSerge Van CalenberghU MULLER-LADNERBert Vander CruyssenAugust Verbruggen et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Adalimumab with or without methotrexate in juvenile rheumatoid arthritis

DJ LOVELLN RUPERTOS GOODMANA REIFFL JUNGK JAROSOVAD NEMCOVAR MOUYC SANDBORGJ BOHNSACK et al.

A1 Journal Article in NEW ENGLAND JOURNAL OF MEDICINE

Cyclodextrin polysulphate protects articular cartilage in experimental lapine knee osteoarthritis

Sara GroeneboerP PASTOUREAUE VIGNONBert Vander CruyssenDirk ElewautAugust Verbruggen

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Dendritic Cells from Spondyloarthritis-prone HLA-B27 Transgenic Rat Display Altered Cytoskeletal Dynamics, MHC Class II Expression, and Viability.

Maarten DhaenensIngrid FertSimon GlatignySaskia HaerinckCéline PoulainEmanuel DonnadieuCécile Hacquard-BouderClaudine AndréDirk ElewautDieter Deforce et al.

Dendritic Cells from Spondyloarthritis-prone HLA-B27 Transgenic Rat Display Altered Cytoskeletal Dynamics, MHC Class II Expression, and Viability.

Maarten DhaenensFert IngridGlatigny SimonSaskia HaerinckCeline PoulainEmanuel DonnadieuCéline Hacquard-BouderClaudine AndréDirk ElewautDieter Deforce et al.

Differential proteome analysis of normal and osteoarthritic chondrocytes reveals distortion of vimentin network in osteoarthritis

Stijn LambrechtGert VerbruggenPETER VERDONKDirk ElewautDieter Deforce

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Do all anti-citrullinated protein/peptide antibody tests measure the same? Evaluation of discrepancy between anti-citrullinated protein/peptide antibody tests in patients with and without rheumatoid arthritis

Bert Vander CruyssenL NOGUEIRAJens Van PraetDieter DeforceDirk ElewautG SERREFilip De Keyser

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Enhanced TNF-driven crosstalk to invariant NKT cells favours regulation of murine spondyloarthritis

Peggy JacquesKatrien Van BenedenSylvie SeeuwsMartine De VosDirk Elewaut

Evidence for Altered Cytoskeleton Mobilization Pathway in Splenic Dendritic Cells (DC) from HLA-B27/human b2 microglobulin Transgenic Rats (B27-rats)

Maarten DhaenensIngrid FertSimon GlatignySaskia HaerinckCeline Hacquard-BouderClaudine AndréDirk ElewautDieter DeforceMaxime Breban

FILA-1127 Transgenic rat OX62(+) DCs exhibit multiple cellular deficiencies and the tolerigenic CD4(-) subset suffers reduced viability

M DHAENENSI FRETS GLATIGNYS HAERINCKC HACQUARD-BOUDERC ANDREDirk ElewautDieter DeforceM BREBAN

HLA-B27 transgenic rat OX62+DCs exhibit multiple cellular deficiencies and the tolerigenic CD4-subset suffers reduced viability

M DHAENEUSI FERTS GLATIGNYS HAERINCKC HACQUARD-BOUDERC ANDREDirk ElewautDieter DeforceM BREHAN

Identification and possible citrullination of antigens in immune complexes in patients with rheumatoid arthritis

Katleen Van SteendamKelly TillemanMarlies De CeuleneerMaarten DhaenensDirk ElewautFilip De KeyserDieter Deforce

Invariant NKT cells promote CD8(+) cytotoxic T cell responses by inducing CD70 expression on dendritic cells

Vadim Y. TarabanSonya MartinKathrine E. AttfieldMartin J. GlennieTim ElliottDirk ElewautSerge Van CalenberghBruno LinclauAymen Al-Shamkhani

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Joint expedition: linking gut inflammation to arthritis

Peggy JacquesDirk Elewaut

A1 Journal Article in Mucosal Immunology

Local and systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

BERNARD VANDOORENLode MelisElli KruithofPeggy JacquesMartine De VosHerman MielantsAugust VerbruggenFilip De KeyserDirk Elewaut

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

Maria ARMAKAMaria APOSTOLAKIPeggy JacquesDimitris KONTOYIANNISDirk ElewautGeorge KOLLIAS

Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

Maria ArmakaMaria ApostolakiPeggy JacquesDimitris KontoyiannisDirk ElewautGeorge Kollias

A1 Journal Article in Journal of Experimental Medicine

NKT cells contribute to tumor destruction by TNF

L HUYGHEA GOETHALSJ HOSTENSM VAN DEN HEMELDirk ElewautP BROUCKAERT

Proteomics in rheumatology: The beginning of a fairy tale?

Stijn LambrechtKelly TillemanDirk ElewautDieter Deforce

A1 Journal Article in PROTEOMICS CLINICAL APPLICATIONS

Reduced metallothionein expression in colonic Crohn's disease: evidence for a new disease-modifying gene

Debby LaukensHarald PeetersAnouk WaeytensSara BogaertBert Vander CruyssenDirk ElewautFilip De KeyserHerman MielantsClaude CuvelierKenny Knecht et al.

Reduced metallothionein expression in colonic Crohn's disease: evidence for it new disease-modifying gene

Debby LaukensHarald PeetersAnouk WaeytensSara BogaertBert Vander CruyssenDirk ElewautFilip De KeyserHerman MielantsClaude CuvelierP Van Hummelen et al.

SMALL HEAT-SHOCK PROTEINS, NOVEL IDENTIFIED MEDIATORS OF MATRIX GENE EXPRESSION, ARE DIFFERENTIALLY EXPRESSED IN OA CHONDROCYTES

Stijn LambrechtAugust VerbruggenDirk ElewautDieter Deforce

Spondyloarthropathies: progress and challenges

Peggy JacquesHerman MielantsMartine De VosDirk Elewaut

A1 Journal Article in Best Practice & Research in Clinical Rheumatology

Synovial detection and autoantibody reactivity of processed citrullinated isoforms of vimentin in inflammatory arthritides

Kelly TillemanKatleen Van SteendamTineke CantaertFilip De KeyserDirk ElewautDieter Deforce

A1 Journal Article in RHEUMATOLOGY

Synthesis and in vitro evaluation of α-GalCer epimers

Matthias TrappeniersStijn GoormansKatrien Van BenedenTine DecruyBruno LinclauAymen Al-ShamkhaniTim ElliottChristian OttensmeierJoern M. WernerDirk Elewaut et al.

A1 Journal Article in CHEMMEDCHEM

Synthesis and in vivo evaluation of 4-Deoxy-4,4-difluoro-KRN7000

L LeungC TomassiKatrien Van BenedenTine DecruyDirk ElewautT ElliottA Al-ShamkhaniC OttensmeierSerge Van CalenberghJ Werner et al.

A1 Journal Article in ORGANIC LETTERS

Transgenic rat OX62(+) DCs exhibit multiple cellular deficiencies and the tolerigenic CD4(-) subset suffers reduced viability

Maarten DhaenensIngrid FertSimon GlatignySaskia HaerinckCeline Hacquard-BouderClaudine AndréDirk ElewautDieter DeforceMaxime Breban

What drives the inflammation in SpA?

2007

A comparison of TNF dependent and independent features of murine spondyloarthropathy

Peggy JacquesKen CoppietersKatrien Van BenedenHerman MietantsSylvie SeeuwsAugust VerbruggenMartine De VosDirk Elewaut

A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner

Ken CoppietersKatrien Van BenedenPeggy JacquesPieter DewintAnn VervloetBert Vander CruyssenSerge Van CalenberghGuangwu ChenRichard FranckAugust Verbruggen et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

Agalactosyl immunoglobulins are a useful marker for clinical progression and successful therapy of collagen-induced arthritis

Katrien Van BenedenKen CoppietersWouter LaroyPieter RottiersAugust VerbruggenNico CallewaertDirk Elewaut

CARD15 variants determine a disturbed early response of monocytes to adherent-invasive Escherichia coli strain LF82 in Crohn's disease

Harald PeetersSara BogaertDebby LaukensPieter RottiersFilip De KeyserA Darfeuille-MichaudAL GlasserDirk ElewautMartine De Vos

A1 Journal Article in INTERNATIONAL JOURNAL OF IMMUNOGENETICS

Cell-based meniscus tissue engineering

HANS VAN DER BRACHTRené VerdonkAugust VerbruggenDirk ElewautPeter Verdonk

Bookchapter in Topics in tissue engineering

In pursuit of B-cell synovial autoantigens in rheumatoid arthritis: Confirmation of citrullinated fibrinogen, detection of vimentin, and introducing carbonic anhydrase as a possible new synovial autoantigen

Kelly TillemanAnn UnionT CANTAERTS DE KEYSERA DANIELSDirk ElewautFilip De KeyserDieter Deforce

A1 Journal Article in PROTEOMICS CLINICAL APPLICATIONS

NKT cells: manipulable managers of joint inflammation

Ken CoppietersPieter DewintKatrien Van BenedenPeggy JacquesSylvie SeeuwsAugust VerbruggenDieter DeforceDirk Elewaut

A1 Journal Article in RHEUMATOLOGY

Osteochondral repair in synovial joints

August VerbruggenRuth WittoekSara GroeneboerBert Vander CruyssenStefan GoemaereDirk Elewaut

A1 Journal Article in CURRENT OPINION IN RHEUMATOLOGY

Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis

Bert Vander CruyssenLieve NuytinckLuc BoullartDirk ElewautWillem WaegemanMira Van ThielenE. DE MEESTERK. LEBEERR. ROSSAUFilip De Keyser

A1 Journal Article in RHEUMATOLOGY

The intimate relationship between gut and joint in spondyloarthropathies

Peggy JacquesHerman MielantsKen CoppietersMartine De VosDirk Elewaut

A1 Journal Article in CURRENT OPINION IN RHEUMATOLOGY

The unconventional role of LT alpha beta in T cell differentiation

Dirk ElewautCF WARE

A1 Journal Article in TRENDS IN IMMUNOLOGY

2006

A unique LT alpha beta dependent pathway regulates thymic emigration of V alpha 14i NKT cells

Pieter DewintAnn-Sophie FrankiKatrien Van BenedenKirsten HammondStijn LambrechtGeorges LeclercqDieter DeforceMitchell KronenbergDirk Elewaut

A unique lymphotoxin alpha beta dependent pathway regulates thymic emigration of V alpha 14iNKT cells

Dirk ElewautAnn-Sophie FrankiKatrien Van BenedenPieter DewintKirstin HammondGeorges LeclercqDieter DeforceMitchell Kronenberg

A unique lymphotoxin alpha,beta-dependent pathway regulates thymic emigration of V alpha 14 invariant natural killer T cells

Ann-Sophie FrankiKatrien Van BenedenPieter DewintKJL HAMMONDStijn LambrechtGeorges LeclercqM KRONENBERGDieter DeforceDirk Elewaut

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered gut transcriptome in spondyloarthropathy

Debby LaukensHarald PeetersBert Vander CruyssenTom BoonefaesDirk ElewautFilip De KeyserHerman MielantsClaude CuvelierEric VeysKenny Knecht et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Alternative method to identify susceptibility genes for Crohn's disease through transcriptome analysis

D LAUKERSH PECTERSFilip De KeyserEric VeysClaude CuvelierDirk ElewautErik RemautMartine De VosP ROTTIERS

Comparison of the anti-human citrullinated fibrinogen antibodies assayed by ELISA with 2 other ACPA assays: Diagnostic value and agreement between assays

Bert Vander CruyssenL NOGUEIRATineke CantaertC CAVELLEEN DE RYCKEM SEBAGDieter DeforceDirk ElewautG SERREFilip De Keyser

Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays

Bert Vander CruyssenTineke CantaertL NOGUEIRAC CLAVELLEEN DE RYCKEA DENDOVENM SEBAGDieter DeforceC VINCENTDirk Elewaut et al.

A1 Journal Article in ARTHRITIS RESEARCH & THERAPY

DIFFERENTIAL PROTEOME ANALYSIS OF NORMAL AND OA-AFFECTED CHONDROCYTES

Stijn LambrechtAugust VerbruggenPETER VERDONKDirk ElewautDieter Deforce

Disease mechanism in Spondyloarthropathies: a proteome analysis of spleen dendritic cells from HLA-B27 transgenic rats.

Maarten DhaenensIngrid FertCecile Hacquard-BouderDirk ElewautDieter DeforceMaxime Breban

Effect of age on prevalence of anticitrullinated protein/peptide antibodies in polyarticular juvenile idiopathic arthritis

Pieter DewintIlse HoffmanS ROGGER JOOSAnn UnionJ DEHOORNEJ DELANGHEEric VeysFilip De KeyserDirk Elewaut

A1 Journal Article in RHEUMATOLOGY

Entering the era of proteomics in rheumatalogy

Stijn LambrechtDieter DeforceDirk Elewaut

A2 Journal Article in Expert Opinion on Drug Discovery

Entering the era of proteomics in rheumatology

Stijn LambrechtDieter DeforceDirk Elewaut

A1 Journal Article in EXPERT OPINION ON DRUG DISCOVERY

Formatted anti-TNF alpha nanobodies show superior efficacy in a collagen induced arthritis model in mice

Ken CoppietersT DreierK SilenceDirk ElewautP Rottiers

Formatted anti-tumor necrosis factor alpha VHH proteins derived from camelids show superior potency and targeting to inflamed joints in a murine model of collagen-induced arthritis

Ken CoppietersTorsten DreierKaren SilenceHans de HaardMarc LauwereysPeter CasteelsEls BeirnaertHeidi JonckheereChristophe Van De WieleLudovicus Staelens et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Long term IFN-gamma dependent efficacy of activated Valpha14i Natural Killer T cells in the prevention of collagen induced arthritis

Ken CoppietersKatrien Van BenedenM TsujiP RottiersDirk Elewaut

Long-term IFN-gamma dependent efficacy of activated V alpha 14I natural killer T-cells in the prevention of collagen-induced arthritis

Ken CoppietersKatrien Van BenedenAnn VervloetPieter DewintPeggy JacquesSara GroeneboerMoriya TsujiAugust VerbruggenDieter DeforcePatrick Matthys et al.

Long-term IFN-gamma dependent efficacy of activated V alpha 14i NKT cells in collagen-induced arthritis

Dirk ElewautKen CoppietersKatrien Van BenedenRichard FranckMoriya TsujiPatrick MatthysPieter Rottiers

Long-term IFN-gamma dependent efficacy of activated valpha141 natural killer T cells in the prevention of collagen-induced arthritis

Katrien Van BenedenKen CoppietersAnn VervloetB VandercruyssenPeggy JacquesPieter DewintB De KlerckH HeremansM TsujiG Verbruggen et al.

Protein expression profiling of normal and osteoarthritic chondrocytes points to distortion of vimentin organisation in osteoarthritis

Stijn LambrechtG VERBRUGGENPETER VERDONKDirk ElewautDieter Deforce

The diagnostic value of the anti-human citrullinated fibrinogen antibodies by elisa compared to anti-CCP2 antibodies, and their agreement with ACPA detected by 3 other substrates

Bert Vander CruyssenL NogueiraT CantaertC CavelLies De RyckeM SebagDieter DeforceDirk ElewautG SerreFilip De Keyser

2005

A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection

TA BANKSS RICKERTCA BENEDICTL MAM KOJ MEIERW HAK SCHNEIDERSW GRANGERO TUROVSKAYA et al.

A1 Journal Article in JOURNAL OF IMMUNOLOGY

A plant-derived compound with fully dissociated properties on glucocorticoid receptor-mediated gene regulation

R DEWINTK DE BOSSCHERW VANDEN BERGHEBert Vander CruyssenEric VeysG HAEGEMANDirk Elewaut

A unique LT alpha beta dependent pathway regulates thymic emigration of V alpha 14i NKT cells

Ann-Sophie FrankiKatrien Van BenedenPieter DewintKJL HAMMONDS LAMBRECHTG LECLERCQM KRONENBERGDieter DeforceDirk Elewaut

A unique LT dependent pathway regulates thymic emigration of V alpha 14i NKT cells

Ann-Sophie FrankiKatrien Van BenedenPieter DewintStijn LambrechtDieter DeforceDirk Elewaut

Beta-cyclodextrin polysulphate represses TNFalpha-mediated IL-1 beta cascades in osteoarthritic chondrocytes

Sara GroeneboerDirk ElewautEric VeysGert Verbruggen

CARD15 gene polymorphisms in patients with spondyloarthropathies identify a specific phenotype previously related to Crohn's disease

Debby LaukensHarald PeetersDENIS MARICHALBert Vander CruyssenHerman MielantsDirk ElewautPieter DemetterClaude CuvelierM VAN DEN BERGHEPieter Rottiers et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Chronically inflamed synovium from spondyloarthropathy and rheumatoid arthritis investigated by protein expression profiling followed by tandem mass spectrometry

Kelly TillemanKatrien Van BenedenAline DhondtIlse HoffmanFilip De KeyserEric VeysDirk ElewautDieter Deforce

A1 Journal Article in PROTEOMICS

Cyclodextrin polysulphates repress IL-1 and promote chondrocyte extracellular matrix repair

René VerdonkSara GroeneboerJ WANGC BRODDELEZDirk ElewautEric VeysGert Verbruggen

Cyclodextrin polysulphates repress IL-1 and promote the accumulation of chondrocyte extracellular matrix

PETER VERDONKJ WANGSara GroeneboerCarine BroddelezDirk ElewautEric VeysGert Verbruggen

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Differential expression of hypoxia activated proteins in synovial tissue of inflammatory arthritides

Kelly TillemanAline DhondtPieter DewintFilip De KeyserDirk ElewautDieter Deforce

Differential proteome analysis of Chronic lymphocytic leukemia subtypes

Ben GeeraertsAline DhondtDirk ElewautJan Van BocxlaerDieter Deforce

Formatted anti-TNF-alpha nanobodies show superior efficacy in a collagen-induced arthritis model in mice

Ken CoppietersT DreierK SilenceH De GaardM LauwereysC PeterChristophe Van De WieleL StaelensJ HostensH Revets et al.

Juvenile chronic arthritis displays synovial features distinct from both spondyloarthropathy and rheumatoid arthritis

Elli KruithofV VAN DEN BOSSCHELeen De RyckeBERNARD VANDOORENR JOOSDirk ElewautFilip De KeyserEric VeysDominique Baeten

Ly49 and CD94/NKG2 receptor acquisition by NK cells does not require lymphotoxin-beta receptor expression

Frederik StevenaertKatrien Van BenedenVeerle De ColvenaerAnn-Sophie FrankiVeronique DebackerTom BoterbergDieter DeforceK PFEFFERJean PlumDirk Elewaut et al.

A1 Journal Article in BLOOD

Lymphotoxin alpha 1 beta 2: a critical mediator in V alpha 14i NKT cell differentiation

Ann-Sophie FrankiKatrien Van BenedenPieter DewintIvan MeeusEric VeysDieter DeforceDirk Elewaut

A1 Journal Article in MOLECULAR IMMUNOLOGY

Lymphotoxins alpha and beta are indispensable for phenotypical and functional development of V alpha 14i NKT cells during fetal ontogeny

Ann-Sophie FrankiKatrien Van BenedenPieter DewintStijn LambrechtDieter DeforceDirk Elewaut

Natural killer T cells and rheumatoid arthritis: friend or foe?

Editorial material

Potent anti-inflammatory, fully dissociative compound for glucocorticoid receptor-mediated gene regulation

Pieter DewintKarolien De BosscherValerie GossyeWim Vanden BergheBert Vander CruyssenEric VeysGuy HaegemanDirk Elewaut

Rheumatology: a close encounter with proteomics

Kelly TillemanDieter DeforceDirk Elewaut

A1 Journal Article in RHEUMATOLOGY

X linked agammaglobulinaemia and rheumatoid arthritis

G VERBRUGGENSofie De BackerDieter DeforcePieter DemetterClaude CuvelierEric VeysDirk Elewaut

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2004

Analysis of chondrocyte functional markers and pericellular matrix components by flow cytometry

August VerbruggenJ WangL WangDirk ElewautEric Veys

A4 Journal Article in METHODS IN MOLECULAR MEDICINE

Biology of articular cartilage

G VERBRUGGENJun WangDirk ElewautE VEYS

Flow cytometric measurement of mRNA in living cells by FISH

August VerbruggenJ WangPeter VerdonkDirk ElewautEric Veys

Homeostasis of CD4+CD25+regulatory T cells in naive and arthritic mice

Katrien Van BenedenA VAN DER AADieter DeforceEric VeysDirk Elewaut

Indispensable role of lymphotoxins alpha and beta in phenotypical and functional development of V alpha 14i NKT cells during fetal ontogeny

Ann-Sophie FrankiKatrien Van BenedenEric VeysDieter DeforceDirk Elewaut

Lymphotoxin beta receptor mediated activation of RelB by NIK defines a unique signaling pathway for the development of V alpha 14i NKT cells

Ann-Sophie FrankiKatrien Van BenedenR ShaikhDieter DeforceDirk Elewaut

Lymphotoxins alpha and beta are indispensable for phenotypical and functional development of V alpha 14i NKT cells during fetal ontogeny

Pieter DewintKatrien Van BenedenAnn-Sophie FrankiDieter DeforceDirk Elewaut

Lymphotoxins alpha and beta are indispensable for phenotypical and functional development of V alpha 14i NKT cells during fetal ontogeny

Katrien Van BenedenAnn-Sophie FrankiEric VeysDieter DeforceDirk Elewaut

Lymphotoxins alpha and beta are indispensable for phenotypical and functional development of V alpha 14i NKT cells during fetal ontogeny

Katrien Van BenedenAnn-Sophie FrankiEric VeysDieter DeforceDirk Elewaut

Mapping of the leptin binding sites and design of a leptin antagonist

Frank PeelmanKatrien Van BenedenLennart ZabeauHannes IserentantPeter UlrichtsDelphine DefeauAnnick VerheeDominiek CatteeuwDirk ElewautJan Tavernier

A1 Journal Article in JOURNAL OF BIOLOGICAL CHEMISTRY

Physiological levels of hydrocortisone maintain an optimal chondrocyte extracellular matrix metabolism

Jun WangDirk ElewautIlse HoffmanEric VeysGert Verbruggen

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Protein expression profiling of inflamed synovial tissue in rheumatoid arthritis, spondyloarthropathy and osteoarthritis

Kelly TillemanAline DhondtIlse HoffmanFilip De KeyserEric VeysDieter DeforceDirk Elewaut

Synovial tissue proteomics in rheumatoid arthritis and spondyloarthropathy

Kelly TillemanKatrien Van BenedenFilip De KeyserEric VeysDieter DeforceDirk Elewaut

2003

Association between ASCA-positivity and carrier of a CARD-15 mutation in patients with Crohn's disease

B VAN DER CRUYSSENFilip De KeyserHarald PeetersM VAN DEN BERGHED MARICHALIlse HoffmanT VAN OOSTVELDTDebby LaukensErik RemautL STEIDLER et al.

CARD15 mutations in patients with spondyloarthropathy are linked with disease progression and evolution to Crohn's disease

Martine De VosDebby LaukensDENIS MARICHALM VAN DEN BERGHEHarald PeetersDirk ElewautHerman MielantsFilip De KeyserClaude CuvelierEric Veys et al.

Crohn's disease patients with CARD15 variants have higher risk of developing axial joint involvement

Martine De VosHarald PeetersBert Vander CruyssenDebby LaukensDenis MarichalMarthe VandenbergheT Van OostveldtDirk ElewautFilip De KeyserClaude Cuvelier et al.

Homeostasis of the extracellular matrix of normal and osteoarthritic human articular cartilage chondrocytes in vitro

J WANGPeter VerdonkDirk ElewautEric VeysG VERBRUGGEN

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Insulin-like growth factor 1-induced interleukin-1 receptor II overrides the activity of interleukin-1 and controls the homeostasis of the extracellular matrix of cartilage

J WANGDirk ElewautEric VeysG VERBRUGGEN

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Lymphotoxin beta receptor mediated activation of RelB by NIK defines a unique signaling pathway for the development of V alpha 14i NKT cells

Ann-Sophie FrankiKatrien Van BenedenR ShaikhDieter DeforceM VeysC WareM KronenbergDirk Elewaut

NIK-dependent RelB activation defines a unique signaling pathway for the development of V alpha 14i NKT cells

Dirk ElewautRB SHAIKHKJL HAMMONDHilde De WinterAJ LEISHMANS SIDOBREO TUROVSKAYATI PRIGOZYL MATA BANKS et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of V alpha 14i NKT cells

Dirk ElewautAP LAWTONNA NAGARAJANE MAVERAKISA KHURANAS HONINGCA BENEDICTE SERCARZO BAKKEM KRONENBERG et al.

A1 Journal Article in JOURNAL OF EXPERIMENTAL MEDICINE

The protein expression pattern of CLL cells is stable over six months intervals

Ben GeeraertsJan Van BocxlaerWilly LambertCarlos Van PeteghemDieter DeforceDirk Elewaut

2002

Regulation of mucosal immune responses by recombinant interleukin 10 produced by intestinal epithelial cells in mice.

Hilde De WinterDirk ElewautO TUROVSKAYAM HUFLEJTC SHIMELDA HAGENBAUGHS BINDERI TAKAHASHIM KRONENBERGH CHEROUTRE

A1 Journal Article in GASTROENTEROLOGY

Successful use of infliximab in a patient with treatment resistant spondyloarthropathy related uveitis

Elli KruithofPhilippe KestelynC ElewautDirk ElewautFilip Van den BoschHerman MielantsEric VeysFilip De Keyser

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

2001

Flow cytometric analysis of the human articular chondrocyte phenotype in vitro.

Lai WangG VERBRUGGENKarl AlmqvistDirk ElewautC BRODDELEZEric Veys

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Glycolipid antigen processing for presentation by CD1d molecules

TI PRIGOZYOV NAIDENKOP QASBADirk ElewautL BROSSAYA KHURANAT NATORIY KOEZUKAA. KulkarniM. Kronenberg

A1 Journal Article in SCIENCE

Gut mucosal T cell lines from ankylosing spondylitis patients are enriched with alpha E beta 7 integrin.

Nancy Van DammeDirk ElewautDominique BaetenPieter DemetterClaude CuvelierG VERBRUGGENHerman MielantsEric VeysMartine De VosFilip De Keyser

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

2000

Broadening of the T cell receptor spectrum among rheumatoid arthritis synovial cell-lines in relation to disease duration

Dirk ElewautFilip De KeyserFilip Van den BoschAugust VerbruggenEric Veys

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Chemical agents and enzymes used for the extraction of gut lymphocytes influence flow cytometric detection of T cell surface markers.

Nancy Van DammeDominique BaetenMartine De VosPieter DemetterDirk ElewautHerman MielantsG VERBRUGGENClaude CuvelierEric VeysFilip De Keyser

A1 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Focal up-regulation of E-cadherin-catenin complex in inflamed bowel mucosa but reduced expression in ulcer associated cell lineage.

Pieter DemetterMartine De VosNancy Van DammeDominique BaetenDirk ElewautS VERMEULENMarcus MareelGillian BullockHerman MielantsG VERBRUGGEN et al.

A1 Journal Article in AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Human cartilage gp-39+, CD16+monocytes in peripheral blood and synovium : correlation with joint destruction in rheumatoid arthritis

Dominique BaetenAnnemieke MH BootsPeter GA SteenbakkersDirk ElewautEbo BosGijs FM VerheijdenAugust VerbruggenAndré MM MiltenburgAnthonius WM RijndersEric Veys et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Immune-mediated pathology following hepatitis B vaccination. Two cases of polyarteritis nodosa and one case of pityriasis rosea-like drug eruption.

Filip De KeyserJM NAEYAERTP HINDRICKXDirk ElewautP VERPLANCKEIsabelle PeeneMarleen PraetEric Veys

A1 Journal Article in CLINICAL AND EXPERIMENTAL RHEUMATOLOGY

Influence of aging on the synthesis and morphology of the aggrecans synthesized by differentiated human articular chondrocytes

August VerbruggenMaria CornelissenKarl AlmqvistLai WangDirk ElewautCarine BroddelezLeo De RidderEric Veys

A1 Journal Article in OSTEOARTHRITIS AND CARTILAGE

Subclinical gut inflammation in spondyloarthropathy patients is associated with upregulation of the E-cadherin/catenin complex.

Pieter DemetterDominique BaetenFilip De KeyserMartine De VosNancy Van DammeG VERBRUGGENS VERMEULENMarcus MareelDirk ElewautHerman Mielants et al.

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

There is no disease-specific role for streptococci-responsive synovial T lymphocytes in the pathogenesis of psoriatic arthritis.

H THOMSSENB HOFFMANNM SCHANKDirk ElewautKHM ZUM BUSCHENFELDEE MARKER-HERMANN

A1 Journal Article in MEDICAL MICROBIOLOGY AND IMMUNOLOGY

1999

Effects of chemical agents and enzymes on lymphocyte surface markers

Nancy Van DammeDominique BaetenMartine De VosPieter DemetterDirk ElewautHerman MielantsAugust VerbruggenClaude CuvelierEric VeysFilip De Keyser

Expression and regulation of the human β-defensins hBD-1 and hBD-2 in intestinal epithelium

Deborah O'NeilEdith Martin PorterDirk ElewautMark AndersonLars EckmannThomas GanzMartin Kagnoff

A1 Journal Article in JOURNAL OF IMMUNOLOGY

High frequency of 'missed' HLA-B loci by serologic determination in patients with spondyloarthropathy and chronic gut inflammation

Dirk ElewautHerman MielantsB VandekerckhoveAugust VerbruggenFilip De KeyserClaude CuvelierMartine De VosK GranforsEric Veys

Inflammatory bowel disease and subclinical gut inflammation in spondyloarthropathy patients are associated with increased expression of the E-cadherin/catenin complex

Pieter DemetterMartine De VosDominique BaetenNancy Van DammeFilip De KeyserDirk ElewautS VermeulenMarcus MareelAugust VerbruggenHerman Mielants et al.

Inflammatory bowel disease and subclinical gut inflammation in spondyloarthropathy patients are associated with increased expression of the E-cadherin/catenin complex

Pieter DemetterMartine De VosDominique BaetenNancy Van DammeFilip De KeyserDirk ElewautS VermeulenMarcus Mareel

Influence of polysulfated polysaccharides on aggrecans synthesized by differentiated human articular chondrocytes.

G VERBRUGGENMaria CornelissenDirk ElewautC BRODDELEZLeo De RidderEric Veys

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

Intestinal mucosa of patients with spondyloarthropathy is enriched with T cells carrying alpha E beta 7 integrin, even in the absence of histologically defined inflammation

Dirk ElewautNancy Van DammeDominique BaetenPieter DemetterS SasMartine De VosClaude CuvelierAugust VerbruggenHerman MielantsFilip De Keyser et al.

Needle arthroscopy of the knee with synovial biopsy sampling: technical experience in 150 patients

Dominique BaetenFilip Van den BoschDirk ElewautA StuerEric VeysFilip De Keyser

A1 Journal Article in CLINICAL RHEUMATOLOGY

Polyarteritis nodosa mimicking polymyalgia rheumatica.

Elli KruithofDirk ElewautJean NaeyaertMarleen PraetHerman MielantsEric VeysFilip De Keyser

A1 Journal Article in CLINICAL RHEUMATOLOGY

Proinflammatory cytokine production and cell adhesion molecule expression compared in rheumatoid nodules and synovial membranes : comment on the article by Wikaningrum et al.

Dirk ElewautFilip De KeyserAugust VerbruggenEric Veys

A1 Journal Article in ARTHRITIS AND RHEUMATISM

T cell cytokines in gut mucosa of patients with spondyloarthropathy reflect immune alterations in Crohn's disease

Nancy Van DammeMartine De VosDominique BaetenPieter DemetterDirk ElewautClaude CuvelierHerman MielantsAugust VerbruggenEric VeysFilip De Keyser

1998

A comparative phenotypical analysis of rheumatoid nodules and rheumatoid synovium with special reference to adhesion molecules and activation markers.

Dirk ElewautFilip De KeyserN DE WEVERDominique BaetenNancy Van DammeG VERBRUGGENClaude CuvelierEric Veys

A1 Journal Article in ANNALS OF THE RHEUMATIC DISEASES

Altered expression of ocEß7 integrin on intra-epithelial and lamina propria lymphocytes in patients with Crohn's disease

Dirk ElewautNancy Van DammeFilip De KeyserDominique BaetenPascale De PaepeHans Van VlierbergheHerman MielantsClaude CuvelierAugust VerbruggenEric Veys et al.

A1 Journal Article in ACTA GASTRO-ENTEROLOGICA BELGICA

Bowel inflammation and the spondyloarthropathies.

Filip De KeyserDirk ElewautMartine De VosKurt De VlamClaude CuvelierHerman MielantsEric Veys

A1 Journal Article in RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Distinctive activated cellular subsets in colon from patients with Crohn's disease and ulcerative colitis

Dirk ElewautFilip De KeyserClaude CuvelierAI LazarovitsHerman MielantsAugust VerbruggenS SasMartine De VosEric Veys

A1 Journal Article in SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Effects of chemical agents and enzymes on the detection of lymphocyte surface markers.

Nancy Van DammeDominique BaetenMartine De VosPieter DemetterDirk ElewautHerman MielantsG VERBRUGGENC CUVELIEREM VEYSFilip De Keyser

A2 Journal Article in Clinical and Experimental Immunology

Enrichment of T cells carrying 137 integrins in inflamed synovial tissue from patients with early spondyloarthropathy, compared to rheumatoid arthritis

Dirk ElewautFilip De KeyserFilip Van den BoschAI LazarovitsMartine De VosClaude CuvelierAugust VerbruggenHerman MielantsEric Veys

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

Increased expression of E 7 integrin in uninflamed mucosa of patients with spondyloarthropathy

Dirk ElewautNancy Van DammeDominique BaetenPieter DemetterS SASMartine De VosC CUVELIERG VERBRUGGENHerman MielantsFilip De Keyser et al.

A2 Journal Article in Gastroenterology, 1998

Isolation of colonie mucosal lamina propria and intra-epithelial lymphocytes : mechanical versus enzymatic isolation

Nancy Van DammeDominique BaetenFilip De KeyserPieter DemetterDirk ElewautMartine NeckebroekHans Van VlierbergheHerman MielantsG. VerbruggenC. Cuvelier et al.

A2 Journal Article in JOURNAL OF IMMUNOLOGICAL METHODS

Upregulation of E-cadherin and associated molecules (a-, ß- and y-catenins) in inflamed bowel mucosa

Pieter DemetterMartine De VosNancy Van DammeDominique BaetenE CESMELIDirk ElewautS VERMEULENM MAREELGillian BullockHerman Mielants et al.

A2 Journal Article in Am. J. Pathol, 1998

1997

Dominant T cell receptor rearrangements in interleukin 2 expanded lymphocytes from rheumatoid nodules suggest antigen driven T cell activation in situ.

Filip De KeyserDirk ElewautJPM OVERMEERGRAUSP VANDENBROEKAWM RIJNDERSEric Veys

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

Extra-intestinal manifestations of enteropathies : why are the joints involved?

Dirk ElewautK GranforsFilip De KeyserIlse HoffmanEric Veys

A2 Journal Article in RHEUMATOLOGY IN EUROPE

Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis.

GFM VERHEIJDENAWM RIJNDERSE BOSCJJC DEROOCJ VANSTAVERENAMM MILTENBURGJH MEIJERINKDirk ElewautFilip De KeyserEric Veys et al.

A1 Journal Article in ARTHRITIS AND RHEUMATISM

Immunopathology of the enteropathies

Claude CuvelierN De WeverDirk ElewautK BensbahoFilip De Keyser

A2 Journal Article in RHEUMATOLOGY IN EUROPE

Selection of self-reactive peptides within human aggrecan by use of a HLA-DRB1*0401 peptide binding motif.

AMH BOOTSGFM VERHEIJDENR SCHONINGHCJ VAN STAVERENE BOSDirk ElewautFilip De KeyserEric VeysI JOOSTENAWM RIJNDERS

A1 Journal Article in JOURNAL OF AUTOIMMUNITY

Specific immune activation in chronic arthritis and molecular targets for immune modulation

Dirk ElewautEric VeysFilip De Keyser

1996

Lusoria dysphagia in a patient with retroperitoneal fibrosis and Riedel's thyroiditis

Dirk ElewautRobert RubensAndré ElewautMarc Kunnen

A1 Journal Article in JOURNAL OF INTERNAL MEDICINE

The gut associated addressins : lymphocyte homing in the gut

Filip De KeyserDirk ElewautNathalie De WeverKhalid BensbahoClaude Cuvelier

A1 Journal Article in BAILLIERES CLINICAL RHEUMATOLOGY

1995

Gut inflammation in psoriatic arthritis: a prospective ileocolonoscopic study

L SchattemanHerman MielantsEric VeysClaude CuvelierMartine De VosL GyselbrechtDirk ElewautStefan Goemaere

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

The evolution of spondyloarthropathies in relation to gut histology, 1: clinical aspects

Herman MielantsEric VeysMartine De VosClaude CuvelierStefan GoemaereL DeclercqL SchattemanDirk Elewaut

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

The evolution of spondyloarthropathies in relation to gut histology, 2: histological aspects

Herman MielantsEric VeysClaude CuvelierMartine De VosStefan GoemaereL DeclercqL SchattemanDirk Elewaut

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

The evolution of spondyloarthropathies in relation to gut histology, 3: relation between gut and joint

Herman MielantsEric VeysClaude CuvelierMartine De VosStefan GoemaereL DeclercqL SchattemanL GyselbrechtDirk Elewaut

A1 Journal Article in JOURNAL OF RHEUMATOLOGY

THE ROLE OF T-CELLS IN RHEUMATOID-ARTHRITIS.

Filip De KeyserDirk ElewautJ VERMEERSCHN DEWEVERClaude CuvelierEric Veys

A1 Journal Article in CLINICAL RHEUMATOLOGY

1994

AN UNUSUAL CASE OF DYSPHAGIA

Dirk ElewautRobert Rubens

A1 Journal Article in POSTGRADUATE MEDICAL JOURNAL

Monoclonal-antibody therapy in rheumatoid-arthritis.

Filip De KeyserDirk ElewautAnne-Marie MalfaitEric Veys

A1 Journal Article in CLINICAL IMMUNOTHERAPEUTICS

Total Dependence of the Cerebral Circulation on the Right Vertebral Artery in Takayasu's Disease - A Case Report.

Dirk ElewautDaniel DuprezMarc De BuyzereMarc KunnenDenis Clement

A2 Journal Article in International Journal of Angiology

1993

Comparison of different diagnostic criteria for the diagnosis of Takayasu's arteritis.

Dirk ElewautDaniel DuprezMarc De BuyzereDenis Clement

A2 Journal Article in ACTA CARDIOLOGICA

T cell receptor Vbeta usage in rheumatoid nodules - marked oligoclonality among DL-2 expanded lymphocytes.

Filip De KeyserG VERBRUGGENEric VeysClaude CuvelierAnne-Marie MalfaitDominique BenoitDirk ElewautJ VERMEERSCHA HEIRWEGH

A1 Journal Article in CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY

Vertebral artery involvement in Takayasu's disease.

Dirk ElewautDaniel DuprezMarc De BuyzereDenis Clement

A2 Journal Article in ACTA CLINICA BELGICA

1992

Lusoria dysphagia in a patient with Riedel's thyroiditis and retroperitoneal fibrosis: a case report.

Dirk ElewautRobert RubensAndré ElewautA VERMEULEN

A2 Journal Article in ACTA CLINICA BELGICA

T-cell receptor expression in patients with rheumatic diseases

Filip De KeyserDominique BenoitDirk ElewautBart LeroyAnne-Marie MalfaitAugust VerbruggenEric Veys

T-cell receptor expression in patients with rheumatic diseases

Filip De KeyserDominique BenoitDirk ElewautBart LeroyAnne-Marie MalfaitAugust VerbruggenEric Veys

A1 Journal Article in PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY