Research Explorer

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Researcher

Delfien Bogaert

Awards & Distinctions

65 Results

2023

Editorial : the role of transcription factors in inborn errors of immunity

Delfien BogaertHye Sun KuehnVictoria BordonFilomeen Haerynck

Editorial material

How to recognize inborn errors of immunity in a child presenting with a malignancy : guidelines for the pediatric hemato-oncologist

Jutte van der Werff ten BoschEva HlaváčkováCharlotte DerpoorterUte FischerFrancesco SaettiniSujal GhoshRoula FarahDelfien BogaertRabea WagenerJan Loeffen et al.

A1 Journal Article in PEDIATRIC HEMATOLOGY AND ONCOLOGY

2022

Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50

Manfred FliegaufMatias KinnunenSara Posadas-CanteraNadezhda Camacho-OrdonezHassan AbolhassaniLaia AlsinaFaranaz AtschekzeiDelfien BogaertSiobhan O. BurnsJoseph A. Church et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Familial hemophagocytic lymphohistiocytosis type 3 presenting as neonatal cholestasis and splenomegaly

Delfien BogaertRuth De BruyneArnaud VanlanderLara GarabedianYves LouisFilomeen HaerynckVictoria BordonBarbara De Moerloose

A1 Journal Article in PEDIATRIC ALLERGY AND IMMUNOLOGY

GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141

Leslie NaesensSantoshi MuppalaDhiraj AcharyaJosephine NemegeerDelfien BogaertJung-Hyun LeeKatrien StaesVeronique DebackerPieter De BleserMarieke De Bruyne et al.

A1 Journal Article in SCIENCE IMMUNOLOGY

2021

Congenital defects of phagocytes

Delfien BogaertFilomeen Haerynck

Bookchapter in Cellular primary immunodeficiencies

GTF3A mutations in a patient with herpes simplex encephalitis reveals a novel role in viral immunity by transcribing 5S rRNA pseudogenes serving as RIG-I ligands

Leslie NaesensSantoshi MuppalaJung-Hyun LeeJosephine NemegeerDhiraj AcharyaDelfien BogaertMichiel van GentJens StaalKatrien StaesVeronique Debacker et al.

Immunoglobulin g subclass and specific polysaccharide antibody deficiency : a clinical and immunological profile in a tertiary cohort

Levi HosteJudith ClausSimon SchelfhoutJarno De CraemerLaurens De KetelaereDelfien BogaertCarolien BonroyJan PhilippéJulie WillekensTessa Kerre et al.

Paediatrician in Training Discussion Panel 1 : the challenges of tele-paediatrics : a lockdown-inspired clinical grand round

Eline HermansBram MeertensDelfien BogaertLien DosscheLevi Hoste

2020

Case report : convalescent plasma, a targeted therapy for patients with CVID and severe COVID-19

Karel Van DammeSimon TavernierNele Van RoyElisabeth De LeeuwJozefien DeclercqCédric BosteelsBastiaan MaesMarieke De BruyneDelfien BogaertVictor Bosteels et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

Expect the unexpected : clinical case

Delfien BogaertMarieke De BruyneFrederic Rieux-LaucateElfride De BaereFilomeen Haerynck

GATA2 deficiency and haematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertGenevieve LaureysLeslie NaesensDominiek MazureMarieke De BruyneAmy P. HsuVictoria Bordon MariaErik WoutersSimon TavernierBart Lambrecht et al.

A1 Journal Article in BRITISH JOURNAL OF HAEMATOLOGY

Hematopoietic stem cell transplantation in children with primary immunodeficiencies : a Belgian single center experience

Delfien BogaertCatharina DhoogeFilomeen HaerynckVictoria Bordon Maria

Severe phototoxicity associated with concomitant use of methotrexate and voriconazole, an overlooked drug-drug interaction

Delfien BogaertLouisa VerlindenEls VandecruysGenevieve LaureysEvelien VerhaegheTieneke Bauters

A1 Journal Article in PEDIATRIC BLOOD & CANCER

2019

'Every sweet has its sour' : rare skin lesions in a boy with combined immunodeficiency

Delfien BogaertMargo HagendorensMarieke De BruyneHilde LapeereAnnick CoventsElfride De BaereFrans De BaetsFilomeen Haerynck

A computational pipeline for the diagnosis of CVID patients

Annelies EmmaneelDelfien BogaertSofie Van GassenSimon TavernierMelissa DullaersFilomeen HaerynckYvan Saeys

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

Simon TavernierV AthanasopoulosPATRICK VERLOOG BehrensJens StaalDelfien BogaertLeslie NaesensMarieke De BruyneSofie Van GassenEef Parthoens et al.

A1 Journal Article in NATURE COMMUNICATIONS

Congenital myeloperoxidase deficiency caused by a homozygous MPO splice site mutation in a patient with recurrent candida otomastoiditis

Frederic AckeDelfien BogaertHelen Van HoeckeKatrien BonteCarolien BonroyPetra SchelstraeteMarieke De BruyneElfride De BaereIngeborg DhoogeFilomeen Haerynck

GATA2 deficiency and hematopoietic stem cell transplantation : challenges for the clinical practitioner

Delfien BogaertLeslie NaesensGenevieve LaureysVictoria Bordon MariaErik WoutersSimon TavernierBart LambrechtFilomeen HaerynckTessa Kerre

Immune dysregulation with lymphoproliferation progressing to a rare T-cell non-hodgkin lymphoma

Leslie NaesensHilde DemuynckKristof CokelaereCiel De VriendtDelfien BogaertCarolien BonroyRik SchrijversFilomeen HaerynckTessa Kerre

Immunoglobulin g subclass and specific polysaccharide antibody deficiency : a clinical and immunological profile in a tertiary cohort

Levi HosteJudith ClausSimon SchelfhoutJarno De CraemerLaurens De KetelaereDelfien BogaertCarolien BonroyJan PhilippéJulie WillekensTessa Kerre et al.

Rare skin lesions in a boy with activated phosphoinositide 3-kinase delta syndrome

Delfien BogaertMarieke De BruyneMargo HagendorensHilde LapeereAnnick CoventsElfride De BaereFrans De BaetsFilomeen Haerynck

2018

A CARD9 founder mutation disrupts NF-κB signaling by inhibiting BCL10 and MALT1 recruitment and signalosome formation

Marieke De BruyneLevi HosteDelfien BogaertLien Van den BosscheSimon TavernierEef ParthoensMélanie MigaudDeborah KonopnickiJean Cyr YombiBart Lambrecht et al.

A1 Journal Article in FRONTIERS IN IMMUNOLOGY

A novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B-cell maturation defects

Delfien BogaertHye Sun KuehnCarolien BonroyKatherine R CalvoJo DehoorneArnaud VanlanderMarieke De BruyneUrszula CytlakVenetia BigleyFrans De Baets et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A novel LPS-responsive beige-like anchor protein (LRBA) mutation presents with normal cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and overactive TH17 immunity

Marieke De BruyneDelfien BogaertKoen VenkenLien Van den BosscheCarolien BonroyLisa RoelsSimon TavernierEls van de VijverAnn DriessenMarielle van Gijn et al.

A1 Journal Article in JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Ikaros family zinc finger 1 regulates dendritic cell development and function in humans

U. CytlakA. ResteuDelfien BogaertH. S. KuehnT. AltmannA. GenneryG. JacksonA. KumanovicsMelissa DullaersJ. Reichenbach et al.

Ikaros family zinc finger 1 regulates dendritic cell development and function in humans

Urszula CytlakAnastasia ResteuDelfien BogaertHye Sun KuehnThomas AltmannAndrew GenneryGraham JacksonAttila KumanovicsKarl V VoelkerdingSeraina Prader et al.

A1 Journal Article in NATURE COMMUNICATIONS

Molecular diagnosis of Common Variable Immunodeficiency and related antibody disorders : an integrated immunological and genetic approach

Delfien Bogaert

Editorial material

Molecular diagnosis of patients with antibody deficiency

Delfien Bogaert

Primary antibody deficiencies from bedside to bench : the role of molecular diagnostics

Delfien Bogaert

The complex differential diagnosis underlying fungal infections : a clinical practice guideline regarding persistent, recurrent or invasive candidiasis

Levi HosteDelfien BogaertMarieke De BruyneVictoria Bordon MariaPetra SchelstraeteCarolien BonroySimon TavernierFilomeen Haerynck

Zuigeling met aseptische meningo-encefalitis gecompliceerd door een brachiale plexusneuritis

Delfien BogaertHelene VerhelstRuth Van der LoovenNicola De ConoKatrien De Schynkel

2017

A CARD9 Turkisch founder mutation disrupts NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne PuelJean-Christophe Goffard et al.

A CARD9 founder mutation p.Arg70Trp in Belgian and French patients of Turkish origin with a spectrum of chronic mucocutaneous and invasive fungal infections

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardAnne PuelElfride De BaereFilomeen HaerynckMelissa Dullaers

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneLevi HosteDelfien BogaertMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

CARD9 p.R70W, a Turkish founder mutation associated with mucosal and invasive fungal infections, disrupts downstream NF-κB signaling by inhibiting Bcl10 recruitment

Marieke De BruyneDelfien BogaertLevi HosteMélanie MigaudJean-Christophe GoffardDeborah KonopnickiBart LambrechtRudi BeyaertElfride De BaereAnne Puel et al.

Early-onset primary antibody deficiency resembling common variable immunodeficiency challenges the diagnosis of Wiedeman-Steiner and Roifman syndromes

Delfien BogaertMelissa DullaersHye Sun KuehnBart LeroyJulie E NiemelaHans De WildeSarah De SchryverMarieke De BruyneFrauke CoppietersBart Lambrecht et al.

A1 Journal Article in SCIENTIFIC REPORTS

Molecular diagnosis of Common Variable Immunodeficiency and related antibody disorders : an integrated immunological and genetic approach

Delfien BogaertElfride De BaereFilomeen HaerynckMelissa Dullaers

Molecular genetics of common variable immunodeficiency

Delfien BogaertMelissa DullaersElfride De BaereFilomeen Haerynck

Bookchapter in eLS

The immunophenotypic fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

Delfien BogaertMarieke De BruyneVeronique DebackerPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéVictoria Bordon MariaBart LambrechtTessa Kerre et al.

A1 Journal Article in HAEMATOLOGICA

The immunophenotypical fingerprint of patients with primary antibody deficiencies is partially present in their asymptomatic first-degree relatives

Delfien BogaertMarieke De BruyneVeronique DebackerPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéVictoria Bordon MariaBart LambrechtTessa Kerre et al.

To B or not to B matured : a novel IKAROS haploinsufficiency kindred with incomplete penetrance both at clinical and cellular level

Delfien BogaertHye Sun KuehnCarolien BonroyKatherine CalvoJo DehoorneArnaud VanlanderMarieke De BruyneVenetia BigleyPetra SchelstraeteFrans De Baets et al.

To B or not to B matured : a novel IKAROS haploinsufficiency kindred with unexpectedly late and variable B cell maturation defects

Delfien BogaertHye Sun KuehnCarolien BonroyKatherine CalvoJo DehoorneArnaud VanlanderPetra SchelstraeteMarieke De BruyneUrszula CytlakVenetia Bigley et al.

2016

CVID, isolated IgG deficiency and isolated IgG subclass deficiency : clinical features and B cell maturation of the Ghent cohort

Delfien BogaertVeronique De BackerTessa KerreVictoria Bordon MariaBart LambrechtKarim VermaelenFrans De BaetsElfride De BaereMelissa DullaersFilomeen Haerynck

Chronic and invasive fungal infections in a family with CARD9 deficiency

Ana Alves de MedeirosEVELYNE LODEWICKDelfien BogaertFilomeen HaerynckSabine Van daeleBart LambrechtSarah BosmaLaure VanderdoncktOlivier LortholaryMélanie Migaud et al.

A1 Journal Article in JOURNAL OF CLINICAL IMMUNOLOGY

Chronic and invasive fungal infections in a family with CARD9 deficiency (vol 36, pg 204, 2016)

Ana Karina Alves de MedeirosEVELYNE LODEWICKDelfien BogaertFilomeen HaerynckSabine Van daeleBart LambrechtSarah BosmaLaure VanderdoncktOlivier LortholaryMélanie Migaud et al.

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakGiusi PrencipeAntonella InsalacoFilip Van HauwermeirenDieter Demon et al.

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genes associated with common variable immunodeficiency: one diagnosis to rule them all?

Delfien BogaertMelissa DullaersBart LambrechtKarim VermaelenElfride De BaereFilomeen Haerynck

A1 Journal Article in JOURNAL OF MEDICAL GENETICS

Inflammasomes in inflammatory disease

Hanne Van GorpPedro Henrique Viana SaavedraNathalia Moraes de VasconcelosNina Van OpdenboschLieselotte Vande WalleMagdalena MatusiakFilip Van HauwermeirenG. PrencipeDelfien BogaertMelissa Dullaers et al.

JAK2 deficiency as a novel cause of impaired Th17 immunity

FILOMEEN HAERYNCKDelfien BogaertElfride De BaereKristof Van SchilFrauke CoppietersMarieke De BruyneMargot HagendorensTessa KerreFrans De BaetsVictoria Bordon Maria et al.

Persistent rotavirus diarrhea post-transplant in a novel JAK3-SCID patient after vaccination

Delfien BogaertKristof Van SchilTom TaghonVictoria Bordon MariaCarolien BonroyMelissa DullaersElfride De BaereFilomeen Haerynck

A1 Journal Article in PEDIATRIC ALLERGY AND IMMUNOLOGY

RC3H1 mutation with increased ICOS expression causes an autoinflammatory syndrome

FILOMEEN HAERYNCKPATRICK VERLOODelfien BogaertJoél SmetArnaud VanlanderVictoria Bordon MariaHelene VerhelstRudy Van CosterBjörn MentenMelissa Dullaers

Recurrent cutaneous abscesses as the presenting manifestation of STAT1 gain-of-function mutation

Levi HosteMarieke De BruyneDelfien BogaertElfride De BaereCarolien BonroyPetra SchelstraeteMelissa DullaersTom VercruysseFilomeen Haerynck

The immunophenotypical landscape of patients with primary antibody deficiencies and their asymptomatic first-degree relatives : arguments for a multifactorial aetiology

Delfien BogaertPauline DepuydtKatleen De PreterCarolien BonroyJan PhilippéVictoria Bordon MariaTessa KerreBart LambrechtAndrea CeruttiKarim Vermaelen et al.

2015

A novel Janus kinase 3 (JAK3) mutation in a patient with severe combined immunodeficiency

Delfien BogaertKristof Van SchilTom TaghonVictoria Bordon MariaMelissa DullaersElfride De BaereFilomeen Haerynck

A novel STAT1 mutation in a patient with pneumocystis jiroveci and chronic mucocutaneous candidiasis

Delfien BogaertMelissa DullaersJens StaalSarah GerloElien VandermarliereVeronique De BackerVictoria Bordon MariaKATHLEEN DE WAELEIsabelle MeytsLeen Moens et al.

Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells

Ruth De BruyneDelfien BogaertNatalie De RuyckBart LambrechtMyriam Van WinckelPhilippe GevaertMelissa Dullaers

A1 Journal Article in CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunological characterization of pediatric liver transplant associated food allergy

Ruth De BruynePhilippe GevaertMyriam Van WinckelNatalie De RuyckAurelie MinneDelfien BogaertStephanie Van BiervlietSaskia Vande VeldeFrançoise SmetsEtienne Sokal et al.

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in paediatric liver transplant patients

Ruth De BruynePhilippe GevaertMyriam Van WinckelNatalie De RuyckAurelie MinneDelfien BogaertStephanie Van BiervlietSaskia Vande VeldeFrancoise SmetsEtienne Sokal et al.

A1 Journal Article in CLINICAL AND EXPERIMENTAL ALLERGY

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in pediatric liver transplant patients

Ruth De BruyneMyriam Van WinckelPhilippe GevaertNatalie De RuyckDelfien BogaertBart LambrechtMelissa DullaersFrancoise SmetsEtienne SokalFréderic Gottrand et al.

2014

A case of isolated cerebral nocardiosis caused by a defect in the IL12-IFNG axis

Delfien BogaertVeronique DebackerSteven CallensDirk OmmeslaghMelissa DullaersKarim Vermaelen

Acquired partial lipodystrophy : a rare clinical presentation of a complement deficiency

Delfien BogaertMelissa DullaersJohan Vande WallePatrick StordeurElke GovaereFilomeen Haerynck

Clinical presentation of hyper-IgE syndrome in a family with impaired IL-22 production and STAT3 phosphorylation

Filomeen HaerynckDelfien BogaertElfride De BaereBart LambrechtKarim VermaelenVeronique DebackerKristof Van SchilFrans De BaetsPetra SchelstraeteVictoria Bordon Maria et al.

Use of an integrative classification system and next-generation sequencing strategies for gene identification in common variable immunodeficiency disorder (CVID)

Delfien BogaertMelissa DullaersFilomeen HaerynckElfride De BaereKarim Vermaelen