Research Explorer

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Researcher

Chris Vervaet

Awards & Distinctions

448 Results

2024

Development and evaluation of a continuous spin freeze-drying technology : shedding light on the drying kinetics

Laurens LeysThomas De BeerChris Vervaet

In-situ dynamic X-ray imaging of drug release

Niloofar Moazami GoudarziMatthieu BooneChris Vervaet

Preclinical activity of two paclitaxel nanoparticle formulations after intraperitoneal administration in ovarian cancer murine xenografts

Jesse DemuytereCharlotte CarlierLeen Van de SandeAnne HoorensKaat De ClercqSilvia GiordanoLavinia MorosiCristina MatteoMassimo ZucchettiEnrico Davoli et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF NANOMEDICINE

2023

CO2-driven nebulization of pH-sensitive supramolecular polymers for intraperitoneal hydrogel formation and the treatment of peritoneal metastasis

Helena BraetPeter-Paul FransenRemco MariënGiovanna LolloWim CeelenChris VervaetLieve BalcaenFrank VanhaeckeChristian VanhoveStefan van der Vegte et al.

A1 Journal Article in ACS APPLIED MATERIALS & INTERFACES

Co-spray drying for continuous tablet manufacturing of conventional formulations : development of a formulation platform via co-spray drying

Elisa De PauwValérie VanhoorneChris Vervaet

Development of diclofenac sodium 3D printed cylindrical and tubular-shaped tablets through hot melt extrusion and fused deposition modelling techniques

Tryfon DigkasAlina PorfireJeroen Van RenterghemAseel SamaroGheorghe BorodiChris VervaetAndrea Gabriela CrișanSonia IurianThomas De BeerIoan Tomuta

A1 Journal Article in PHARMACEUTICALS

Evaluation of fused filament fabrication for oral solid dosage form production

Silke HenryChris VervaetValérie Vanhoorne

Identification of continuous twin-screw melt granulation mechanisms for different screw configurations, process settings and formulation

Shana Van de SteeneJeroen Van RenterghemValérie VanhoorneChris VervaetAshish KumarThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Increasing aqueous drug solubility by solvent electrospinning of poly(2-ethyl-2-oxazoline) based stable amorphous solid dispersions with high drug loading

Olmo FrateurJana BecelaereChris VervaetRichard HoogenboomKaren De Clerck

Making the insoluble soluble : PEtOx based amorphous solid dispersions with high drug loadings using solvent electrospinning as a formulation technique

Jana BecelaereKaren De ClerckRichard HoogenboomChris Vervaet

Solvent electrospinning amorphous solid dispersions with high itraconazole, celecoxib, mebendazole and fenofibrate drug loading and release potential

Jana BecelaereOlmo FrateurElla SchoolaertValérie VanhoorneDagmar D'hoogeChris VervaetRichard HoogenboomKaren De Clerck

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

The effect of particle size on the sublimation behavior of butylhydroxytoluene as antioxidant in tablets during storage and coating

Milan DecorteNiloofar Moazami GoudarziMatthieu BooneBen Van HoveFlorentina-Maria PredaEllen VerheyenChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2022

Continuous direct compression: development of an empirical predictive model and challenges regarding PAT implementation

Bram BekaertB. Van SnickKenny PandelaereJ. DhondtG. Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS-X

Development and characterisation of a continuous freeze-drying technology for unit doses

Joris LammensChris VervaetThomas De Beer

Development of flow-through cell dissolution method for in situ visualization of dissolution processes in solid dosage forms using X-ray μCT

Niloofar Moazami GoudarziAseel SamaroChris VervaetMatthieu Boone

A1 Journal Article in PHARMACEUTICS

Effect of feed frame on lubricant sensitivity during upscaling from a compaction simulator to a rotary tablet press

Cedrine de BackereThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Formation of delta-mannitol by co-spray drying : enhancing the tabletability of paracetamol/mannitol formulations

Elisa De PauwChris VervaetValérie Vanhoorne

A1 Journal Article in JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Impact of alternative lubricants on process and tablet quality for direct compression

Cedrine de BackereJulian QuodbachThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of blend properties and process variables on the blending performance

Bram BekaertW. GrymonpréA. NovikovaChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of lubrication on process and tablet quality in a direct compression process

Cedrine de BackereChris VervaetValérie Vanhoorne

Improving flubendazole efficiency through time-stable electrospun amorphous solid dispersions

Jana BecelaereElias Van Den BroeckVeronique Van SpeybroeckChris VervaetRichard HoogenboomKaren De Clerck

In-depth analysis of the long-term processability of materials during continuous feeding

Bram BekaertB. Van SnickK. PandelaereJ. DhondtG. Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multi-frame DVC for temporal image sequences

Zaira ManigrassoWannes GoethalsNiloofar Moazami GoudarziMatthieu BooneAseel SamaroChris VervaetWilfried PhilipsJan Aelterman

A1 Journal Article in FRONTIERS IN MATERIALS

Novel design for an additively manufactured nozzle to produce tubular scaffolds via fused filament fabrication

Bahaa ShaqourŻaneta GóreckaAgnieszka ChmielewskaBartłomiej WysockiMarcin HeljakMaarten GernaeyBart VerleijeKoen BeyersChris VervaetEmilia Choińska et al.

A1 Journal Article in ADDITIVE MANUFACTURING

Poly(2-alkyl-2-oxazoline)s : a polymer platform to sustain the release from tablets with a high drug loading

Aseel SamaroMaarten VergaelenMartin PurinoAli TigrineVictor Retamero De La RosaNiloofar Moazami GoudarziMatthieu BooneValérie VanhoorneRichard HoogenboomChris Vervaet

A1 Journal Article in MATERIALS TODAY BIO

Stable amorphous solid dispersion of flubendazole with high loading via electrospinning

Jana BecelaereElias Van Den BroeckElla SchoolaertValérie VanhoorneJoachim Van GuyseMaarten VergaelenSander BorgmansKarolien CreemersVeronique Van SpeybroeckChris Vervaet et al.

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Technological, biochemical and microbiological evaluation of dehydrated Pleurotus ostreatus powder for nutraceutical applications

Daily Arias-RamosIdelsy Chil-NunezHumberto J. MorrisMiladis Camacho-PozoYamila Lebeque-PerezGabriel Llaurado-MauryPaul CosChris Vervaet

A2 Journal Article in CURRENT NUTRITION & FOOD SCIENCE

The effect of binder types on the breakage and drying behavior of granules in a semi-continuous fluid bed dryer after twin screw wet granulation

Lise VandeviverePhaedra DenduyverChristoph PortierO. HäuslerThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Visualization and characterization of the dynamic structure of solid dosage forms during the dissolution process using high- resolution X-ray tomography

Niloofar Moazami GoudarziAseel SamaroZaira ManigrassoChris VervaetJan AeltermanMatthieu Boone

2021

A NIR-based study of desorption kinetics during continuous spin freeze-drying

Laurens LeysGust NuyttenJoris LammensPieter-Jan Van BockstalJos CorverChris VervaetThomas De Beer

A1 Journal Article in PHARMACEUTICS

Can filaments, pellets and powder be used as feedstock to produce highly drug-loaded ethylene-vinyl acetate 3D printed tablets using extrusion-based additive manufacturing?

Aseel SamaroBahaa ShaqourNiloofar Moazami GoudarziMichael GhijsLudwig CardonMatthieu BooneBart VerleijeKoen BeyersValérie VanhoornePaul Cos et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous direct compression : improved process knowledge about the feeding and blending unit operation

Bram BekaertChris VervaetValérie Vanhoorne

Continuous granulation

Chris VervaetThomas De BeerValérie Vanhoorne

Bookchapter in Handbook of pharmaceutical granulation technology

Continuous twin screw granulation : a review of recent progress and opportunities in formulation and equipment design

Christoph PortierChris VervaetValérie Vanhoorne

A1 Journal Article in PHARMACEUTICS

Continuous twin screw granulation : impact of microcrystalline cellulose batch-to-batch variability during granulation and drying : a QbD approach

Christoph PortierTamas VighGiustino Di PretoroJan LeysDidier KlingeleersThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS-X

Determination of a quantitative relationship between material properties, process settings and screw feeding behavior via multivariate data-analysis

Bram BekaertL. PenneW. GrymonpréB. Van SnickJ. DhondtJ. BoeckxJ. VogeleerThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development and application of a mechanistic cooling and freezing model of the spin freezing step within the framework of continuous freeze-drying

Gust NuyttenSusan Ríos RevattaPieter-Jan Van BockstalAshish KumarJoris LammensLaurens LeysBrecht VanbillemontJos CorverChris VervaetThomas De Beer

A1 Journal Article in PHARMACEUTICS

Development of a 3D-printed dosing platform to aid in zolpidem withdrawal therapy

Silke HenryLien De VadderMilan DecorteSusanna FranciaMagali Van SteenkisteJan SaevelsValérie VanhoorneChris Vervaet

A1 Journal Article in PHARMACEUTICS

Development of flow cell for in-situ visualization of dissolution processes in solid dosage forms

Niloofar Moazami GoudarziAseel SamaroChris VervaetMatthieu Boone

Development of flow through cell method for in-situ visualization of dissolution processes in solid dosage forms

Niloofar Moazami GoudarziAseel SamaroChris VervaetMatthieu Boone

Effect of binder type and lubrication method on the binder efficacy for direct compression

Cedrine de BackereThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of torque as an in-process control for granule size during twin-screw wet granulation

Alexander RyckaertFanny StaufferA. FunkeD. DjuricValérie VanhoorneChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exploring high pressure nebulization of pluronic F127 hydrogels for intraperitoneal drug delivery

Helena BraetMohammad Rahimi GorjiCharlotte DebbautG GhorbaniaslThibault Van WalleghemSenne CornelisSarah CosynsChris VervaetWouter WillaertWim Ceelen et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Extrusion-based 3D printing of oral solid dosage forms : material requirements and equipment dependencies

Silke HenryAseel SamaroFlavio H. MarchesiniBahaa ShaqourJ. MacedoValérie VanhoorneChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans

Thibaux Van der StedeLaura BlancquaertFlore StassenRuud Van ThienenInge EveraertChris VervaetLasse GliemannYlva HellstenWim Derave

A1 Journal Article in SCIENCE ADVANCES

Identifying critical binder attributes to facilitate binder selection for efficient formulation development in a continuous twin screw wet granulation process

Lise VandevivereMaxine VangampelaereChristoph PortierCedrine de BackereOlaf HäuslerThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in PHARMACEUTICS

Improved process and formulation understanding during continuous twin screw wet granulation and downstream processing

Christoph PortierChris VervaetValérie Vanhoorne

Increasing angiogenesis factors in hypoxic diabetic wound conditions by siRNA delivery : additive effect of LbL-gold nanocarriers and desloratadine-induced lysosomal escape

Elnaz Shaabani SichaniMaryam SharifiaghdamJoris LammensHerlinde De KeersmaeckerChris VervaetThomas De BeerElahe MotevaseliMohammad Hossein GhahremaniParvin MansouriStefaan De Smedt et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Influence of print settings on the critical quality attributes of extrusion-based 3D-printed caplets : a quality-by-design approach

Silke HenryLotte De WeverValérie VanhoorneThomas De BeerChris Vervaet

A1 Journal Article in PHARMACEUTICS

Innovative applications of hot-melt extrusion and additive manufacturing for the development of oral solid dosage forms

Aseel SamaroChris VervaetValérie Vanhoorne

Macrophage reprogramming into a pro-healing phenotype by siRNA delivered with LBL assembled nanocomplexes for wound healing applications

Maryam SharifiaghdamElnaz Shaabani SichaniZeynab SharifiaghdamHerlinde De KeersmaeckerBart LucasJoris LammensHossein GhanbariLadan Teimoori-ToolabiChris VervaetThomas De Beer et al.

A1 Journal Article in NANOSCALE

Melt granulation

Shana Van de SteeneValérie VanhoorneChris VervaetThomas De Beer

Bookchapter in Handbook of pharmaceutical granulation technology

Spin freezing and its impact on pore size, tortuosity and solid state

Joris LammensNiloofar Moazami GoudarziLaurens LeysGust NuyttenPieter-Jan Van BockstalChris VervaetMatthieu BooneThomas De Beer

A1 Journal Article in PHARMACEUTICS

TPLS as predictive platform for twin-screw wet granulation process and formulation development

Alexander RyckaertDaan Van HauwermeirenJens DhondtAlexander De ManAdrian FunkeDejan DjuricChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The impact of binders on formulation design in a continuous pharmaceutical manufacturing process based on twin screw wet granulation

Lise VandevivereChris VervaetValérie Vanhoorne

The influence of equipment design and process parameters on granule breakage in a semi-continuous fluid bed dryer after continuous twin-screw wet granulation

Alexander RyckaertMichael GhijsChristoph PortierDejan DjuricAdrian FunkeChris VervaetThomas De Beer

A1 Journal Article in PHARMACEUTICS

2020

4D micro-computed X-ray tomography as a tool to determine critical process and product information of spin freeze-dried unit doses

Brecht VanbillemontJoris LammensWannes GoethalsChris VervaetMatthieu BooneThomas De Beer

A1 Journal Article in PHARMACEUTICS

A primary drying model-based comparison of conventional batch freeze-drying to continuous spin-freeze-drying for unit doses

Laurens LeysBrecht VanbillemontPieter-Jan Van BockstalJoris LammensGust NuyttenJos CorverChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Comparative pharmacokinetics of imepitoin after oral and rectal administration in healthy dogs

Valentine MartléMathias DevreeseSaskia RauchLuc Van HamSiska CroubelsValérie VanhoorneChris VervaetSofie Bhatti

A1 Journal Article in VETERINARY JOURNAL

Continuous twin screw granulation : a complex interplay between formulation properties, process settings and screw design

Christoph PortierKenny PandelaereUrbain DelaetTamas VighGiustino Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous twin screw granulation : impact of binder addition method and surfactants on granulation of a high-dosed, poorly soluble API

Christoph PortierTamas VighGiustino Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous twin screw granulation : influence of process and formulation variables on granule quality attributes of model formulations

Christoph PortierKenny PandelaereUrbain DelaetTamas VighAshish KumarGiustino Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous twin screw granulation : robustness of lactose/MCC-based formulations

Christoph PortierCharlotte De VriendtTamas VighGiustino Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Delta-mannitol to enable continuous twin-screw granulation of a highly dosed, poorly compactable formulation

Valérie VanhoorneRuben AlmeyThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of an external lubrication system implemented in a compaction simulator

Cedrine de BackereThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-line temperature measurement to improve the understanding of the wetting phase in twin-screw wet granulation and its use in process development

Fanny StaufferAlexander RyckaertValérie VanhoorneDaan Van HauwermeirenAdrian FunkeDejan DjuricChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-situ X-ray imaging of sublimating spin-frozen solutions

Wannes GoethalsBrecht VanbillemontJoris LammensThomas De BeerChris VervaetMatthieu Boone

A1 Journal Article in MATERIALS

Influence of binder attributes on binder effectiveness in a continuous twin screw wet granulation process via wet and dry binder addition

Lise VandeviverePhaedra DenduyverChristoph PortierOlaf HäuslerThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy

Pieterjan MerckxJoris LammensGust NuyttenBram BogaertRoberta GuagliardoTania MaesChris VervaetThomas De BeerStefaan De SmedtKoen Raemdonck

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Prilling of API/fatty acid suspensions : an innovative pharmaceutical production technique for multiparticulate dosage forms

Elien De ConinckChris VervaetValérie Vanhoorne

Prilling of API/fatty acid suspensions : screening of additives for drug release modification

Elien De ConinckValérie VanhoorneMatthieu BooneG Van AsscheBruno De GeestThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Processability of poly(vinyl alcohol) based filaments with paracetamol prepared by hot-melt extrusion for additive manufacturing

Joana MacedoAseel SamaroValérie VanhoorneChris VervaetJoao Pinto

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Production of drug delivery systems using fused filament fabrication : a systematic review

Bahaa ShaqourAseel SamaroBart VerleijeKoen BeyersChris VervaetPaul Cos

A1 Journal Article in PHARMACEUTICS

Quality by design for pharmaceutical hot melt extrusion via rheology and process analytical technology

Jeroen Van RenterghemThomas De BeerChris Vervaet

Recent progress in continuous manufacturing of oral solid dosage forms

Valérie VanhoorneChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Screening of pharmaceutical polymers for Extrusion-Based Additive Manufacturing of patient-tailored tablets

Aseel SamaroPauline JanssensValérie VanhoorneJeroen Van RenterghemMia EeckhoutLudwig CardonThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Structural study of L-ascorbic acid 2-phosphate magnesium, a raw material in cell and tissue therapy

Xiaolong XuMagdalena WozniczkaKristof Van HeckeDieter BuystDimitrije MaraChris VervaetKaren HermanEvelien WynendaeleEric DeconinckBart De Spiegeleer

A1 Journal Article in JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Viscosity of API/fatty acid suspensions : pitfalls during analysis

Elien De ConinckFlavio H. MarchesiniValérie VanhoorneThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2019

A multivariate approach to predict the volumetric and gravimetric feeding behavior of a low feed rate feeder based on raw material properties

Nils BostijnJens DhondtAlexander RyckaertEdina SzabóW DhondtBernd Van SnickValérie VanhoorneChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Assessment of volumetric scale-up law for processing of a sustained release formulation on co-rotating hot-melt extruders

Jeroen Van RenterghemShana Van de SteeneTryfon DigkasMargarethe RichterChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous manufacturing of a pharmaceutical cream : investigating continuous powder dispersing and residence time distribution (RTD)

Nils BostijnJeroen Van RenterghemBrecht VanbillemontW DhondtChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Development of paclitaxel-loaded gelatin microspheres with a dual application for the treatment of advanced ovarian cancer : prevention of postsurgical peritoneal adhesions and recurrence of peritoneal carcinomatosis

Kaat De ClercqChris VervaetWim Ceelen

Dry amorphisation of mangiferin, a poorly water-soluble compound, using mesoporous silica

Adrienn BaánPeter AdriaensensJoris LammensRené Delgado HernandezWim Vanden BergheLuc PietersChris VervaetFilip Kiekens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept : determination of the optimal dynamic infrared heater temperature during primary drying

Laurens De MeyerJoris LammensBrecht VanbillemontPieter-Jan Van BockstalJos CorverChris VervaetWolfgang FriessThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a tablet press

Fien De LeersnyderValérie VanhoorneAshish KumarChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Experimental and model-based analysis of a continuous direct compression platform for oral solid dosage manufacturing

Bernd Van SnickChris Vervaet

Impact of material properties and process variables on the residence time distribution in twin screw feeding equipment

Bernd Van SnickAshish KumarMaxim VerstraetenKenny PandelaereJens DhondtG Di PretoroThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-depth evaluation of data collected during a continuous pharmaceutical manufacturing process : a multivariate statistical process monitoring approach

Ana Filipa Costa da SilvaJurgen VercruysseChris VervaetJean Paul RemonJoão A. LopesThomas De BeerMafalda C. Sarraguça

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Managing API raw material variability during continuous twin-screw wet granulation

Fanny StaufferValérie VanhoorneG PilcerPierre-François ChavezChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Managing API raw material variability in a continuous manufacturing line : prediction of process robustness

Fanny StaufferValérie VanhoorneG PilcerPierre-François ChavezChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding

Fanny StaufferValérie VanhoorneG PilcerP-F ChavezMA SchubertChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Model-based analysis of treatment effects of paclitaxel microspheres in a microscopic peritoneal carcinomatosis model in mice.

Feifan XieKaat De ClercqChris VervaetJan Van BocxlaerPieter ColinAn Vermeulen

A1 Journal Article in PHARMACEUTICAL RESEARCH

Native starch as in situ binder for continuous twin screw wet granulation

Lise VandevivereChristoph PortierValérie VanhoorneOlaf HäuslerDenis SimonThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

PAT-based batch statistical process control of a manufacturing process for a pharmaceutical ointment

Nils BostijnW. DhondtChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

Timothy DouglasMichal DziadekJosefien SchietseMatthieu BooneHeidi DeclercqTom CoenyeValérie VanhoorneChris VervaetLieve BalcaenMaria Buchweitz et al.

A1 Journal Article in CARBOHYDRATE POLYMERS

Pharmaceutical compounding of orphan active ingredients in Belgium : how community and hospital pharmacists can address the needs of patients with rare diseases

Valérie VanhoorneE PeetersInge Van TongelenKoen BousseryEvelien WynendaeleBart De SpiegeleerJean Paul RemonChris Vervaet

A1 Journal Article in ORPHANET JOURNAL OF RARE DISEASES

Preclinical evaluation of local prolonged release of paclitaxel from gelatin microspheres for the prevention of recurrence of peritoneal carcinomatosis in advanced ovarian cancer

Kaat De ClercqFeifan XieOlivier De WeverBenedicte DescampsAnne HoorensAn VermeulenWim CeelenChris Vervaet

A1 Journal Article in SCIENTIFIC REPORTS

Predicting and testing bioavailability of magnesium supplements

Laura BlancquaertChris VervaetWim Derave

A1 Journal Article in NUTRIENTS

Prilling of API/fatty acid suspensions : processability and characterisation

Elien De ConinckValérie VanhoorneAhmed ElmahdyMatthieu BooneG Van AsscheD MarklBruno De GeestThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Therapeutic nanofibers? Innovative oral drug delivery for improved bioavailability

Jana BecelaereChris VervaetRichard HoogenboomKaren De Clerck

2018

3D printing of high drug loaded dosage forms using thermoplastic polyurethanes

Glenn VerstraeteAseel SamaroWouter GrymonpréValérie VanhoorneBernd Van SnickMatthieu BooneTom HellemansLuc Van HoorebekeJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

A continuous manufacturing concept for a pharmaceutical oral suspension

Nils BostijnJeroen Van RenterghemW. DhondtChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A multivariate raw material property database to facilitate drug product development and enable in-silico design of pharmaceutical dry powder processes

Bernd Van SnickJens DhondtKenny PandelaereJohny BertelsRoel MertensDidier KlingeleersGiustino Di PretoroJean Paul RemonChris VervaetThomas De Beer et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

A novel approach to support formulation design on twin screw wet granulation technology : understanding the impact of overarching excipient properties on drug product quality attributes

Nina WilleckeA SzepesM WunderlichJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Breakage and drying behaviour of granules in a continuous fluid bed dryer : influence of process parameters and wet granule transfer

Fien De LeersnyderValérie VanhoorneH BekaertJurgen VercruysseMichael GhijsNils BostijnMaxim VerstraetenP CappuynsI Van AsscheY Vander Heyden et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Changing to a vegetarian diet reduces the body creatine pool in omnivorous women, but appears not to affect carnitine and carnosine homeostasis : a randomised trial

Laura BlancquaertAudrey BaguetTine BexAnneke VolkaertInge EveraertJoris DelangheMirko PetrovicChris VervaetStefaan De HenauwDumitru Constantin-Teodosiu et al.

A1 Journal Article in BRITISH JOURNAL OF NUTRITION

Development and validation of an in-line NIR spectroscopic method for continuous blend potency determination in the feed frame of a tablet press

Fien De LeersnyderElisabeth PeetersHasna DjalabiValérie VanhoorneBernd Van SnickKe HongStephen HammondAngela Yang LiuEric ZiemonsChris Vervaet et al.

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Downscaling of the tableting process : feasibility of miniaturized forced feeders on a high-speed rotary tablet press

Wouter GrymonpréBarbora Blahova PrudilovaValérie VanhoorneBernd Van SnickFrederik DetobelJean Paul RemonThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Downstream processing from melt granulation towards tablets : in-depth analysis of a continuous twin-screw melt granulation process using polymeric binders

Wouter GrymonpréGlenn VerstraeteValérie VanhoorneJean Paul RemonThomas De BeerChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Formulation design for continuous twin screw wet granulation

Nina WilleckeChris VervaetThomas De BeerAnikó SzepesMartin Wunderlich

Humans significantly metabolize and excrete the mycotoxin deoxynivalenol and its modified form deoxynivalenol-3-glucoside within 24 hours

Arnau Vidal CorominasLiesel ClaeysMarcel MengelersValérie VanhoorneChris VervaetBart HuybrechtsSarah De SaegerMarthe De Boevre

A1 Journal Article in SCIENTIFIC REPORTS

Impact of blend properties on die filling during tableting

Bernd Van SnickWouter GrymonpréJens DhondtKenny PandelaereG Di PretoroJean Paul RemonThomas De BeerChris VervaetValérie Vanhoorne

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-line UV spectroscopy for the quantification of low-dose active ingredients during the manufacturing of pharmaceutical semi-solid and liquid formulations

Nils BostijnM HellingsM Van Der VeenChris VervaetThomas De Beer

A1 Journal Article in ANALYTICA CHIMICA ACTA

Increasing pharmaceutical process understanding for twin-screw extrusion and tablet manufacturing

Wouter GrymonpréChris VervaetJean Paul Remon

Influence of extended dwell time during pre- and main compression on the properties of ibuprofen tablets

Elisabeth PeetersAna Tavares da SilvaMargot FonteyneThomas De BeerChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Model-based NIR spectroscopy implementation for in-line assay monitoring during a pharmaceutical suspension manufacturing process

Maxim VerstraetenDaan Van HauwermeirenMario HellingsEline HermansJeroen GeensChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Novel injectable gellan gum hydrogel composites incorporating Zn- and Sr-enriched bioactive glass microparticles : high-resolution X-ray microcomputed tomography, antibacterial and in vitro testing

Timothy DouglasMichal DziadekSvetlana GorodzhaJana LiskovaGilles BrackmanValérie VanhoorneChris VervaetLieve BalcaenMaria del Rosario Florez GarciaAldo R Boccaccini et al.

A1 Journal Article in JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE

Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration : physiochemical and microcomputer tomographical characterization

Timothy DouglasJosefien SchietseAneta ZimaSvetlana GorodzhaBogdan ParakhonskiyDmitry KhalenkowRoman ShkarinAnna IvanovaTilo BaumbachVenera Weinhardt et al.

A1 Journal Article in JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Optimizing feed frame design and tableting process parameters to increase die-filling uniformity on a high-speed rotary tablet press

Wouter GrymonpréValérie VanhoorneBernd Van SnickBarbora Blahova PrudilovaFrederik DetobelJean Paul RemonThomas De BeerChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Potential of near-infrared chemical imaging as process analytical technology tool for continuous freeze-drying

Davinia BrouckaertLaurens De MeyerBrecht VanbillemontPieter-Jan Van BockstalJoris LammensSéverine MortierJos CorverChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in ANALYTICAL CHEMISTRY

Preclinical activity of two paclitaxel nanoparticle formulations after IP administration in ovarian cancer xenografts

Charlotte CarlierAnne HoorensKaat De ClercqSilvia GiordanoLavinia MorosiEnrico DavoliJo Van DorpeChris VervaetFrank VanhaeckeWim Ceelen

Process monitoring and evaluation of a continuous pharmaceutical twin-screw granulation and drying process using multivariate data analysis

Antonio Pires da Silva BaptistaJurgen VercruysseChris VervaetJean Paul RemonJ.A. LopesThomas De BeerM.C. Sarraguça

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The impact of the injection mold temperature upon polymer crystallization and resulting drug release from immediate and sustained release tablets

Jeroen Van RenterghemHeleen DhondtGlenn VerstraeteMichiel De BruyneChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The relevance of shear, sedimentation and diffusion during spin freezing, as potential first step of a continuous freeze-drying process for unit doses

Joris LammensSéverine MortierLaurens De MeyerBrecht VanbillemontPieter-Jan Van BockstalSimon Van HerckJos CorverIngmar NopensValérie VanhoorneBruno De Geest et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Thermal imaging as a noncontact inline process analytical tool for product temperature monitoring during continuous freeze-drying of unit doses

Pieter-Jan Van BockstalJos CorverLaurens De MeyerChris VervaetThomas De Beer

A1 Journal Article in ANALYTICAL CHEMISTRY

Thermoplastic polyurethanes for the manufacturing of high drug loaded sustained release matrices

Glenn VerstraeteJean Paul RemonChris Vervaet

2017

Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization

Sabah KasmiBenoit LouageLutz NuhnGlenn VerstraeteSimon Van HerckMies J van SteenbergenChris VervaetWim E HenninkBruno De Geest

A1 Journal Article in POLYMER CHEMISTRY

Continuous direct compression as manufacturing platform for sustained release tablets

Bernd Van SnickJ. HolmanC. CunninghamAshish KumarJurgen VercruysseThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a continuous direct compression platform for low-dose drug products

Bernd Van SnickJ. HolmanValérie VanhoorneAshish KumarThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Downstream processing from hot-melt extrusion towards tablets : a quality by design approach

Wouter GrymonpréNils BostijnSimon Van HerckGlenn VerstraeteValérie VanhoorneLutz NuhnPieter RomboutsThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effects of histidine and β-alanine supplementation on human muscle carnosine storage

Laura BlancquaertInge EveraertMaarten MissinneAudrey BaguetSanne StegenAnneke VolkaertMirko PetrovicChris VervaetEric AchtenMieke De Maeyer et al.

A1 Journal Article in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Elucidation and visualization of solid-state transformation and mixing in a pharmaceutical mini hot melt extrusion process using in-line Raman spectroscopy

Jeroen Van RenterghemAshish KumarChris VervaetJean Paul RemonIngmar NopensYvan Vander HeydenThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of combination therapy for Burkholderia cenocepacia lung infection in different in vitro and in vivo models

Freija Van den DriesscheBieke VanhoutteGilles BrackmanAurélie CrabbéPetra RigoleJurgen VercruysseGlenn VerstraeteDavie CappoenChris VervaetPaul Cos et al.

A1 Journal Article in PLOS ONE

Identifying overarching excipient properties towards an in-depth understanding of process and product performance for continuous twin-screw wet granulation

Nina WilleckeA SzepesM WunderlichJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed process understanding

Maxim VerstraetenDaan Van HauwermeirenKai LeeNeil TurnbullDavid WilsdonMary Am EndePankaj DoshiChris VervaetDavinia BrouckaertSéverine Mortier et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-line monitoring of compaction properties on a rotary tablet press during tablet manufacturing of hot-melt extruded amorphous solid dispersions

Wouter GrymonpréGlenn VerstraetePieter-Jan Van BockstalJeroen Van RenterghemPieter RomboutsThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis

Tessa HoremansGaëlle BouletMarian van KerckhovenJohannes BogersSofie ThysChris VervaetAnouk VervaeckPeter DelputteLouis MaesPaul Cos

A1 Journal Article in EUROPEAN JOURNAL OF CANCER PREVENTION

Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process

Pieter-Jan Van BockstalSéverine MortierLaurens De MeyerJos CorverChris VervaetIngmar NopensThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses

Laurens De MeyerJoris LammensSéverine MortierBrecht VanbillemontPieter-Jan Van BockstalJos CorverIngmar NopensChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Multivariate statistical process control of a continuous pharmaceutical twin-screw granulation and fluid bed drying process

Ana Tavares da SilvaMC SarraguçaMargot FonteyneJurgen VercruysseFien De LeersnyderValérie VanhoorneNils BostijnMaxim VerstraetenChris VervaetJean Paul Remon et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Noncontact infrared-mediated heat transfer during continuous freeze-drying of unit doses

Pieter-Jan Van BockstalLaurens De MeyerJos CorverChris VervaetThomas De Beer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Pharmacokinetic analysis of modified-release metoprolol formulations : an interspecies comparison

Elien De ThayeAnouk VervaeckEleonora MarosticaJean Paul RemonJan Van BocxlaerChris VervaetAn Vermeulen

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Practical implementation of dynamic primary drying settings in a continuous freeze-drying process

Brecht VanbillemontNiels NicolaïPieter-Jan Van BockstalLaurens De MeyerSéverine MortierJos CorverChris VervaetThomas De Beer

Rheological characterization of molten polymer-drug dispersions as a predictive tool for pharmaceutical hot-melt extrusion processability

Jeroen Van RenterghemChris VervaetThomas De Beer

A1 Journal Article in PHARMACEUTICAL RESEARCH

The use of partially hydrolysed polyvinyl alcohol for the production of high drug-loaded sustained release pellets via extrusion-spheronisation and coating : in vitro and in vivo evaluation

Glenn VerstraeteWesley De JaeghereJ VercruysseWouter GrymonpréValérie VanhoorneFanny StaufferThomas De BeerAdam BezuijenJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Thermoplastic polyurethane-based intravaginal rings for prophylaxis and treatment of (recurrent) bacterial vaginosis

Glenn VerstraeteL. VandenbusscheSabah KasmiLutz NuhnD. BrouckaertJeroen Van RenterghemW. GrymonpreValérie VanhoorneTom CoenyeBruno De Geest et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2016

A comparative study between melt granulation/compression and hot melt extrusion/injection molding for the manufacturing of oral sustained release thermoplastic polyurethane matrices

Glenn VerstraetePieter MertensWouter GrymonpréPieter-Jan Van BockstalThomas De BeerMatthieu BooneLuc Van HoorebekeJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Assessment and prediction of tablet properties using transmission and backscattering Raman spectroscopy and transmission NIR spectroscopy

Elisabeth PeetersAna Tavares da SilvaMaunu ToiviainenJeroen Van RenterghemJurgen VercruysseMikko JuutiJoao Almeida LopesThomas De BeerChris VervaetJean Paul Remon

A1 Journal Article in ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES

Blend uniformity evaluation during continuous mixing in a twin screw granulator by in-line NIR using a moving F-test

Margot FonteyneJurgen VercruysseFien De LeersnyderRut BesselingAd GerichWim OostraJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in ANALYTICA CHIMICA ACTA

Comparison of metoprolol tartrate multiple-unit lipid matrix systems produced by different technologies

Aleksandar AleksovskiPieter-Jan Van BockstalRobert RoškarTamás SoványGéza RegdonThomas De BeerChris VervaetRok Dreu

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Continuous manufacturing of delta mannitol by cospray drying with PVP

Valérie VanhoornePieter-Jan Van BockstalBernd Van SnickE PeetersTinne MonteyneP GomesThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Continuous melt granulation: Influence of process and formulation parameters upon granule and tablet properties

Tinne MonteyneJochem VancoillieJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Continuous twin screw granulation of controlled release formulations with various HPMC grades

Valérie VanhoorneL JanssensJ VercruysseThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a controlled release formulation by continuous twin screw granulation : influence of process and formulation parameters

Valérie VanhoorneBrecht VanbillemontJ VercruysseFien De LeersnyderP GomesThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development of a process map : a step towards a regime map for steady-state high shear wet twin screw granulation

Ashish KumarJens DhondtJurgen VercruysseFien De LeersnyderValérie VanhoorneChris VervaetJean Paul RemonKrist V. GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Development of formulation and process knowledge for continuous twin-screw melt granulation

Tinne MonteyneThomas De BeerChris Vervaet

Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions : in vitro and in vivo characterization

Kaat De ClercqCharlotte SchelfhoutMarc BrackeOlivier De WeverMieke Van BockstalWim CeelenJean Paul RemonChris Vervaet

A1 Journal Article in BIOMATERIALS

Hydrophilic thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding

Glenn VerstraeteJeroen Van RenterghemPieter-Jan Van BockstalSabah KasmiBruno De GeestThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Improved tabletability after a polymorphic transition of delta-mannitol during twin screw granulation

Valérie VanhoorneBram BekaertE PeetersThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Linking granulation performance with residence time and granulation liquid distributions in twin-screw granulation : an experimental investigation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenFien De LeersnyderJurgen VercruysseMikko JuutiJarkko KetolainenChris VervaetJean Paul Remon et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Lubricant sensitivity in function of paddle movement in the forced feeder of a high-speed tablet press

Elisabeth PeetersValérie VanhoorneChris VervaetJean Paul Remon

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Model-based analysis of a twin-screw wet granulation system for continuous solid dosage manufacturing

Ashish KumarJurgen VercruysseSéverine MortierChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in COMPUTERS & CHEMICAL ENGINEERING

Partially hydrolyzed polyvinyl alcohol as functional excipient in oral solid dosage forms prepared via extrusion

Wesley De JaeghereJean Paul RemonChris Vervaet

Rationale and safety assessment of a novel intravaginal drug-delivery system with sustained DL-lactic acid release, intended for long-term protection of the vaginal microbiome

Hans VerstraelenChris VervaetJean Paul Remon

A1 Journal Article in PLOS ONE

Spectroscopic evaluation of a freeze-dried vaccine during an accelerated stability study

Laurent HansenJeroen Van RenterghemRim DaoussiChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation

Tinne MonteynePeter AdriaensensDavinia BrouckaertJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The impact of hot-melt extrusion on the tableting behaviour of polyvinyl alcohol

Wouter GrymonpréWesley De JaeghereElisabeth PeetersP AdriaensensJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The use of rheology combined with differential scanning calorimetry to elucidate the granulation mechanism of an immiscible formulation during continuous twin-screw melt granulation

Tinne MonteyneLiza HeezeSéverine MortierKlaus OldörpRuth CardinaelsIngmar NopensChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in PHARMACEUTICAL RESEARCH

The use of rheology to elucidate the granulation mechanisms of a miscible and immiscible system during continuous twin-screw melt granulation

Tinne MonteyneLiza HeezeSéverine MortierKlaus OldörpIngmar NopensJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Towards continuous pharmaceutical tablet manufacturing : implementation of continuous agglomeration techniques

Valérie VanhoorneChris VervaetJean Paul Remon

pH-independent immediate release polymethacrylate formulations : an observational study

Bart ClaeysReinout VandeputteBruno De GeestJean Paul RemonChris Vervaet

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

2015

Calendering as a direct shaping tool for the continuous production of fixed-dose combination products via co-extrusion

An-Katrien VynckierH LinJA ZeitlerJ-F WillartE BongaersJody VoorspoelsJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Co-extrusion as a continuous production process for fixed-dose combination dosage forms

An-Katrien VynckierJean Paul RemonChris Vervaet

Combined experimental and computational approach to elucidate the twin-screw granulation process

Ashish KumarJurgen VercruysseChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

Comparison of Newcastle disease vaccine administered as powder or liquid in relation to the serum antibody response and adverse vaccinal reactions in broilers

WJM LandmanKatrien HuygeJean Paul RemonChris VervaetJHH van Eck

A1 Journal Article in AVIAN PATHOLOGY

Conceptual framework for model-based analysis of residence time distribution in twin-screw granulation

Ashish KumarJurgen VercruysseValérie VanhoorneMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiChris VervaetJean Paul RemonKrist V GernaeyThomas De Beer et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Enteric protection of naproxen in a fixed-dose combination product produced by hot-melt co-extrusion

An-Katrien VynckierM De BeerTinne MonteyneJody VoorspoelsThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Evaluation of an in-line particle imaging tool for monitoring twin-screw granulation performance

Ashish KumarJens DhondtFien De LeersnyderJurgen VercruysseValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De BeerIngmar Nopens

A1 Journal Article in POWDER TECHNOLOGY

Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses

Laurens De MeyerPieter-Jan Van BockstalJos CorverChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Experimental investigation linking granulation performance with Residence time and granulation liquid distributions in TwinScrew granulation

Ashish KumarMaija AlkarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyIngmar NopensThomas De Beer

Experimental investigation of residence time, granulation liquid and granule size distributions in twin-screw granulation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyThomas De BeerIngmar Nopens

Experimental investigation of the link between granulation performance, residence time and granulation liquid distribution in twin-screw granulation

Ashish KumarMaija AlakarjulaValérie VanhoorneMaunu ToiviainenMikko JuutiChris VervaetJarkko KetolainenKrist V GernaeyThomas De BeerIngmar Nopens

FTIR spectroscopy for the detection and evaluation of live attenuated viruses in freeze dried vaccine formulations

Laurent HansenThomas De BeerKarin PierreSoumya PastoretAstrid Bonnegarde-BernardRim DaoussiChris VervaetJean Paul Remon

A1 Journal Article in BIOTECHNOLOGY PROGRESS

Fatty acids for controlled release applications: a comparison between prilling and solid lipid extrusion as manufacturing techniques

Anouk VervaeckTinne MonteyneFlorence SiepmannMatthieu BooneLuc Van HoorebekeThomas De BeerJürgen SiepmannJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Freeze-drying of live virus vaccines : a review

Laurent HansenR DaoussiChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in VACCINE

Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications

Wesley De JaeghereThomas De BeerJan Van BocxlaerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Impact of screw configuration on the particle size distribution of granules produced by twin screw granulation

Jurgen VercruysseAnneleen BurggraeveMargot FonteyneP CappuynsU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Non-conventional polymers as matrix excipients for hot melt extruded oral-release formulations

Bart ClaeysChris VervaetJean Paul Remon

Prilling of fatty acids as innovative technology for oral controlled release multiple-unit systems

Anouk VervaeckChris VervaetJean Paul Remon

Process analytical technology for continuous manufacturing of solid-dosage forms

Margot FonteyneJurgen VercruysseFien De LeersnyderBernd Van SnickChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Reduction of tablet weight variability by optimizing paddle speed in the forced feeder of a high-speed rotary tablet press

Elisabeth PeetersThomas De BeerChris VervaetJean Paul Remon

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

The effects of superabsorbent polymers on the water vapour sorption properties of cementitious materials

Didier SnoeckLF VelascoArn MignonChris VervaetSandra Van VlierberghePeter DubruelP LodewyckxNele De Belie

Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding

Bart ClaeysAnouk VervaeckXander HillewaereSam PossemiersLaurent HansenThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Use of a continuous twin screw granulation and drying system during formulation development and process optimization

Jurgen VercruysseElisabeth PeetersMargot FonteyneP CappuynsU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2014

A model based analysis of IPEC dosing of paclitaxel in rats

Pieter ColinLieselotte De SmetChris VervaetJean Paul RemonWim CeelenJan Van BocxlaerKoen BousseryAn Vermeulen

A1 Journal Article in PHARMACEUTICAL RESEARCH

Co-extruded solid solutions as immediate release fixed-dose combinations

Lien DierickxBernd Van SnickTinne MonteyneThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Crystal coating via spray drying to improve powder tabletability

Valérie VanhoorneElisabeth PeetersBernd Van SnickJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Distribution of binder in granules produced by means of twin screw granulation

Margot FonteyneAndrew Luke FussellJurgen VercruysseChris VervaetJean Paul RemonClare StrachanThomas RadesThomas De Beer

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effects of hyperthermia versus drug dose on toxicity and pharmacodynamics of oxaliplatin-based intraoperative chemoperfusion : results of a phase II trial

Lieselotte De SmetAndrei IzmerFrank VanhaeckeJean Paul RemonChris VervaetWim Ceelen

Enzymatic tumour tissue digestion coupled to SPE-UPLC–tandem mass spectrometry as a tool to explore paclitaxel tumour penetration

Pieter ColinLieselotte De SmetLies De BockWim GoeteynKoen BousseryChris VervaetJan Van Bocxlaer

A1 Journal Article in TALANTA

Experimental investigation of granule size and shape dynamics in twin-screw granulation

Ashish KumarJurgen VercruysseGiacomo BellandiKrist V GernaeyChris VervaetJean Paul RemonThomas De BeerIngmar Nopens

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs

Lieselotte De SmetLien SaerensThomas De BeerRobert CarleerPeter AdriaensensJan Van BocxlaerChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Hot-melt co-extrusion as manufacturing technique for multilayer oral dosage forms

Lien DierickxJean Paul RemonChris Vervaet

Hot-melt co-extrusion for the production of fixed-dose combination products with a controlled release ethylcellulose matrix core

An-Katrien VynckierLien DierickxLien SaerensJody VoorspoelsYves GonnissenThomas De BeerChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Hot-melt co-extrusion: requirements, challenges and opportunities for pharmaceutical applications

An-Katrien VynckierLien DierickxJody VoorspoelsYves GonnissenJean Paul RemonChris Vervaet

A1 Journal Article in JOURNAL OF PHARMACY AND PHARMACOLOGY

In-line solid state prediction during pharmaceutical hot-melt extrusion in a 12 mm twin screw extruder using Raman spectroscopy

Lien SaerensDima GhanamCedric RaemdonckKjell FrancoisJürgen ManzRainer KrügerSusan KrügerChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Influence of raw material properties upon critical quality attributes of continuously produced granules and tablets

Margot FonteyneHenrika WickströmElisabeth PeetersJurgen VercruysseHenrik EhlersBjörn-Hendrik PetersJean Paul RemonChris VervaetJarkko KetolainenNiklas Sandler et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Innovation in pharmaceutical manufacturing of solid dosage forms via continuous wet granulation

Jurgen VercruysseChris VervaetJean Paul Remon

Investigation of active pharmaceutical ingredient loss in pharmaceutical compounding of capsules

Matthias D'HondtEvelien WynendaeleKirsten VandercruyssenTieneke BautersJohan VandenbrouckeSteven MullensChris VervaetJean Paul RemonBart De Spiegeleer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Investigation of the tableting process in continuous production: influence of feeding and extended dwell time during compression on dependent process variables and tablet properties

Elisabeth PeetersJean Paul RemonChris Vervaet

Mixing and transport during pharmaceutical twin-screw wet granulation : experimental analysis via chemical imaging

Ashish KumarJurgen VercruysseMaunu ToiviainenPierre-Emmanuel PanouillotMikko JuutiValérie VanhoorneChris VervaetJean Paul RemonKrist V GernaeyThomas De Beer et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Moisture and drug solid-state monitoring during a continuous drying process using empirical and mass balance models

Margot FonteyneDelphine GildemynElisabeth PeetersSéverine MortierJurgen VercruysseKrist V GernaeyChris VervaetJean Paul RemonIngmar NopensThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

NIR spectroscopic method for the in-line moisture assessment during drying in a six-segmented fluid bed dryer of a continuous tablet production line : validation of quantifying abilities and uncertainty assessment

Margot FonteyneJulen ArruabarrenaJacques de BeerMario HellingsTom Van Den KerkhofAnneleen BurggraeveChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Preparation, characterization and in vitro osteoblast growth of waste-derived biomaterials

Eduardo Saez RojoMilagros RamosMalcolm YatesMaria Angeles Martin-LuengoAna Maria Martínez SerranoAna CivantosJose Luis López-LacombaGwendolen ReillyChris VervaetJaume Lluis Tarterra et al.

A1 Journal Article in RSC ADVANCES

Prilling as manufacturing technique for multiparticulate lipid/PEG fixed-dose combinations

Anouk VervaeckTinne MonteyneLien SaerensThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Process monitoring and visualization solutions for hot-melt extrusion : a review

Lien SaerensChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in JOURNAL OF PHARMACY AND PHARMACOLOGY

Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers: a case study with diprophylline

Bart ClaeysSander De BruynLaurent HansenThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The beta-alanine dose for maintaining moderately elevated muscle carnosine levels

Sanne StegenTine BexChris VervaetLander VanheeEric AchtenWim Derave

A1 Journal Article in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Validation of an in-line Raman spectroscopic method for continuous active pharmaceutical ingredient quantification during pharmaceutical hot-melt extrusion

Lien SaerensN SegherChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in ANALYTICA CHIMICA ACTA

Visualization and understanding of the granulation liquid mixing and distribution during continuous twin screw granulation using NIR chemical imaging

Jurgen VercruysseMaunu ToiviainenMargot FonteyneNiko HelkimoJarkko KetolainenMikko JuutiUrbain DelaetIvo Van AsscheJean Paul RemonChris Vervaet et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2013

Co-extrusion as manufacturing technique for multilayer mini-matrices with dual drug release

Lien DierickxJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Formulation of poorly water-soluble drugs via coacervation : a pilot study using febantel

Wesley De JaeghereBruno De GeestJan Van BocxlaerJean Paul RemonChris VervaetAndré Antunes

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Gelucire 44/14 based immediate release formulations for poorly water-soluble drugs

André AntunesBruno De GeestChris VervaetJean Paul Remon

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Multiparticulates for vaginal drug delivery

Samata MehtaHans VerstraelenChris VervaetJean Paul Remon

Near-infrared spectroscopic evaluation of lyophilized viral vaccine formulations

Laurent HansenThomas De BeerSigrid PietersYvan Vander HeydenChris VervaetJean Paul RemonJean-Pierrre MontenezRim Daoussi

A1 Journal Article in BIOTECHNOLOGY PROGRESS

Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent

Lieselotte De SmetWim CeelenJean Paul RemonChris Vervaet

A1 Journal Article in SCIENTIFIC WORLD JOURNAL

Particle sizing measurements in pharmaceutical applications : comparison of in-process methods versus off-line methods

Ana Tavares da SilvaAnneleen BurggraeveQuenten DenonPaul Van der MeerenNiklas SandlerTom Van Den KerkhofMario HellingsChris VervaetJean Paul RemonJoão Almeida Lopes et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Prilling of fatty acids as a continuous process for the development of controlled release multiparticulate dosage forms

Anouk VervaeckLien SaerensBruno De GeestThomas De BeerR CarleerP AdriaensensJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Process analytical tools for monitoring, understanding, and control of pharmaceutical fluidized bed granulation: a review

Anneleen BurggraeveTinne MonteyneChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations

Sigrid PietersYvan Vander HeydenJean-Michel RogerMatthias D'HondtLaurent HansenBernard PalagosBart De SpiegeleerJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Real-time assessment of critical quality attributes of a continuous granulation process

Margot FonteyneJurgen VercruysseDamián Córdoba DíazDelphine GildemynChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Solid crystal suspensions containing griseofulvin: preparation and bioavailability testing

Elena ReitzChris VervaetReinhard HH NeubertMarkus Thommes

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Solvent-free drug crystal engineering for drug nano- and micro suspensions

André AntunesBruno De GeestChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Spectroscopic process monitoring for quality assessment, visualization and understanding of pharmaceutical hot-melt extrusion

Lien SaerensThomas De BeerChris Vervaet

Stability and repeatability of a continuous twin screw granulation and drying system

Jurgen VercruysseU DelaetI Van AsscheP CappuynsF ArataG CaporicciThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Stability of Staphylococcus aureus phage ISP after freeze-drying (lyophilization)

Maia MerabishviliChris VervaetJean-Paul PirnayDaniel De VosGilbert VerbekenJan MastNino ChanishviliMario Vaneechoutte

A1 Journal Article in PLOS ONE

Structural modifications of polymethacrylates: impact on thermal behavior and release characteristics of glassy solid solutions

Bart ClaeysRuben De CoenBruno De GeestVictor Retamero De La RosaRichard HoogenboomRobert CarleerPeter AdriaensensJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Treatment of peritoneal carcinomatosis via (hyperthermic) intraperitoneal chemotherapy : towards a unified standard of care

Lieselotte De SmetChris VervaetWim CeelenJean Paul Remon

Vaginal distribution and retention of tablets comprising starch-based multiparticulates: evaluation by colposcopy

Samata MehtaHans VerstraelenLeen VandaeleEls MehuysJean Paul RemonChris Vervaet

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Visualization and process understanding of material behavior in the extrusion barrel during a hot-melt extrusion process using Raman spectroscopy

Lien SaerensChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in ANALYTICAL CHEMISTRY

2012

Co-extrusion as manufacturing technique for fixed-dose combination mini-matrices

Lien DierickxLien SaerensAna AlmeidaThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Continuous twin screw granulation: influence of process variables on granule and tablet quality

Jurgen VercruysseD Córdoba DíazElisabeth PeetersMargot FonteyneU DelaetI Van AsscheThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development of a fluid bed granulation process control strategy based on real-time process and product measurements

Anneleen BurggraeveAna Tavares da SilvaTom Van den KerkhofMario HellingsChris VervaetJean Paul RemonYvan Vander HeydenThomas De Beer

A1 Journal Article in TALANTA

Development of a nanocrystalline Paclitaxel formulation for HIPEC treatment

Lieselotte De SmetPieter ColinWim CeelenMarc BrackeJan Van BocxlaerJean Paul RemonChris Vervaet

A1 Journal Article in PHARMACEUTICAL RESEARCH

Development of process analytical and control methodologies for pharmaceutical wet granulation processes

Anneleen BurggraeveThomas De BeerChris Vervaet

Dry powder vaccines for mass vaccination of poultry : new formulations, comparison with liquid vaccines and feasibility to decrease adverse vaccinal reactions

Katrien HuygeChris VervaetWJM LandmanJean Paul Remon

Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules

Samata MehtaThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Electrospun cellulose acetate phthalate fibers for semen induced anti-HIV vaginal drug delivery

Chaobo HuangStefaan SoenenEllen van GulckGuido VanhamJoanna RejmanSerge Van CalenberghChris VervaetTom CoenyeHans VerstraelenMarleen Temmerman et al.

A1 Journal Article in BIOMATERIALS

Engineered (hep/pARG)2 polyelectrolyte capsules for sustained release of bioactive TGF-β1

Liesbeth De CockOlivier De WeverSandra Van VlierbergheEls VanderleydenPeter DubruelFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in SOFT MATTER

Engineered 3D microporous gelatin scaffolds to study cell migration

Liesbeth De CockOlivier De WeverHamida HammadBart LambrechtEls VanderleydenPeter DubruelFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL COMMUNICATIONS

Hot-melt extrusion developments in the pharmaceutical industry

Ana AlmeidaBart ClaeysJean Paul RemonChris Vervaet

Bookchapter in Hot-melt extrusion : pharmaceutical applications

In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion

Lien SaerensLien DierickxThomas QuintensPeter AdriaensensRobert CarleerChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Interaction between polymeric multilayer capsules and immune cells

Marijke DierendonckStefaan De KokerChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Mechanistic modelling of the drying behaviour of single pharmaceutical granules

Séverine MortierThomas De BeerKrist GernaeyJurgen VercruysseMargot FonteyneJean Paul RemonChris VervaetIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Near-infrared spectroscopy for in-line monitoring of protein unfolding and its interactions with lyoprotectants during freeze-drying

Sigrid PietersThomas De BeerJulia KasperDorien BoulpaepOliwia WaszkiewiczMohammad GoodarziChristophe TistaertWolfgang FriessJean Paul RemonChris Vervaet et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

Poly(2-ethyl-2-oxazoline) as matrix excipient for drug formulation by hot melt extrusion and injection molding

Bart ClaeysAnouk VervaeckChris VervaetJean Paul RemonRichard HoogenboomBruno De Geest

A1 Journal Article in MACROMOLECULAR RAPID COMMUNICATIONS

Polymeric multilayer capsule-mediated vaccination induces protective immunity against cancer and viral infection

Bruno De GeestMonique WillartHamida HammadBart LambrechtCharlotte PollardPieter BogaertMarina De FiletteXavier SaelensChris VervaetJean Paul Remon et al.

A1 Journal Article in ACS NANO

Prediction of quality attributes of continuously produced granules using complementary pat tools

Margot FonteyneSandra Liliana De Oliveira SoaresJurgen VercruysseElisabeth PeetersAnneleen BurggraeveChris VervaetJean Paul RemonNiklas SandlerThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Preparation and evaluation of sustained-release matrix tablets based on metoprolol and an acrylic carrier using injection moulding

Thomas QuintenGP AndrewsThomas De BeerLien SaerensWim Bouquet-GeerardynDS JonesP HornsbyJean Paul RemonChris Vervaet

A1 Journal Article in AAPS PHARMSCITECH

Suitability of differently formulated dry powder Newcastle disease vaccines for mass vaccination of poultry

Katrien HuygeKristien Van ReethThomas De BeerWil JM LandmanJo HH van EckJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function

Bruno De GeestMonique WillartBart LambrechtCharlotte PollardChris VervaetJean Paul RemonJohan GrootenStefaan De Koker

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sustained release from hot-melt extruded matrices based on ethylene vinyl acetate and polyethylene oxide

Ana AlmeidaLoes BrabantFlorence SiepmannThomas De BeerWim Bouquet-GeerardynLuc Van HoorebekeJurgen SiepmannJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The Ghent Marfan trial: a randomized, double-blind placebo controlled trial with losartan in Marfan patients treated with β-blockers

Katarina MöbergSylvia De NobeleDaniel DevosEls GoetghebeurPatrick SegersBram TrachetChris VervaetMarjolijn RenardPaul CouckeBart Loeys et al.

A1 Journal Article in INTERNATIONAL JOURNAL OF CARDIOLOGY

Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations

Ana AlmeidaLien SaerensThomas De BeerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Vaginal distribution and retention of a multiparticulate drug delivery system, assessed by gamma scintigraphy and magnetic resonance imaging

Samata MehtaHans VerstraelenKathelijne PeremansGeert VilleirsSimon VermeireFilip De VosEls MehuysJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2011

Adjuvant effect of Gantrez®AN nanoparticles during oral vaccination of piglets against F4+enterotoxigenic Escherichia coli

Katrien VandammeVesna MelkebeekEric CoxJean Paul RemonChris Vervaet

A1 Journal Article in VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Antitumour efficacy of two paclitaxel formulations for hyperthermic intraperitoneal chemotherapy (HIPEC) in an in vivo rat model

Wim Bouquet-GeerardynSteven DeleyeSteven StaelensLieselotte De SmetNancy Van DammeISABELLE DEBERGHWim CeelenFilip De VosJean Paul RemonChris Vervaet

A1 Journal Article in PHARMACEUTICAL RESEARCH

Batch statistical process control of a fluid bed granulation process using in-line spatial filter velocimetry and product temperature measurements

Anneleen BurggraeveT Van den KerkhofM HellingsJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Chiral inversion of R(-) to S(+) ketoprofen in pigs

Eva NeirinckxSiska CroubelsJean Paul RemonMathias DevreesePatrick De BackerChris Vervaet

A1 Journal Article in VETERINARY JOURNAL

Designing polymeric particles for antigen delivery

Stefaan De KokerBart LambrechtMonique WillartYvette van KooykJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in CHEMICAL SOCIETY REVIEWS

Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion

Ana AlmeidaSam PossemiersMatthieu BooneThomas De BeerThomas QuintenLuc Van HoorebekeJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Feasibility of the Ussing chamber technique for the determination of in vitro jejunal permeability of passively absorbed compounds in different animal species

Eva NeirinckxChris VervaetJoris MichielsStefaan De SmetWim Van Den BroeckJean Paul RemonPatrick De BackerSiska Croubels

A1 Journal Article in JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Fluorescence single particle tracking for sizing of nanoparticles in undiluted biological fluids

Kevin BraeckmansKevin BuyensWim Bouquet-GeerardynChris VervaetPhilippe JoyeFilip De VosLaurent PlawinskiLoïc DoeuvreEduardo Angles-CanoNiek Sanders et al.

Influence of polymer hydrolysis on adjuvant effect of Gantrez®AN nanoparticles: implications for oral vaccination

Katrien VandammeVesna MelkebeekEric CoxPeter AdriaensensSandra Van VlierberghePeter DubruelChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Lyophilization of protein-loaded polyelectrolyte microcapsules

Marie-Luce De TemmermanJoanna RejmanJohan GrootenThomas De BeerChris VervaetJo DemeesterStefaan De Smedt

A1 Journal Article in PHARMACEUTICAL RESEARCH

Mechanistic modelling of fluidized bed drying processes of wet porous granules: a review

Séverine MortierThomas De BeerKrist V GernaeyJean Paul RemonChris VervaetIngmar Nopens

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Modelling of drying processes of pharmaceutical granules

Séverine MortierSreepriya VedantamThomas De BeerKV GernaeyJean Paul RemonChris VervaetIngmar Nopens

Modelling of drying processes of pharmaceutical granules

Séverine MortierSreepriya VedantamThomas De BeerKV GernaeyMargot FonteyneJurgen VercruysseJean Paul RemonChris VervaetIngmar Nopens

Mucosal irritation potential of polyelectrolyte multilayer capsules

Liesbeth De CockJoke LenoirStefaan De KokerVincent VermeerschAndre SkirtachPeter DubruelEls AdriaensChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in BIOMATERIALS

Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes

Thomas De BeerAnneleen BurggraeveMargot FonteyneLien SaerensJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Optimization of a pharmaceutical freeze-dried product and its process using an experimental design approach and innovative process analyzers

Thomas De BeerM WiggenhornA HaweJC KasperAna AlmeidaThomas QuintenW FriessG WinterChris VervaetJean Paul Remon

A1 Journal Article in TALANTA

Oral bioavailability of ATP after prolonged administration

Erik JCM CoolenIlja CW ArtsOtto BekersChris VervaetAalt BastPieter C Dagnelie

A1 Journal Article in BRITISH JOURNAL OF NUTRITION

Polymeric multilayer capsules delivering biotherapeutics

Stefaan De KokerLiesbeth De CockPilar Rivera-GilWolfgang J ParakRachel Auzély VeltyChris VervaetJean Paul RemonJohan GrootenBruno De Geest

A1 Journal Article in ADVANCED DRUG DELIVERY REVIEWS

Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process

Lien SaerensLien DierickxB LenainChris VervaetJean Paul RemonThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Real-time image-based investigation of spheronization and drying phenomena using different pellet formulations

Anneleen BurggraeveN SandlerJ HeinämäkiH RäikkönenJean Paul RemonChris VervaetThomas De BeerJ Yliruusi

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Single-step formation of degradable intracellular biomolecule microreactors

Marijke DierendonckStefaan De KokerRiet De RyckePieter BogaertJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in ACS NANO

Species comparison of enantioselective oral bioavailability and pharmacokinetics of ketoprofen

Eva NeirinckxSiska CroubelsSandra De BoeverJean Paul RemonTim BosmansSylvie DaminetPatrick De BackerChris Vervaet

A1 Journal Article in RESEARCH IN VETERINARY SCIENCE

Sustained-release and swelling characteristics of xanthan gum/ethylcellulose-based injection moulded matrix tablets: in vitro and in vivo evaluation

Thomas QuintenThomas De BeerFO OnofreG Mendez-MontealvoYJ WangJean Paul RemonChris Vervaet

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

The adjuvant effect of Gantrez®AN nanoparticles on oral vaccination of pigs and mice with F4 fimbriae is strongly influenced by polymer degradation

Katrien VandammeVesna MelkebeekChris VervaetJean Paul RemonEric Cox

The adjuvant effect of Gantrez®AN nanoparticles on oral vaccination of pigs and mice with F4 fimbriae is strongly influenced by polymer degradation

Vesna MelkebeekKatrien VandammeChris VervaetEric Cox

2010

A batch modelling approach to monitor a freeze-drying process using in-line Raman spectroscopy

Mafalda Cruz SarraguçaThomas De BeerChris VervaetJean Paul RemonJoão Almeida Lopes

A1 Journal Article in TALANTA

A single step process for the synthesis of antigen laden thermosensitive microparticles

Bruno De GeestStefaan De KokerYves GonnissenLiesbeth De CockJohan GrootenJean Paul RemonChris Vervaet

A1 Journal Article in SOFT MATTER

Adjustment of dosing of antimicrobial agents for bodyweight in adults

Els MehuysEgide KayitareChris VervaetJean Paul Remon

A1 Journal Article in LANCET

Adjuvant effect of Gantrez AN nanoparticles during oral vaccination with F4 fimbriae

Katrien VandammeVesna MelkebeekEric CoxP AdriaensensChris VervaetJean Paul Remon

Aminopeptidase N as a target for oral vaccine delivery

Vesna MelkebeekKatrien VandammeChris VervaetJean Paul RemonEric Cox

Controlled crystallization of the lipophilic drug fenofibrate during freeze-drying: elucidation of the mechanism by in-line Raman spectroscopy

Hans de WaardThomas De BeerWouter LJ HinrichsChris VervaetJean Paul RemonHenderik W Frijlink

A1 Journal Article in AAPS JOURNAL

Development of Gantrez® AN nanoparticles for oral delivery of antigens

Katrien VandammeJean Paul RemonChris Vervaet

Development of solid paediatric oral dosage forms

Egide KayitareJean Paul RemonChris Vervaet

Development of titanium bone scaffolds with drug delivery system

Matthieu RavelingienJean Paul RemonChris Vervaet

Evaluation of in-line spatial filter velocimetry as PAT monitoring tool for particle growth during fluid bed granulation

Anneleen BurggraeveTom Van Den KerkhofMario HellingsJean Paul RemonChris VervaetThomas De Beer

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Evaluation of injection molding as a pharmaceutical production technology for sustained-release matrix tablets

Thomas QuintenJean Paul RemonChris Vervaet

Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants

Marc TwagirumukizaPierre Claver KayumbaJan KipsBernard VrijensRobert Vander SticheleChris VervaetJean Paul RemonLucas Van Bortel

A1 Journal Article in MALARIA JOURNAL

Facile two-step synthesis of porous antigen-loaded degradable polyelectrolyte microspheres

Marijke DierendonckStefaan De KokerClaude CuvelierJohan GrootenChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

In vitro evaluation of gentamicin- and vancomycin-containing minitablets as a replacement for fortified eye drops

S BozdagW WeyenbergEls AdriaensMMM DhondtV VergoteChris VervaetKristof De PrijckHans NelisBart De SpiegeleerA Ludwig et al.

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

In vivo toxicity and bioavailability of taxol (R) and a paclitaxel/beta-cyclodextrin formulation in a rat model during HIPEC

Wim Bouquet-GeerardynWim CeelenEls AdriaensAna AlmeidaThomas QuintenFilip De VosPiet PattynMarc PeetersJean Paul RemonChris Vervaet

A1 Journal Article in ANNALS OF SURGICAL ONCOLOGY

Influence of reaction medium during synthesis of Gantrez® AN 119 nanoparticles for oral vaccination

Katrien VandammeVesna MelkebeekEric CoxDieter DeforceJoke LenoirEls AdriaensChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Influence of surface topography and pore architecture of alkali-treated titanium on in vitro apatite deposition

Matthieu RavelingienANNE-SOPHIE HERVENTSteven MullensJan LuytenChris VervaetJean Paul Remon

A1 Journal Article in APPLIED SURFACE SCIENCE

Layer-by-layer incorporation of growth factors in decellularized aortic heart valve leaflets

Liesbeth De CockStefaan De KokerFilip De VosChris VervaetJean Paul RemonBruno De Geest

A1 Journal Article in BIOMACROMOLECULES

Polymeric multilayer capsules in drug delivery

Liesbeth De CockStefaan De KokerBruno De GeestJohan GrootenChris VervaetJean Paul RemonGleb B SukhorukovMaria N Antipina

A1 Journal Article in ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sizing nanomatter in biological fluids by fluorescence single particle tracking

Kevin BraeckmansKevin BuyensWim Bouquet-GeerardynChris VervaetPhilippe JoyeFilip De VosLaurent PlawinskiLoic DoeuvreEduardo Angles-CanoNiek Sanders et al.

A1 Journal Article in NANO LETTERS

Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen

Eva NeirinckxChris VervaetSandra De BoeverJean Paul RemonKris GommerenSylvie DaminetPatrick De BackerSiska Croubels

A1 Journal Article in RESEARCH IN VETERINARY SCIENCE

Taste-masked quinine pamoate tablets for treatment of children with uncomplicated Plasmodium falciparum malaria

Egide KayitareChris VervaetEls MehuysPC KayumbaJD NtawukulilyayoC KaremaLucas Van BortelJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Towards a veterinary biopharmaceutics classification system: oral bioavailability and ex vivo intestinal permeability studies of paracetamol and ketoprofen in different animal species

Eva NeirinckxSiska CroubelsChris Vervaet

Unbreakable codes in electrospun fibers : digitally encoded polymers to stop medicine counterfeiting

Chaobo HuangBart LucasChris VervaetKevin BraeckmansSerge Van CalenberghIzet KaralicMado VandewoestyneDieter DeforceJo DemeesterStefaan De Smedt

A1 Journal Article in ADVANCED MATERIALS

Unbreakable codes in electrospun fibers to stop medicine counterfeiting

Chaobo HuangBart LucasChris VervaetKevin BraeckmansSerge Van CalenberghIzet KaralicMado VandewoestyneDieter DeforceJo DemeesterStefaan De Smedt

Vancomycin release from poly(D,L-lactic acid) spray-coated hydroxyapatite fibers

Matthieu RavelingienSteven MullensJan LuytenMatthias D'HondtJente BoonenBart De SpiegeleerTom CoenyeChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2009

A pilot study evaluating the safety of vaginal administration of a multi-particulate pellet formulation.

Guido Lopes dos Santos SantiagoHans VerstraelenNele PoelvoordeSteven De CorteGeert ClaeysMarijke TrogEllen De BackerBart SaerensChris VervaetFabienne De Boeck et al.

A1 Journal Article in European Journal of Pharmaceutics and Biopharmaceutics

Comparison of two twin-screw extruders for continuous granulation

Dejan DjuricBarbara Van MelkebekePeter KleinebuddeJean Paul RemonChris Vervaet

A1 Journal Article in European Journal of Pharmaceutics and Biopharmaceutics

Detection of very small density fluctuations in pharmaceutical samples by application of the Modified Bronnikov Algorithm on micro-CT data

Matthieu BooneAna AlmeidaYoni De WitteManuel DierickJean Paul RemonChris VervaetLuc Van Hoorebeke

Development and evaluation of a continuous granulation technique using a twin-screw extruder

Barbara Van MelkebekeJean Paul RemonChris Vervaet

Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery

Nele PoelvoordeJean Paul RemonChris Vervaet

Development of a platform for nasal delivery of peptides and vaccines using powder carriers based on starch/poly(acrylic) acid

Delphine CouckeJean Paul RemonChris Vervaet

Development of fixed dose combination tablets containing zidovudine and lamivudine for paediatric applications

Egide KayitareChris VervaetJD NtawukulilyayoB SeminegaLucas Van BortelJean Paul Remon

A1 Journal Article in International Journal of Pharmaceutics

Development of injection moulded matrix tablets based on mixtures of ethylcellulose and low-substituted hydroxypropylcellulose

Thomas QuintenYves GonnissenEls AdriaensThomas De BeerVeerle CnuddeBert MasschaeleLuc Van HoorebekeJ SiepmannJean Paul RemonChris Vervaet

A1 Journal Article in European Journal of Pharmaceutical Sciences

Development of porous delivery systems for oral drug and vaccine administration

An CosijnsJean Paul RemonChris Vervaet

Drug delivery of paclitaxel for an intraperitoneal chemotherapy

Wim Bouquet-GeerardynJean Paul RemonChris Vervaet

Effect on the nasal bioavailability of co-processing drug and bioadhesive carrier via spray-drying

Delphine CouckeChris VervaetP. ForemanP. AdriaensensR. CarleerJean Paul Remon

A1 Journal Article in International Journal of Pharmaceutics

Evaluation of injection moulding as a pharmaceutical technology to produce matrix tablets

Thomas QuintenThomas De BeerChris VervaetJean Paul Remon

A1 Journal Article in European Journal of Pharmaceutics and Biopharmaceutics

Importance of using complementary process analyzers for the process monitoring, analysis, and understanding of freeze drying

Thomas De BeerM WiggenhornR VeillonC DebacqY MayeresseB MoreauAnneleen BurggraeveThomas QuintenW FriessG Winter et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

In vitro cytotoxicity of paclitaxel/β-cyclodextrin complexes for HIPEC

Wim Bouquet-GeerardynTom BoterbergWim CeelenPiet PattynMarc PeetersMarc BrackeJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In vivo evaluation of the vaginal distribution and retention of a multi-particulate pellet formulation

Nele PoelvoordeHans VerstraelenRita VerhelstBart SaerensEllen De BackerGuido Lopes dos Santos SantiagoChris VervaetMario VaneechoutteFabienne De BoeckLucas Van Bortel et al.

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

In-Line and Real-Time Process Monitoring of a Freeze Drying Process Using Raman and NIR Spectroscopy as Complementary Process Analytical Technology (PAT) Tools

Thomas De BeerPieter VercruysseAnneleen BurggraeveThomas QuintenJ. OuyangX. ZhangChris VervaetJean Paul RemonWilly Baeyens

A1 Journal Article in Journal of Pharmaceutical Sciences

Influence of Tropical Climate Conditions on the Quality of Antihypertensive Drugs from Rwandan Pharmacies

Marc TwagirumukizaAn CosijnsEveline PringelsJean Paul RemonChris VervaetLucas Van Bortel

A1 Journal Article in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Influence of heat treatment on spray-dried mixtures of Amioca (R) starch and Carbopol (R) 974P used as carriers for nasal drug delivery

Delphine CouckeEveline PringelsP ForemanP AdriaensensR CarleerJean Paul RemonChris Vervaet

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of polyethylene glycol/polyethylene oxide on the release characteristics of sustained-release ethylcellulose mini-matrices produced by hot-melt extrusion: in vitro and in vivo evaluations

Ellen VerhoevenThomas De BeerEtienne SchachtG Van den MooterJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Interspecies comparison of oral bioavailability and jejunal permeability of paracetamol in the framework of a veterinary biopharmaceutics classification system

Eva NeirinckxChris VervaetSandra De BoeverJean Paul RemonPatrick De BackerSiska Croubels

Modeling drug release from hot-melt extruded mini-matrices with constant and non-constant diffusivities

Ellen VerhoevenF SiepmannThomas De BeerDenis Van LooG. Van den MooterJean Paul RemonJ SiepmannChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Porous pellets as drug delivery system

An CosijnsD NizetI NikolakakisChris VervaetThomas De BeerF SiepmannJ SiepmannB EvrardJean Paul Remon

A1 Journal Article in Drug Development and Industrial Pharmacy

Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: a critical review

Aleksandra Dukic-OttM ThommesJean Paul RemonPeter KleinebuddeChris Vervaet

A1 Journal Article in European Journal of Pharmaceutics and Biopharmaceutics

Safety and colonisation potential of a new multi-particulate pellet formulation for vaginal delivery of probiotic lactobacilli

Rita VerhelstHans VerstraelenNele PoelvoordeGuido Lopes dos Santos SantiagoEllen De BackerBart SaerensMarijke TrogChris VervaetLucas Van BortelJean Paul Remon et al.

Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine

Delphine CouckeMichael SchotsaertClaude LibertEveline PringelsChris VervaetP ForemanXavier SaelensJean Paul Remon

A1 Journal Article in Vaccine

Starch phosphates prepared by reactive extrusion as a sustained release agent

Stephen O'BrienYa-Jane WangChris VervaetJean Paul Remon

A1 Journal Article in Carbohydrate Polymers

Thermal decomposition of bioactive sodium titanate surfaces

Matthieu RavelingienSteven MullensJan LuytenVera MeynenEvi VinckChris VervaetJean Paul Remon

A1 Journal Article in APPLIED SURFACE SCIENCE

2008

A multi-center prospective, randomized, double-blind trial studying the effect of misoprostol on the outcome of intrauterine insemination

Kelly BillietMarc DhontChris VervaetAn VermeireJan GerrisD DE NEUBOURGL DELBEKEWillem OmbeletPetra De Sutter

A1 Journal Article in GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Coprocessing via spray drying as a formulation platform to improve the compactability of various drugs

Yves GonnissenEllen VerhoevenElisabeth PeetersJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Effect of maltodextrin and superdisintegrant in directly compressible powder mixtures prepared via co-spray drying

Yves GonnissenJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Hot-melt extrusion as processing technique for multiparticulate dosage forms containing lipophilic and hydrophilic polymers

Ellen VerhoevenJean Paul RemonChris Vervaet

In-vitro and in-vivo evaluation of enteric-coated starch-based pellets prepared via extrusion/spheronisation

A DUKIC-OTTThomas De BeerJean Paul RemonWilly BaeyensP FOREMANChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Influence of formulation and process parameters on the release characteristics of ethylcellulose sustained-release mini-matrices produced by hot-melt extrusion

Ellen VerhoevenThomas De BeerG VAN DEN MOOTERJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Mixture design applied to optimize a directly compressible powder produced via cospray drying

Yves GonnissenSIV GONCALVESJean Paul RemonChris Vervaet

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Multicomponent complexation between ibuprofen, cyclodextrin and HPMC monitored by NMR

Katelijne GheysenWim Bouquet-GeerardynChris VervaetBernd FritzingerJosé Martins

Opportunities for digitally encoded microcarriers in pharmacy and cell-based assays

Farzaneh FayazpourBart LucasN HUYGEBAERTKevin BraeckmansStefaan DerveauxRoosmarijn VandenbrouckeJean Paul RemonJo DemeesterChris VervaetStefaan De Smedt

Optimisation of an enteric coated, layered multi-particulate formulation for ileal delivery of viable recombinant Lactococcus lactis

Nele PoelvoordeNathalie HuyghebaertChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Porous pellets as carriers of F4 fimbriae used for oral vaccination of suckling piglets against enterotoxigenic Escherchia coli infections

Philippe BellotAn CosijnsEdith StuyvenChris VervaetJean Paul RemonEric Cox

Process design applied to optimise a directly compressible powder produced via a continuous manufacturing process

Yves GonnissenSIV GONCALVESBruno De GeestJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Raman spectroscopy as a process analytical technology (PAT) tool for the in-line monitoring and understanding of a powder blending process

Thomas De BeerC BODSONB DEJAEGHERB WALCZAKPieter VercruysseAnneleen BurggraeveA LEMOSL DELATTREYV HEYDENJean Paul Remon et al.

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Taste-masked quinine sulphate pellets: bio-availability in adults and steady-state plasma concentrations in children with uncomplicated Plasmodium falciparum malaria

Pierre KayumbaMarc TwagirumukizaNathalie HuyghebaertJD NTAWUKULIRYAYOLucas Van BortelChris VervaetJean Paul Remon

A1 Journal Article in ANNALS OF TROPICAL PAEDIATRICS

The addition of calcium ions to starch/Carbopol (R) mixtures enhances the nasal bioavailability of insulin

E PringelsChris VervaetRonald VerbeeckP FOREMANJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The quality of antihypertensive drugs marketed in Rwanda

Marc TwagirumukizaAn CosijnsE PringelsJean Paul RemonChris VervaetLucas Van Bortel

Vaccination of broiler chickens with dispersed dry powder vaccines as an alternative for liquid spray and aerosol vaccination

Evy CorbanieChris VervaetJHH VAN ECKJean Paul RemonWJM LANDMAN

A1 Journal Article in VACCINE

Validation of a continuous granulation process using a twin-screw extruder

Barbara Van MelkebekeChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

WGA-conjugated silica nanoparticles: development and association to Caco-2 cells

Katrien VandammeBasu NagaralliNathalie HuyghebaertEllen Van BelleClaude CuvelierChris VervaetJean Paul Remon

2007

A strategy to implement a PAT system in a pharmaceutical production process: a case study: freeze-drying

Thomas De BeerWilly BaeyensChris VervaetJean Paul Remon

A2 Journal Article in STP PHARMA PRATIQUES

Compounding of vitamin A, D-3, E and K-3 supplements for cystic fibrosis patients: formulation and stability study

Nathalie HuyghebaertJ DE BEERChris VervaetJean Paul Remon

A1 Journal Article in JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Correlation between the permeability of metoprolol tartrate through plasticized isolated ethylcellulose/hydroxypropyl methylcellulose films and drug release from reservoir pellets

Zhi-Wei YePatrick RomboutJean Paul RemonChris VervaetGuy Van den Mooter

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development of directly compressible powders via co-spray drying

Yves GonnissenJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development of starch-based pellets via extrusion/spheronisation

Aleksandra Dukic - OttR MENSP ADRIAENSENSP FOREMANJ GELANJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Digitally encoded drug tablets to combat counterfeiting

Farzaneh FayazpourBart LucasN HUYGHEBAERTKevin BraeckmansStefaan DerveauxBG STUBBEJean Paul RemonJo DemeesterChris VervaetStefaan De Smedt

A1 Journal Article in ADVANCED MATERIALS

Evaluation of the in vivo behaviour of gentamicin sulphate ocular mini-tablets in ponies

Frank GasthuysK POCKELEChris VervaetW WEYENBERGKristof De PrijckFrederik PilleLieven VlaminckHans NelisJean Paul Remon

A1 Journal Article in JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Immediate release of poorly soluble drugs from starch-based pellets prepared via extrusion/spheronisation

A DUKIC-OTTJean Paul RemonP FOREMANChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Implementation of a process analytical technology system in a freeze-drying process using Raman Spectroscopy for in-line process monitoring

Thomas De BeerM ALLESOFrederik GoethalsA COPPENSY VANDER HEYDENHL DE DIEGOJ RANTANENFrancis VerpoortChris VervaetJean Paul Remon et al.

A1 Journal Article in ANALYTICAL CHEMISTRY

Influence of particle size on the quantitative determination of salicylic acid in a pharmaceutical ointment using FT-Raman spectroscopy

Thomas De BeerWilly BaeyensY VANDER HEYDENJean Paul RemonChris VervaetFrancis Verpoort

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Paclitaxel/β-cyclodextrin complexes for hyperthermic peritoneal perfusion: formulation and stability

Wim Bouquet-GeerardynWim CeelenBernd FritzingerPiet PattynMarc PeetersJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Porous hydroxyapatite tablets as carriers for low-dosed drugs

An CosijnsChris VervaetJ LuytenS MullensF SiepmannLuc Van HoorebekeBert MasschaeleVeerle CnuddeJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Quinine sulphate pellets for flexible pediatric drug dosing: Formulation development and evaluation of taste-masking efficiency using the electronic tongue

Pierre KayumbaNathalie HuyghebaertC CORDELLAJD NTAWUKULIRYAYOChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Raman spectroscopic method for the determination of medroxyprogesterone acetate in a pharmaceutical suspension: validation of quantifying abilities, uncertainty assessment and comparison with the high performance liquid chromatography reference method

Thomas De BeerWilly BaeyensA VERMEIRED BROESJean Paul RemonChris Vervaet

A1 Journal Article in ANALYTICA CHIMICA ACTA

Spray drying of an attenuated live Newcastle disease vaccine virus intended for respiratory mass vaccination of poultry

Evy CorbanieJean Paul RemonKristien Van ReethWJM LANDMANJHH VAN ECKChris Vervaet

A1 Journal Article in VACCINE

2006

Deposition of differently sized airborne microspheres in the respiratory tract of chickens

Evy CorbanieMGR MATTHIJSJHH VAN ECKJean Paul RemonWJM LANDMANChris Vervaet

A1 Journal Article in AVIAN PATHOLOGY

Influence of deposition and spray pattern of nasal powders on insulin bioavailability

E PringelsC CALLENSChris VervaetFilip DumontGuido SlegersP FOREMANJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Melt granulation using a twin-screw extruder: A case study

Barbara Van MelkebekeBrenda VermeulenChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Raman spectroscopy as a process analytical technology tool for the understanding and the quantitative in-line monitoring of the homogenization process of a pharmaceutical suspension

Thomas De BeerWilly BaeyensJin OuyangChris VervaetJean Paul Remon

A1 Journal Article in ANALYST

Subjective and objective evaluation of noncultured epidermal cellular grafting for repigmenting vitiligo

Nanja van GeelKatia OngenaeYves Vander HaeghenChris VervaetJean Naeyaert

A1 Journal Article in DERMATOLOGY

The Biopharmaceutics Classification System in veterinary medicine: pH-solubility relationship of analgesic and anti-inflammatory drugs

Eva NeirinckxJean Paul RemonPatrick De BackerChris Vervaet

Xanthan gum to tailor drug release of sustained-release ethylcellulose mini-matrices prepared via hot-melt extrusion: in vitro and in vivo evaluation

Ellen VerhoevenChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2005

Continuous granulation in the pharmaceutical industry

Chris VervaetJean Paul Remon

A1 Journal Article in Chemical Engineering Science

Human bioavailability of propranolol from a matrix-in-cylinder system with a HPMC-Gelucire (R) core

Els MehuysJean Paul RemonA KORSTLucas Van BortelR MOLSP AUGUSTIJNSC PORTERChris Vervaet

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Impact du climat tropical sur la stabilité des médicaments: cas de l'acide acétylsalicylique et du paracétamol échantilonnés sur le marché rwandais

P KAYUMBAJ NTAWUKULIRYAYOChris VervaetJean Paul Remon

A2 Journal Article in Le pharmacien d'Afrique

Liquid chromatographic-mass spectrometric assay for simultaneous pyrimethamine and sulfadoxine determination in human plasma samples

Bart SinnaeveTineke DecaesteckerPG RISHAJean Paul RemonChris VervaetJan Van Bocxlaer

A1 Journal Article in JOURNAL OF CHROMATOGRAPHY A

Production of enteric capsules by means of hot-melt extrusion

Els MehuysJean Paul RemonChris Vervaet

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Starch/Carbopol (R) spray-dried mixtures as excipients for oral sustained drug delivery

E PringelsD AMEYEChris VervaetP FOREMANJean Paul Remon

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Tablets prepared by single-step granulation/tabletting : interparticulate binding mechanism and stability

A VERMEIREEI KELEBF KIEKENSIsabel Van DriesscheSerge HosteJean Paul RemonChris Vervaet

A1 Journal Article in PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Taxol versus paclitaxel beta-cyclodextrin complexes for hyperthermic peritoneal perfusion: an in vivo study

Wim Bouquet-GeerardynTom BoterbergWIM CEELENChris VervaetMarcus MareelMarc Peeters

2004

Aerosol profile extracted from spacers as a determinant of actual dose

S VERBANCKChris VervaetD SCHUERMANSW VINCKEN

A1 Journal Article in PHARMACEUTICAL RESEARCH

Assessment of a new utero-tubal junction insemination device in dairy cattle

Steven VerberckmoesAnn Van SoomIsabel De PauwJeroen DewulfChris VervaetAart de Kruif

A1 Journal Article in THERIOGENOLOGY

Bioavailability of ibuprofen from hot-melt extruded mini-matrices

C DE BRABANDERChris VervaetLucas Van BortelJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Compaction of enteric-coated pellets: influence of formulation and process parameters on tablet properties and in vivo evaluation

Ann DebunneChris VervaetD MANGELINGSJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Continuous processing of pharmaceuticals

Jean Paul RemonChris Vervaet

Bookchapter in Encyclopedia of pharmaceutical technology

Development and validation of a direct, non-destructive quantitative method for medroxyprogesterone acetate in a pharmaceutical suspension using FT-Raman spectroscopy

Thomas De BeerGJ VERGOTEWilly BaeyensJean Paul RemonChris VervaetFrancis Verpoort

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Double-blind placebo-controlled study of autologous transplanted epidermal cell suspensions for repigmenting vitiligo

Nanja van GeelKatia OngenaeMartine De MilYves Vander HaeghenChris VervaetJean Naeyaert

A1 Journal Article in ARCHIVES OF DERMATOLOGY

Extrusion granulation and high shear granulation of different grades of lactose and highly dosed drugs: A comparative study

EI KELEBA VERMEIREChris VervaetJean Paul Remon

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Hot-melt extruded ethylcellulose cylinders containing a HPMC-gelucire((R)) core for sustained drug delivery

Els MehuysChris VervaetJean Paul Remon

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

In vitro and in vivo evaluation of a matrix-in-cylinder system for sustained drug delivery

Els MehuysChris VervaetIngrid GielenHenri van BreeJean Paul Remon

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

In-line monitoring of a pharmaceutical blending process using FT-Raman spectroscopy

GJ VERGOTEThomas De BeerChris VervaetJean Paul RemonWilly BaeyensN DIERICXFrancis Verpoort

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Influence of the punch diameter and curvature on the yield pressure of MCC-compacts during Heckel analysis

F KIEKENSAnn DebunneChris VervaetL BAERTF VANHOUTTEI VAN ASSCHEF MENARDJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Single-step granulation/tabletting of different grades of lactose: a comparison with high shear granulation and compression

EI KELEBA VERMEIREChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

The quality of essential antimicrobial and antimalarial drugs marketed in Rwanda and Tanzania: influence of tropical storage conditions on in vitro dissolution

Pierre KayumbaPG RISHAD SHEWIYOA MSAMIG MASUKID AMEYEG VERGOTEJD NTAWUKULIRYAYOJean Paul RemonChris Vervaet

A1 Journal Article in JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Twin screw granulation as a simple and efficient tool for continuous wet granulation

EI KELEBA VERMEIREChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

2003

Development and evaluation of sustained release mini-matrices prepared via hot melt extrusion

C DE BRABANDERChris VervaetJean Paul Remon

A1 Journal Article in JOURNAL OF CONTROLLED RELEASE

Drug formulations intended for the global market should be tested for stability under tropical climatic conditions

PG RISHAChris VervaetG VERGOTELucas Van BortelJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Formes orales matricielles et multiparticulaires utilisant l'extrusion à chaud

Jean Paul RemonChris VervaetC DE BRABANDER

A2 Journal Article in Bulletin Technique Gattefossé

Reduced availability of trimethoprim/sodium sulfadiazin and doxycyclin hyclate in drinking water systems

Chris VervaetJ VOORSPOELSF KIEKENSJean Paul Remon

A2 Journal Article in J. Appl. Res. Vet. Med.

2002

Bioavailability of hydrochlorothiazide from isomalt-based moulded tablets.

Faustin NdindayinoChris VervaetG VAN DEN MOOTERJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterization of ibuprofen as a nontraditional plasticizer of ethyl cellulose.

Caroline De BrabanderG VAN DEN MOOTERChris VervaetJean Paul Remon

A1 Journal Article in JOURNAL OF PHARMACEUTICAL SCIENCES

Continuous twin screw extrusion for the wet granulation of lactose.

EI KELEBAn VermeireChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Development and in vitro evaluation of an enteric-coated multiparticulate drug delivery system for the administration of piroxicam to dogs.

Ann DebunneChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Direct compression and moulding properties of co-extruded isomalt/drug mixtures.

Faustin NdindayinoChris VervaetG VAN DEN MOOTERJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Direct compression properties of melt-extruded isomalt.

Faustin NdindayinoDominiek HenristFilip KiekensG VAN DEN MOOTERChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

In vitro evaluation of the quality of essential drugs on the Tanzanian market.

PG RISHAD SHEWIYOA MSAMIG MASUKIGeert VERGOTEChris VervaetJean Paul Remon

A1 Journal Article in TROPICAL MEDICINE & INTERNATIONAL HEALTH

In vivo evaluation of matrix pellets containing nanocrystalline ketoprofen

Geert VERGOTEChris VervaetIsabel Van DriesscheSerge HosteStefaan De SmedtJo DemeesterRA JAINS RUDDYJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Isomalt comme excipient dans la fabrication des comprimés

Faustin NdindayinoJean Paul RemonChris Vervaet

Near-infrared FT-Raman spectroscopy as a rapid analytical tool for the determination of diltiazem hydrochloride in tablets.

Geert VERGOTEChris VervaetJean Paul RemonTimothy HaemersFrancis Verpoort

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Principal component analysis of dissolution data with missing elements.

E ADAMSB WALCZAKChris VervaetPG RISHADL MASSART

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Scaling-up of a lactose wet granulation process in Mi-Pro high shear mixers.

Dieter AmeyeE KELEBChris VervaetJean Paul RemonE ADAMSDL MASSART

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Wax beads as cushioning agents during the compression of coated diltiazem pellets.

Geert VERGOTEFilip KiekensChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

2001

An oral controlled release matrix pellet formulation containing nanocrystalline ketoprofen

Geert VERGOTEChris VervaetIsabel Van DriesscheSerge HosteStefaan De SmedtJo DemeesterRA JAINS RUDDYJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Characterisation and disintegration properties of irradiated starch.

Martine De KerfW MONDELAERSP LAHORTEChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cold extrusion as a continuous single-step granulation and tabletting process.

EI KELEBAn VermeireChris VervaetJean Paul Remon

A1 Journal Article in EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

2000

A validated HPLC method for the determination of thiazinamium methylsulphate in pharmaceutical preparations.

Els SmetWilly BaeyensG VAN DER WEKENFilip KiekensChris VervaetJean Paul Remon

A1 Journal Article in JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Bioavailability of ibuprofen from matrix mini-tablets based on a mixture of starch and microcrystalline wax.

Caroline De BrabanderChris VervaetJP GORTZJean Paul RemonJA BERLO

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Matrix mini-tablets based on starch/microcrystalline wax mixtures.

Caroline De BrabanderChris VervaetLucien FiermansJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Polystyrene microsphere spray standards based on CFC-free inhaler technology.

Chris VervaetPR BYRON

A1 Journal Article in JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG

1999

Characterization and Evaluation of Isolmalt Performance in Direct Compression.

Faustin NdindayinoDominiek HenristFilip KiekensChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pharmacokinetics of florfenicol after treatment of pigs with single oral or intramuscular doses or with medicated feed for three days.

Jody VoorspoelsEva D'HaeseBA DE CRAENEChris VervaetD DE RIEMAECKERPiet DeprezHans NelisJean Paul Remon

A1 Journal Article in VETERINARY RECORD

1998

Bioavailability of ibuprofen from matrix pellets based on the combination of waxes and starch derivatives.

F ZHOUChris VervaetM SCHELKENSRomain LefebvreJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Optimization of the processing of matrix pellets based on the combination of waxes and starch using experimental design.

F ZHOUChris VervaetDL MASSARTB MASSARTJean Paul Remon

A1 Journal Article in DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

1997

Bioavailability of hydrochlorothiazide from pellets, made by extrusion/spheronisation, containing polyethylene glycol 400 as a dissolution enhancer.

Chris VervaetJean Paul Remon

A1 Journal Article in PHARMACEUTICAL RESEARCH

Influence of processing on the characteristics of matrix pellets based on microcrystalline waxes and starch derivatives.

F ZHOUChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Invloed van proces- en formulatie-parameters op de kwaliteit van pellets geproduceerd door middel van extrusie/sferonisatie

Chris VervaetJ.P. Remon

1996

In vitro and in vivo evaluation of a xanthan gum-n-octenylsuccinate starch matrix tablet containing ibuprofen as a model drug.

JD NTAWUKULILYAYOChris VervaetJean Paul RemonJP GORTZJA BERLO

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of impeller design, method of screen perforation and perforation geometry on the quality of pellets made by extrusion-spheronisation.

Chris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Matrix pellets based on the combination of waxes, starches and maltodextrins

F ZHOUChris VervaetJean Paul Remon

A2 Journal Article in Int. J. Pharm., nr. 133

Matrix pellets based on the combination of waxes, starches and maltodextrins.

F ZHOUChris VervaetJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

1995

Extrusion-spheronisation - A literature-review.

Chris VervaetLieven BaertJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

Influence of the impeller design, the method of screen perforation and the perforation geometry on pellet quality made by extrusion-spheronisation

Chris VervaetJean Paul Remon

Matrix pellets based on the combination of waxes, starches and malto dextrins

F ZHOUChris VervaetJean Paul Remon

1994

Enhancement of in-vitro drug release using PEG 400 and PEG 40 hydrogenated castor-oil in pellets made by extrusion/speronisation.

Chris VervaetLieven BaertJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

PARAMETERS INFLUENCING GRANULE QUALITY USING A CONTINUOUS GRANULATOR.

Chris VervaetHubert VermeerschMS KHOTZL MASSARTJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS

The influence of the extrusion screen on pellet quality using an instrumented basket extruder.

Chris VervaetLieven BaertPA RISHAJean Paul Remon

A1 Journal Article in INTERNATIONAL JOURNAL OF PHARMACEUTICS