Research Explorer

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Candy Kumps

Prijzen & Erkenningen

75 Resultaten

2023

Methylation signatures in clinically variable syndromic disorders: a familial <i>DNMT3A</i> variant in two adults with Tatton-Brown-Rahman syndrome

Candy KumpsErika D'haenensJennifer KerkhofHaley McconkeyMarielle AldersBekim SadikovicOlivier Vanakker

Redactioneel materiaal

Valuable insights after one year whole exome sequencing in a fetal/prenatal setting

Sarah DelbaereMachteld BaetensCandy KumpsEllen RoetsNOORTJE VAN OOSTRUMBert CallewaertSandra JanssensOlivier VanakkerBjörn Menten

2022

MYT1L-associated neurodevelopmental disorder : description of 40 new cases and literature review of clinical and molecular aspects

Juliette CoursimaultAnne-Marie GuerrotMichelle M. MorrowCatherine SchrammFrancisca Millan ZamoraAnita ShanmughamShuxi LiuFanggeng ZouFrederic BilanGwenael Le Guyader et al.

A1 Artikel in een tijdschrift in HUMAN GENETICS

2021

IQSEC2 disorder : a new disease entity or a Rett spectrum continuum?

Diego LopergoloFlavia PriviteraGiuseppe CastelloCaterina Lo RizzoMaria Antonietta MencarelliAnna Maria PintoFrancesca ArianiAurora CurròVittoria LamacchiaRoberto Canitano et al.

A1 Artikel in een tijdschrift in CLINICAL GENETICS

Pathogenic variants in CDH11 impair cell adhesion and cause Teebi hypertelorism syndrome

Dong LiMichael E. MarchPaola FortugnoLiza L. CoxLeticia S. MatsuokaRosanna MonettaChristoph SeilerLouise C. PyleEmma C. BedoukianMaría José Sánchez-Soler et al.

A1 Artikel in een tijdschrift in HUMAN GENETICS

Phenotypic spectrum of the RBM10-mediated intellectual disability and congenital malformation syndrome beyond classic TARP syndrome features

Candy KumpsErika D'haenensSarah VergultJasmine LeusRudy Van CosterAnna JansenKoen DevriendtAnna OostraOlivier Vanakker

A1 Artikel in een tijdschrift in CLINICAL GENETICS

2020

Phenotyping nocturnal polyuria : circadian and age-related variations in diuresis rate, free water clearance and sodium clearance

Thomas F MonaghanDonald L BliwiseMarie-Astrid DenysAn-Sofie GoessaertVeerle DecalfCandy KumpsJohan Vande WalleJeffrey P WeissMatthew R EpsteinJeremy Weedon et al.

A1 Artikel in een tijdschrift in AGE AND AGEING

The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness

Liselot MusIrina LambertzShana ClaeysCandy KumpsWouter Van LoockeChristophe Van NesteGanesh UmapathyMarica VaapilChristoph BartenhagenGenevieve Laureys et al.

A1 Artikel in een tijdschrift in SCIENTIFIC REPORTS

2019

ALK positively regulates MYCN activity through repression of HBP1 expression

Shana ClaeysGeertrui DeneckerKaat DurinckBieke DecaestekerLiselot MusSiebe LoontiensSuzanne VanhauwaertKristina AlthoffCaroline WigerupDaniel Bexell et al.

A1 Artikel in een tijdschrift in ONCOGENE

Smart diapers for nursing home residents with dementia : a pilot study

Anja HuionVeerle DecalfCandy KumpsNico De WitteKarel Everaert

A1 Artikel in een tijdschrift in ACTA CLINICA BELGICA

2018

Prognostic and therapeutic implications of circulating androgen receptor gene copy number in prostate cancer patients using droplet digital polymerase chain reaction

Sarah BuelensTom ClaeysBert DhondtFilip PoelaertMatthijs VynckNurten YigitOlivier ThasPiet OstJo VandesompeleNicolaas Lumen et al.

A1 Artikel in een tijdschrift in CLINICAL GENITOURINARY CANCER

2017

Androgen receptor gene copy number and protein expression in treatment-naïve prostate cancer

Filip PoelaertCandy KumpsNicolaas LumenStéphanie VerschuereLouis LibbrechtMarleen PraetSylvie RotteyTom ClaeysPiet OstKarel Decaestecker et al.

A1 Artikel in een tijdschrift in UROLOGIA INTERNATIONALIS

Androgen receptor gene copy number detection using droplet digital PCR and its therapeutic consequences in prostate cancer patients

Sarah BuelensTom ClaeysCandy KumpsBert DhondtFilip PoelaertNurten YigitMatthijs VynckOlivier ThasPiet OstJo Vandesompele et al.

Circadian variation in post void residual in nursing home residents with moderate impairment in activities of daily living

Veerle DecalfAnja HuionMarie-Astrid DenysCandy KumpsMirko PetrovicKarel Everaert

A1 Artikel in een tijdschrift in JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION

Circadian variations in water and sodium handling according to the age : a comparison between subjects with and without nocturnal polyuria

Marie-Astrid DenysAn-Sofie GoessaertVeerle DecalfCandy KumpsJohan Vande WalleKarel Everaert

Clean intermittent self-catheterization as a treatment modality for urinary retention : perceptions of urologists

Laurens WeynantsFrançois HervéVeerle DecalfCandy KumpsRonny PietersBart de TroyerKarel Everaert

A1 Artikel in een tijdschrift in INTERNATIONAL NEUROUROLOGY JOURNAL

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome

Shana ClaeysGeertrui DeneckerRobrecht CannoodtCandy KumpsKaat DurinckFranki SpelemanKatleen De Preter

A1 Artikel in een tijdschrift in ONCOTARGET

Instruction video of urodynamic studies in adults with air filled catheters

Veerle DecalfAnne-Françoise SpinoitINGE RAGOLLECandy KumpsMarie-Astrid DenysPiet HoebekeKarel Everaert

Pathophysiology of nocturnal lower urinary tract symptoms in older patients with urinary incontinence

Marie-Astrid DenysVeerle DecalfCandy KumpsMirko PetrovicAn-Sofie GoessaertKarel Everaert

A1 Artikel in een tijdschrift in INTERNATIONAL JOURNAL OF UROLOGY

Pathophysiology of nocturnal lower urinary tract symptoms in older patients with urinary incontinence : a major role for nocturnal sodium excretion

Marie-Astrid DenysVeerle DecalfCandy KumpsMirko PetrovicAn-Sofie GoessaertKarel Everaert

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The ETV5 oncogene is a target of activated ALK signaling in neuroblastoma

Liselot MusIrina LambertzCandy KumpsShana ClaeysGeertrui DeneckerWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van Roy et al.

The HBP1 tumour suppressor is a negative epigenetic regulator of MYCN-driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysGeertrui DeneckerBieke DecaestekerEls JanssensCandy KumpsSara De BrouwerIrina LambertzAnnelies FieuwSuzanne VanhauwaertKristina Althoff et al.

The independent oncological role for cytoreductive nephrectomy in metastatic renal cell carcinoma : prognostic features in the era of targeted therapies

Tom ClaeysNicolaas LumenCandy KumpsMarleen PraetGert De MeerleerSylvie RotteyPiet OstPieter De VisschereGeert VilleirsValerie Fonteyne et al.

A1 Artikel in een tijdschrift in UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

The occurrence and therapeutic consequences of androgen receptor copy number gain in prostate cancer patients using Droplet Digital PCR

Sarah BuelensTom ClaeysCandy KumpsBert DhondtFilip PoelaertY NurtenMatthijs VynckOlivier ThasPiet OstJo Vandesompele et al.

2016

ETV5 functionally connect ALK and CXCR4 signaling in neuroblastoma

Irina LambertzShana ClaeysCandy KumpsLiselot MusEls JanssensNadine Van RoyBram De WildeGenevieve LaureysJan CoolsOlivier De Wever et al.

ETV5 functionally connects ALK and CXCR4 signaling in neuroblastoma

Irina LambertzLiselot MusCandy KumpsShana ClaeysNadine Van RoyBram De WildeGenevieve LaureysJohannes ShulteOlivier De WeverKatleen De Preter et al.

Exploring nocturia in an older population

Marie-Astrid DenysVeerle DecalfElke BruneelCandy KumpsAnja VelgheMirko PetrovicKarel Everaert

Impact of side effects on choice of anti-cholinergic medications for overactive bladder in an older population : a discrete choice experiment

Candy KumpsVeerle DecalfDries BenoitAnja HuionMarie-Astrid DenysNico De WitteKarel Everaert

Sensing mutant ALK: Capicua and ETV5 as executors of aberrant ALK-driven MAPK signaling

Irina LambertzLiselot MusCandy KumpsShana ClaeysWouter Van LoockeChristophe Van NesteJan KosterRogier VersteegNadine Van RoyBram De Wilde et al.

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenBram De Wilde et al.

The HBP1 tumor suppressor is a negative epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzEls JanssensSuzanne VanhauwaertBieke DecaestekerCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenBram De Wilde et al.

The HBP1 tumor suppressor is an epigenetic regulator of MYCN driven neuroblastoma through interaction with the PRC2 complex

Shana ClaeysIrina LambertzAlan Van GoethemCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenKristina AlthoffJohannes SchulteJean-Baptiste Demoulin et al.

The circadian variation of post-void residuals in a population of institutionalized older people

Candy KumpsVeerle DecalfMarie-Astrid DenysAnja HuionMirko PetrovicKarel Everaert

Unravelling nocturnal polyuria in older patients

Marie-Astrid DenysVeerle DecalfElke BruneelCandy KumpsAnja VelgheMirko PetrovicKarel Everaert

2015

A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies

Kristina AlthoffAnneleen BeckersEmma BellMaike NortmeyerTheresa ThorAnnika SprüsselSven LindnerKatleen De PreterAlexandra FlorinLukas C Heukamp et al.

A1 Artikel in een tijdschrift in ONCOGENE

ETV5 functionally connect ALK and RET signaling in neuroblastoma

Irina LambertzShana ClaeysCandy KumpsLiselot MusAnneleen BeckersEls JanssensNadine Van RoyGenevieve LaureysJohannes SchulteOlivier De Wever et al.

HBP1 downregulation through mutant ALK represents a novel mechanism for cooperative MYCN activation in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemCandy KumpsSara De BrouwerAnnelies FieuwTom Van MaerkenKristina AlthoffJohannes SchulteJean-Baptiste Demoulin et al.

Synergistic combined molecular treatment targeting the HBP1 tumor suppressor gene in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemAnneleen BeckersCandy KumpsTom Van MaerkenJohannes SchulteKatleen De PreterFranki Speleman

The HBP1 tumour suppressor at multiple regulatory cross roads in neuroblastoma

Shana ClaeysIrina LambertzAlan Van GoethemAnneleen BeckersCandy KumpsTom Van MaerkenJohannes SchulteKatleen De PreterFranki Speleman

The value of a frequency-volume chart with post-void residuals in a normal population of institutionalized older people

Candy KumpsVeerle DecalfAnja HuionMarie-Astrid DenysMirko PetrovicNico De WitteKarel Everaert

The value of a frequency-volume chart with post-void residuals in a population of institutionalized older adults without cognitive impairment

Veerle DecalfAnja HuionNico De WitteCandy KumpsMarie-Astrid DenysMirko PetrovicKarel Everaert

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel R CarterAlex CazesBelamy B CheungMarilena De Mariano et al.

A1 Artikel in een tijdschrift in CLINICAL CANCER RESEARCH

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

Upregulation of MAPK negative feedback regulators and RET in mutant ALK neuroblastoma : implications for targeted treatment

Irina LambertzCandy KumpsShana ClaeysSven LindnerAnneleen BeckersEls JanssensDaniel CarterAlex CazesBelamy CheungMarilena De Mariano et al.

2014

Activated Alk triggers prolonged neurogenesis and Ret upregulation providing a therapeutic target in ALK-mutated neuroblastoma

Alex CazesLucille Lopez-DelisleKonstantina TsarovinaCécile Pierre-EugèneKatleen De PreterMichel PeuchmaurAndré NicolasClaire ProvostCaroline Louis-BrennetotRomain Daveau et al.

A1 Artikel in een tijdschrift in ONCOTARGET

Characterization of ALK driven molecular networks identifies perturbed RET and cholinergic signaling in neuroblastoma

Irina LambertzCandy KumpsShana ClaeysSven LindlerAnneleen BeckersEls JanssensMarilena De MarianoSara De BrouwerJay GibbonsGenevieve Laureys et al.

The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity

Shana ClaeysCandy KumpsIrina LambertzSara De BrouwerSven LindnerAlan Van GoethemTom Van MaerkenJorge VialardJan CoolsJohannes Schulte et al.

The HBP1 tumor suppressor is a druggable ALK downregulated gene controlling MYCN activity

Shana ClaeysCandy KumpsIrina LambertzSara De BrouwerSven LindnerAlan Van GoethemTom Van MaerkenJorge VialardJan CoolsJohannes Schulte et al.

2013

Effective Alu repeat based RT-qPCR normalization in cancer cell perturbation experiments

Ali RihaniTom Van MaerkenFilip PattynGert Van PeerAnneleen BeckersSara De BrouwerCandy KumpsEvelien MetsJoni Van der MeulenPieter Rondou et al.

A1 Artikel in een tijdschrift in PLOS ONE

Focal DNA copy number changes in neuroblastoma target MYCN regulated genes

Candy KumpsAnnelies FieuwPieter MestdaghBjörn MentenSteve LefeverFilip PattynSara De BrouwerTom SanteJohannes Hubertus SchulteAlexander Schramm et al.

A1 Artikel in een tijdschrift in PLOS ONE

Genome wide expression, mutation and methylation analysis validates three new mouse models for neuroblastoma targeting MYCN, ALK and LIN28B for pre-clinical studies

Anneleen BeckersBram De WildeMaté OngenaertCandy KumpsJohannes H SchulteJo VandesompeleKatleen De PreterFranki Speleman

Perturbed signaling pathways in neuroblastoma : from MYCN to ALK and back

Candy KumpsFranki SpelemanKatleen De Preter

The need for transparency and good practices in the qPCR literature

Stephen A BustinVladimir BenesJeremy GarsonJan HellemansJim HuggettMikael KubistaReinhold MuellerTania NolanMichael W PfafflGregory Shipley et al.

A1 Artikel in een tijdschrift in NATURE METHODS

2012

ALK(F1174L) is a driving oncogene of neuroblastoma in transgenic mice

Johannes SchulteLukas HeukampTheresa ThorCandy KumpsKatleen De PreterBram De WildeJo VandesompeleFranki SpelemanAlexander SchrammAngelika Eggert

Genomic profiling of MYCN and ALKF1174L transgenic neuroblastoma mouse models provides insights into the dynamic process of tumor formation

Katleen De PreterAnneleen BeckersCandy KumpsPieter MestdaghAngelika EggertJo VandesompeleFranki SpelemanJohannes H Schulte

Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas

Annelies FieuwCandy KumpsAlexander SchrammFilip PattynBjörn MentenFrancesca AntonacciPeter SudmantJohannes H SchulteNadine Van RoySarah Vergult et al.

A1 Artikel in een tijdschrift in INTERNATIONAL JOURNAL OF CANCER

Isolation of disseminated neuroblastoma cells from bone marrow aspirates for pretreatment risk assessment by array comparative genomic hybridization

Mado VandewoestyneCandy KumpsKatrien SwertsBjörn MentenTim LammensJan PhilippéKatleen De PreterGenevieve LaureysNadine Van RoyFranki Speleman et al.

A1 Artikel in een tijdschrift in INTERNATIONAL JOURNAL OF CANCER

MiR-137 is epigenetically silenced in MYCN amplified neuroblastoma and targets the polycomb repressive complex 2 (PRC2) component EZH2

Anneleen BeckersMaté OngenaertAnneleen DecockCandy KumpsFilip PattynPieter MestdaghJohannes H. SchulteFranki SpelemanKatleen De Preter

MiR-137 is epigenetically silenced in MYCN amplified neuroblastomas and targets the polycomb repressive complex 2 (PRC2) component EZH2

Anneleen BeckersMaté OngenaertAnneleen DecockCandy KumpsFilip Pattynthe Neuroblastoma Research Consortium (NRC)Pieter MestdaghJohannes H SchulteFranki SpelemanKatleen De Preter

Targeted expression of mutated ALK induces neuroblastoma in transgenic mice

Lukas C HeukampTheresa ThorAlexander SchrammKatleen De PreterCandy KumpsBram De WildeAndrea OderskyMartin PeiferSven LindnerAnnika Spruessel et al.

A1 Artikel in een tijdschrift in SCIENCE TRANSLATIONAL MEDICINE

2011

Identification of a new rare recurrent 1q42.2-qter deletion in neuroblastoma

Annelies FieuwCandy KumpsAlexander SchrammBjörn MentenJohannes SchulteNadine Van RoySarah VergultRosa NogueraRogier VersteegR Stallings et al.

Identification of tumoral glial precursor cells in neuroblastoma

Sandra AcostaGemma MayolEva RodríguezCinzia LavarinoKatleen De PreterCandy KumpsIdoia GarciaCarmen de TorresJaume Mora

A1 Artikel in een tijdschrift in CANCER LETTERS

MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival

EA AfanasyevaPieter MestdaghCandy KumpsJo VandesompeleV EhemannJ TheissenMark ZapatkaBenedikt BrorsL SavelyevaV Sagulenko et al.

A1 Artikel in een tijdschrift in CELL DEATH AND DIFFERENTIATION

2010

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Pieter MestdaghE FredlundFilip PattynAli RihaniTom Van MaerkenJoëlle VermeulenCandy KumpsBjörn MentenKatleen De PreterA Schramm et al.

A1 Artikel in een tijdschrift in ONCOGENE

An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Pieter MestdaghErik FredlundFilip PattynAli RihaniTom Van MaerkenJoëlle VermeulenCandy KumpsBjörn MentenKatleen De PreterAlexander Schramm et al.

MYCN/c-MYC-induced microRNAs repress coding gene networks associated with poor outcome in MYCN/c-MYC-activated tumors

Pieter MestdaghE FredlundFilip PattynJH SchulteD MuthJoëlle VermeulenCandy KumpsS SchlierfKatleen De PreterNadine Van Roy et al.

A1 Artikel in een tijdschrift in ONCOGENE

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

Sara De BrouwerKatleen De PreterCandy KumpsPiotr ZabrockiMichael PorcuEllen M WesterhoutArjan LakemanJo VandesompeleJasmien HoebeeckTom Van Maerken et al.

A1 Artikel in een tijdschrift in CLINICAL CANCER RESEARCH

Multiplex Amplicon Quantification (MAQ), a fast and efficient method for the simultaneous detection of copy number alterations in neuroblastoma

Candy KumpsNadine Van RoyL HeyrmanD GoossensJ Del-FaveroR NogueraJo VandesompeleFranki SpelemanKatleen De Preter

A1 Artikel in een tijdschrift in BMC GENOMICS

The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors

Deborah CastellettiGiulio FiaschettiValeria Di DatoUrs ZieglerCandy KumpsKatleen De PreterMassimo ZolloFranki SpelemanTarek ShalabyDaniela De Martino et al.

A1 Artikel in een tijdschrift in MOLECULAR CANCER THERAPEUTICS

2009

Smoothing waves in array CGH tumor profiles

Mark A van de WielRebecca BrosensPaul HC EilersCandy KumpsGerrit A MeijerBjörn MentenErik SistermansFranki SpelemanMarieke E TimmermanBauke Ylstra

A1 Artikel in een tijdschrift in BIOINFORMATICS

2008

Copy number alterations and copy number variation in cancer: close encounters of the bad kind

Franki SpelemanCandy KumpsKaren BuysseBruce PoppeBjörn MentenKatleen De Preter

A1 Artikel in een tijdschrift in CYTOGENETIC AND GENOME RESEARCH

Low-cost dedicated mini-arrays for high-throughput analysis of DNA copy-number alterations in neuroblastoma

Katleen De PreterBjörn MentenSara De BrouwerCandy KumpsEvi MichelsNadine Van RoyJo VandesompeleFranki Speleman

A1 Artikel in een tijdschrift in CANCER LETTERS