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Onderzoeker
Boel De Paepe
Profiel
Projecten
Publicaties & datasets
Activiteiten
Prijzen & Erkenningen
Octrooien
236
Resultaten
2025
Changes to the autophagy-related muscle proteome following short-term treatment with ectoine in the Duchenne muscular dystrophy mouse model mdx
Eulàlia Gómez Armengol
Caroline Merckx
Hanne De Sutter
Jan De Bleecker
Boel De Paepe
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2025
Early taurine administration decreases the levels of receptor-interacting serine/threonine protein kinase 1 in the Duchenne mouse model mdx
Marthe Dias
Hanne Dhuyvetter
Ella Byttebier
Caroline Merckx
Jan De Bleecker
Boel De Paepe
A1
Artikel in een tijdschrift
in
BRAIN SCIENCES
2025
Genetic architecture of idiopathic inflammatory myopathies from meta‐analyses
Catherine Zhu
Younghun Han
Jinyoung Byun
Xiangjun Xiao
Simon Rothwell
Frederick W. Miller
Ingrid E. Lundberg
Peter K. Gregersen
Jiri Vencovsky
Vikram R. Shaw
et al.
A1
Artikel in een tijdschrift
in
ARTHRITIS & RHEUMATOLOGY
2025
The cytokine growth differentiation factor-15 as a disease biomarker for skeletal muscle health and beyond
Boel De Paepe
U
Conferentie
2025
2024
Autoantibodies against a subunit of mitochondrial respiratory chain complex I in inclusion body myositis
Antonella Notarnicola
Ceke Hellstrom
Begum Horuluoglu
Elisa Pin
Charlotta Preger
Francesco Bonomi
Boel De Paepe
Jan De Bleecker
Anneke J. Van der Kooi
Marianne De Visser
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF AUTOIMMUNITY
2024
Comparison of clinical features between patients with anti-synthetase syndrome and dermatomyositis : results from the MYONET registry
Ryan Malcolm Hum
James B Lilleker
Janine A Lamb
Alexander G S Oldroyd
Guochun Wang
Lucy R Wedderburn
Louise P Diederichsen
Jens Schmidt
Maria Giovanna Danieli
Paula Oakley
et al.
A1
Artikel in een tijdschrift
in
RHEUMATOLOGY
2024
Discovery of new myositis genetic associations through leveraging other immune-mediated diseases
Guillermo Reales
Christopher I. Amos
Olivier Benveniste
Hector Chinoy
Jan De Bleecker
Boel De Paepe
Andrea Doria
Peter K. Gregersen
Janine A. Lamb
Vidya Limaye
et al.
A2
Artikel in een tijdschrift
in
HUMAN GENETICS AND GENOMICS ADVANCES
2024
Ectoine treatment stimulates protein markers of autophagy efficiency in the Duchenne muscular dystrophy mouse model mdx
Eulàlia Gómez Armengol
Caroline Merckx
Jan De Bleecker
Boel De Paepe
C3
Conferentie
2024
Maak kennis met de UGent studenten betrokken bij innovatief onderzoek naar spinale musculaire atrofie
Boel De Paepe
Lennart Mariën
A4
Artikel in een tijdschrift
in
SPIERKRACHT
2024
Potential new autoimmune target in inclusion body myositis
A Notarnicola
C Hellstrom
B Horuluoglu
C Preger
F Bonomi
Boel De Paepe
Jan De Bleecker
A Van der Kooi
M de Visser
S Sacconi
et al.
C3
Conferentie
2024
2023
C-terminal frameshift variant of TDP-43 with pronounced aggregation-propensity causes rimmed vacuole myopathy but not ALS/FTD
Pedro Ervilha Pereira
Nika Schuermans
Antoon Meylemans
Pontus LeBlanc
Lauren Versluys
KE Copley
JD Rubien
C Altheimer
Myra Peetermans
Elke Debackere
et al.
A1
Artikel in een tijdschrift
in
ACTA NEUROPATHOLOGICA
2023
De toekomst van innovatief onderzoek naar Duchenne spierdystrofie: Maak kennis met de huidige lichting studenten in het laboratorium voor neuropathologie
Boel De Paepe
Artikel in een magazine
2023
Diagnose en subtypering van myositis op basis van cytokine profielen : hoe wetenschappelijke inzichten langzaam de weg kunnen vinden naar de kliniek
Boel De Paepe
A4
Artikel in een tijdschrift
in
SPIERKRACHT
2023
Identification of novel associations and localization of signals in idiopathic inflammatory myopathies using genome‐wide imputation
Simon Rothwell
Christopher I. Amos
Frederick W. Miller
Lisa G. Rider
Ingrid E. Lundberg
Peter K. Gregersen
Jiri Vencovsky
Neil McHugh
Vidya Limaye
Albert Selva‐O'Callaghan
et al.
A1
Artikel in een tijdschrift
in
ARTHRITIS & RHEUMATOLOGY
2023
Low gene copy numbers of complement C4 and complement C4A deficiency are strong and highly significant genetic risk factors for idiopathic inflammatory myopathy and its major subgroups
Daniel Zhou
Emily King
Simon Rothwell
Olga Krystufkova
Antonella Notarnicola
Rabheh Aziz
Emeli Lundstrom
Blanka Stiburkova
Lauren Pachman
Gulnara Mamyrova
et al.
C3
Conferentie
2023
mTOR inhibition enhances delivery and activity of antisense oligonucleotides in uveal melanoma cells
Shanna Dewaele
Louis Delhaye
Boel De Paepe
Bram Bogaert
Ramiro Martinez
Jasper Anckaert
Nurten Yigit
Justine Nuytens
Rudy Van Coster
Sven Eyckerman
et al.
A1
Artikel in een tijdschrift
in
NUCLEIC ACID THERAPEUTICS
2023
Neonatal lactic acidosis explained by LARS2 defect
Boel De Paepe
Joél Smet
Robert Kopajtich
Holger Prokisch
Rudy Van Coster
Arnaud Vanlander
A1
Artikel in een tijdschrift
in
PEDIATRIC RESEARCH
2023
Organic osmolytes and Duchenne muscular dystrophy : from homeostasis, inflammation and skeletal muscle regeneration to therapeutic target
Sandrine Herbelet
Caroline Merckx
Boel De Paepe
Hoofdstuk in een boek
in
Novel Research Aspects in Medicine and Medical Science Vol. 7
2023
Osmolytes and their therapeutic applicability in the mdx mouse
Caroline Merckx
Jan De Bleecker
Boel De Paepe
Proefschrift
2023
Retrospective study shows that serum levels of chemokine CXCL10 and cytokine GDF15 support a diagnosis of sporadic inclusion body myositis and immune-mediated necrotizing myopathy
Boel De Paepe
Ken Bracke
Jan De Bleecker
A1
Artikel in een tijdschrift
in
BRAIN SCIENCES
2023
2022
A structural variant of the C-terminal prion-like domain of TDP-43 causes vacuolar muscle degeneration
Pedro Ervilha Pereira
Nika Schuermans
Antoon Meylemans
Pontus LeBlanc
L Versluys
Elke Debackere
Olivier Vanakker
Sara Janssens
Jonathan Baets
K Verhoeven
et al.
C3
Conferentie
2022
An exploratory study of circulating cytokines and chemokines in patients with muscle disorders proposes CD40L and CCL5 represent general disease markers while CXCL10 differentiates between patients with an autoimmune myositis
Boel De Paepe
Ken Bracke
Jan De Bleecker
A2
Artikel in een tijdschrift
in
CYTOKINE. X
2022
Clinical features of extra-muscular disease in dermatomyositis and anti-synthetase syndrome patients with skin involvement classified by presence of disease-specific autoantibodies : results from the EuroMyositis registry
Ryan M Hum
James B Lilleker
Janine A Lamb
William E Ollier
Guochung Wang
Lucy R Wedderburn
Louise P Diederichsen
Jens Schmidt
Paula Oakley
Olivier Benveniste
et al.
C3
Conferentie
2022
Clinical heterogeneity in MT-ATP6 pathogenic variants : same genotype—different onset
Sara Capiau
Joél Smet
Boel De Paepe
Yilmaz Yildiz
Mutluay Arslan
Olivier Stevens
Maxime Verschoore
Hedwig Stepman
Sara Seneca
Arnaud Vanlander
A1
Artikel in een tijdschrift
in
CELLS
2022
Description of osmolyte pathways in maturing mdx mice reveals altered levels of taurine and sodium/myo-inositol co-transporters
Caroline Merckx
Gwenny Cosemans
Jana Zschüntzsch
Robrecht Raedt
Jens Schmidt
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022
Description of osmolyte pathways in maturing MDX mice reveals altered taurine and sodium/myo-inositol co-transporter levels
Caroline Merckx
Gwenny Cosemans
Jana Zschuentzsch
Jens Schmidt
Boel De Paepe
Jan De Bleecker
C3
Conferentie
2022
Expanded phenotyping by microscopic imaging
Frank Roels
PATRICK VERLOO
Boel De Paepe
Jan De Bleecker
Rudy Van Coster
C3
Conferentie
2022
Expanding the TDP-43 proteinopathy pathway from neurons to muscle : physiological and pathophysiological functions
Lauren Versluys
Pedro Ervilha Pereira
Nika Schuermans
Boel De Paepe
Jan De Bleecker
Elke Bogaert
Bart Dermaut
A1
Artikel in een tijdschrift
in
FRONTIERS IN NEUROSCIENCE
2022
Exploring the therapeutic potential of ectoine in Duchenne Muscular Dystrophy : comparison with taurine, a supplement with known beneficial effects in the mdx mouse
Caroline Merckx
Jana Zschüntzsch
Stefanie Meyer
Robrecht Raedt
Hanne Verschuere
Jens Schmidt
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2022
Inducible heat shock protein 70 levels in patients and the mdx mouse affirm regulation during skeletal muscle regeneration in muscular dystrophy
Gwenny Cosemans
Caroline Merckx
Jan De Bleecker
Boel De Paepe
A2
Artikel in een tijdschrift
in
FRONTIERS IN BIOSCIENCE (SCHOLAR ED.)
2022
Osmolyten als ondersteunende therapie voor Duchenne musculaire dystrofie : het potentieel van taurine en ectoïne als voedingssupplement
Boel De Paepe
A4
Artikel in een tijdschrift
in
SPIERKRACHT
2022
Osmotic stress-associated sodium/myo-inositol co-transporter is upregulated in skeletal muscle of the mdx mouse
Caroline Merckx
Gwenny Cosemans
Jana Zschuentzsch
Jens Schmidt
Jan De Bleecker
Boel De Paepe
C3
Conferentie
2022
The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival
Shanna Dewaele
Louis Delhaye
Boel De Paepe
Eric de Bony de Lavergne
Jilke De Wilde
Katrien Vanderheyden
Jasper Anckaert
Nurten Yigit
Justine Nuytens
Eveline Vanden Eynde
et al.
A1
Artikel in een tijdschrift
in
ONCOGENE
2022
The long non-coding RNA SAMMSON is essential for uveal melanoma cell survival (Sept, 10.1038/s41388-021-02006-x, 2021)
Shanna Dewaele
Louis Delhaye
Boel De Paepe
Eric James de Bony
Jilke De Wilde
Katrien Vanderheyden
Jasper Anckaert
Nurten Yigit
Justine Nuytens
Eveline Vanden Eynde
et al.
Correctie
2022
The role of taurine in skeletal muscle functioning and its potential as a supportive treatment for Duchenne Muscular Dystrophy
Caroline Merckx
Boel De Paepe
A1
Artikel in een tijdschrift
in
METABOLITES
2022
Urine lactate concentration as a non-invasive screener for metabolic abnormalities : findings in children with autism spectrum disorder and regression
Sofie Boterberg
Elise Vantroys
Boel De Paepe
Rudy Van Coster
Herbert Roeyers
A1
Artikel in een tijdschrift
in
PLOS ONE
2022
2021
Diagnostic muscle biopsies in the era of genetics : the added value of myopathology in a selection of limb-girdle muscular dystrophy patients
Boel De Paepe
Elise Velghe
Linnea Salminen
Balint Toth
Pieter Olivier
Jan De Bleecker
A1
Artikel in een tijdschrift
in
ACTA NEUROLOGICA BELGICA
2021
Duchenne muscular dystrophy fibrosis potentially explained by abnormal NFAT5 physiology in Duchenne muscular dystrophy fibroblasts
Sandrine Herbelet
Boel De Paepe
Jan De Bleecker
Hoofdstuk in een boek
in
New Innovations in Chemistry and Biochemistry Vol. 5
2021
Hoe ontstaan chronische klachten bij patiënten met fibromyalgie? De insula, een hersengebied met een mogelijke sleutelrol
Boel De Paepe
Joél Smet
Chris Baeken
Mira Meeus
Indra De Greef
Arnaud Vanlander
Jessica Van Oosterwijck
A2
Artikel in een tijdschrift
in
HUISARTS NU (BERCHEM)
2021
NFAT5 in myositis and Duchenne muscular dystrophy : localization, expression and interaction with glucocorticoids in in vitro cell models
Sandrine Herbelet
Jan De Bleecker
Boel De Paepe
Proefschrift
2021
Pathologie van dunne vezels als link tussen de zeldzame diagnose van dunnevezelneuropathie en de vaak voorkomende aandoening fibromyalgie
Boel De Paepe
A4
Artikel in een tijdschrift
in
SPIERKRACHT
2021
Studies on anti-inflammatory and general glucocorticoid physiology in skeletal muscles affected by Duchenne muscular dystrophy : an approach towards exploration of steroid-sparing agents
Sandrine Herbelet
Arthur Rodenbach
Boel De Paepe
Jan De Bleecker
Hoofdstuk in een boek
in
Current advances in chemistry and biochemistry, vol. 7
2021
Study of NFAT5 physiology in Duchenne muscular dystrophy fibroblasts : provisionary explanation for the permanent fibrosis formation in Duchenne muscular dystrophy
Sandrine Herbelet
Boel De Paepe
Jan De Bleecker
Hoofdstuk in een boek
in
Recent Research Advances in Biology Vol. 9
2021
The heterogeneity of immune-mediated necrotizing myopathy illustrated in a cohort of Belgian patients : consequences for diagnosis and disease management
Boel De Paepe
Jan De Bleecker
Hoofdstuk in een boek
in
Advances in health and disease
2021
The PKA-p38MAPK-NFAT5-organic osmolytes pathway in Duchenne muscular dystrophy : from essential player in osmotic homeostasis, inflammation and skeletal muscle regeneration to therapeutic target
Sandrine Herbelet
Caroline Merckx
Boel De Paepe
A1
Artikel in een tijdschrift
in
BIOMEDICINES
2021
2020
A capital role for the brain’s insula in the diverse fibromyalgia-associated symptoms
Boel De Paepe
Joél Smet
Chris Baeken
Jessica Van Oosterwijck
Mira Meeus
A1
Artikel in een tijdschrift
in
MEDICAL HYPOTHESES
2020
Abnormal NFAT5 physiology in Duchenne muscular dystrophy fibroblasts as a putative explanation for continuous fibrotic tissue production and the interaction between NFAT5 and glucocorticoid receptor
Sandrine Herbelet
Boel De Paepe
Jan De Bleecker
C3
Conferentie
2020
Abnormal NFAT5 physiology in Duchenne muscular dystrophy fibroblasts as a putative explanation for the permanent fibrosis formation in Duchenne muscular dystrophy
Sandrine Herbelet
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
Anti-inflammatory and general glucocorticoid physiology in skeletal muscles affected by Duchenne muscular dystrophy : exploration of steroid-sparing agents
Sandrine Herbelet
Arthur Rodenbach
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
Description of a novel mechanism possibly explaining the antiproliferative properties of glucocorticoids in Duchenne muscular dystrophy fibroblasts based on glucocorticoid receptor GR and NFAT5
Sandrine Herbelet
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
Localization and expression of nuclear factor of activated T-cells 5 in myoblasts exposed to pro-inflammatory cytokines or hyperosmolar stress and in biopsies from myositis patients
Sandrine Herbelet
Elly De Vlieghere
Amanda Gonçalves
Boel De Paepe
Karsten Schmidt
Eline Nys
Laurens Weynants
Joachim Weis
Gert Van Peer
Jo Vandesompele
et al.
Hoofdstuk in een boek
in
Myokines, adipokines, cytokines in muscle pathophysiology
2020
mTor inhibitor GDC-0349 improves ASO induced SAMMSON knock down resulting in enhanced anti-tumor efficacy in uveal melanoma
Shanna Dewaele
Boel De Paepe
Louis Delhaye
Eric de Bony de Lavergne
Jilke De Wilde
Katrien Vanderheyden
Jasper Anckaert
Nurten Yigit
Eveline Vanden Eynde
Fariba Nemati
et al.
C3
Conferentie
2020
mTor inhibitor GDC-0349 improves ASO induced SAMMSON knock down resulting in enhanced anti-tumor efficacy in uveal melanoma
Shanna Dewaele
Boel De Paepe
Louis Delhaye
Eric de Bony de Lavergne
Jilke De Wilde
Katrien Vanderheyden
Jasper Anckaert
Nurten Yigit
Eveline Vanden Eynde
Fariba Nemati
et al.
C3
Conferentie
2020
Myo-inositol transporter SLC5A3 associates with degenerative changes and inflammation in sporadic inclusion body myositis
Boel De Paepe
Caroline Merckx
Jana Jarosova
Miryam Cannizzaro
Jan De Bleecker
A1
Artikel in een tijdschrift
in
BIOMOLECULES
2020
Nanoscopic X-ray imaging and quantification of the iron cellular architecture within single fibroblasts of Friedreich's ataxia patients
Björn De Samber
Tom Vanden Berghe
Eline Meul
Stephen Bauters
Martin Seyrich
Joél Smet
Boel De Paepe
Julio Cesar da Silva
Sylvain Bohic
Peter Cloetens
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF SYNCHROTRON RADIATION
2020
Progressive skeletal muscle atrophy in muscular dystrophies : a role for toll-like receptor-signaling in disease pathogenesis
Boel De Paepe
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2020
The myokine GDF-15 is a potential biomarker for myositis and associates with the protein aggregates of sporadic inclusion body myositis.
Boel De Paepe
Fien Verhamme
Jan De Bleecker
A1
Artikel in een tijdschrift
in
Cytokine
2020
2019
How mitochondrial DNA-driven changes to chromosomal DNA methylation add a layer of complexity to mitochondrial disease
Boel De Paepe
Redactioneel materiaal
2019
Idiopathic inflammatory myopathy : interrater variability in muscle biopsy reading
Pieter Olivier
Boel De Paepe
Eleonora Aronica
Florieke Berfelo
Roos Colman
Anthony Amato
Dalia Dimitri
Eduard Gallardo
Romain Gherardi
Hans-Hilmar Goebel
et al.
A1
Artikel in een tijdschrift
in
NEUROLOGY
2019
Muscular dystrophy with arrhythmia caused by loss-of-function mutations in BVES
Willem De Ridder
Isabelle Nelson
Bob Asselbergh
Boel De Paepe
Maud Beuvin
Rabah Ben Yaou
Cécile Masson
Anne Boland
Jean-François Deleuze
Thierry Maisonobe
et al.
A1
Artikel in een tijdschrift
in
NEUROLOGY-GENETICS
2019
Sporadic inclusion body myositis : an acquired mitochondrial disease with extras
Boel De Paepe
A1
Artikel in een tijdschrift
in
BIOMOLECULES
2019
The changed transcriptome of muscular dystrophy and inflammatory myopathy : contributions of non-coding RNAs to muscle damage and recovery
Boel De Paepe
A2
Artikel in een tijdschrift
in
OBM GENETICS
2019
Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma
Shanna Dewaele
Katrien Vanderheyden
Boel De Paepe
Louis Delhaye
Fariba Nemati
Didier Decaudin
Sven Eyckerman
Rudy Van Coster
Jo Vandesompele
Pieter Mestdagh
C3
Conferentie
2019
Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma
Shanna Dewaele
Katrien Vanderheyden
Boel De Paepe
Louis Delhaye
Fariba Nemati
Didier Decaudin
Sven Eyckerman
Rudy Van Coster
Jo Vandesompele
Pieter Mestdagh
C3
Conferentie
2019
Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma
Shanna Dewaele
Katrien Vanderheyden
Boel De Paepe
Louis Delhaye
Fariba Nemati
Didier Decaudin
Sven Eyckerman
Rudy Van Coster
Jo Vandesompele
Pieter Mestdagh
C3
Conferentie
2019
2018
BVES loss-of-function mutations in limb-girdle muscular dystrophy 2X with cardiac conduction disorders
I Nelson
W De Ridder
B Asselbergh
Boel De Paepe
M Beuvin
R Ben Yaou
A Boland
J Deleuze
T Maisonobe
B Eymard
et al.
C3
Conferentie
2018
Complex III deficiency due to a homozygous mutation in the nuclear encoded subunit UQCRQ
Rudy Van Coster
Joél Smet
Boel De Paepe
Elise Vantroys
Femke Nachtergaele
Sarah Vergult
Björn Menten
Arnaud Vanlander
François-Guillaume Debray
C3
Conferentie
2018
Cyclic vomiting in a subject with homoplasmic m.14674T>C alteration
Elise Vantroys
Boel De Paepe
Joél Smet
Femke Nachtergaele
Sara Seneca
Arnaud Vanlander
Rudy Van Coster
C3
Conferentie
2018
Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis
Joanna E Parkes
Simon Rothwell
Alexander Oldroyd
Hector Chinoy
Janine A Lamb
the Myositis Genetics Consortium (MYOGEN)
Jan De Bleecker
Boel De Paepe
A1
Artikel in een tijdschrift
in
ARTHRITIS RESEARCH & THERAPY
2018
How long noncoding RNAs enforce their will on mitochondrial activity : regulation of mitochondrial respiration, reactive oxygen species production, apoptosis, and metabolic reprogramming in cancer
Boel De Paepe
Steve Lefever
Pieter Mestdagh
A1
Artikel in een tijdschrift
in
CURRENT GENETICS
2018
Induction of osmolyte pathways in skeletal muscle inflammation : novel biomarkers for myositis
Boel De Paepe
Jana Zschüntzsch
Tea Šokčević
Joachim Weis
Jens Schmidt
Jan De Bleecker
A1
Artikel in een tijdschrift
in
FRONTIERS IN NEUROLOGY
2018
Localization and expression of nuclear factor of activated T-cells 5 in myoblasts exposed to pro-inflammatory cytokines or hyperosmolar stress and in biopsies from myositis patients
Sandrine Herbelet
Elly De Vlieghere
Amanda Gonçalves
Boel De Paepe
Karsten Schmidt
Eline Nys
Laurens Weynants
Joachim Weis
Gert Van Peer
Jo Vandesompele
et al.
A1
Artikel in een tijdschrift
in
FRONTIERS IN PHYSIOLOGY
2018
Nanoscopic X-ray fluorescence imaging and quantification of intracellular key-elements in cryofrozen Friedreich's ataxia fibroblasts
Björn De Samber
Eline Meul
Brecht Laforce
Boel De Paepe
Joél Smet
Michiel De Bruyne
Riet De Rycke
Sylvain Bohic
Peter Cloetens
Rudy Van Coster
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2018
Near-infrared spectroscopy screening to allow detection of pathogenic mitochondrial DNA variants in individuals with unexplained abnormal fatigue : a preliminary study
Bert Celie
An Mariman
Jan Boone
LIESBETH DELESIE
Els Tobback
Sara Seneca
Boel De Paepe
Dirk Vogelaers
Rudy Van Coster
Jan Bourgois
A1
Artikel in een tijdschrift
in
APPLIED SPECTROSCOPY
2018
NFAT5 and p38 MAPKs interact in muscle cells responding to osmotic and inflammatory stress and in polymyositis
Boel De Paepe
Sandrine Herbelet
Jens Schmidt
Jan De Bleecker
C3
Conferentie
2018
The clinical heterogeneity of the NARS2 c.822G>C mutation clearly illustrated in two siblings : epilepsy and myopathy
Arnaud Vanlander
Helene Verhelst
Elise Vantroys
Joél Smet
Boel De Paepe
Sarah Vergult
Björn Menten
Rudy Van Coster
C3
Conferentie
2018
The EuroMyositis registry : an international collaborative tool to facilitate myositis research
James B Lilleker
Jiri Vencovsky
Guochun Wang
Lucy R Wedderburn
Louise Pyndt Diederichsen
Jens Schmidt
Paula Oakley
Olivier Benveniste
Maria Giovanna Danieli
Katalin Danko
et al.
A1
Artikel in een tijdschrift
in
ANNALS OF THE RHEUMATIC DISEASES
2018
Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma
Shanna Dewaele
Katrien Vanderheyden
Boel De Paepe
Fariba Nemati
Sergio Roman Roman
Rudy Van Coster
Jo Vandesompele
Pieter Mestdagh
C3
Conferentie
2018
Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma
Shanna Dewaele
Katrien Vanderheyden
Boel De Paepe
Fariba Nemati
Sergio Roman Roman
Rudy Van Coster
Jo Vandesompele
Pieter Mestdagh
C3
Conferentie
2018
2017
A critical assessment of the therapeutic potential of resveratrol supplements for treating mitochondrial disorders
Boel De Paepe
Rudy Van Coster
A1
Artikel in een tijdschrift
in
NUTRIENTS
2017
A recipe for myositis : nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines
Boel De Paepe
A2
Artikel in een tijdschrift
in
AIMS ALLERGY AND IMMUNOLOGY
2017
Cytokines as orchestrators of skeletal muscle tissue maintenance and the inflammation associated with acquired autoimmune and hereditary muscle diseases
Boel De Paepe
Hoofdstuk in een boek
in
Cytokine effector functions in tissues
2017
Immune-array analysis in sporadic inclusion body myositis reveals HLA-DRB1 amino acid heterogeneity across the myositis spectrum
Simon Rothwell
Robert G Cooper
Ingrid E Lundberg
Peter K Gregersen
Michael G Hanna
Pedro M Machado
Megan K Herbert
Ger JM Pruijn
James B Lilleker
Mark Roberts
et al.
A1
Artikel in een tijdschrift
in
ARTHRITIS & RHEUMATOLOGY
2017
New insights into the phenotype of FARS2 deficiency
Elise Vantroys
Austin Larson
Marisa Friederich
Kaz Knight
Michael A Swanson
Christopher A Powell
Joél Smet
Sarah Vergult
Boel De Paepe
Sara Seneca
et al.
A1
Artikel in een tijdschrift
in
MOLECULAR GENETICS AND METABOLISM
2017
Osmolyte accumulator expression is induced in muscle cells in response to inflammation
Boel De Paepe
Jana Zschuntzsch
Jan De Bleecker
Jens Schmidt
C3
Conferentie
2017
Osmolyte transporters of Betaine GABA (SLC6Al2) and taurine (SLC5A3) are expressed in muscle-infiltrating mononuclear cells in inflammatory myopathies
Boel De Paepe
Joachim Weis
Jan De Bleecker
C3
Conferentie
2017
Osmolytes as mediators of the muscle tissue’s responses to inflammation : emerging regulators of myositis with therapeutic potential
Boel De Paepe
A2
Artikel in een tijdschrift
in
EUROPEAN MEDICAL JOURNAL. RHEUMATOLOGY
2017
POLG2 deficiency causes adult-onset syndromic sensory neuropathy, ataxia and parkinsonism
Lionel Van Maldergem
Arnaud Besse
Boel De Paepe
Emma L Blakely
Vivek Appadurai
Margaret M Humble
Juliette Piard
Kate Craig
Langping He
Pierre Hella
et al.
A1
Artikel in een tijdschrift
in
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
2017
Therapeutic applications of SAMMSON lncRNA inhibition in uveal melanoma
Shanna Dewaele
Katrien Vanderheyden
Boel De Paepe
Fariba Nemati
Sergio Roman Roman
Rudy Van Coster
Jo Vandesompele
Pieter Mestdagh
C3
Conferentie
2017
Vascular changes and perifascicular muscle fiber damage in dermatomyositis : another question of the chicken or the egg that is on our mind
Boel De Paepe
Redactioneel materiaal
2017
2016
Activation of osmolyte pathways in inflammatory myopathy and Duchenne muscular dystrophy points to osmoregulation as a contributing pathogenic mechanism
Boel De Paepe
Jean-Jacques Martin
Sandrine Herbelet
Cecilia Jimenez-Mallebrera
Estibaliz Iglesias
Cristina Jou
Joachim Weis
Jan De Bleecker
A1
Artikel in een tijdschrift
in
LABORATORY INVESTIGATION
2016
Biallelic mutations in TMEM126B cause severe complex I deficiency with a variable clinical phenotype
Charlotte L Alston
Alison G Compton
Luke E Formosa
Valentina Strecker
Monika Oláhová
Tobias B Haack
Joél Smet
Katrien Stouffs
Peter Diakumis
Elżbieta Ciara
et al.
A1
Artikel in een tijdschrift
in
AMERICAN JOURNAL OF HUMAN GENETICS
2016
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups
Simon Rothwell
Robert G Cooper
Ingrid E Lundberg
Frederick W Miller
Peter K Gregersen
John Bowes
Jiri Vencovsky
Katalin Danko
Vidya Limaye
Albert Selva-O'Callaghan
et al.
A1
Artikel in een tijdschrift
in
ANNALS OF THE RHEUMATIC DISEASES
2016
Inflammatory mediators in inflammatory myopathies
Boel De Paepe
C3
Conferentie
2016
Mild early epileptic encephalopathy evolving to spastic paraplegia, neurogenic bladder and generalized slow colon transit in an 18-year old patient with pathogenic mutations in FARS2
Elise Vantroys
Joél Smet
Arnaud Vanlander
Boel De Paepe
Sarah Vergult
Tom Sante
Björn Menten
Rudy Van Coster
C3
Conferentie
2016
NFAT5 in Duchenne muscular dystrophy cultured myoblasts after exposure to hyperosmolar salt conditions
Sandrine Herbelet
Amanda Gonçalves
Elly De Vlieghere
Gert Van Peer
Boel De Paepe
Chris Guerin
Jo Vandesompele
Olivier De Wever
Jan De Bleecker
C3
Conferentie
2016
NFAT5 in inflammatory myopathies and Duchenne muscular dystrophy
Sandrine Herbelet
Amanda Gonçalves
Elly De Vlieghere
Boel De Paepe
Chris Guerin
Olivier De Wever
Jan De Bleecker
C3
Conferentie
2016
Osmoregulatory pathways are activated in polymyositis: increased expression of osmolyte accumulators in muscle fibers and immune cells
Boel De Paepe
Johan Ronnelid
Jens Schmidt
Jan De Bleecker
C3
Conferentie
2016
Pathogenic mutations in FARS2 in a patient with motor regression and epilepsy as first signs, later evolving to spastic paraplegia associated with autonomic disturbances
Elise Vantroys
Joél Smet
Arnaud Vanlander
Boel De Paepe
Sarah Vergult
Tom Sante
Björn Menten
Rudy Van Coster
C3
Conferentie
2016
Pathogenic mutations in TMEM126b, a recently discovered complex I assembly factor, identified in four siblings from two Belgian families
Rudy Van Coster
Joél Smet
Boel De Paepe
Arnaud Vanlander
Elise Vantroys
C Alston
A Compton
D Torburn
S Seneca
R Taylor
C3
Conferentie
2016
Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis
Qiang Gang
Conceicão Bettencourt
Pedro M Machado
Stefen Brady
Janice L Holton
Alan M Pittman
Deborah Hughes
Estelle Healy
Matthew Parton
David Hilton-Jones
et al.
A1
Artikel in een tijdschrift
in
NEUROBIOLOGY OF AGING
2016
The core protein to myogenesis NFAT5 forms aggresomes in normal and Duchenne muscular dystrophy myotubes exposed to cell stressors
Sandrine Herbelet
Elly De Vlieghere
Amanda Gonçalves
Boel De Paepe
Chris Guerin
Olivier De Wever
Jan De Bleecker
C3
Conferentie
2016
The core protein to myogenesis NFAT5 forms aggresomes in normal and Duchenne muscular dystrophy myotubes exposed to cell stressors
Sandrine Herbelet
Elly De Vlieghere
Gert Van Peer
Boel De Paepe
Eline Nys
Laurens Weynants
Jo Vandesompele
Olivier De Wever
Jens Schmidt
Jan De Bleecker
C3
Conferentie
2016
2015
205th ENMC international workshop: pathology diagnosis of idiopathic inflammatory myopathies part II, 28-30 March 2014, Naarden, The Netherlands
Jan De Bleecker
Boel De Paepe
for the ENMC Myositis Muscle Biopsy Study group
Anthony Amato
Eleonora Aronica
Olivier Benveniste
Onno de Boer
Marianne de Visser
Mazen Dimachkie
Romain Gherardi
et al.
A1
Artikel in een tijdschrift
in
NEUROMUSCULAR DISORDERS
2015
Activation of the nuclear factor of activated T-cells 5 pathway is characteristic of the perifascicular muscle fiber atrophy observed in dermatomyositis
Boel De Paepe
Cecilia Jimenez-Mallebrera
E Iglesias
C Jou
Jean-Jacques Martin
Joachim Weis
Sandrine Herbelet
Jan De Bleecker
C3
Conferentie
2015
Addition of NaCl upregulates NFAT5 expression in Duchenne muscular dystrophy cultured myotubes
Laurens Weynants
Eline Nys
Sandrine Herbelet
Boel De Paepe
Elly De Vlieghere
Liselot Mus
Lynn Feys
Olivier De Wever
Jan De Bleecker
C3
Conferentie
2015
Analysis of the whole mitochondrial genome: translation of the Ion Torrent Personal Genome Machine system to the diagnostic bench?
Sara Seneca
Kim Vancampenhout
Rudy Van Coster
Joél Smet
Willy Lissens
Arnaud Vanlander
Boel De Paepe
An Jonckheere
Katrien Stouffs
Linda De Meirleir
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF HUMAN GENETICS
2015
Does perinatal infection affect the capacity of umbilical vein endothelial cells to produce adenosine triphosphate?
Boel De Paepe
Redactioneel materiaal
2015
Inflammatory- and NaCl-induced expression of NFAT5 in muscle cells point to common stress response mechanisms
Sandrine Herbelet
Karsten Schmidt
Jana Zschüntzsch
Eline Nys
Laurens Weynants
Boel De Paepe
Olivier De Wever
Jan De Bleecker
Jens Schmidt
C3
Conferentie
2015
Interferons as components of the complex web of reactions sustaining inflammation in idiopathic inflammatory myopathies
Boel De Paepe
A1
Artikel in een tijdschrift
in
CYTOKINE
2015
Possible pathogenic mechanism of propofol infusion syndrome involves coenzyme Q
Arnaud Vanlander
Juergen Guenther Okun
ANNIK DE JAEGER
Joél Smet
Elien De Latter
Boel De Paepe
Georges Dacremont
Brigitte Wuyts
Bert Vanheel
Peter De Paepe
et al.
A1
Artikel in een tijdschrift
in
ANESTHESIOLOGY
2015
Pro-inflammatory cell stress in muscle cells is directed by NFAT5
Sandrine Herbelet
Jens Schmidt
Olivier De Wever
Eline Nys
Laurens Weynants
Dorien Clarisse
Glenn Vergauwen
Boel De Paepe
Jan De Bleecker
C3
Conferentie
2015
Scanning for therapeutic targets within the cytokine network of idiopathic inflammatory myopathies
Boel De Paepe
Jana Zschüntzsch
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2015
SQSTM1 and VCP mutations in a series of 205 inclusion body myositis cases
Q Gang
C Bettencourt
S Brady
JL Holton
AM Pittman
D Hughes
E Healy
M Parton
D Hilton-Jones
PB Shieh
et al.
C3
Conferentie
2015
Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies
Joanna Parkes
Simon Rothwell
Philip Day
Neil J McHugh
Zoë Betteridge
Robert Cooper
William E Ollier
Hector Chinoy
Janine Lamb
the MYOGEN group
et al.
C3
Conferentie
2015
The effects of an intronic polymorphism in TOMM40 and APOE genotypes in sporadic inclusion body myositis
Qiang Gang
Conceicao Bettencourt
Pedro M Machado
Zoe Fox
Stefen Brady
Estelle Healy
Matt Parton
Janice L Holton
David Hilton-Jones
Perry B Shieh
et al.
A1
Artikel in een tijdschrift
in
NEUROBIOLOGY OF AGING
2015
Treatment of idiopathic inflammatory myopathies: targets inside the cytokine network
Boel De Paepe
C3
Conferentie
2015
Two siblings with homozygous pathogenic splice-site variant in mitochondrial asparaginyl-tRNA synthetase (NARS2)
Arnaud Vanlander
Björn Menten
Joél Smet
Linda De Meirleir
Tom Sante
Boel De Paepe
Sara Seneca
Sarah F Pearce
Christopher A Powell
Sarah Vergult
et al.
A1
Artikel in een tijdschrift
in
HUMAN MUTATION
2015
2014
A bumpy ride on the diagnostic bench of massive parallel sequencing, the case of the mitochondrial genome
Kim Vancampenhout
Ben Caljon
Claudia Spits
Katrien Stouffs
An Jonckheere
Linda De Meirleir
Willy Lissens
Arnaud Vanlander
Joél Smet
Boel De Paepe
et al.
A1
Artikel in een tijdschrift
in
PLOS ONE
2014
Clinical variability in neurohepatic syndrome due to combined mitochondrial DNA depletion and Gaucher disease
Julie Harvengt
Catherine Wanty
Boel De Paepe
Christine Sempoux
Nicole Revencu
Joél Smet
Rudy Van Coster
Willy Lissens
Sara Seneca
Laurent Weekers
et al.
A2
Artikel in een tijdschrift
in
MOLECULAR GENETICS AND METABOLISM REPORTS
2014
Did lightning strike twice?
Sara Seneca
E Fosselle
Jan De Bleecker
Kim Vancampenhout
Willy Lissens
K Stouffs
A Jonckheere
Rudy Van Coster
Joél Smet
Boel De Paepe
et al.
C3
Conferentie
2014
Effect of resveratrol on cultured skin fibroblasts from patients with oxidative phosphorylation defects
Boel De Paepe
Katrien Vandemeulebroecke
Joél Smet
Arnaud Vanlander
Sara Seneca
Willy Lissens
Johan LK Van Hove
Ellen Deschepper
Paz Briones
Rudy Van Coster
A1
Artikel in een tijdschrift
in
PHYTOTHERAPY RESEARCH
2014
International immunochip study in the idiopathic inflammatory myopathies identifies novel susceptability loci and confirms HLA as strongest genetic risk factor
Simon Rothwell
Robert G Cooper
Ingrid E Lundberg
Frederick W Miller
Peter K Gregersen
Jiri Vencovsky
Katalin Danko
Lucy R Wedderburn
Vidya Limaye
Albert Selva O'Callaghan
et al.
C3
Conferentie
2014
NFAT5 in idiopathic inflammatory myopathies and Duchenne muscular dystrophy
Sandrine Herbelet
Jens Schmidt
Boel De Paepe
Laurens Weynants
Eline Nys
Kim Creus
Jan De Bleecker
C3
Conferentie
2014
Transcriptomic profiling of TK2 deficient human skeletal muscle suggests a role for the p53 signalling pathway and identifies growth and differentiation factor-15 as a potential novel biomarker for mitochondrial myopathies
Susana G Kalko
Sonia Paco
Cristina Jou
Maria Angels Rodríguez
Marija Meznaric
Mihael Rogac
Maja Jekovec-Vrhovsek
Monica Sciacco
Maurizio Moggio
Gigliola Fagiolari
et al.
A1
Artikel in een tijdschrift
in
BMC GENOMICS
2014
Treating mitochondrial myopathy : can we boost oxidative phosphorylation activities by enhancing mitochondrial biogenesis?
Boel De Paepe
A2
Artikel in een tijdschrift
in
AUSTIN JOURNAL OF MUSCULOSKELETAL DISORDERS
2014
Two siblings with myopathy, mild mental retardation and combined OXPHOS deficiencies caused by a mutation in the gene encoding asparaginyl tRNA synthetase, NARS2
Arnaud Vanlander
M Minczuk
Tom Sante
Joél Smet
Boel De Paepe
Linda De Meirleir
Björn Menten
Rudy Van Coster
C3
Conferentie
2014
Ullrich congenital muscular dystrophy: a new cellular study on cultured skin fibroblasts
Nicolas Deconinck
Boel De Paepe
Sofie Symoens
Arnaud Vanlander
C Gartioux
Valerie Allamand
Joél Smet
Bart Devreese
Rudy Van Coster
C3
Conferentie
2014
2013
193rd ENMC International workshop: Pathology diagnosis of idiopathic inflammatory myopathies, 30 November-2 December 2012, Naarden, The Netherlands
Jan De Bleecker
Ingrid E Lundberg
Marianne de Visser
the ENMC Myositis Muscle Biopsy Study Group
Boel De Paepe
A1
Artikel in een tijdschrift
in
NEUROMUSCULAR DISORDERS
2013
A homozygous mutation in IBA57 involved in intramitochondrial iron-sulfur cluster synthesis causes severe encephalopathy and mypathy in two neonates
Arnaud Vanlander
Claudia Willbrecht
Nikhita Ajit Bolar
Joél Smet
Boel De Paepe
Elien De Latter
Lut Van Laer
Bart Loeys
Roland Lill
Rudy Van Coster
C3
Conferentie
2013
A novel compound heterozygous mutation in NFU1 as cause of iron-sulfur cluster biosynthesis
Rudy Van Coster
Joél Smet
Boel De Paepe
Arnaud Vanlander
Elien De Latter
Linda De Meirleir
Willy Lissens
Sara Seneca
C3
Conferentie
2013
Anti-angiogenic therapy for cancer: past, present and future
Boel De Paepe
Hoofdstuk in een boek
in
Topics in anti-cancer research, vol. 2
2013
Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
MEDIATORS OF INFLAMMATION
2013
Fatal outcome of iron-sulfur cluster scaffold NFU1 gene mutations in a neonatal patient
Sara Seneca
Joél Smet
Arnaud Vanlander
Rudy Van Coster
D Roland
Boel De Paepe
Willy Lissens
M Bonduelle
Linda De Meirleir
C3
Conferentie
2013
Heat-shock proteins in autoimmunity
Kamal D Moudgil
Stephen J Thompson
Fabiana Geraci
Boel De Paepe
Yehuda Shoenfeld
Redactioneel materiaal
2013
Les cytokines TNF dans les myopathies inflammatoires: une cible thérapeutique potentielle
Boel De Paepe
Jan De Bleecker
A4
Artikel in een tijdschrift
in
NEURONE (EDITION FRANCAISE)
2013
Morphological spectrum and clinical features of myopathies with tubular aggregates
Fabian Funk
Chantal Ceuterick-de Groote
Jean-Jacques Martin
Axel Meinhardt
Ana Taratuto
Jan De Bleecker
Rudy Van Coster
Boel De Paepe
Ulrike Schara
Matthias Vorgerd
et al.
A1
Artikel in een tijdschrift
in
HISTOLOGY AND HISTOPATHOLOGY
2013
Mutation of the iron-sulfur cluster assembly gene IBA57 causes severe myopathy and encephalopathy
Nikhita Ajit Bolar
Arnaud Vanlander
Claudia Wilbrecht
Nathalie Van der Aa
Joél Smet
Boel De Paepe
Geert Vandeweyer
Frank Kooy
François Eyskens
Elien De Latter
et al.
A1
Artikel in een tijdschrift
in
HUMAN MOLECULAR GENETICS
2013
Mutation of the iron-sulfur cluster assembly IBA57 gene causes lethal myopathy and encephalopathy
N Ajit Bolar
Arnaud Vanlander
C Wilbrecht
Nathalie Van der Aa
Joél Smet
Boel De Paepe
G Vandeweyer
F Kooy
François Eyskens
Elien De Latter
et al.
C3
Conferentie
2013
The nonnecrotic invaded muscle fibers of polymyositis and sporadic inclusion body myositis: on the interplay of chemokines and stress proteins
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
NEUROSCIENCE LETTERS
2013
TNF-cytokines in inflammatoire myopathieën: potentiële targets voor behandeling
Boel De Paepe
Jan De Bleecker
A4
Artikel in een tijdschrift
in
NEURON (NEDERLANDSE ED.)
2013
Unraveling the mechanisms behind the enhanced MTT conversion by irradiated breast cancer cells
Stéphanie Blockhuys
Barbara Vanhoecke
Joél Smet
Boel De Paepe
Rudy Van Coster
Marc Bracke
Carlos De Wagter
A1
Artikel in een tijdschrift
in
RADIATION RESEARCH
2013
2012
Expression of chemokines and their receptors in muscle tissues from Duchenne muscular dystrophy patients
Boel De Paepe
Kim Creus
J-J Martin
Jan De Bleecker
C3
Conferentie
2012
Fluorescence imaging of mitochondria in cultured skin fibroblasts: a useful method for detection of oxidative phosphorylation defects
Boel De Paepe
Joél Smet
Arnaud Vanlander
Sara Seneca
Willy Lissens
Linda De Meirleir
Mado Vandewoestyne
Dieter Deforce
Richard J Rodenburg
Rudy Van Coster
A1
Artikel in een tijdschrift
in
PEDIATRIC RESEARCH
2012
Heat shock protein families 70 and 90 in Duchenne muscular dystrophy and inflammatory myopathy: balancing muscle protection and destruction
Boel De Paepe
Kim Creus
Joachim Weis
Jan De Bleecker
A1
Artikel in een tijdschrift
in
NEUROMUSCULAR DISORDERS
2012
Heat-shock proteins in autoimmunity
Boekeditor
2012
Inborn oxidative phosphorylation defect as risk factor for propofol infusion syndrome
Arnaud Vanlander
PG Jorens
Joél Smet
Boel De Paepe
W Verbrugghe
GG Van den Eynden
F Meire
P Pauwels
N Van der Aa
S Seneca
et al.
A1
Artikel in een tijdschrift
in
ACTA ANAESTHESIOLOGICA SCANDINAVICA
2012
Lymphotoxin beta : an important cytokine in inflammatory myopathy
Kim Creus
Boel De Paepe
J Weis
Jan De Bleecker
C3
Conferentie
2012
Mitochondrial markers for cancer : relevance to diagnosis, therapy and prognosis, and general understanding of malignant disease mechanisms
Boel De Paepe
A2
Artikel in een tijdschrift
in
ISRN PATHOLOGY
2012
Proteomic analysis in giant axonal neuropathy: new insights into disease mechanisms
Silke Mussche
Boel De Paepe
Joél Smet
Katrien Devreese
Willy Lissens
Vedrana Milic Rasic
Matthew Murnane
Bart Devreese
Rudy Van Coster
A1
Artikel in een tijdschrift
in
MUSCLE & NERVE
2012
Proteomic analysis of cultured skin fibroblasts from UCMD patients reveals the involvement of two new cellular pathways
N Deconinck
Silke Mussche
Boel De Paepe
C Gartioux
V Allamand
P Richard
Joél Smet
Bart Devreese
Rudy Van Coster
C3
Conferentie
2012
The multifaceted character of the cytokine lymphotoxinβ in inflammatory myopathies
Jan De Bleecker
Kim Creus
Joachim Weis
Boel De Paepe
C3
Conferentie
2012
The tumor necrosis factor superfamily of cytokines in the inflammatory myopathies : potential targets for therapy
Boel De Paepe
Kim Creus
Jan De Bleecker
A1
Artikel in een tijdschrift
in
CLINICAL & DEVELOPMENTAL IMMUNOLOGY
2012
TNF-cytokines in inflammatoire myopathieën : potentiële targets voor behandeling
Boel De Paepe
Jan De Bleecker
A2
Artikel in een tijdschrift
in
ORTHO-RHEUMATO
2012
Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis
Boel De Paepe
Kim Creus
Jean-Jacques Martin
Jan De Bleecker
A1
Artikel in een tijdschrift
in
MUSCLE & NERVE
2012
2011
Analysis of the giant axonal neuropathy fibroblasts proteome
Rudy Van Coster
Silke Mussche
Boel De Paepe
Joél Smet
Willy Lissens
V Rasic
Bart Devreese
C3
Conferentie
2011
Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster
Helene Verhelst
PATRICK VERLOO
Karlien Dhondt
Boel De Paepe
Björn Menten
Josep Dalmau
Rudy Van Coster
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
2011
ATP synthase deficiency: a diagnostic strategy for not such an uncommon cause of OXPHOS dysfunction
Rudy Van Coster
Joél Smet
Boel De Paepe
Sara Seneca
Linda De Meirleir
Luc Regal
A Evangeliou
Willy Lissens
C3
Conferentie
2011
Complex III staining in blue native polyacrylamide gels
Joél Smet
Boel De Paepe
Sara Seneca
Willy Lissens
Heike Kotarsky
Linda De Meirleir
Vineta Fellman
Rudy Van Coster
A1
Artikel in een tijdschrift
in
JOURNAL OF INHERITED METABOLIC DISEASE
2011
Hashimoto encephalopathy and antibodies against dimethylargininase-1: a rare cause of cognitive decline in a pediatric Down's syndrome patient
Helene Verhelst
PATRICK VERLOO
Boel De Paepe
Beatrice Gini
Bruno Bonetti
Rudy Van Coster
A1
Artikel in een tijdschrift
in
CLINICAL NEUROLOGY AND NEUROSURGERY
2011
JC-1-based fluorescence to evaluate oxidative phosphorylation defects generates both qualitative and quantitative information
Boel De Paepe
Joél Smet
Sara Seneca
Willy Lissens
Linda De Meirleir
Mado Vandewoestyne
Dieter Deforce
Silke Mussche
Emmanuel Scalais
Rudy Van Coster
C3
Conferentie
2011
Localization of chemokines and their receptors in muscle tissues from Duchenne muscular dystrophy patients
Jan De Bleecker
Kim Creus
Jean Jacques Martin
Boel De Paepe
C3
Conferentie
2011
2010
Deleterious mutations in RRM2B result in severe reduction of mtDNA content in skeletal muscle
Rudy Van Coster
Joél Smet
Boel De Paepe
Willy Lissens
Linda De Meirleir
Sara Seneca
C3
Conferentie
2010
Deleterious mutations in RRM2B, a gene responsible for maintenance of mtDNA, result in severe reduction of mtDNA content in skeletal muscle
Rudy Van Coster
Joél Smet
Boel De Paepe
Willy Lissens
Linda De Meirleir
Sara Seneca
C3
Conferentie
2010
Expression of heat shock proteins in skeletal muscle from idiopathic inflammatory myopathy and Duchenne muscular dystrophy patients
Jan De Bleecker
Kim Creus
Jean-Jacques Martin
Joachim Weis
Boel De Paepe
C3
Conferentie
2010
Mutations in TMEM70 causes severe encephalocardiomyopathy as well as mild encephalopathy
Rudy Van Coster
Joél Smet
Willy Lissens
Boel De Paepe
Sara Seneca
Linda De Meirleir
Martha Spilioti
Fitsioris Xenophon
Athanasios Evangeliou
C3
Conferentie
2010
Mutations in TMEM70, a gene coding for an assembly factor of complex V, can cause a severe encephalocardiomyopathy in the neonatal period as wel as mild non-progressive encephalopathy in adolescence
Rudy Van Coster
Joél Smet
Willy Lissens
Boel De Paepe
Sara Seneca
Linda De Meirleir
Martha Spilioti
Fitsioris Xenophon
Athanasios Evangeliou
C3
Conferentie
2010
Progressive myoclonic epilepsy as an adult-onset manifestation of Leigh syndrome due to m.14487T > C
Bart Dermaut
S Seneca
L Dom
K Smets
L Ceulemans
Joél Smet
Boel De Paepe
S Tousseyn
S Weckhuysen
M Gewillig
et al.
A1
Artikel in een tijdschrift
in
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
2010
2009
A Dual Role for HSP90 and HSP70 in the Inflammatory Myopathies From Muscle Fiber Protection to Active Invasion by Macrophages
Boel De Paepe
Kim Creus
JJ Martin
J Weis
Jan De Bleecker
A1
Artikel in een tijdschrift
in
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
2009
Distribution of the NF-kappa B Complex in the Inflammatory Exudates Characterizing the Idiopathic Inflammatory Myopathies
Kim Creus
Boel De Paepe
BART WERBROUCK
VEERLE VERVAET
J Weis
Jan De Bleecker
A1
Artikel in een tijdschrift
in
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
2009
Expression of HSP90 alpha and HSP90 beta in the idiopathic inflammatory myopathies and Duchenne muscular dystrophy
Jan De Bleecker
Boel De Paepe
Kim Creus
JJ Martin
J Weis
C3
Conferentie
2009
Histochemical methods for the diagnosis of mitochondrial diseases
Boel De Paepe
Jan De Bleecker
Rudy Van Coster
Hoofdstuk in een boek
in
Current protocols in human genetics
2009
Idiopathic inflammatory myopathies and the classical NF-kappa B complex: Current insights and implications for therapy
Kim Creus
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
AUTOIMMUNITY REVIEWS
2009
Immunohistochemical analysis of the oxidative phosphorylation complexes in skeletal muscle from patients with mitochondrial DNA encoded tRNA gene defects
Boel De Paepe
Joél Smet
M Lammens
S Seneca
JJ Martin
Jan De Bleecker
L De Meirleir
W Lissens
Rudy Van Coster
A1
Artikel in een tijdschrift
in
JOURNAL OF CLINICAL PATHOLOGY
2009
Lactic Acidosis in a Newborn With Adrenal Calcifications
Aleksandra Zecic
Joél Smet
Claudine De Praeter
Piet Vanhaesebrouck
Carlo Viscomi
Caroline Van den Broecke
Boel De Paepe
Peter Lohse
Jean-Jacques Martin
Joshua Jackson
et al.
A1
Artikel in een tijdschrift
in
PEDIATRIC RESEARCH
2009
MITOCHONDRIAL ABNORMALITIES IN A NEWBORN WITH LACTIC ACIDOSIS AND ADRENAL CALCIFICATIONS
Rudy Van Coster
Joél Smet
PATRICK VERLOO
Piet Vanhaesebrouck
C Viscomi
Caroline Van den Broecke
Boel De Paepe
L De Meirleir
M Zeviani
S Seneca
et al.
C3
Conferentie
2009
Mitochondrial mosaics in the liver of 3 infants with mtDNA defects
Frank Roels
PATRICK VERLOO
François Eyskens
Baudouin François
Sara Seneca
Boel De Paepe
Jean-Jacques Martin
VALERIE MEERSSCHAUT
Marleen Praet
Emmanuel Scalais
et al.
A2
Artikel in een tijdschrift
in
BMC Clinical Pathology
2009
Progressive myoclonic epilepsy as an adult-onset manifestation of Leigh syndrome due to the m.14487T>C mutation in ND6
Sara Seneca
Bart Dermaut
Patrick Santens
Lina Dom
Katrien Smets
Luc Ceulemans
Joél Smet
Boel De Paepe
Simon Tousseyn
Sarah Weckhuysen
et al.
C3
Conferentie
2009
Role of cytokines and chemokines in idiopathic inflammatory myopathies
Boel De Paepe
Kim Creus
Jan De Bleecker
A1
Artikel in een tijdschrift
in
CURRENT OPINION IN RHEUMATOLOGY
2009
Subcomplexes of mitochondrial complex V reveal mutations in mitochondrial DNA
Joél Smet
Sara Seneca
Boel De Paepe
Ann Meulemans
Helene Verhelst
Juliaan Leroy
Linda De Meirleir
Willy Lissens
Rudy Van Coster
A1
Artikel in een tijdschrift
in
ELECTROPHORESIS
2009
2008
Chemokines in idiopathic inflammatory myopathies
Boel De Paepe
Kim Creus
Jan De Bleecker
A1
Artikel in een tijdschrift
in
FRONTIERS IN BIOSCIENCE
2008
Immunostaining technniques in patients with mtDNA depletion
Rudy Van Coster
Boel De Paepe
Joél Smet
S SENECA
W LISSENS
L DE MEIRLEIR
Frank Roels
C3
Conferentie
2008
Role of BN-page in the diagnosis of mitochondrial DNA depletion
Rudy Van Coster
Joél Smet
Boel De Paepe
S SENECA
W LISSENS
L DE MEIRLEIR
C3
Conferentie
2008
TNF alpha receptor genotype influences smoking-induced muscle-fibre-type shift and atrophy in mice
Boel De Paepe
Guy Brusselle
Tania Maes
Kim Creus
Sophie D'hose
Nele D'Haese
Ken Bracke
An D'hulst
Guy Joos
Jan De Bleecker
A1
Artikel in een tijdschrift
in
ACTA NEUROPATHOLOGICA
2008
2007
A new family with the mitochondrial tRNAGLU gene mutation m.14709T > C presenting with hydrops fetalis
Ann Meulemans
Sara Seneca
Joél Smet
Boel De Paepe
Willy Lissens
Rudy Van Coster
Anne Debeer
Linda De Meirleir
Jaak Jaeken
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
2007
ATP synthase subcomplexes are the hallmark of a defective intramitochondrial protein translation
Rudy Van Coster
Joél Smet
Boel De Paepe
S SENECA
A MEULEMANS
W LISSENS
L DE MEIRLEIR
C3
Conferentie
2007
Chemokine profile of different inflammatory myopathies reflects humoral versus cytotoxic immune responses
Boel De Paepe
Kim Creus
Jan De Bleecker
A1
Artikel in een tijdschrift
in
Annals of the New York Academy of Sciences
2007
Detection of complex III deficient patients using a novel activity staining method in the BN-page gel
Rudy Van Coster
Joél Smet
Boel De Paepe
S Seneca
A Meulemans
W Lissens
H Kotarsky
L De Meirleir
V Fellman
C3
Conferentie
2007
Distribution of glucocorticoid receptor alpha and beta subtypes in the idiopathic inflammatory myopathies
Jan De Bleecker
Boel De Paepe
VEERLE VERVAET
BO ARYS
Kim Creus
BF WERBROUCK
JJ MARTIN
A1
Artikel in een tijdschrift
in
NEUROMUSCULAR DISORDERS
2007
Immunohistochemical studies of oxidative phosphorylation in skeletal muscle of patients with mitochondrial tRNA gene mutations
Boel De Paepe
Joél Smet
Martin Lammens
S SENECA
J MARTIN
Jan De Bleecker
Rudy Van Coster
C3
Conferentie
2007
Infantile presentation of the mitochondrial A8344G mutation.
E SCALAIS
C NUTTIN
S SENECA
Joél Smet
Boel De Paepe
J MARTIN
R STEVENS
F PIERART
O BATTISTI
W LISSENS
et al.
A2
Artikel in een tijdschrift
in
European journal of neurology
2007
The evaluation of complex III activity using a novel in-gel activity staining method
Joél Smet
Boel De Paepe
S SARA
A MEULEMANS
W LISSENS
H KOTARSKY
L DE MEIRLEIR
V FELLMAN
Rudy Van Coster
C3
Conferentie
2007
The presence of complex V subcomplexes in patients with defective intramitochondrial protein translation
Rudy Van Coster
Joél Smet
Boel De Paepe
S SENECA
A MEULEMANS
W LISSENS
L DE MEIRLEIR
C3
Conferentie
2007
The presence of complex V subcomplexes in patients with defective intramitochondrial protein translation.
Rudy Van Coster
Joél Smet
Boel De Paepe
S SENECA
A MEULEMANS
W LISSENS
L DE MEIRLEIR
C3
Conferentie
2007
TNF alpha receptor signalling influences the expression of myosin heavy chain isoforms in musculus gastrocnemius of the mouse
Boel De Paepe
Kim Creus
Sophie D'hose
Guy Brusselle
Jan De Bleecker
C3
Conferentie
2007
Two novel mitochondrial DNA mutations in muscle tissue of a patient with limb-girdle myopathy
A MEULEMANS
Boel De Paepe
Jan De Bleecker
Joél Smet
W LISSENS
Rudy Van Coster
L DE MEIRLEIR
S SENECA
A1
Artikel in een tijdschrift
in
ARCHIVES OF NEUROLOGY
2007
Visualizing oxidative phosphorylation defects in skeletal muscle of patients with mitochondrial tRNA gene mutations using immunohistochemistry
Rudy Van Coster
Boel De Paepe
Joél Smet
Martin Lammens
J MARTIN
Jan De Bleecker
S SENECA
W LISSENS
L DE MEIRLEIR
C3
Conferentie
2007
2006
A novel mitochondrial transfer RNA(Asn) mutation causing multiorgan failure
Ann Meulemans
Sara Seneca
Lieven Lagae
Willy Lissens
Boel De Paepe
Joél Smet
Rudy Van Coster
Linda De Meirleir
A1
Artikel in een tijdschrift
in
ARCHIVES OF NEUROLOGY
2006
A novel mitochondrial tRNA Asn mutation causing multi-organ failure
A Meulemans
S Seneca
L Lagae
W Lissens
Boel De Paepe
Joél Smet
Rudy Van Coster
L De Meirleir
C3
Conferentie
2006
Complex V subcomplexes detected by BN PAGE are a sign of a defective intramitochondrial protein translation
Rudy Van Coster
Joél Smet
Boel De Paepe
S Seneca
A Meulemans
W Lissens
L De Meirleir
C3
Conferentie
2006
Complex V subcomplexes suggestive of a defective intramitochondrial protein translation
Rudy Van Coster
Joél Smet
Boel De Paepe
S Seneca
A Meulemans
W Lissens
L De Meirleir
C3
Conferentie
2006
Complex V subcomplexes suggestive of a defective intramitochondrial protein translation.
Rudy Van Coster
Joél Smet
Boel De Paepe
S SENECA
A MEULEMANS
W LISSENS
L DE MEIRLEIR
C3
Conferentie
2006
Diagnostic value of immunostaining in cultured skin fibroblasts from patients with oxidative phosphorylation defects
Boel De Paepe
Joél Smet
Juliaan Leroy
S Seneca
EDITH GEORGE
Dirk Matthys
L Van Maldergem
E Scalais
W Lissens
L De Meirleir
et al.
A1
Artikel in een tijdschrift
in
PEDIATRIC RESEARCH
2006
Expression of inhibitor kappa B-alpha in idiopathic inflammatory myopathies
Kim Creus
Boel De Paepe
N D'Haese
BART WERBROUCK
G De Coninck
Jan De Bleecker
C3
Conferentie
2006
Potential therapeutic targets for idiopathic inflammatory myopathies
Jan De Bleecker
Kim Creus
Boel De Paepe
A1
Artikel in een tijdschrift
in
DRUG NEWS & PERSPECTIVES
2006
The distribution of IkappaBalpha in inflammatory myopathies
Jan De Bleecker
Kim Creus
N D'HAESE
BART WERBROUCK
G DE CONINCK
Boel De Paepe
C1
Conferentie
2006
2005
Alpha-chemokine receptors CXCR1-3 and their ligands in idiopathic inflammatory myopathies
Boel De Paepe
KRISTEL DE KEYZER
JJ MARTIN
Jan De Bleecker
A1
Artikel in een tijdschrift
in
ACTA NEUROPATHOLOGICA
2005
Denaturating high performance liquid chromatography, a rapid mutation screening technique for the entire mitochondrial genome.
A MEULEMANS
S SENECA
W LISSENS
Rudy Van Coster
J JAEKEN
Joél Smet
Boel De Paepe
L DE MEIRLEIR
C3
Conferentie
2005
Distribution of glucocorticoid receptor subtypes in inflammatory myopathy
Jan De Bleecker
Boel De Paepe
V VERVAET
BO ARYS
Nele D'Haese
C3
Conferentie
2005
High dose statins and skeletal muscle metabolism in man: A randomized controlled trial.
Rudy Van Coster
Joél Smet
Boel De Paepe
H PAIVA
K THELEN
K MATTILA
J LAAKSO
T LEHTIMAKI
K VON BERGMANN
D LUTJOHANN
et al.
C3
Conferentie
2005
High dose statins and skeletal muscle metabolism in man: A randomized controlled trial.
Rudy Van Coster
Joél Smet
Boel De Paepe
H PAIVA
K THELEN
K MATTILA
J LAAKSO
T LEHTIMAKI
K VON BERGMANN
D LUTJOHANN
et al.
C3
Conferentie
2005
High-dose statins and skeletal muscle metabolism in humans: A randomized, controlled trial
H PAIVA
KM THELEN
Rudy Van Coster
Joél Smet
Boel De Paepe
KM MATTILA
J LAAKSO
T LEHTIMAKI
K VON BERGMANN
D LUTJOHANN
et al.
A1
Artikel in een tijdschrift
in
CLINICAL PHARMACOLOGY & THERAPEUTICS
2005
Immunocytochemical staining of cultured fibroblasts is a valuable first line screening test for oxidative phosphorylation defects.
Boel De Paepe
Joél Smet
Juliaan Leroy
S SENECA
EDITH GEORGE
Dirk Matthys
L VAN MALDERGEM
E SCALAIS
W LISSENS
L DE MEIRLEIR
et al.
C3
Conferentie
2005
Immunocytochemiscal staining of cultured fibroblasts is available first line screening test for oxidative phosphorylation.
Boel De Paepe
Joél Smet
Juliaan Leroy
S SENECA
EDITH GEORGE
Dirk Matthys
L VAN MALDERGEM
E SCALAIS
W LISSENS
L DE MEIRLEIR
et al.
C3
Conferentie
2005
Localization of glucocorticoid receptor alpha and beta subtypes in inflammatory myopathy
Boel De Paepe
VEERLE VERVAET
BO ARYS
Nele D'Haese
Jan De Bleecker
C3
Conferentie
2005
β-chemokine receptor expression in idiopathic inflammatory myopathies
Boel De Paepe
Jan De Bleecker
A1
Artikel in een tijdschrift
in
MUSCLE & NERVE
2005
2004
Expression and distribution of the nitric oxide synthases in idiopathic inflammatory myopathies
Boel De Paepe
GZ RACZ
JM SCHRODER
Jan De Bleecker
A1
Artikel in een tijdschrift
in
ACTA NEUROPATHOLOGICA
2004
Localization of the alpha-chemokine SDF-1 and its receptor CXCR4 in idiopathic inflammatory myopathies
Boel De Paepe
JM SCHRODER
JJ MARTIN
GZ RACZ
Jan De Bleecker
A1
Artikel in een tijdschrift
in
NEUROMUSCULAR DISORDERS
2004
2003
Alpha-chemokines and Th1 mediated inflammation in polymyositis and inclusion body myositis
Jan De Bleecker
Boel De Paepe
KRISTEL DE KEYZER
C1
Conferentie
2003
Combination of proteomic techniques as powerful tool in the search for the underlying defect in OXPROS complex deficiencies
Joél Smet
Boel De Paepe
Bart Devreese
JJ MARTIN
L DE MEIRLEIR
W LISSENS
S SENECA
Rudy Van Coster
C3
Conferentie
2003
Localization of Th1 associated chemokines in inflammatory myopathies
Jan De Bleecker
Boel De Paepe
C3
Conferentie
2003
Localization of Th1 associated chemokines in inflammatory myopathies
Jan De Bleecker
Boel De Paepe
K De Keyser
C3
Conferentie
2003
The idiopathic inflammatory myopathies
Jan De Bleecker
Boel De Paepe
Hoofdstuk in een boek
in
Advances in Clinical Neurosciences
2003
2002
Beta chemokines and their receptors in inflammatory myopathies
Jan De Bleecker
Boel De Paepe
G Racz
JM Schröder
C3
Conferentie
2002
Chemokine receptors in inflammatory myopathy
Boel De Paepe
V MEIRE
G RACZ
JM SCHRODER
Jan De Bleecker
C3
Conferentie
2002
CXCR4 chemokine receptor density in inflammatory myopathies
V MEIRE
Jan De Bleecker
Boel De Paepe
J SCHRODER
C1
Conferentie
2002
Differential expression of chemokines in inflammatory myopathies
Jan De Bleecker
Boel De Paepe
IRIS VANWALLEGHEM
JM Schröder
A1
Artikel in een tijdschrift
in
NEUROLOGY
2002
Differential organ involvement in peroxisomal disorders
Frank Roels
Marianne Depreter
Marisa Giros
Sylvia Stockler
Hannah Mandel
D Troost
Boel De Paepe
Jan De Bleecker
Marc D'Hooghe
Christian Nuttin
et al.
C3
Conferentie
2002
Expression of MCP-1 and its receptors CCR2 and CCR4 in the inflammatory myopathies
Jan De Bleecker
Boel De Paepe
JM Schröder
C3
Conferentie
2002
Immunolocalization of the chemokine CXCL12 and its receptor CXCR4 in the inflammatory myopathies
Boel De Paepe
Jan De Bleecker
G RACZ
JM SCHROEDER
C3
Conferentie
2002
Increased angiotensin II type-2 receptor density in hyperplasia, DCIS and invasive carcinoma of the breast is paralleled with increased iNOS expression
Boel De Paepe
Valerie Verstraeten
Christian De Potter
Gillian Bullock
A1
Artikel in een tijdschrift
in
HISTOCHEMISTRY AND CELL BIOLOGY
2002
2001
Chemokines in inflammatory myopathies
Jan De Bleecker
Boel De Paepe
J SCHRODER
C1
Conferentie
2001
Differential expression of beta-chemokines in inflammatory myopathies
Jan De Bleecker
Boel De Paepe
JM Schröder
C3
Conferentie
2001
Distribution of type-1 and type-2 angiotensin receptors in the normal human lung and in lungs from patients with chronic obstructive pulmonary disease.
Gillian Bullock
I STEYAERT
G BILBE
RM CAREY
Johan Kips
Boel De Paepe
Romain Pauwels
Marleen Praet
HM SIRAGY
M DE GASPARO
A1
Artikel in een tijdschrift
in
HISTOCHEMISTRY AND CELL BIOLOGY
2001
Growth stimulatory angiotensin II type-1 receptor is upregulated in breast hyperplasia and in situ carcinoma but not in invasive carcinoma
Boel De Paepe
Valerie Verstraeten
Christian De Potter
Luc Vakaet
Gillian Bullock
A1
Artikel in een tijdschrift
in
HISTOCHEMISTRY AND CELL BIOLOGY
2001
2000
Properties of the ventricular adrenergic signal transduction system during ontogeny of spontaneous hypertension in rats.
Ariane Bazan
ERIC VAN DE VELDE
Boel De Paepe
Norbert Fraeyman
A1
Artikel in een tijdschrift
in
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
2000