Research Explorer

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Researcher

Björn Heindryckx

217 Results

2022

CRISPR/Cas gene editing in the human germline

Bieke BekaertAnnekatrien BoelGwenny CosemansLisa De WitteBjörn MentenBjörn Heindryckx

A1 Journal Article in SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Fertilization failure after human ICSI and the clinical potential of PLCZ1

Arantxa Cardona BarberánAnnekatrien BoelFrauke Vanden MeerschautDominic StoopBjörn Heindryckx

A1 Journal Article in REPRODUCTION

Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts

Krishna PavaniTim MeeseOsvaldo Américo Bogado PascottiniXueFeng GuanXiaoyuan LinLuc PeelmanJoachim HamacherFilip Van NieuwerburghDieter DeforceAnnekatrien BoelBjörn HeindryckxKelly TillemanAnn Van SoomBart GadellaAn HendrixKatrien Smits

A1 Journal Article in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human germline nuclear transfer to overcome mitochondrial disease and failed fertilization after ICSI

Maoxing TangAnnekatrien BoelNoemi CastelluccioArantxa Cardona BarberánAntonia ChristodoulakiBieke BekaertMina PopovicFrauke Vanden MeerschautPetra De SutterBjörn MentenSofie SymoensArnaud VanlanderDominic StoopPaul CouckeBjörn Heindryckx

A1 Journal Article in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

TEAD4 regulates trophectoderm differentiation upstream of CDX2 in a GATA3-independent manner in the human preimplantation embryo

Panagiotis StamatiadisGwenny CosemansAnnekatrien BoelBjörn MentenPetra De SutterDominic StoopSusana Chuva de Sousa LopesFrederic LluisPaul CouckeBjörn Heindryckx

U Journal Article in Human Reproduction

2021

Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

Swati MishraJasin TaelmanMina PopovicLaurentijn TillemanEvi DuthooMargot Van der JeughtDieter DeforceFilip Van NieuwerburghBjörn MentenPetra De SutterAnnekatrien BoelSusana Marina Chuva de Sousa LopesBjörn Heindryckx

A1 Journal Article in STEM CELLS

Calcium analysis and embryonic development of in vitro matured oocytes from transgender men

Antonia ChristodoulakiHaitang HeArantxa Cardona BarberánChloë De RooSusana Marina Chuva de Sousa LopesBjörn MentenAnn Van SoomPetra De SutterDominic StoopAnnekatrien BoelBjörn Heindryckx

Comparative analysis of mouse and human preimplantation development following POU5F1 CRISPR/Cas9 targeting reveals interspecies differences

Panagiotis StamatiadisAnnekatrien BoelGwenny CosemansMina PopovicBieke BekaertRamesh Reddy GuggillaMaoxing TangPetra De SutterFilip Van NieuwerburghBjörn MentenDominic StoopSusana Marina Chuva de Sousa LopesPaul CouckeBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisS M Chuva de Sousa LopesPetra De SutterBjörn MentenDominic StoopPaul CouckeBjörn Heindryckx

Digital polymerase chain reaction for assessment of mutant mitochondrial carry-over after nuclear transfer for In Vitro fertilization

Olivier TytgatMX TangWillem van SnippenbergAnnekatrien BoelRR GuggillaYannick GansemansMichiel Van HerpSofie SymoensWim TrypsteenDieter DeforceBjörn HeindryckxPaul CouckeWard De SpiegelaereFilip Van Nieuwerburgh

A1 Journal Article in CLINICAL CHEMISTRY

Prospects of germline nuclear transfer in women with diminished ovarian reserve

Antonia ChristodoulakiAnnekatrien BoelMaoxing TangChloë De RooDominic StoopBjörn Heindryckx

A1 Journal Article in FRONTIERS IN ENDOCRINOLOGY

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

Liselot MusStéphane Van HaverMina PopovicWim TrypsteenSteve LefeverNadja ZeltnerYudelca OgandoEva JacobsGeertrui DeneckerEllen SandersChristophe Van NesteSuzanne VanhauwaertBieke DecaestekerDieter DeforceFilip Van NieuwerburghPieter MestdaghJo VandesompeleBjörn MentenKatleen De PreterLorenz StuderBjörn HeindryckxKaat DurinckStephen RobertsFranki Speleman

A1 Journal Article in GENES CHROMOSOMES & CANCER

Sex-specific isolation and propagation of human premeiotic fetal germ cells and germ cell-like cells

Swati MishraJasin TaelmanYolanda W. ChangAnnekatrien BoelPetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in CELLS

Strand-specific single-cell methylomics reveals distinct modes of DNA demethylation dynamics during early mammalian development

Maya SenDylan MooijmanAlex ChialastriJean-Charles BoissetMina PopovicBjörn HeindryckxSusana Marina Chuva de Sousa LopesSiddharth S. DeyAlexander van Oudenaarden

A1 Journal Article in NATURE COMMUNICATIONS

2020

A proof-of-concept study to investigate DNA repair mechanisms in the human embryo after the application of CRISPR/Cas9 gene editing in the germ line

Bieke BekaertAnnekatrien BoelLisa De WitteMina PopovicRamesh Reddy GuggillaSwati MishraGwenny CosemansLise TordeursSusana Marina Chuva de Sousa LopesPetra De SutterBjörn MentenDominic StoopPaul CouckeBjörn Heindryckx

Chromosomal mosaicism in human blastocysts : the ultimate diagnostic dilemma

Mina PopovicLien DhaenensAnnekatrien BoelBjörn MentenBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Chromosomal mosaicism in human blastocysts : the ultimate diagnostic dilemma (vol 26, pg 313, 2020)

Mina PopovicLien DhaenensAnnekatrien BoelBjörn MentenBjörn Heindryckx

Comparative study of preimplantation development following distinct assisted oocyte activation protocols in a PLC-zeta knockout mouse model

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysA HachemAnnekatrien BoelFilip Van NieuwerburghDieter DeforceLuc LeybaertPetra De SutterJ. ParringtonBjörn Heindryckx

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Correcting PLCζ mutation in the germ line to overcome transmission of hereditary infertility in mice

Bieke BekaertAnnekatrien BoelVanessa ThysPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterJohn ParringtonBjörn MentenDominic StoopPaul CouckeBjörn Heindryckx

Correcting a PLCζ mutation in the human germ line to overcome hereditary infertility

Bieke BekaertAnnekatrien BoelMina PopovicPanagiotis StamatiadisSusana Marina Chuva de Sousa LopesPetra De SutterPaul CouckeBjörn Heindryckx

Diagnosis and treatment of male infertility-related fertilization failure

Arantxa Cardona BarberánAnnekatrien BoelFrauke Vanden MeerschautDominic StoopBjörn Heindryckx

A1 Journal Article in JOURNAL OF CLINICAL MEDICINE

Germline nuclear transfer in mice may rescue poor embryo development associated with advanced maternal age and early embryo arrest

Maoxing TangMina PopovicPanagiotis StamatiadisMargot Van der JeughtRudy Van CosterDieter DeforcePetra De SutterPaul CouckeBjörn MentenDominic StoopAnnekatrien BoelBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

Germline nuclear transfer to overcome mitochondrial diseases and female infertility

Maoxing TangBjörn HeindryckxPetra De Sutter

Modelling human embryogenesis : embryo-like structures spark ethical and policy debate

AM Pereira DaoudMina PopovicWJ DondorpM Trani BustosAL BredenoordSusana Marina Chuva de Sousa LopesSC van den BrinkRoelen BAJde Wert GMWRBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Pan-cancer pharmacogenetics : targeted sequencing panels or exome sequencing?

Laurentijn TillemanBjörn HeindryckxDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in PHARMACOGENOMICS

Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes

Davina BonteVanessa ThysPetra De SutterAnnekatrien BoelLuc LeybaertBjörn Heindryckx

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

2019

17q gain provides proliferative advantage to human embryonic stem cells under conditions of replicative stress

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne VanhauwaertKaat DurinckBjörn MentenKatleen De PreterBjörn HeindryckxLorenz StuderStephen RobertsFranki Speleman

17q gain provides proliferative advantage to human embryonic stem cells under replicative stress

Liselot MusStéphane Van HaverGeertrui DeneckerNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne VanhauwaertVanessa VermeirssenKaat DurinckBjörn MentenKatleen De PreterBjörn HeindryckxLorenz StuderStephen RobertsFranki Speleman

Assessment of the calcium releasing machinery in oocytes that failed to fertilize after conventional ICSI and assisted oocyte activation

Minerva Ferrer BuitragoDavina BonteLien DhaenensSanne VermorgenYuechao LuPetra De SutterBjörn Heindryckx

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic sperm injection : a 17-year retrospective study

Davina BonteMinerva Ferrer BuitragoLien DhaenensMina PopovicVanessa ThysIlse De CrooStefanie De GheselleNathalie SteyaertAnnekatrien BoelFrauke Vanden MeerschautPetra De SutterBjörn Heindryckx

A1 Journal Article in FERTILITY AND STERILITY

Bta-miR-10b secreted by bovine embryos negatively impacts preimplantation embryo quality

Xiaoyuan LinKrishna PavaniKatrien SmitsDieter DeforceBjörn HeindryckxAnn Van SoomLuc Peelman

A1 Journal Article in FRONTIERS IN GENETICS

Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

Maoxing TangR ReddyYannick GansemansMargot Van der JeughtAnnekatrien BoelPanagiotis StamatiadisRudy Van CosterDieter DeforceFilip Van NieuwerburghPetra De SutterBjörn Heindryckx

Comparative analysis of different nuclear transfer techniques to prevent the transmission of mitochondrial DNA variants

Maoxing TangRamesh Reddy GuggillaYannick GansemansMargot Van der JeughtAnnekatrien BoelMina PopovicPanagiotis StamatiadisMinerva Ferrer BuitragoVanessa ThysRudy Van CosterDieter DeforcePetra De SutterFilip Van NieuwerburghBjörn Heindryckx

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Contemporary pharmacogenetic assays in view of the PharmGKB database

Laurentijn TillemanJana WeymaereBjörn HeindryckxDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in PHARMACOGENOMICS

Exploring the contribution of gene dosage effects of 17q gain genes on hESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne VanhauwaertKaat DurinckBjörn MentenKatleen De PreterBjörn HeindryckxLorenz StuderStephen RobertsFranki Speleman

Extended in vitro culture of human embryos demonstrates the complex nature of diagnosing chromosomal mosaicism from a single trophectoderm biopsy

Mina PopovicL. DhaenensJ. TaelmanAnnelies DheedeneM. BialeckaPetra De SutterS. M. Chuva de Sousa LopesBjörn MentenBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

Human blastocyst outgrowths recapitulate primordial germ cell specification events

Mina PopovicMonika BialeckaMaria Gomes FernandesJasin TaelmanMargot Van der JeughtPetra De SutterBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Increased primordial germ cell (PGC) specification from human embryonic stem cells (hESC) derived in Activin A

Swati MishraMargot Van der JeughtMina PopovicJasin TaelmanEvi DuthooKatarzyna Szymańska-VandendriesschePetra De SutterLaurentijn TillemanFilip Van NieuwerburghAnnekatrien BoelSM Chuva de Sousa LopesBjörn Heindryckx

Intracellular localisation of platelet-activating factor during mammalian embryo development in vitro : a comparison of cattle, mouse and human

Lynn VandenbergheBjörn HeindryckxKatrien SmitsMina PopovicKatarzyna Szymańska-VandendriesscheDavina BonteLuc PeelmanDieter DeforcePetra De SutterAnn Van SoomCatharina De Schauwer

A1 Journal Article in REPRODUCTION FERTILITY AND DEVELOPMENT

Losing balance : investigating the prevalence and impact of chromosomal instability during early human development

Mina PopovicBjörn HeindryckxPetra De Sutter

Robust protocol for feeder-free adaptation of cryopreserved human pluripotent stem cells

Jeffrey AaldersNatasja Van den VrekenMina PopovicSwati MishraBjörn HeindryckxJolanda van Hengel

A1 Journal Article in IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

The importance of calcium : the quest for optimal diagnosis and treatment for fertilization failure and embryo arrest in human

Davina BonteBjörn HeindryckxPetra De Sutter

The use of pronuclear transfer to overcome infertility disorders in mice

Björn HeindryckxAnnekatrien BoelPanagiotis StamatiadisMargot Van der JeughtRamesh Reddy GuggillaDieter DeforceRudy Van CosterPetra De Sutter

Two decades of embryonic stem cells : a historical overview

Cristina EguizabalBegoña AranSusana Marina Chuva de Sousa LopesM. GeensBjörn HeindryckxS. PanulaMina PopovicRita VassenaAnna Veiga

A1 Journal Article in HUMAN REPRODUCTION OPEN

Untargeted histone profiling during naive conversion uncovers conserved modification markers between mouse and human

Laura De ClerckJasin TaelmanMina PopovicSander WillemsMargot Van der JeughtBjörn HeindryckxPetra De SutterHendrik MarksDieter DeforceMaarten Dhaenens

A1 Journal Article in SCIENTIFIC REPORTS

WNT inhibition and increased fibroblast growth factor signaling promotes derivation of less heterogeneous primed human embryonic stem cells, compatible with differentiation

Jasin TaelmanMina PopovicMonika BialeckaLaurentijn TillemanSharat WarrierMargot Van der JeughtBjörn MentenDieter DeforcePetra De SutterFilip Van NieuwerburghKuniya AbeBjörn HeindryckxSusana Marina Chuva de Sousa Lopes

A1 Journal Article in STEM CELLS AND DEVELOPMENT

2018

Assisted oocyte activation significantly increases fertilization and pregnancy rates resulting in healthy live births in patients with oocyte activation deficiencies

Davina BonteLien DhaenensMinerva Ferrer BuitragoStefanie De GheselleIlse De CrooPetra De SutterBjörn Heindryckx

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

Eva JacobsSharat WarrierPieter-Jan VoldersEva D'haeneEva VanlombergenLies VantommeMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

Eva JacobsSharat WarrierPieter-Jan VoldersEva D'haeneEva VanlombergenLies VantommeMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

Chromosomal mosaicism in human blastocysts : the ultimate challenge of preimplantation genetic testing?

Mina PopovicAnnelies DheedeneCHRISTODOULOS CHRISTODOULOUJasin TaelmanLien DhaenensFilip Van NieuwerburghDieter DeforceEtienne Van den AbbeelPetra De SutterBjörn MentenBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background

Sabitri GhimireMargot Van der JeughtJitesh NeupaneMatthias S RoostJasper AnckaertMina PopovicFilip Van NieuwerburghPieter MestdaghJo VandesompeleDieter DeforceBjörn MentenSusana Chuva de Sousa LopesPetra De SutterBjörn Heindryckx

A1 Journal Article in SCIENTIFIC REPORTS

Culture conditions affect Ca2+ release in artificially activated mouse and human oocytes

Yuechao LuDavina BonteMinerva Ferrer BuitragoMina PopovicJitesh NeupaneMargot Van der JeughtLuc LeybaertPetra De SutterBjörn Heindryckx

A1 Journal Article in REPRODUCTION FERTILITY AND DEVELOPMENT

Deciphering the origin of human embryonic stem cells and different pluripotency states

Sharat WarrierPetra De SutterBjörn Heindryckx

Diagnosis and treatment of oocyte activation deficiency in assisted reproduction technology

Minerva Ferrer BuitragoPetra De SutterBjörn Heindryckx

Exploring the contribution of gene dosage effects of 17Q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne VanhauwaertKaat DurinckBjörn MentenKatleen De PreterBjörn HeindryckxLorenz SuderStephen RobertsFranki Speleman

Exploring the contribution of gene dosage effects of 17q gain genes on hESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerStéphane Van HaverNadja ZeltnerYudelca OgandoEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne VanhauwaertKaat DurinckBjörn MentenKatleen De PreterBjörn HeindryckxLorenz StuderStephen RobertsFranki Speleman

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne VanhauwaertKaat DurinckBjörn MentenKatleen De PreterBjörn HeindryckxLorenz StuderStephen RobertsFranki Speleman

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Liselot MusGeertrui DeneckerNadja ZeltnerYudelca OgandoStéphane Van HaverEllen SandersEva JacobsMina PopovicChristophe Van NesteSuzanne VanhauwaertKaat DurinckBjörn MentenKatleen De PreterBjörn HeindryckxLorenz StuderStephen RobertsFranki Speleman

Human germline gene editing : recommendations of ESHG and ESHRE

Guido de WertGuido PenningsAngus ClarkeUrsula Eichenlaub-RitterCarla G van ElFrancesca ForzanoMariëtte GoddijnBjörn HeindryckxHeidi C HowardDragica RadojkovicEmmanuelle Rial-SebbagBasil C TarlatzisMartina C Cornel

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Human germline gene editing : recommendations of ESHG and ESHRE

Guido de WertGuido PenningsAngus ClarkeUrsula Eichenlaub-RitterCarla G van ElFrancesca ForzanoMariëtte GoddijnBjörn HeindryckxHeidi C HowardDragica RadojkovicEmmanuelle Rial-SebbagBasil C TarlatzisMartina C Cornel

A1 Journal Article in HUMAN REPRODUCTION OPEN

Human in vitro spermatogenesis from pluripotent stem cells : in need of a stepwise differentiation protocol?

C RombautHeidi MertesBjörn HeindryckxE Goossens

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Human oocyte calcium analysis predicts the response to assisted oocyte activation in patients experiencing fertilization failure after ICSI

Minerva Ferrer BuitragoLien DhaenensYuechao LuDavina BonteFrauke Vanden MeerschautPetra De SutterLuc LeybaertBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

Impact of pluripotency state and Activin A supplementation on derivation of primordial germ cell-like cells from human

Swati MishraMargot Van der JeughtJasin TaelmanMina PopovicKatarzyna Szymańska-VandendriesscheDieter DeforcePetra De SutterSusana Marina Chuva de Sousa LopesBjörn Heindryckx

Onderzoek op menselijke embryo’s in België : een overzicht

Guido PenningsSeppe SegersSophie DebrockBjörn HeindryckxVelichka Kontozova-DeutschUsha PunjabiHilde vande VeldeAndré van SteirteghemHeidi Mertes

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

PLCz knock-out sperm reveals the sole effect of altering calcium signals during assisted oocyte activation on later mouse embryogenesis

Minerva Ferrer BuitragoLaurentijn TillemanVanessa ThysA HachemFilip Van NieuwerburghLuc LeybaertPetra De SutterDieter DeforceJ ParringtonBjörn Heindryckx

Patients with a high proportion of immature and meiotically resistant oocytes experience defective nuclear oocyte maturation patterns and impaired pregnancy outcomes

Yuechao LuMinerva Ferrer BuitragoMina PopovicJitesh NeupaneWinnok De VosSylvie LiermanEtienne Van den AbbeelMargot Van der JeughtDimitra NikiforakiPetra De SutterBjörn Heindryckx

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

Platelet-activating factor acetylhydrolase 1B3 (PAFAH1 B3) is required for the formation of the meiotic spindle during in vitro oocyte maturation

Lynn VandenbergheBjörn HeindryckxKatrien SmitsKatarzyna Szymańska-VandendriesscheNerea Ortiz EscribanoMinerva Ferrer BuitragoKrishna PavaniLuc PeelmanDieter DeforcePetra De SutterAnn Van SoomCatharina De Schauwer

A1 Journal Article in REPRODUCTION FERTILITY AND DEVELOPMENT

Responsible innovation in human germline gene editing : background document to the recommendations of ESHG and ESHR

Guido de WertBjörn HeindryckxGuido PenningsAngus ClarkeUrsula Eichenlaub-RitterCarla G van ElFrancesca ForzanoMariëtte GoddijnHeidi C HowardDragica RadojkovicEmmanuelle Rial-SebbagWybo DondorpBasil C TarlatzisMartina C Cornel

A1 Journal Article in HUMAN REPRODUCTION OPEN

Responsible innovation in human germline gene editing : background document to the recommendations of ESHG and ESHRE

Guido De WertBjörn HeindryckxGuido PenningsAngus ClarkeUrsula Eichenlaub-RitterCarla G van ElFrancesca ForzanoMariëtte GoddijnHeidi C HowardDragica RadojkovicEmmanuelle Rial-SebbagWybo DondorpBasil C TarlatzisMartina C Cornel

A1 Journal Article in EUROPEAN JOURNAL OF HUMAN GENETICS

Robust protocol for feeder-free adaptation of frozen pluripotent stem cells using StemFlex

Jeffrey AaldersNatasja Van den VrekenBjörn HeindryckxJolanda van Hengel

Single Ca2+ transients vs oscillatory Ca2+ signaling for assisted oocyte activation : limitations and benefits

Minerva Ferrer BuitragoDavina BontePetra De SutterLuc LeybaertBjörn Heindryckx

A1 Journal Article in REPRODUCTION

Stem cell-derived spermatozoa

Jasin TaelmanSwati MishraMargot Van der JeughtBjörn Heindryckx

Bookchapter in Reproductomics : the -omics revolution and its impact on human reproductive medicine

Strontium fails to induce Ca2+ release and activation in human oocytes despite the presence of functional TRPV3 channels

Y LuR ReddyMinerva Ferrer BuitragoMargot Van der JeughtJitesh NeupaneWinnok De VosEtienne Van den AbbeelSylvie LiermanPetra De SutterBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION OPEN

The role of the reprogramming method and pluripotency state in gamete differentiation from patient-specific human pluripotent stem cells

Swati MishraE KacinPanagiotis StamatiadisS FranckMargot Van der JeughtHeidi MertesGuido PenningsPetra De SutterK SermonBjörn HeindryckxM Geens

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

The use of vitrified-thawed mouse oocytes and lysolecithin to determine the oocyte activation potential of human sperm by Ca2+ pattern analysis

Davina BonteVanessa ThysLuc LeybaertPetra De SutterBjörn Heindryckx

Transcriptional landscape changes during human embryonic stem cell derivation

Sharat WarrierJasin TaelmanLaurentijn TillemanMargot Van der JeughtGalbha DuggalSylvie LiermanMina PopovicAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter DeforceSusana Marina Chuva de Sousa LopesPetra De SutterBjörn Heindryckx

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Unraveling the causes of failed fertilization after intracytoplasmic sperm injection due to oocyte activation deficiency

Davina BonteRamesh Reddy GuggillaPanagiotis StamatiadisPetra De SutterBjörn Heindryckx

Bookchapter in Reproductomics : the -omics revolution and its impact on human reproductive medicine

Unravelling the molecular pathways responsible for sex determination in humans

Jasin TaelmanMina PopovicLaurentijn TillemanMargot Van der JeughtDieter DeforcePetra De SutterFilip Van NieuwerburghBjörn HeindryckxS Chuva De Sousa Lopes

Using vitrified mouse oocytes and lysolecithin to evaluate the oocyte-activating potential of human sperm by Ca2+ pattern analysis

Davina BonteVanessa ThysLuc LeybaertPetra De SutterBjörn Heindryckx

2017

CRISPR/Cas9-mediated genome editing in naive human embryonic stem cells followed by neural differentiation : an optimized workflow

Eva JacobsSharrat WarrierEva D'haeneMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

Eva JacobsSharat WarrierPieter-Jan VoldersEva D'haeneEva Van LombergenLies VantommeMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

A1 Journal Article in SCIENTIFIC REPORTS

Can vitrified-thawed mouse oocytes be efficiently used to determine the oocyte activation potential of human sperm?

Davina BonteMinerva Ferrer BuitragoVanessa ThysDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

Comprehensive comparison of inner cell mass and trophectoderm reveals the complex nature of chromosomal mosaicism in human embryos

Mina PopovicAnnelies DheedeneCHRISTODOULOS CHRISTODOULOUMargot Van der JeughtFilip Van NieuwerburghDieter DeforcePetra De SutterEtienne Van den AbbeelBjörn MentenBjörn Heindryckx

Direct comparison of distinct naive pluripotent states in human embryonic stem cells

Sharat WarrierMargot Van der JeughtGalbha DuggalLaurentijn TillemanElla SutherlandJasin TaelmanMina PopovicSylvie LiermanSusana Marina Chuva de Sousa LopesAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter De ConinckBjörn MentenPieter MestdaghJo VandesompeleDieter DeforcePetra De SutterBjörn Heindryckx

A1 Journal Article in NATURE COMMUNICATIONS

Human embryo research in Belgium : an overview

Guido PenningsSeppe SegersSophie DebrockBjörn HeindryckxVelichka Kontozova-DeutschUsha PunjabiHilde vande VeldeAndré van SteirteghemHeidi Mertes

A1 Journal Article in FERTILITY AND STERILITY

Metabolic plasticity complements the unique nature and demands of distinct pluripotency states

Mina PopovicBjörn Heindryckx

Novel reproductive technologies to prevent mitochondrial disease

Lyndsey CravenMaoxing TangGrainne S GormanPetra De SutterBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Origins of Human Embryonic Stem Cell Fate: Role of the Post Inner Cell Mass Intermediate

Sharat WarrierMina PopovicJasin TaelmanLaurentijn TillemanSylvie LiermanM. Ferrer-BuitragoS. Chuva De Sousa LopesAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter DeforcePetra De SutterBjörn Heindryckx

PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence

Alaa HachemJonathan GodwinMargarida RuasHoi Chang LeeMinerva Ferrer BuitragoGoli ArdestaniAndrew BassettSebastian FoxFelipe NavarretePetra De SutterBjörn HeindryckxRafael FissoreJohn Parrington

A1 Journal Article in DEVELOPMENT

Preimplantation genetic diagnosis for chromosomal rearrangements with the use of array comparative genomic hybridization at the blastocyst stage

CHRISTODOULOS CHRISTODOULOUAnnelies DheedeneBjörn HeindryckxFilip Van NieuwerburghDieter DeforcePetra De SutterBjörn MentenEtienne Van den Abbeel

A1 Journal Article in FERTILITY AND STERILITY

The role of calcium during oocyte maturation, activation and ageing

Yuechao LuPetra De SutterBjörn Heindryckx

Vitrified-thawed mouse oocytes can be efficiently used to determine the oocyte activation potential of human sperm

Davina BonteMinerva Ferrer BuitragoVanessa ThysDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

Wnt inhibition during hESC culture provides an improved pluripotent state starting point for directed differentiation

Jasin TaelmanLaurentijn TillemanFilip Van NieuwerburghSharat WarrierMina PopovicMargot Van der JeughtDieter DeforcePetra De SutterBjörn HeindryckxS. M. Chuva de Sousa Lopes

2016

Assessing the impact of minimizing arginine conversion in fully defined SILAC culture medium in human embryonic stem cells

Ellen ScheerlinckKatleen Van SteendamSimon DaledElisabeth GovaertLiesbeth VossaertPaulien MeertFilip Van NieuwerburghAnn Van SoomLuc PeelmanPetra De SutterBjörn HeindryckxMaarten DhaenensDieter Deforce

A1 Journal Article in PROTEOMICS

CRISPR/Cas9-mediated genome editing in naive human embryonic stem cells : an optimized workflow

Eva JacobsSharrat WarrierEva D'haeneMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

Effect of two assisted oocyte activation protocols used to overcome fertilization failure on the activation potential and calcium releasing pattern

Dimitra NikiforakiFrauke Vanden MeerschautChloë De RooYuechao LuMinerva Ferrer BuitragoPetra De SutterBjörn Heindryckx

A1 Journal Article in FERTILITY AND STERILITY

Elucidating the role of coding and noncoding genes in neuronal development using human embryonic stem cells and the CRISPR/Cas9 system

Eva JacobsSharat WarrierEva Van LombergenEva D'haeneMargot Van der JeughtBjörn HeindryckxSarah VergultBjörn Menten

Genome egineering through CRISPR/Cas9 technology in the human germline and pluripotent stem cells

Rita VassenaBjörn HeindryckxR PecoGuido PenningsA Raya

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Manipulating cell fate in mouse embryos and embryonic stem cells

Sabitri GhimirePetra De SutterBjörn Heindryckx

Massive parallel sequencing uncovers chromosomal mosaicism in human embryonic stem cells in both primed and naive culture conditions

Mina PopovicMargot Van der JeughtFranki SpelemanFilip Van NieuwerburghPetra De SutterBjörn MentenBjörn Heindryckx

Preimplantation genetic diagnosis (PGD) for translocation carriers using whole genome screening by microarray analysis at the blastocyst stage

CHRISTODOULOS CHRISTODOULOUAnnelies DheedeneIlse De CrooBjörn HeindryckxLieselot DeleyeFilip Van NieuwerburghDieter DeforcePetra De SutterBjörn MentenEtienne Van den Abbeel

Uncovering the novel role of mTORC2 subunit of the PI3K/AKT/mTORC pathway in establishing naive pluripotency in human embryonic stem cells

Sharat WarrierMargot Van der JeughtGalbha DuggalJasin TaelmanSylvie LiermanS. Chuva De Sousa LopesAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter De ConinckBjörn MentenJeroen Van de SompeleDieter DeforcePetra De SutterBjörn Heindryckx

Zinc chelation promotes oocyte activation in human oocytes

Davina BonteMinerva Ferrer BuitragoEtienne Van den AbbeelMargot Van der JeughtDieter DeforceLuc LeybaertPetra De SutterBjörn Heindryckx

2015

Alternative routes to induce naive pluripotency in human embryonic stem cells

Galbha DuggalSharat WarrierSabitri GhimireDorien BroekaertMargot Van der JeughtSylvie LiermanTom DerooLuc PeelmanAnn Van SoomMaria CornelissenBjörn MentenPieter MestdaghJo VandesompeleMatthias RoostRoderick C SliekerBastiaan T HeijmansDieter DeforcePetra De SutterSusana Marina Chuva de Sousa LopesBjörn Heindryckx

A1 Journal Article in STEM CELLS

Application of small molecules favoring naive pluripotency during human embryonic stem cell derivation

Margot Van der JeughtJasin TaelmanGalbha DuggalSabitri GhimireSylvie LiermanSusana Marina Chuva de Sousa LopesDieter DeforceTom DerooPetra De SutterBjörn Heindryckx

A1 Journal Article in CELLULAR REPROGRAMMING

CRISPR/Cas9-mediated genome editing in primed versus naïve human embryonic stem cells

Eva JacobsSharat WarrierEva D'haeneFilip MatthijssensMargot Van der JeughtBjörn HeindryckxBjörn MentenSarah Vergult

Cellular heterogeneity in the level of mtDNA heteroplasmy in mouse embryonic stem cells

Jitesh NeupaneSabitri GhimireMado VandewoestyneYuechao LuJan GerrisRudy Van CosterTom DerooDieter DeforceStijn VansteelandtPetra De SutterBjörn Heindryckx

A1 Journal Article in CELL REPORTS

Comparative analysis of different culture conditions inducing naive pluripotency in human embryonic stem cells

Sharat WarrierGalbha DuggalJasin TaelmanSylvie LiermanS Chuva de Sousa LopesAnn Van SoomLuc PeelmanFilip Van NieuwerburghDieter De ConinckBjörn MentenJeroen Van de SompeleDieter DeforceMargot Van der JeughtPetra De SutterBjörn Heindryckx

Cyclin E1 plays a key role in balancing between totipotency and differentiation in human embryonic cells

MV KrivegaM GeensBjörn HeindryckxS Santos-RibeiroH TournayeH Van de Velde

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Derivation conditions affect pluripotency and differentiation propensity of mouse embryonic stem cells

S. GhimireMargot Van der JeughtJitesh NeupaneFilip Van NieuwerburghDieter DeforceS. Chuva de Sousa LopesPetra De SutterBjörn Heindryckx

Exogenous supplementation of Activin A enhances germ cell differentiation of human embryonic stem cells

Galbha DuggalBjörn HeindryckxSharat WarrierJasin TaelmanMargot Van der JeughtDieter DeforceSusana Marina Chuva de Sousa LopesPetra De Sutter

A1 Journal Article in MOLECULAR HUMAN REPRODUCTION

Human oocyte activation and the causes of fertilization failure

Dimitra NikiforakiPetra De SutterBjörn Heindryckx

Inhibition of transforming growth factor β signaling promotes epiblast formation in mouse embryos

Sabitri GhimireBjörn HeindryckxMargot Van der JeughtJitesh NeupaneThomas O'LearySylvie LiermanWinnok De VosSusana Marina Chuva de Sousa LopesTom DerooPetra De Sutter

A1 Journal Article in STEM CELLS AND DEVELOPMENT

PLCζ disruption with complete fertilization failure in normozoospermia

Mercè DurbanMontserrat BarraganMarta ColodronMinerva Ferrer BuitragoPetra De SutterBjörn HeindryckxValérie VernaeveRita Vassena

A1 Journal Article in JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

PLCζ disruption with complete fertilization failure in normozoospermia (vol 32, pg 879, 2015)

Mercè DurbanMontserrat BarragánMarta ColodronMinerva Ferrer-BuitragoPetra De SutterBjörn HeindryckxValérie VernaeveRita Vassena

Procaine induces cytokinesis in horse oocytes via a pH-dependent mechanism

Bart LeemansBart M GadellaTom AE StoutSonia Heras GarciaKatrien SmitsMinerva Ferrer BuitragoEline ClaesBjörn HeindryckxWinnok De VosHilde NelisMaarten HoogewijsAnn Van Soom

A1 Journal Article in BIOLOGY OF REPRODUCTION

Procaine induces parthenogenetic cytokinesis in horse oocytes via a pH dependent mechanism

Bart LeemansBart M GadellaTom AE StoutSonia Heras GarciaKatrien SmitsMinerva Ferrer BuitragoEline ClaesBjörn HeindryckxWinnok De VosHilde NelisMaarten HoogewijsAnn Van Soom

Shallow whole genome sequencing is well suited for the detection of chromosomal aberrations in human blastocysts

Lieselot DeleyeAnnelies DheedeneDieter De ConinckTom SanteCHRISTODOULOS CHRISTODOULOUBjörn HeindryckxEtienne Van den AbbeelPetra De SutterDieter DeforceBjörn MentenFilip Van Nieuwerburgh

A1 Journal Article in FERTILITY AND STERILITY

Stem cells in reproductive medicine: ready for the patient?

R VassenaC EguizabalBjörn HeindryckxK SermonC SimonAMM van PeltA VeigaF Zambelli

A1 Journal Article in HUMAN REPRODUCTION

The post-inner cell mass intermediate : implications for stem cell biology and assisted reproductive technology

Margot Van der JeughtThomas O'LearyGalbha DuggalPetra De SutterSusana Marina Chuva de Sousa LopesBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Whole genome amplification with SurePlex results in better copy number alteration detection using sequencing data compared to the MALBAC method

Lieselot DeleyeDieter De ConinckCHRISTODOULOS CHRISTODOULOUTom SanteAnnelies DheedeneBjörn HeindryckxEtienne Van den AbbeelPetra De SutterBjörn MentenDieter DeforceFilip Van Nieuwerburgh

A1 Journal Article in SCIENTIFIC REPORTS

2014

A systematic analysis of the suitability of preimplantation genetic diagnosis for mitochondrial diseases in a heteroplasmic mitochondrial mouse model

Jitesh NeupaneMado VandewoestyneBjörn HeindryckxSabitri GhimireYuechao LuChen QianSylvie LiermanRudy Van CosterJan GerrisTom DerooDieter DeforcePetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Assessment of cellular heterogeneity in the level of mitochondrial DNA heteroplasmy in mouse embryonic stem cells

Jitesh NeupaneBjörn HeindryckxMado VandewoestyneSabitri GhimireYuechao LuRudy Van CosterDieter DeforceTom DerooPetra De Sutter

Assessment of nuclear transfer techniques to prevent the transmission of heritable mitochondrial disorders without compromising embryonic development competence in mice

Jitesh NeupaneMado VandewoestyneSabitri GhimireYuechao LuChen QianRudy Van CosterJan GerrisTom DerooDieter DeforcePetra De SutterBjörn Heindryckx

A1 Journal Article in MITOCHONDRION

Assisted oocyte activation following ICSI fertilization failure

Frauke Vanden MeerschautDimitra NikiforakiBjörn HeindryckxPetra De Sutter

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

Detailed method description for noninvasive monitoring of differentiation status of human embryonic stem cells

Ellen ScheerlinckKatleen Van SteendamMado VandewoestyneTrees LepezVeerle GobinPaulien MeertLiesbeth VossaertFilip Van NieuwerburghAnn Van SoomLuc PeelmanBjörn HeindryckxPetra De SutterMaarten DhaenensDieter Deforce

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Effect of ionomycin and calcium in the culture medium on the calcium releasing pattern of mouse oocytes and their subsequent embryonic development

Yuechao LuDimitra NikiforakiFrauke Vanden MeerschautJitesh NeupaneChen QianWinnok De VosJP OzilTom DerooPetra De SutterBjörn Heindryckx

Identification of histone H3 clipping activity in human embryonic stem cells

Liesbeth VossaertPaulien MeertEllen ScheerlinckPieter GlibertNadine Van RoyBjörn HeindryckxPetra De SutterMaarten DhaenensDieter Deforce

A1 Journal Article in STEM CELL RESEARCH

Inhibition of TGFß signaling supports embryonic stem cell derivation and the ground state of pluripotency in mouse

Sabitri GhimireBjörn HeindryckxJitesh NeupaneDieter DeforceTom DerooPetra De Sutter

Language development of children born following intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA)

Evelien D'haeseleerFrauke Vanden MeerschautKim BettensAnke LuytenHannelore GyselsYlenia ThienpontGriet De WitteBjörn HeindryckxAnn OostraHerbert RoeyersPetra De SutterKristiane Van Lierde

A1 Journal Article in INTERNATIONAL JOURNAL OF LANGUAGE & COMMUNICATION DISORDERS

Mutation-free baby born from a mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome carrier after blastocyst trophectoderm preimplantation genetic diagnosis

Björn HeindryckxJitesh NeupaneMado VandewoestyneCHRISTODOULOS CHRISTODOULOUYens JackersJan GerrisEtienne Van den AbbeelRudy Van CosterDieter DeforcePetra De Sutter

A1 Journal Article in MITOCHONDRION

Neonatal and neurodevelopmental outcome of children aged 3-10 years born following assisted oocyte activation

Frauke Vanden MeerschautEvelien D'haeseleerHannelore GyselsYlenia ThienpontGrietje DewitteBjörn HeindryckxAnn OostraHerbert RoeyersKristiane Van LierdePetra De Sutter

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

Oocyte cryopreservation and in vitro culture affect calcium signalling during human fertilization

Dimitra NikiforakiFrauke Vanden MeerschautChen QianIlse De CrooYuechao LuTom DerooEtienne Van den AbbeelBjörn HeindryckxPetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Sperm involved in recurrent partial hydatidiform moles cannot induce the normal pattern of calcium oscillations

Dimitra NikiforakiFrauke Vanden MeerschautStefanie De GheselleChen QianEtienne Van den AbbeelWinnok De VosTom DerooPetra De SutterBjörn Heindryckx

A1 Journal Article in FERTILITY AND STERILITY

Toxic effects of Hoechst staining and UV irradiation on preimplantation development of parthenogenetically activated mouse oocytes

Karen VersierenBjörn HeindryckxChen QianJan GerrisPetra De Sutter

A1 Journal Article in ZYGOTE

Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation

Margot Van der JeughtBjörn HeindryckxThomas O'LearyGalbha DuggalSabitri GhimireSylvie LiermanNadine Van RoySusana Marina Chuva de Sousa LopesTom DerooDieter DeforcePetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Use of pluripotent stem cells for reproductive medicine: are we there yet?

Galbha DuggalBjörn HeindryckxTom DerooPetra De Sutter

A1 Journal Article in VETERINARY QUARTERLY

2013

Analysis of calcium oscillations pattern triggered by human sperm showing failed or low fertilization

Björn HeindryckxDimitra NikiforakiLeen CaluwaertsFrauke Vanden MeerschautTom DerooPetra De Sutter

Belgium: ISO 9001:2000 certification as a base for total quality management in ART

Kelly TillemanEtienne Van den AbbeelIlse De CrooAnneleen Van De VeldeBjörn HeindryckxSandra DeltombeIsabelle StuyverAnnick GerilPetra De Sutter

Bookchapter in Quality management in ART clinics : a practical guide

Comparison of pre- and post-implantation development following the application of three artificial activating stimuli in a mouse model with round-headed sperm cells deficient for oocyte activation

Frauke Vanden MeerschautDimitra NikiforakiChloë De RooSylvie LiermanChen QianT Schmitt-JohnPetra De SutterBjörn Heindryckx

A1 Journal Article in HUMAN REPRODUCTION

De taalontwikkeling van kinderen geboren na kunstmatige bevruchting met geassisteerde eicelactivatie, een pilootstudie

Evelien D'haeseleerFrauke Vanden MeerschautKim BettensAnke LuytenHannelore GyselsYlenia ThienpontGriet De WitteBjörn HeindryckxAnn OostraHerbert RoeyersPetra De SutterKristiane Van Lierde

A2 Journal Article in LOGOPEDIE (HERENTALS)

Derivation of human embryonic stem cells using a post-inner cell mass intermediate

Thomas O'LearyBjörn HeindryckxSylvie LiermanMargot Van der JeughtGalbha DuggalPetra De SutterSusana M Chuva de Sousa Lopes

A1 Journal Article in NATURE PROTOCOLS

Diagnostic and prognostic value of calcium oscillatory pattern analysis for patients with ICSI fertilization failure

Frauke Vanden MeerschautLuc LeybaertDimitra NikiforakiChen QianBjörn HeindryckxPetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Efficiency and safety of assisted oocyte activation (AOA) in the mouse and the human

Frauke Vanden MeerschautPetra De SutterBjörn Heindryckx

Evaluation of calcium machinery in a meiosis defect mouse model

Yuechao LuDimitra NikiforakiFrauke Vanden MeerschautJitesh NeupaneWinnok De VosSylvie LiermanTom DerooBjörn HeindryckxPetra De Sutter

Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential

Galbha DuggalBjörn HeindryckxSharat WarrierThomas O'LearyMargot Van der JeughtSylvie LiermanLiesbeth VossaertTom DerooDieter DeforceSusana Marina Chuva de Sousa LopesPetra De Sutter

A1 Journal Article in STEM CELLS AND DEVELOPMENT

Nuclear transfer can prevent mitochondrial DNA carry-over without compromising embryonic development potential in mice

Jitesh NeupaneMado VandewoestyneBjörn HeindryckxTom DerooYuechao LuSabitri GhimireSylvie LiermanChen QianDieter DeforcePetra De Sutter

Reference loci for RT-qPCR analysis of differentiating human embryonic stem cells

Liesbeth VossaertThomas O'LearyChristophe Van NesteBjörn HeindryckxJo VandesompelePetra De SutterDieter Deforce

A1 Journal Article in BMC MOLECULAR BIOLOGY

Regulation of inositol 1,4,5-trisphosphate receptor during human oocyte maturation and fertilization

Dimitra NikiforakiLiesbeth VossaertFrauke Vanden MeerschautChen QianYuechao LuJ ParysWinnok De VosDieter DeforceTom DerooEtienne Van den AbbeelLuc LeybaertBjörn HeindryckxPetra De Sutter

The combination of inhibitors of FGF/MEK/Erk and GSK3β signaling increases the number of OCT3/4-and NANOG-positive cells in the human inner cell mass, but does not improve stem cell derivation

Margot Van der JeughtThomas O'LearySabitri GhimireSylvie LiermanGalbha DuggalKaren VersierenDieter DeforceSusana Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

A1 Journal Article in STEM CELLS AND DEVELOPMENT

Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability

Junaid KashirCeline JonesGinny MounceWalaa M RamadanBernadette LemmonBjörn HeindryckxPetra De SutterJohn ParringtonKaren TurnerTim ChildEnda McVeighKevin Coward

A1 Journal Article in FERTILITY AND STERILITY

2012

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility

Junaid KashirMichalis KonstantinidisCeline JonesBernadette LemmonHoi Chang LeeRebecca HamerBjörn HeindryckxCharlotte M DeanePetra De SutterRafael A FissoreJohn ParringtonDagan WellsKevin Coward

A1 Journal Article in HUMAN REPRODUCTION

A sperm's tail: the need to consider temporal aspects of specific physiological mechanisms during and following gamete fusion

J KashirBjörn HeindryckxC JonesPetra De SutterJ ParringtonKevin Coward

A1 Journal Article in HUMAN REPRODUCTION

Assisted oocyte activation is not beneficial for all patients with a suspected oocyte-related activation deficiency

Frauke Vanden MeerschautDimitra NikiforakiStefanie De GheselleValerie DullaertsEtienne Van den AbbeelJan GerrisBjörn HeindryckxPetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Calcium response during human oocyte activation : the effect of in vitro maturation and cryopreservation

Dimitra NikiforakiFrauke Vanden MeerschautChen QianEtienne Van den AbbeelBjörn HeindryckxPetra De Sutter

Calciumpatroonanalyse tijdens eicelrijping en na toepassing van geassisteerde eicelactivatie

Chloë De RooDimitra NikiforakiFrauke Vanden MeerschautYuechao LuSylvie LiermanChen QianBjörn HeindryckxPetra De Sutter

Challenges and possible clinical applications of human embryonic stem cell research

Björn HeindryckxThomas O'LearyMargot Van der JeughtPetra De Sutter

A2 Journal Article in PROCEEDINGS OF THE BELGIAN ROYAL ACADEMIES OF MEDICINE

Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells

Junaid KashirMichalis KonstantinidisCeline JonesBjörn HeindryckxPetra De SutterJohn ParringtonDagan WellsKevin Coward

A1 Journal Article in FERTILITY AND STERILITY

Comparison of the effect of ionomycin versus calcimycin on the intracellular calcium level in mouse and human oocytes and subsequent oocyte activation

Frauke Vanden MeerschautChloë De RooDimitra NikiforakiSylvie LiermanChen QianBjörn HeindryckxPetra De Sutter

Diagnostic calcium pattern analysis in mouse oocytes for patients with previous fertilization failure following ICSI

Frauke Vanden MeerschautDimitra NikiforakiChen QianBjörn HeindryckxLuc LeybaertPetra De Sutter

Dose-dependent effect of inhibition of the transforming growth factor beta pathway during early mouse lineage segregation

Sabitri GhimireMargot Van der JeughtJitesh NeupaneSylvie LiermanThomas O'LearySusana Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

Effect of small molecule supplements during in vitro culture of mouse zygotes and parthenogenetic embryos on hypoblast formation and stem cell derivation

Karen VersierenMargot Van der JeughtThomas O'LearyGalbha DuggalJan GerrisS Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

A1 Journal Article in STEM CELL REVIEWS AND REPORTS

Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots

Elias EllnatiPaul KuentzClaire RedinSara JaberFrauke Vanden MeerschautJoelle MakarianIsabelle KoscinskiMohammad H Nasr-EsfahaniAygul DemirolTimur GurganNoureddine LouanjliNaeem IqbalMazen BisharahFrédérique Carré PigeonH GourabiDominique De BrielFlorence BrugnonSusan A GitlinJean-Marc GrilloKamran GhaediMohammad R DeemehSomayeh TanhaeiParastoo ModarresBjörn HeindryckxMoncef BenkhalifaDimitra NikiforakiSergio C OehningerPetra De SutterJean MullerStéphane Viville

A1 Journal Article in HUMAN MOLECULAR GENETICS

Human embryonic stem cell derivation : influences and origin

Thomas O'LearyPetra De SutterBjörn Heindryckx

Influence of hESC derivation conditions on germ cell differentiation potential

Galbha DuggalBjörn HeindryckxThomas O'LearySylvie LiermanDieter DeforceSusana Chuva de Sousa LopesPetra De Sutter

Influence of human sperm motility and cryopreservation on the oocyte activating factor phospholipase C zeta

Björn HeindryckxDimitra NikiforakiFrauke Vanden MeerschautWinnok De VosSylvie LiermanPetra De Sutter

Morphological survival of twice-cryopreserved human embryos

Sylvie LiermanIlse De CrooBjörn HeindryckxEtienne Van den AbbeelPetra De Sutter

Poor correlation between polar bodies and blastomere mutation load in a patient with m.3243A>G tRNALeu(UUR) point mutation

Mado VandewoestyneBjörn HeindryckxStefanie De GheselleTrees LepezJitesh NeupaneJan GerrisRudy Van CosterPetra De SutterDieter Deforce

A1 Journal Article in MITOCHONDRION

Pronuclear transfer in mice yields minimal mitochondrial DNA carry-over

Mado VandewoestyneJitesh NeupaneBjörn HeindryckxSylvie LiermanDieter DeforcePetra De Sutter

Reliability of pre-implantation genetic diagnosis in a heteroplasmic mitochondrial mouse model

Jitesh NeupaneMado VandewoestyneBjörn HeindryckxSabitri GhimireYuechao LuSylvie LiermanChen QianDieter DeforcePetra De Sutter

Reliability of pre-implantation genetic diagnosis in a heteroplasmic mitochondrial mouse model

Jitesh NeupaneMado VandewoestyneBjörn HeindryckxSabitri GhimireYuechao LuChen QianDieter DeforcePetra De Sutter

The TGFβ pathway plays a pivotal role in early embryo lineage segregation

Margot Van der JeughtSabitri GhimireThomas O'LearySylvie LiermanDieter DeforceSusana Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

The effect of oocyte aging on the calcium oscillations and embryo development of in vivo and in vitro matured oocytes

Yuechao LuDimitra NikiforakiFrauke Vanden MeerschautJitesh NeupaneBjörn HeindryckxPetra De Sutter

The influence of patient and cohort parameters on the incidence and developmental potential of embryos with poor quality traits for use in human embryonic stem cell derivation

Thomas O'LearyGalbha DuggalSylvie LiermanEtienne Van den AbbeelBjörn HeindryckxPetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Tracking the progression of X-chromosome inactivation and reactivation during female human embryonic stem cell derivation

Thomas O'LearyBjörn HeindryckxMargot Van der JeughtGalbha DuggalSusana Chuva de Sousa LopesPetra De Sutter

Tracking the progression of the human inner cell mass during embryonic stem cell derivation

Thomas O'LearyBjörn HeindryckxSylvie LiermanDavid van BruggenJelle J GoemanMado VandewoestyneDieter DeforceSusana M Chuva de Sousa LopesPetra De Sutter

A1 Journal Article in NATURE BIOTECHNOLOGY

Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation

Margot Van der JeughtThomas O'LearySylvie LiermanDieter DeforceSusana Chuva de Sousa LopesBjörn HeindryckxPetra De Sutter

2011

Aberrant spindle structures responsible for recurrent human metaphase I oocyte arrest with attempts to induce meiosis artificially

Björn HeindryckxSylvie LiermanCM CombellesClaude CuvelierJan GerrisPetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Calcium releasing ability of human sperm with deficient oocyte activation capacity

Dimitra NikiforakiFrauke Vanden MeerschautChen QianDieter DeforceEsther Van den AbbeelK CowardJ ParringtonLuc LeybaertBjörn HeindryckxPetra De Sutter

Culture optimisation to direct differentiation of human embryonic stem cells into primordial germ cells

Galbha DuggalBjörn HeindryckxThomas O'LearySylvie LiermanDieter DeforceS Chuva de Sousa LopesPetra De Sutter

Differential apoptotic staining of mammalian blastocysts based on double immunofluorescent CDX2 and active caspase-3 staining

Eline WydoogheLeen VandaeleJosine BeekHerman FavoreelBjörn HeindryckxPetra De SutterAnn Van Soom

A1 Journal Article in ANALYTICAL BIOCHEMISTRY

Efficiency of polarized microscopy as a predictive tool for human oocyte quality

Björn HeindryckxStefanie De GheselleSylvie LiermanJan GerrisPetra De Sutter

A1 Journal Article in HUMAN REPRODUCTION

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

Junaid KashirCeline JonesHoi Chang LeeKatja RietdorfDimitra NikiforakiClaire DurransMargarida RuasSze Tian TeeBjörn HeindryckxAntony GalionePetra De SutterRafael FissoreJohn ParringtonKevin Coward

A1 Journal Article in HUMAN REPRODUCTION

Phospholipase Cβ1 as a possible oocyte factor responsible for successful oocyte activation and embryo development

Frauke Vanden MeerschautBjörn HeindryckxChen QianDieter DeforceLuc LeybaertPetra De Sutter

Polar body mutation load analysis in a patient with A3243G tRNALeu(UUR) point mutation

Mado VandewoestyneBjörn HeindryckxTrees LepezRudy Van CosterJan GerrisPetra De SutterDieter Deforce

A1 Journal Article in MITOCHONDRION

Slow controlled-rate freezing of human in vitro matured oocytes: effects on maturation rate and kinetics and parthenogenetic activation

Karen VersierenBjörn HeindryckxThomas O'LearyIlse De CrooEtienne Van den AbeelJan GerrisPetra De Sutter

A1 Journal Article in FERTILITY AND STERILITY

Slow controlled-rate freezing of human in vitro matured oocytes: effects on maturation rate and kinetics, parthenogenesis and spindle structure

Karen VersierenBjörn HeindryckxIlse De CrooSylvie LiermanWinnok De VosEsther Van den AbbeelJan GerrisPetra De Sutter

The influence of early embryo traits on human embryonic stem cell derivation efficiency

Thomas O'LearyBjörn HeindryckxSylvie LiermanMargot Van der JeughtBjörn MentenDieter DeforceMaria CornelissenSusana Chuva de Sousa LopesPetra De Sutter

A1 Journal Article in STEM CELLS AND DEVELOPMENT

2010

Comparison of three artificial activating stimuli using a mouse model deficient for oocyte activation

Björn HeindryckxFrauke Vanden MeerschautSylvie LiermanChen QianThomas O'LearyJan GerrisPetra De Sutter

Developmental competence of parthenogenetic mouse and human embryos after chemical or electrical activation

Karen VersierenBjörn HeindryckxSylvie LiermanJan GerrisPetra De Sutter

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

Efficiency of assisted oocyte activation (AOA) in patients with an oocyte factor deficiency diagnosed by the mouse oocyte activation test (MOAT)

Frauke Vanden MeerschautBjörn HeindryckxStefanie De GheselleValerie DullaertsJan GerrisPetra De Sutter

Identification and functional characterization of a point mutation in the gene encoding the sperm factor phospholipase C zeta in an infertile male

J KashirC JonesC YoungM RuasP GrasaK RietdorfElke HeytensBjörn HeindryckxSY YoonRA FissoreCM DeaneD NikiforakiST TeePetra De SutterJ ParringtonK Coward

Oocyte activation, phospholipase C zeta and human infertility

J KashirBjörn HeindryckxC JonesPetra De SutterJ ParringtonK Coward

A1 Journal Article in HUMAN REPRODUCTION UPDATE

Techniques to prevent mitochondrial mutation transmission

Björn HeindryckxMado VandewoestyneDieter DeforcePetra De Sutter

Toxic effects of Hoechst staining and UV-irradiation on preimplantation development of parthenogenetically activated mouse oocytes

Karen VersierenBjörn HeindryckxChen QianJan GerrisPetra De Sutter

2009

Behandeling van gefaalde bevruchting na ICSI

Björn HeindryckxPetra De Sutter

A4 Journal Article in Freya

Somatic Nuclear Transfer to In Vitro-Matured Human Germinal Vesicle Oocytes

Björn HeindryckxPetra De SutterJan Gerris

Bookchapter in Stem Cells in Human Reproduction - Basic Science and Therapeutic Potential

2008

Efficiency of assisted oocyte activation as a solution for failed intracytoplasmic sperm injection

Björn HeindryckxSTEFANIE DE GHESELLEJan GerrisMARC DHONTPetra De Sutter

A1 Journal Article in REPRODUCTIVE BIOMEDICINE ONLINE

Optimization of Somatic Cell Nuclear Transfer (SCNT).

Björn HeindryckxJan GerrisMARC DHONTPetra De Sutter

Polscope imaging in the IVF&research lab

Björn Heindryckx

2007

Embryo development after successful somatic cell nuclear transfer to in vitro matured human germinal vesicle oocytes

Björn HeindryckxPetra De SutterJan GerrisMARC DHONTJosiane Van der Elst

A1 Journal Article in HUMAN REPRODUCTION

High success rate of assisted oocyte activation after a diagnostic mouse oocyte activation test in couples with low or failed fertilization after ICSI

Björn HeindryckxSTEFANIE DE GHESELLELeen VanhoutteJan GerrisMARC DHONTPetra De Sutter

Kunstmatige geslachtscellen en geassisteerde eicelactivatie. Een experimentele bijdrage tot onvruchtbaarheidsonderzoek en -behandeling

Björn HeindryckxJosiane Van der ElstPetra De SutterMARC DHONT

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

Kunstmatige geslachtscellen en geassisteerde eicelactivatie. Een experimentele bijdrage tot onvruchtbaarheidsonderzoek en –behandeling.

Björn HeindryckxJosiane Van der ElstPetra De SutterMARC DHONT

A2 Journal Article in TIJDSCHRIFT VOOR GENEESKUNDE

2006

Assisted oocyte activation during ICSI

Björn HeindryckxPetra De SutterMARC DHONTJan Gerris

A2 Journal Article in Embryo Talk

Back muscle transplantation model for ovarian allo- and xenografts

Reza SoleimaniJ LIUBjörn HeindryckxRudy Van den BroeckePetra De SutterJan GerrisMARC DHONTJosiane Van der Elst

Culture medium preferences of pre-implantation cloned mouse embryos

Björn HeindryckxJosiane Van der ElstMarc Dhont

Bookchapter in Nuclear transfer protocols : cell reprogramming and transgenesis

In vitro matured oocytes for human cloning

Björn Heindryckx

Optimisation of Somatic Cell Nuclear Transfer as a Strategy for Infertility Treatment

Björn HeindryckxPetra De SutterMARC DHONTJan Gerris

A4 Journal Article in Embryo Talk

Optimisation of Somatic Cell Nuclear Transfer in Mice as a strategy for Infertility Treatment

Björn HeindryckxPetra De SutterMARC DHONTJan Gerris

A2 Journal Article in Embryo Talk

2005

Treatment option for sperm- or oocyte-related fertilization failure: assisted oocyte activation following diagnostic heterologous ICSI

Björn HeindryckxJosiane Van der ElstPetra De SutterMARC DHONT

A1 Journal Article in HUMAN REPRODUCTION

2004

Chromosome number and development of artificial mouse oocytes and zygotes

Björn HeindryckxSylvie LiermanJosiane Van der ElstMARC DHONT

A1 Journal Article in HUMAN REPRODUCTION

Human Pregnancies after assisted oocyte activation during ICSI in sperm- and oocyte-borne activation failure

Björn HeindryckxJosiane Van der ElstPetra De SutterMARC DHONT

2003

De muizenoöcytactivatietest en geassisteerde eicelactivatie bij ICSI

Björn HeindryckxSylvie LiermanPetra De SutterJosiane Van der ElstMARC DHONT

A2 Journal Article in TIJDSCHRIFT VOOR FERTILITEITSONDERZOEK

2002

Developmental potential of cloned mouse embryos reconstructed by a conventional technique of nuclear injection.

Andrei RybouchkinBjörn HeindryckxJosiane Van der ElstMarc Dhont

A1 Journal Article in REPRODUCTION

Serial pronuclear transfer increases the developmental potential of in vitro-matured oocytes in mouse cloning.

Björn HeindryckxAndrei RybouchkinJosiane Van der ElstMarc Dhont

A1 Journal Article in BIOLOGY OF REPRODUCTION

2001

Effect of culture media on in vitro development of cloned mouse embryos

Björn HeindryckxAndrei RybouchkinJosiane Van der ElstMarc Dhont

A2 Journal Article in CLONING