Research Explorer

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Bart Roman

Publicaties & datasets

Prijzen & Erkenningen

74 Resultaten

2025

HNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis

Céline Van DenderSteven TimmermansMaxime RoesMadeleine HellemansElise MoensLouise NuyttensMaarten ClaesBart RomanKarolien De BosscherJolien Vandewalle et al.

A1 Artikel in een tijdschrift in FRONTIERS IN IMMUNOLOGY

2024

A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death

Céline Van DenderSteven TimmermansVille PaakinahoTineke VanderhaeghenJolien VandewalleMaarten ClaesBruno GarciaBart RomanJan De WaeleSiska Croubels et al.

A1 Artikel in een tijdschrift in EMBO MOLECULAR MEDICINE

Glioblastoma-associated mesenchymal stem/stromal cells and cancer-associated fibroblasts : partners in crime?

Thibault LootensBart RomanChristian StevensOlivier De WeverRobrecht Raedt

A1 Artikel in een tijdschrift in INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

2023

Selective modulation of cancer-associated fibroblasts in the tumor microenvironment by the small molecule inhibitor C16

Christophe MangodtChristian StevensOlivier De WeverBart Roman

2021

Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells

Aranit HarizajBenedicte DescampsChristophe MangodtStephan StremerschArianna StoppaLieve BalcaenToon BransHilde De RoosterNausikaa DevriendtJuan Fraire et al.

A1 Artikel in een tijdschrift in BIOMATERIALS SCIENCE

The expanding role of chemistry in optimizing proteins for human health applications

A1 Artikel in een tijdschrift in JOURNAL OF MEDICINAL CHEMISTRY

2020

Genetic events contributing to tumour promotion and aggressiveness in high-risk neuroblastoma

Liselot MusFranki SpelemanKaat DurinckBart Roman

2019

Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study

Marine MovsisyanLaurens De CoenThomas HeugebaertArno VerleeBart RomanChristian Stevens

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Essay: Avoiding unfounded health claims on small molecules in scientific literature

A1 Artikel in een tijdschrift in BIOORGANIC CHEMISTRY

Plant based Pickering stabilization of emulsions using soluble flaxseed protein and mucilage nano-assemblies

Maryam Nikbakht NasrabadiSayed Amir Hossein GoliAli Sedaghat DoostBart RomanKoen DewettinckChristian StevensPaul Van der Meeren

A1 Artikel in een tijdschrift in COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

2018

Atom- and mass-economical continuous flow production of 3-chloropropionyl chloride and its subsequent amidation

Marine MovsisyanThomas HeugebaertBart RomanRudolf DamsRudy Van CampenhoutMatthias ConradiChristian Stevens

A1 Artikel in een tijdschrift in CHEMISTRY-A EUROPEAN JOURNAL

From natural flavonoids to pharmacological tools : proceed with caution

Medicinal chemistry and use of myosin II inhibitor (S)-blebbistatin and its derivatives

Bart RomanSigrid VerhasseltChristian Stevens

A1 Artikel in een tijdschrift in JOURNAL OF MEDICINAL CHEMISTRY

Recovering actives in multi-antitarget and target design of analogs of the myosin II inhibitor blebbistatin

Bart RomanRita C GuedesChristian StevensAlfonso T García-Sosa

A1 Artikel in een tijdschrift in FRONTIERS IN CHEMISTRY

Synthesis and biological activity of oxazolopyrimidines

Laurens De CoenBart RomanMarine MovsisyanThomas HeugebaertChristian Stevens

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of C-ring-modified blebbistatin derivatives and evaluation of their myosin II ATPase inhibitory potency

Bart RomanSigrid VerhasseltChristophe MangodtOlivier De WeverChristian Stevens

A1 Artikel in een tijdschrift in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Vehicle development, pharmacokinetics and toxicity of the anti-invasive agent 4-fluoro-3’,4’,5’-trimethoxychalcone in rodents

Liselot MusGeertrui DeneckerFranki SpelemanBart Roman

A1 Artikel in een tijdschrift in PLOS ONE

2017

A new class of bicyclic dicationic salts based on the 7-azoniabicyclo[2.2.1]heptane scaffold

Laurens De CoenBart RomanMarine MovsisyanBrecht D'hontNils De VosKristof Van HeckeChristian Stevens

A1 Artikel in een tijdschrift in TETRAHEDRON LETTERS

Anticancer chalcones : selective or multitarget ligands?

Chalcones as anti-invasive agents : challenges and opportunities

A2 Artikel in een tijdschrift in BELGIAN JOURNAL OF MEDICAL ONCOLOGY

Development of novel blebbistatin derivatives in the quest for improved non-muscle myosin II inhibitors

Sigrid VerhasseltChristian StevensBart RomanMarc Bracke

Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties

Sigrid VerhasseltBart RomanOlivier De WeverKristof Van HeckeRik Van DeunMarc BrackeChristian Stevens

A1 Artikel in een tijdschrift in ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery of anti-invasive tools and leads for the study and treatment of metastatic cancer : two case studies

Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs

Sigrid VerhasseltBart RomanMarc BrackeChristian Stevens

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vitro celecoxib supplementation impacts the functional capacities of the gut microbiota

Emma Hernandez SanabriaEvelien HeiremansMarta Calatayud ArroyoBart RomanSven MangelinckxLaurent LeclercqJan SnoeysTom Van de Wiele

Insights into the myosin II inhibitory potency of A-ring-modified (S)-blebbistatin analogs

Sigrid VerhasseltChristian StevensTom Van den broeckeMarc BrackeBart Roman

A1 Artikel in een tijdschrift in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 7-azoniabicyclo[2.2.1]heptane-based dicationic liquids

Laurens De CoenBart RomanBrecht D'hontNils De VosKristof Van HeckeChristian Stevens

2016

4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent : from discovery to initial validation in an in vivo metastasis model

Bart RomanLiselot MusTine De RyckMarc BrackeChristian Stevens

4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model

Bart RomanLiselot MusMarc BrackeChristian Stevens

4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model

Bart RomanLiselot MusTine De RyckMarc BrackeChristian Stevens

Discovery and development of new anti-invasive agents, an unmet clinical need

Bart RomanLiselot MusTine De RyckMarc BrackeChristian Stevens

Discovery of anti-invasive tools and leads for the study and treatment of metastatic cancer : two case studies

Bart RomanSigrid VerhasseltMarc BrackeChristian Stevens

Discovery of novel nonmuscle myosin II inhibitors as antimetastatic therapeutics leads and chemical tools

Sigrid VerhasseltMarc BrackeChristian StevensBart Roman

Discovery of novel nonmuscle myosin II inhibitors as chemical tools and antimetastatic therapeutics leads

Sigrid VerhasseltMarc BrackeChristian StevensBart Roman

Pharmacological evaluation of the anti-invasive agent 4-fluoro-3',4',5'-trimethoxychalcone

Bart RomanLiselot MusTine De RyckMarc BrackeChristian Stevens

2015

4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model

Bart RomanTine De RyckAtanos PatronovSvetoslav H SlavovBarbara WA VanhoeckeAlan R KatritzkyMarc BrackeChristian Stevens

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A new class of antimicrobial biosurfactants: quaternary ammonium sophorolipids

Elisabeth DelbekeBart RomanGuy MarinKevin Van GeemChristian Stevens

A1 Artikel in een tijdschrift in GREEN CHEMISTRY

Beyond the Diketopiperazine Family with Alternatively Bridged Brevianamide F Analogues

Iris WautersHannelore GoossensElisabeth DelbekeKoen MuylaertBart RomanKristof Van HeckeVeronique Van SpeybroeckChristian Stevens

A1 Artikel in een tijdschrift in JOURNAL OF ORGANIC CHEMISTRY

Chick heart invasion assay for testing the invasiveness of cancer cells and the activity of potentially anti-invasive compounds

Marc BrackeBart RomanChristian StevensLiselot MusVirinder ParmarOlivier De WeverMarcus Mareel

A1 Artikel in een tijdschrift in JOVE-JOURNAL OF VISUALIZED EXPERIMENTS

Further studies on anti-invasive chemotypes: an excursion from chalcones to curcuminoids

Bart RomanTine De RyckSigrid VerhasseltMarc BrackeChristian Stevens

A1 Artikel in een tijdschrift in BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Homogeneous gold-catalyzed cyclization reactions of alkynes with N- and S-nucleophiles

Wouter DebrouwerThomas HeugebaertBart RomanChristian Stevens

A1 Artikel in een tijdschrift in ADVANCED SYNTHESIS & CATALYSIS

Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?

Tine De RyckEline VanlanckerCharlotte GrootaertBart RomanLaurens De CoenIsabel VandenbergheChristian StevensMarc BrackeTom Van de WieleBarbara Vanhoecke

A1 Artikel in een tijdschrift in AMB EXPRESS

2014

Feruloyl benzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study

Bart RomanJean-Christophe MonbaliuLaurens De CoenSigrid VerhasseltChristian Stevens

Feruloylbenzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study towards O-, N-, S-, and C- nucleophiles

Bart RomanJean-Christophe MonbaliuLaurens De CoenSigrid VerhasseltBart SchuddinckEvelien Van HoeylandtChristian Stevens

A1 Artikel in een tijdschrift in EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Functions incorporating a halogen and another group other than a halogen or a chalcogen

Bart RomanThomas HeugebaertChristian Stevens

Hoofdstuk in een boek in Reference module in chemistry, molecular sciences and chemical engineering

Green surface-active compounds from the chemical modification of sophorolipids

Elisabeth DelbekeJelle Van den AbeeleBart RomanKevin Van GeemChristian Stevens

On the quest for new anti-invasive agents: from the discovery of 4-fluoro-3',4','5'-trimethoxychalcone to its initial validation in an in vivo metastasis model

Bart RomanTine De RyckSigrid VerhasseltAlan KatritzkyMarc BrackeChristian Stevens

2013

Assessment of the antineoplastic potential of chalcones in animal models

Bart RomanThomas HeugebaertMarc BrackeChristian Stevens

A1 Artikel in een tijdschrift in CURRENT MEDICINAL CHEMISTRY

Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes

Bart RomanLaurens De CoenSéverine MortierTine De RyckBarbara VanhoeckeAlan R KatritzkyMarc BrackeChristian Stevens

A1 Artikel in een tijdschrift in BIOORGANIC & MEDICINAL CHEMISTRY

Feruloyl benzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study

Bart RomanJean-Christophe MonbaliuLaurens De CoenSigrid VerhasseltChristian Stevens

The quest for antimetastatic agents: from natural chalcones to anti-invasive lead candidates

2012

(Q)SAR directed design, synthesis and evaluation of anti-invasive chalcones and analogues

Bart RomanMarc BrackeAlan R KatritzkyChristian Stevens

Continuous synthesis of peralkylated imidazoles and their transformation into ionic liquids with improved (electro)chemical stabilities

Cédric MatonNils De VosBart RomanEvert VanechtNeil R BrooksKoen BinnemansStijn SchaltinJan FransaerChristian Stevens

A1 Artikel in een tijdschrift in CHEMPHYSCHEM

Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues

Bart RomanTine De RyckMarc BrackeAlan KatritzkyChristian Stevens

Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues

Bart RomanTine De RyckLaura DierickxBarbara VanhoeckeAlan R KatritzkyMarc BrackeChristian Stevens

A1 Artikel in een tijdschrift in BIOORGANIC & MEDICINAL CHEMISTRY

QSAR directed design, synthesis and evaluation of anti-invasive chalcones and analogues

Bart RomanTine De RyckMarc BrackeAlan KatritzkyChristian Stevens

QSAR-directed design, synthesis and evaluation of anti-invasive chalcones and analogues

Bart RomanChristian StevensMarc Bracke

Synthesis and reactivity of novel 1H-isochromeno[3,4-d]imidazol-1-onium salts

Bart RomanMarie GuéganNils De VosCédric MatonChristian Stevens

A1 Artikel in een tijdschrift in HETEROCYCLES

Synthesis of isoindoles and related iso-condensed heteroaromatic pyrroles

Thomas HeugebaertBart RomanChristian Stevens

A1 Artikel in een tijdschrift in CHEMICAL SOCIETY REVIEWS

2011

Application of microreactor technology for cyanohydrin production : extending the scope towards renewable resources

Ana CukalovicJean-Christophe MonbaliuBart RomanAnn De BlieckThomas HeugebaertJoris ThybautGuy MarinGeraldine HeynderickxChristian Stevens

Transglucosylation potential of six sucrose phosphorylases toward different classes of acceptors

Dirk AertsTom VerhaegheBart RomanChristian StevensTom DesmetWim Soetaert

A1 Artikel in een tijdschrift in CARBOHYDRATE RESEARCH

2010

A safe production method for acetone cyanohydrin

Thomas HeugebaertBart RomanAnn De BlieckChristian Stevens

A1 Artikel in een tijdschrift in TETRAHEDRON LETTERS

Experimental and computational study of the ring opening of tricyclic oxanorbornenes to polyhydro isoindole phosphonates

Diederica ClaeysChristian StevensBart RomanPieter Van de CaveyeMichel WaroquierVeronique Van Speybroeck

A1 Artikel in een tijdschrift in ORGANIC & BIOMOLECULAR CHEMISTRY

Study on the synthesis, reactivity and melting points of novel 1H-isochromeno[3,4-d]imidazol-1-onium salts

Bart RomanMarie GuéganSebastiaan WuytsChristian Stevens

Synthesis of β-, γ-, δ-, ..., ω-halogenated ketones and aldehydes

Bart RomanNorbert De KimpeChristian Stevens

A1 Artikel in een tijdschrift in CHEMICAL REVIEWS

2009

Cleavage of the Oxanorbornene Oxygen Bridge with Lewis Acids: Computation and Experiment

Diederica ClaeysK. MoonenBart RomanPieter Van de CaveyeVeronique Van SpeybroeckMichel WaroquierChristian Stevens

Exploring multicomponent and heterocyclic coupling reactions using microreactor technology

Christian StevensEric Van Der EyckenBrajendra SinghDavy AckeBart Roman

Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents

Bart RomanChristian StevensBarbara VanhoeckeMarc Bracke

2008

A combined experimental and theoretical investigation of the stereoselectivity in the synthesis of azahetrocyclic phosphonates

Diederica ClaeysKristof MoonenBart RomanVeronique Van SpeybroeckMichel WaroquierChristian Stevens

Microreactor technology : continuous synthesis of 1H-isochromeno[3,4-d]imidazol-5-ones

Davy AckeChristian StevensBart Roman

A1 Artikel in een tijdschrift in ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of tricyclic phosphonopyrrolidines via IMDAF: Experimental and theoretical investigation of the observed stereoselectivity

Diederica ClaeysK MoonenBart RomanVN NEMYKINVV ZHDANKINMichel WaroquierVeronique Van SpeybroeckChristian Stevens

A1 Artikel in een tijdschrift in JOURNAL OF ORGANIC CHEMISTRY

Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents

Bart RomanChristian StevensMarc BrackeBarbara Vanhoecke

Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents

Bart RomanChristian StevensMarc BrackeBarbara Vanhoecke

2007

QSAR directed design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds

Bart RomanChristian StevensMarc BrackeBarbara Vanhoecke