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Onderzoeker
Bart Roman
Profiel
Projecten
Publicaties
Activiteiten
Prijzen & Erkenningen
73
Resultaten
2024
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
Céline Van Dender
Steven Timmermans
Ville Paakinaho
Tineke Vanderhaeghen
Jolien Vandewalle
Maarten Claes
Bruno Garcia
Bart Roman
Jan De Waele
Siska Croubels
et al.
A1
Artikel in een tijdschrift
in
EMBO MOLECULAR MEDICINE
2024
Glioblastoma-associated mesenchymal stem/stromal cells and cancer-associated fibroblasts : partners in crime?
Thibault Lootens
Bart Roman
Christian Stevens
Olivier De Wever
Robrecht Raedt
A1
Artikel in een tijdschrift
in
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
2024
2023
Selective modulation of cancer-associated fibroblasts in the tumor microenvironment by the small molecule inhibitor C16
Christophe Mangodt
Christian Stevens
Olivier De Wever
Bart Roman
Proefschrift
2023
2021
Cytosolic delivery of gadolinium via photoporation enables improved in vivo magnetic resonance imaging of cancer cells
Aranit Harizaj
Benedicte Descamps
Christophe Mangodt
Stephan Stremersch
Arianna Stoppa
Lieve Balcaen
Toon Brans
Hilde De Rooster
Nausikaa Devriendt
Juan Fraire
et al.
A1
Artikel in een tijdschrift
in
BIOMATERIALS SCIENCE
2021
The expanding role of chemistry in optimizing proteins for human health applications
Bart Roman
A1
Artikel in een tijdschrift
in
JOURNAL OF MEDICINAL CHEMISTRY
2021
2020
Genetic events contributing to tumour promotion and aggressiveness in high-risk neuroblastoma
Liselot Mus
Franki Speleman
Kaat Durinck
Bart Roman
Proefschrift
2020
2019
Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study
Marine Movsisyan
Laurens De Coen
Thomas Heugebaert
Arno Verlee
Bart Roman
Christian Stevens
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2019
Essay: Avoiding unfounded health claims on small molecules in scientific literature
Bart Roman
A1
Artikel in een tijdschrift
in
BIOORGANIC CHEMISTRY
2019
Plant based Pickering stabilization of emulsions using soluble flaxseed protein and mucilage nano-assemblies
Maryam Nikbakht Nasrabadi
Sayed Amir Hossein Goli
Ali Sedaghat Doost
Bart Roman
Koen Dewettinck
Christian Stevens
Paul Van der Meeren
A1
Artikel in een tijdschrift
in
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
2019
2018
Atom- and mass-economical continuous flow production of 3-chloropropionyl chloride and its subsequent amidation
Marine Movsisyan
Thomas Heugebaert
Bart Roman
Rudolf Dams
Rudy Van Campenhout
Matthias Conradi
Christian Stevens
A1
Artikel in een tijdschrift
in
CHEMISTRY-A EUROPEAN JOURNAL
2018
From natural flavonoids to pharmacological tools : proceed with caution
Bart Roman
C3
Conferentie
2018
Medicinal chemistry and use of myosin II inhibitor (S)-blebbistatin and its derivatives
Bart Roman
Sigrid Verhasselt
Christian Stevens
A1
Artikel in een tijdschrift
in
JOURNAL OF MEDICINAL CHEMISTRY
2018
Recovering actives in multi-antitarget and target design of analogs of the myosin II inhibitor blebbistatin
Bart Roman
Rita C Guedes
Christian Stevens
Alfonso T García-Sosa
A1
Artikel in een tijdschrift
in
FRONTIERS IN CHEMISTRY
2018
Synthesis and biological activity of oxazolopyrimidines
Laurens De Coen
Bart Roman
Marine Movsisyan
Thomas Heugebaert
Christian Stevens
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2018
Synthesis of C-ring-modified blebbistatin derivatives and evaluation of their myosin II ATPase inhibitory potency
Bart Roman
Sigrid Verhasselt
Christophe Mangodt
Olivier De Wever
Christian Stevens
A1
Artikel in een tijdschrift
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2018
Vehicle development, pharmacokinetics and toxicity of the anti-invasive agent 4-fluoro-3’,4’,5’-trimethoxychalcone in rodents
Liselot Mus
Geertrui Denecker
Franki Speleman
Bart Roman
A1
Artikel in een tijdschrift
in
PLOS ONE
2018
2017
A new class of bicyclic dicationic salts based on the 7-azoniabicyclo[2.2.1]heptane scaffold
Laurens De Coen
Bart Roman
Marine Movsisyan
Brecht D'hont
Nils De Vos
Kristof Van Hecke
Christian Stevens
A1
Artikel in een tijdschrift
in
TETRAHEDRON LETTERS
2017
Anticancer chalcones : selective or multitarget ligands?
Bart Roman
C3
Conferentie
2017
Chalcones as anti-invasive agents : challenges and opportunities
Bart Roman
A2
Artikel in een tijdschrift
in
BELGIAN JOURNAL OF MEDICAL ONCOLOGY
2017
Development of novel blebbistatin derivatives in the quest for improved non-muscle myosin II inhibitors
Sigrid Verhasselt
Christian Stevens
Bart Roman
Marc Bracke
Proefschrift
2017
Discovery of (S)-3′-hydroxyblebbistatin and (S)-3′-aminoblebbistatin : polar myosin II inhibitors with superior research tool properties
Sigrid Verhasselt
Bart Roman
Olivier De Wever
Kristof Van Hecke
Rik Van Deun
Marc Bracke
Christian Stevens
A1
Artikel in een tijdschrift
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2017
Discovery of anti-invasive tools and leads for the study and treatment of metastatic cancer : two case studies
Bart Roman
C3
Conferentie
2017
Improved synthesis and comparative analysis of the tool properties of new and existing D-ring modified (S)-blebbistatin analogs
Sigrid Verhasselt
Bart Roman
Marc Bracke
Christian Stevens
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2017
In vitro celecoxib supplementation impacts the functional capacities of the gut microbiota
Emma Hernandez Sanabria
Evelien Heiremans
Marta Calatayud Arroyo
Bart Roman
Sven Mangelinckx
Laurent Leclercq
Jan Snoeys
Tom Van de Wiele
C3
Conferentie
2017
Insights into the myosin II inhibitory potency of A-ring-modified (S)-blebbistatin analogs
Sigrid Verhasselt
Christian Stevens
Tom Van den broecke
Marc Bracke
Bart Roman
A1
Artikel in een tijdschrift
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2017
Synthesis of 7-azoniabicyclo[2.2.1]heptane-based dicationic liquids
Laurens De Coen
Bart Roman
Brecht D'hont
Nils De Vos
Kristof Van Hecke
Christian Stevens
C3
Conferentie
2017
2016
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent : from discovery to initial validation in an in vivo metastasis model
Bart Roman
Liselot Mus
Tine De Ryck
Marc Bracke
Christian Stevens
C3
Conferentie
2016
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model
Bart Roman
Liselot Mus
Marc Bracke
Christian Stevens
C3
Conferentie
2016
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model
Bart Roman
Liselot Mus
Tine De Ryck
Marc Bracke
Christian Stevens
C3
Conferentie
2016
Discovery and development of new anti-invasive agents, an unmet clinical need
Bart Roman
Liselot Mus
Tine De Ryck
Marc Bracke
Christian Stevens
C3
Conferentie
2016
Discovery of anti-invasive tools and leads for the study and treatment of metastatic cancer : two case studies
Bart Roman
Sigrid Verhasselt
Marc Bracke
Christian Stevens
C3
Conferentie
2016
Discovery of novel nonmuscle myosin II inhibitors as antimetastatic therapeutics leads and chemical tools
Sigrid Verhasselt
Marc Bracke
Christian Stevens
Bart Roman
C3
Conferentie
2016
Discovery of novel nonmuscle myosin II inhibitors as chemical tools and antimetastatic therapeutics leads
Sigrid Verhasselt
Marc Bracke
Christian Stevens
Bart Roman
C3
Conferentie
2016
Pharmacological evaluation of the anti-invasive agent 4-fluoro-3',4',5'-trimethoxychalcone
Bart Roman
Liselot Mus
Tine De Ryck
Marc Bracke
Christian Stevens
C3
Conferentie
2016
2015
4-Fluoro-3',4',5'-trimethoxychalcone as a new anti-invasive agent: from discovery to initial validation in an in vivo metastasis model
Bart Roman
Tine De Ryck
Atanos Patronov
Svetoslav H Slavov
Barbara WA Vanhoecke
Alan R Katritzky
Marc Bracke
Christian Stevens
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
2015
A new class of antimicrobial biosurfactants: quaternary ammonium sophorolipids
Elisabeth Delbeke
Bart Roman
Guy Marin
Kevin Van Geem
Christian Stevens
A1
Artikel in een tijdschrift
in
GREEN CHEMISTRY
2015
Beyond the Diketopiperazine Family with Alternatively Bridged Brevianamide F Analogues
Iris Wauters
Hannelore Goossens
Elisabeth Delbeke
Koen Muylaert
Bart Roman
Kristof Van Hecke
Veronique Van Speybroeck
Christian Stevens
A1
Artikel in een tijdschrift
in
JOURNAL OF ORGANIC CHEMISTRY
2015
Chick heart invasion assay for testing the invasiveness of cancer cells and the activity of potentially anti-invasive compounds
Marc Bracke
Bart Roman
Christian Stevens
Liselot Mus
Virinder Parmar
Olivier De Wever
Marcus Mareel
A1
Artikel in een tijdschrift
in
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
2015
Further studies on anti-invasive chemotypes: an excursion from chalcones to curcuminoids
Bart Roman
Tine De Ryck
Sigrid Verhasselt
Marc Bracke
Christian Stevens
A1
Artikel in een tijdschrift
in
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2015
Homogeneous gold-catalyzed cyclization reactions of alkynes with N- and S-nucleophiles
Wouter Debrouwer
Thomas Heugebaert
Bart Roman
Christian Stevens
A1
Artikel in een tijdschrift
in
ADVANCED SYNTHESIS & CATALYSIS
2015
Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?
Tine De Ryck
Eline Vanlancker
Charlotte Grootaert
Bart Roman
Laurens De Coen
Isabel Vandenberghe
Christian Stevens
Marc Bracke
Tom Van de Wiele
Barbara Vanhoecke
A1
Artikel in een tijdschrift
in
AMB EXPRESS
2015
2014
Feruloyl benzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study
Bart Roman
Jean-Christophe Monbaliu
Laurens De Coen
Sigrid Verhasselt
Christian Stevens
C3
Conferentie
2014
Feruloylbenzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study towards O-, N-, S-, and C- nucleophiles
Bart Roman
Jean-Christophe Monbaliu
Laurens De Coen
Sigrid Verhasselt
Bart Schuddinck
Evelien Van Hoeylandt
Christian Stevens
A1
Artikel in een tijdschrift
in
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
2014
Functions incorporating a halogen and another group other than a halogen or a chalcogen
Bart Roman
Thomas Heugebaert
Christian Stevens
Hoofdstuk in een boek
in
Reference module in chemistry, molecular sciences and chemical engineering
2014
Green surface-active compounds from the chemical modification of sophorolipids
Elisabeth Delbeke
Jelle Van den Abeele
Bart Roman
Kevin Van Geem
Christian Stevens
C3
Conferentie
2014
On the quest for new anti-invasive agents: from the discovery of 4-fluoro-3',4','5'-trimethoxychalcone to its initial validation in an in vivo metastasis model
Bart Roman
Tine De Ryck
Sigrid Verhasselt
Alan Katritzky
Marc Bracke
Christian Stevens
C3
Conferentie
2014
2013
Assessment of the antineoplastic potential of chalcones in animal models
Bart Roman
Thomas Heugebaert
Marc Bracke
Christian Stevens
A1
Artikel in een tijdschrift
in
CURRENT MEDICINAL CHEMISTRY
2013
Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes
Bart Roman
Laurens De Coen
Séverine Mortier
Tine De Ryck
Barbara Vanhoecke
Alan R Katritzky
Marc Bracke
Christian Stevens
A1
Artikel in een tijdschrift
in
BIOORGANIC & MEDICINAL CHEMISTRY
2013
Feruloyl benzotriazole and Weinreb amide as bioinspired building blocks: a reactivity study
Bart Roman
Jean-Christophe Monbaliu
Laurens De Coen
Sigrid Verhasselt
Christian Stevens
C3
Conferentie
2013
The quest for antimetastatic agents: from natural chalcones to anti-invasive lead candidates
Bart Roman
C3
Conferentie
2013
2012
(Q)SAR directed design, synthesis and evaluation of anti-invasive chalcones and analogues
Bart Roman
Marc Bracke
Alan R Katritzky
Christian Stevens
C3
Conferentie
2012
Continuous synthesis of peralkylated imidazoles and their transformation into ionic liquids with improved (electro)chemical stabilities
Cédric Maton
Nils De Vos
Bart Roman
Evert Vanecht
Neil R Brooks
Koen Binnemans
Stijn Schaltin
Jan Fransaer
Christian Stevens
A1
Artikel in een tijdschrift
in
CHEMPHYSCHEM
2012
Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues
Bart Roman
Tine De Ryck
Marc Bracke
Alan Katritzky
Christian Stevens
C3
Conferentie
2012
Exploration of the SAR of anti-invasive chalcones: synthesis and biological evaluation of conformationally restricted analogues
Bart Roman
Tine De Ryck
Laura Dierickx
Barbara Vanhoecke
Alan R Katritzky
Marc Bracke
Christian Stevens
A1
Artikel in een tijdschrift
in
BIOORGANIC & MEDICINAL CHEMISTRY
2012
QSAR directed design, synthesis and evaluation of anti-invasive chalcones and analogues
Bart Roman
Tine De Ryck
Marc Bracke
Alan Katritzky
Christian Stevens
C3
Conferentie
2012
QSAR-directed design, synthesis and evaluation of anti-invasive chalcones and analogues
Bart Roman
Christian Stevens
Marc Bracke
Proefschrift
2012
Synthesis and reactivity of novel 1H-isochromeno[3,4-d]imidazol-1-onium salts
Bart Roman
Marie Guégan
Nils De Vos
Cédric Maton
Christian Stevens
A1
Artikel in een tijdschrift
in
HETEROCYCLES
2012
Synthesis of isoindoles and related iso-condensed heteroaromatic pyrroles
Thomas Heugebaert
Bart Roman
Christian Stevens
A1
Artikel in een tijdschrift
in
CHEMICAL SOCIETY REVIEWS
2012
2011
Application of microreactor technology for cyanohydrin production : extending the scope towards renewable resources
Ana Cukalovic
Jean-Christophe Monbaliu
Bart Roman
Ann De Blieck
Thomas Heugebaert
Joris Thybaut
Guy Marin
Geraldine Heynderickx
Christian Stevens
C3
Conferentie
2011
Transglucosylation potential of six sucrose phosphorylases toward different classes of acceptors
Dirk Aerts
Tom Verhaeghe
Bart Roman
Christian Stevens
Tom Desmet
Wim Soetaert
A1
Artikel in een tijdschrift
in
CARBOHYDRATE RESEARCH
2011
2010
A safe production method for acetone cyanohydrin
Thomas Heugebaert
Bart Roman
Ann De Blieck
Christian Stevens
A1
Artikel in een tijdschrift
in
TETRAHEDRON LETTERS
2010
Experimental and computational study of the ring opening of tricyclic oxanorbornenes to polyhydro isoindole phosphonates
Diederica Claeys
Christian Stevens
Bart Roman
Pieter Van de Caveye
Michel Waroquier
Veronique Van Speybroeck
A1
Artikel in een tijdschrift
in
ORGANIC & BIOMOLECULAR CHEMISTRY
2010
Study on the synthesis, reactivity and melting points of novel 1H-isochromeno[3,4-d]imidazol-1-onium salts
Bart Roman
Marie Guégan
Sebastiaan Wuyts
Christian Stevens
C3
Conferentie
2010
Synthesis of β-, γ-, δ-, ..., ω-halogenated ketones and aldehydes
Bart Roman
Norbert De Kimpe
Christian Stevens
A1
Artikel in een tijdschrift
in
CHEMICAL REVIEWS
2010
2009
Cleavage of the Oxanorbornene Oxygen Bridge with Lewis Acids: Computation and Experiment
Diederica Claeys
K. Moonen
Bart Roman
Pieter Van de Caveye
Veronique Van Speybroeck
Michel Waroquier
Christian Stevens
C3
Conferentie
2009
Exploring multicomponent and heterocyclic coupling reactions using microreactor technology
Christian Stevens
Eric Van Der Eycken
Brajendra Singh
Davy Acke
Bart Roman
C3
Conferentie
2009
Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents
Bart Roman
Christian Stevens
Barbara Vanhoecke
Marc Bracke
C3
Conferentie
2009
2008
A combined experimental and theoretical investigation of the stereoselectivity in the synthesis of azahetrocyclic phosphonates
Diederica Claeys
Kristof Moonen
Bart Roman
Veronique Van Speybroeck
Michel Waroquier
Christian Stevens
C3
Conferentie
2008
Microreactor technology : continuous synthesis of 1H-isochromeno[3,4-d]imidazol-5-ones
Davy Acke
Christian Stevens
Bart Roman
A1
Artikel in een tijdschrift
in
ORGANIC PROCESS RESEARCH & DEVELOPMENT
2008
Synthesis of tricyclic phosphonopyrrolidines via IMDAF: Experimental and theoretical investigation of the observed stereoselectivity
Diederica Claeys
K Moonen
Bart Roman
VN NEMYKIN
VV ZHDANKIN
Michel Waroquier
Veronique Van Speybroeck
Christian Stevens
A1
Artikel in een tijdschrift
in
JOURNAL OF ORGANIC CHEMISTRY
2008
Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents
Bart Roman
Christian Stevens
Marc Bracke
Barbara Vanhoecke
C3
Conferentie
2008
Synthesis, biological evaluation and 2D-QSAR analysis of chalcones as anti-invasive cancer agents
Bart Roman
Christian Stevens
Marc Bracke
Barbara Vanhoecke
C3
Conferentie
2008
2007
QSAR directed design, synthesis and evaluation of anti-invasive chalcones and related heterocyclic compounds
Bart Roman
Christian Stevens
Marc Bracke
Barbara Vanhoecke
C3
Conferentie
2007