The project aims to gain insight into the JAK / STAT pathway in psoriasis and other immune-related inflammatory skin diseases, identification of therapeutic targets after treatment of psoriasis patients with biologicals. and the development of an in vitro and in vivo translational psoriasis model. After validation of the models to serve various classes of therapeutic molecules (siRNA or small molecules) to be tested for the treatment of psoriasis, either administered systemically or topically (in which the liposomal formulation by means of ultradeformable liposomes will be optimized).