Project

Funtionalised Azabicycloalkanes as conformational restricted Skeletons for structural Analogues of physiological active compounds

Duration
01 January 2007 → 31 October 2011
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Natural sciences
    • Organic chemistry
    • Other chemical sciences
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
  • Agricultural and food sciences
    • Agricultural plant production
Keywords
epibatidine azabicycloalkanes methanoproline
 
Project description

The cyanide induced dynamic intramolecular cyclization will be further developed for the synthesis of new azabicyclic skeletons which are important in agrochemistry and pharmaceutical industry. During this study, the attention will be focussed on the synthesis of new 2,4-methanoproline analogues (anti-feedant) as well as tricyclic methanoproline analogues and the syntesis of epibatidine analogues (analgesic activity).