Study of the role of the NF-B regulatory protein A20 in autoimmune central nervous system inflammation

01 January 2011 → 31 December 2014
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Social sciences
    • Biological and physiological psychology
    • Cognitive science and intelligent systems
    • Developmental psychology and ageing
  • Medical and health sciences
    • Neurosciences
    • Neurosciences
    • Neurosciences
CNS Multiple Sclerosis (MS) inflammation NF-kB A20
Project description

The research project concerns the study of the inflammatory mechanisms involving NF-B, more specifically in the context of the autoimmune disease multiple sclerosis. For this purpose, we use mice genetically defective in major NF-B-regulatory genes, and use them in mouse models for multiple sclerosis. With this project we hope to gain a better understanding of the specific functions of some of these genes in multiple sclerosis.