Development of a self-emulsifying solid dosage form via co-processing of polyglycolised glyceride/polymer-mixtures with pharmaceutical carriers: enhancement of the bioavailability of poorly water soluble drugs

01 January 2007 → 31 December 2012
Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Biomarker discovery and evaluation
    • Drug discovery and development
    • Medicinal products
    • Pharmaceutics
    • Pharmacognosy and phytochemistry
    • Pharmacology
    • Pharmacotherapy
    • Toxicology and toxinology
    • Other pharmaceutical sciences
solubility pharmaceutical technology bio-availability
Project description

The first aim of this project is to evaluate the potential of polyglycolised glyceride/polymer-mixtures for improving the solubility and bioavailability of itraconazole (used as a model for poorly water soluble drugs). The second aim of this project is to co-process the drug/SEDDS-mixture with a carrier in order to obtain a product (powder, granules) suitable for compression.