Project

Expedient purification of bioactive small molecules and/or their PEG conjugates using automated preparative HPLC

Code
01B02015
Duration
01 June 2015 → 31 May 2017
Funding
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Medicinal chemistry
    • Small molecules
Keywords
sulfated glycolipids Preparative HPLC system small molecules medicinal chemistry divalent GPCR ligands polyethyleneglycol conjugates phosphonates
 
Project description

Generating compounds of high purity is an absolute necessity in medicinal chemistry. Only preparative HPLC allows us to purify adequate amounts of non crystalline material to an acceptable purity. Our laboratory is frequently highly dependent on HPLC purification. Access to a robust preparative HPLC system is crucial for the purification of several classes of molecules under development in our lab.