Project

Beurs EVDS Siebe Loontiens: Unraveling the functionality of PHF6 in normal and malignant T-cell development and its cooperativity with established oncogenes through zebrafish modeling

Code
365M03418
Duration
01 October 2018 → 30 September 2019
Funding
Funding by bilateral agreement (private and foundations)
Research disciplines
  • Medical and health sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other basic sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Laboratory medicine
    • Palliative care and end-of-life care
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
PHF6 zebrafish modeling
 
Project description

The research project focusses on designing a model that mimics breast cancer metastasis. Today, 90% of breast cancer (BC) death is caused by metastasis. This is largely because we are still unable to understand the mechanisms of metastatic progression. Consequently, we are unable to drug and treat to cure metastatic disease. Better models of cancer metastasis will lead to more fundamental insights. Drug evaluation using this model will enable clinicians to make more rational decisions for drug efficiency. In our project, we will reconstruct the primary breast tumor and metastatic target organs such as liver, lung and bone (the most common clinical breast cancer metastasis organs).