Project

Study of the transcriptional cross-talk between PPARα and ERRα

Duration
01 October 2012 → 30 September 2016
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Systems biology
  • Medical and health sciences
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
    • Medical biochemistry and metabolism
Keywords
gene transcription nuclear receptors molecular endocrinology
 
Project description

We found a direct link between a key regulator of oxidative metabolism, ERR, and a nuclear receptor that mediates not only metabolic but also anti-inflammatory actions (PPAR). The main objectives are to understand the function and mechanism of this interaction, to identify modulators hereof and to investigate the interaction profile in a relevant animal disease model or human heart tissue.