Project

TAOK3 as a regulator of metabolic responses.

Duration
01 October 2015 → 30 September 2019
Funding
Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Biochemistry and metabolism
    • Other biological sciences
  • Medical and health sciences
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Palliative care and end-of-life care
    • Physiology
    • Regenerative medicine
    • Other basic sciences
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Palliative care and end-of-life care
    • Physiology
    • Regenerative medicine
    • Other clinical sciences
    • Other health sciences
    • Nursing
    • Other paramedical sciences
    • Laboratory medicine
    • Medical biochemistry and metabolism
    • Palliative care and end-of-life care
    • Physiology
    • Regenerative medicine
    • Other translational sciences
    • Other medical and health sciences
Keywords
Metabolisme Notch Signaling insulin resistance endoplasmatic reticulum stress high fat PPARγ signaling TAO kinase 3
 
Project description

My host lab previously identified a role for the Ste20 kinase TAOK3 in metabolism. TAOK3 deficient mice are markedly protected against high fat diet induced insulin resistance. The current project aims at deciphering how TAOK3 affects cellular and organismal metabolism looking at both altered lipid metabolism, glucose metabolism and peripheral insulin resistance with specific focus on Notch, PPARg and ER stress pathways.