Although it has been shown that it is possible to protect animals against worm infections through vaccination, currently there are only 2 vaccines commercially available. The main bottleneck is the large-scale production of immune-protective antigens. The reason for failure is mostly attributed to inappropriate recombinant expression. In order to solve this problem, our research is specifically aimed at unravelling the protective immune mechanisms following vaccination and the antigenic components that are needed to trigger such response. Recently, for the first time ever, we have been able to show that the N-linked glycans present on 2 vaccine antigens are important in the recognition of the antigens by the immune system. This information is now being used to steer the recombinant expression work. It is our intention to further pursue this line of research and extend to other nematode species as it could provide a major breakthrough in the area of anti-nematode vaccine development.