Project

Identification of primary target genes of the canonical Wnt pathway and assessment of their clinical relevance to cancer

Duration
01 October 2007 → 30 September 2011
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Animal biology
    • Genetics
  • Medical and health sciences
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
    • Morphological sciences
    • Oncology
  • Agricultural and food sciences
    • Veterinary medicine
Keywords
cancer embryonic development oncogenes
 
Project description

We want to identify novel target genes of the canonical Wnt pathway, which is often aberrantly activated in human cancer. These genes will be identified in different organs of trangenic tadpoles (Xenopus) in which the wnt pathway is genetically manipulated. We will then screen whether these genes are also enriched in human samples with an activated Wnt pathway.