p53 is the most frequently inactivated protein in human cancers. It works as a transcription factor responsible for the majority of stress-responses which protect cells from transformation. Despite thorough studies, the p53 pathway is not fully elucidated. This project investigates p53-mediated and histone-methyl-transferase-dependent epigenetic silencing of genes and stabilisation of chromosomal heterochromatin domains, and will hopefully result in novel epigenetics-based human cancer therapies.