Project

Molecular optimisation of azaphosphonodienes

Code
3E001210
Duration
01 October 2010 → 30 September 2013
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Natural sciences
    • Organic chemistry
Keywords
phosphonoazadienes modified peptides Computational chemistry azaheterocycles aminophosphonic microreactors biologically active molecules
 
Project description

Aminophosphonic derivates are an important class of biologically active molecules. In this research, we consider phosphonoazadienes as valuable building blocks for the synthesis of such compounds. Phosphonoazadienes form a particular class of ambivalent reagents (electrophiles/dienes). A profound understanding of their behaviour (computational chemistry) will guide us in the synthesis of new tunable phosphonoazadienes, opening the way to new 1-phosphono azaheterocycles.