Role of angiogenesis and angiogenic growth factors (VEGF, PLGF) in portal hypertension and fibrosis formation in animal models of cirrhosis, steatosis and portal hypertension

01 January 2009 → 31 October 2013
Regional and community funding: Special Research Fund
Research disciplines
  • Medical and health sciences
    • Gastro-enterology and hepatology
    • Gastro-enterology and hepatology
    • Gastro-enterology and hepatology
cirrhosis portal hypertension angiogenesis
Project description

Models of portal hypertension and cirrhosis are used to study prevention and reversibility of collateral formation (in peripheral, splanchnic and pulmonary area), by treating mice with anti-PLGF and by using PLGF knock-out mice. Fibrosis formation and the role of hepatic stellate cells in the angiogenesis setting will be studied. In mice models of NASH will be the role of angiogenesis in fibrosis and colalteral formation studied in different stages of steatosis.