Code
01J01209
Duration
01 January 2009 → 31 October 2013
Funding
Regional and community funding: Special Research Fund
Promotor
Research disciplines
-
Medical and health sciences
- Gastro-enterology and hepatology
- Gastro-enterology and hepatology
- Gastro-enterology and hepatology
Keywords
cirrhosis
portal hypertension
angiogenesis
Project description
Models of portal hypertension and cirrhosis are used to study prevention and reversibility of collateral formation (in peripheral, splanchnic and pulmonary area), by treating mice with anti-PLGF and by using PLGF knock-out mice. Fibrosis formation and the role of hepatic stellate cells in the angiogenesis setting will be studied. In mice models of NASH will be the role of angiogenesis in fibrosis and colalteral formation studied in different stages of steatosis.