Project

Impact on angiogenesis and ER stress and its effect on chemoresistance through PlGF inhibition in a mice model of hepatocellular carcinoma

Code

3G015612

Duration

01 January 2012 → 31 December 2017

Funding

Research Foundation - Flanders (FWO)

Promotor

Hans Van Vlierberghe

Research disciplines

Medical and health sciences
- Gastro-enterology and hepatology
- Morphological sciences
- Oncology
- Gastro-enterology and hepatology
- Morphological sciences
- Oncology
- Gastro-enterology and hepatology
- Morphological sciences
- Oncology

Keywords

hepatocellular carcinoma chemoresistance angiogenesis ER stress

Project description

Systemic chemotherapy with classical cytotoxic drugs in hepatocellular carcinoma yields low objective response rates due to chemoresistance. It is well known that as wel hypoxia as ER stress could be the cause of chemoresitance. The efficay and safety of anti-PlGF and farnesylthiosalicylic acidmay consitute a novel approach for cancer treatment. This will be evaluated in a HCC mouse model.