Project

Study of the role of RIP4 kinase in cancer and inflammation

Duration
01 October 2007 → 30 September 2014
Funding
Regional and community funding: Special Research Fund, Research Foundation - Flanders (FWO)
Research disciplines
  • Medical and health sciences
    • Dermatology
    • Morphological sciences
    • Oncology
    • Dermatology
    • Morphological sciences
    • Oncology
    • Dermatology
    • Morphological sciences
    • Oncology
Keywords
keratinocyte RIP kinases NF-kB skin disease
 
Project description

Defects in the balance between keratinocyte proliferation and differentiation are at the basis of a wide variety of skin disorders, such as psoriasis, dermatitis and cancer. RIP4 kinase is important for epidermal differentiation. In addition RIP4 has been implicated in B cell lymphoma malignancy. We will study the role of RIP4 in keratinocyte differentiation, inflammation and cancer.